Immunology:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York
Freeman
1997
|
| Ausgabe: | 3. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXIV, 664 S. Ill., zahlr. graph. Darst. |
| ISBN: | 0716728680 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV011745893 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | t | ||
| 008 | 980202s1997 ad|| |||| 00||| eng d | ||
| 020 | |a 0716728680 |9 0-7167-2868-0 | ||
| 035 | |a (OCoLC)36127172 | ||
| 035 | |a (DE-599)BVBBV011745893 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-91 |a DE-19 |a DE-188 | ||
| 050 | 0 | |a QR181 | |
| 082 | 0 | |a 616.07/9 |2 21 | |
| 084 | |a WF 9800 |0 (DE-625)148471: |2 rvk | ||
| 100 | 1 | |a Kuby, Janis |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Immunology |c Janis Kuby |
| 250 | |a 3. ed. | ||
| 264 | 1 | |a New York |b Freeman |c 1997 | |
| 300 | |a XXIV, 664 S. |b Ill., zahlr. graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a Immunology |2 cabt | |
| 650 | 7 | |a Immune system |2 cabt | |
| 650 | 7 | |a B Lymphocytes |2 cabt | |
| 650 | 7 | |a Immune Response |2 cabt | |
| 650 | 7 | |a Immunoglobulins |2 cabt | |
| 650 | 7 | |a Immunological Diseases |2 cabt | |
| 650 | 7 | |a Antigenen |2 gtt | |
| 650 | 7 | |a Cytochemie |2 gtt | |
| 650 | 7 | |a Cytokinen |2 gtt | |
| 650 | 7 | |a Histocompatibiliteit |2 gtt | |
| 650 | 7 | |a Immunoglobulinen |2 gtt | |
| 650 | 4 | |a Immunologie | |
| 650 | 7 | |a Immunologie |2 gtt | |
| 650 | 7 | |a Imunologia |2 larpcal | |
| 650 | 7 | |a Leukocyten |2 gtt | |
| 650 | 7 | |a Recombinant DNA |2 gtt | |
| 650 | 4 | |a Immune System | |
| 650 | 4 | |a Immunity | |
| 650 | 4 | |a Immunology | |
| 650 | 0 | 7 | |a Immunsystem |0 (DE-588)4026643-6 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Immunologie |0 (DE-588)4026637-0 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Immunologie |0 (DE-588)4026637-0 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Immunsystem |0 (DE-588)4026643-6 |D s |
| 689 | 1 | |8 1\p |5 DE-604 | |
| 856 | 4 | 2 | |m HEBIS Datenaustausch Darmstadt |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007924906&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-007924906 | ||
| 883 | 1 | |8 1\p |a cgwrk |d 20201028 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | |
Datensatz im Suchindex
| _version_ | 1804126288189849600 |
|---|---|
| adam_text | M M U N O L O G Y T H I R D E D I T I O N L IH * R **/ WIH/.MJ NIM /MIL
** VIFI ( MIIR IF; / I II/JJ /**ML /I // LL I L *! ILLL I MI I IL) OF
I IHLOIIUI IT LIT,K T L] I-ILI MWRI IVL TTI LS I ,LI I!..( H IN - I!I
- R I I I I M MI I - SI ILLLLT J,, .HLL TW.IJO ID D H 4 ^ » 7 U D R M
B I D D T INV.-NR. W . H . F R E E M A N A N D C O M P A N Y NEW YORK
FOREWORD / XVII PREFACE / XIX P A R T INTRODUCTION /1 C H A P T E R
OVERVIEW OF THE IMMUNE SYSTEM / 3 HISTORICAL PERSPECTIVE 3 DISCOVERY OF
HUMORAL AND CELLULAR IMMUNITY / 5 EARLY THEORIES OF IMMUNITY / 6
COMPONENTS OF IMMUNITY / 6 INNATE (NONSPECIFIC) IMMUNITY 6 ANATOMIC
BARRIERS / 7 PHYSIOLOGIC BARRIERS / 8 ENDOCYTIC AND PHAGOCYTIC BARRIERS
/ 9 BARRIERS CREATED BY THE INFLAMMATORY RESPONSE /10 ACQUIRED
(SPECIFIC) IMMUNITY 12 CELLS OF THE IMMUNE SYSTEM /12 B LYMPHOCYTES /12
T LYMPHOCYTES/ 12 ANTIGEN-PRESENTING CELLS /13 FUNCTIONS OF HUMORAL AND
CELL-MEDIATED IMMUNE RESPONSES/13 RECOGNITION OF ANTIGEN BY B AND T
LYMPHOCYTES /14 GENERATION OF LYMPHOCYTE SPECIFICITY AND DIVERSITY/16
ROLE OF THE MAJOR HISTOCOMPATIBILITY COMPLEX /16 PROCESSING AND
PRESENTATION OF ANTIGENS /17 CLONAL SELECTION OF LYMPHOCYTES /17
CELLULAR INTERACTIONS REQUIRED FOR GENERATION OF IMMUNE RESPONSES / 20
ACTIVATION AND PROLIFERATION OF T HELPER CELLS / 20 GENERATION OF THE
HUMORAL RESPONSE / 21 GENERATION OF THE CELL-MEDIATED RESPONSE / 21
SUMMARY 22 REFERENCES 22 STUDY QUESTIONS 23 C H A P T E R 2 EXPERIMENTAL
SYSTEMS / 25 EXPERIMENTAL ANIMAL MODELS INBRED STRAINS / 26
ADOPTIVE-TRANSFER SYSTEMS / 28 SCID MICE AND SCID-HUMAN MICE / 28
CELL-CULTURE SYSTEMS PRIMARY LYMPHOID CELL CULTURES / 29 CLONED LYMPHOID
CELL LINES /29 HYBRID LYMPHOID CELL LINES / 31 RECOMBINANT DNA
TECHNOLOGY 25 29 32 VIII CONTENTS RESTRICTION-ENDONUCLEASE CLEAVAGE OF
DNA/ 32 CLONING OF DNA SEQUENCES / 32 CLONING VECTORS / 32 CLONING OF
CDNA AND GENOMIC DNA / 33 SELECTION OF DNA CLONES / 34 SOUTHERN BLOTTING
/ 35 NORTHERN BLOTTING / 35 POLYMERASE CHAIN REACTION / 36 ANALYSIS OF
DNA REGULATORY SEQUENCES DNA FOOTPRINTING / 38 GEL-SHIFT ANALYSIS / 39
CAT ASSAY / 39 GENE TRANSFER INTO MAMMALIAN CELLS TRANSFER OF CLONED
GENES INTO CULTURED CELLS / 39 TRANSFER OF CLONED GENES INTO MOUSE
EMBRYOS / 40 TRANSGENIC MICE / 40 GENE-TARGETED KNOCK-OUT MICE / 41
SUMMARY REFERENCES STUDY QUESTIONS C H P T CELLS AND ORGANS OF THE
IMMUNE SYSTEM / 47 HEMATOPOIESIS HEMATOPOIETIC GROWTH FACTORS / 49
REGULATION OF HEMATOPOIESIS / 51 PROGRAMMED CELL DEATH / 53 REGULATORY
ABNORMALITIES AND LEUKEMIA / 54 ENRICHMENT OF HEMATOPOIETIC STEM CELLS /
55 CLINICAL USES OF PLURIPOTENT STEM CELLS / 57 TRANSPLANTATION OF BONE
MARROW / 58 GENE THERAPY WITH ENGINEERED STEM CELLS / 58 IMMUNE-SYSTEM
CELLS 59 LYMPHOID CELLS / 59 B LYMPHOCYTES / 61 T LYMPHOCYTES / 62
NULL CELLS / 63 37 MONONUCLEAR CELLS / 64 PHAGOCYTOSIS /65 ANTIMICROBIAL
AND CYTOTOXIC ACTIVITIES / 65 ANTIGEN PROCESSING AND PRESENTATION / 66
3G SECRETION OF FACTORS / 67 GRANULOCYTIC CELLS / 67 NEUTROPHILS / 67
EOSINOPHILS / 68 BASOPHILS / 68 MAST CELLS / 68 DENDRITIC CELLS / 69
ORGANS OF THE IMMUNE SYSTEM 70 PRIMARY LYMPHOID ORGANS / 71 THYMUS / 71
BONE MARROW / 73 LYMPHATIC SYSTEM / 74 SECONDARY LYMPHOID ORGANS / 74
LYMPH NODES / 75 SPLEEN / 77 47 MUCOSAL-ASSOCIATED LYMPHOID TISSUE / 78
CUTANEOUS-ASSOCIATED LYMPHOID TISSUE / 78 SUMMARY 80 REFERENCES 81 STUDY
QUESTIONS 82 43 44 44 P A R T I I ANTIGENS/87 87 G E N E R A T I O N OF
B-CELL A N D T-CELL R E S P O N S E S / 8 5 CONTRIBUTION OF THE
BIOLOGICAL SYSTEM TO IMMUNOGENICITY / 90 GENOTYPE OF THE RECIPIENT
ANIMAL / 90 IMMUNOCEN DOSAGE AND ROUTE OF ADMINISTRATION / 91 ADJUVANTS
/ 91 EPITOPES 92 PROPERTIES OF B-CELL EPITOPES / 92 PROPERTIES OF T-CELL
EPITOPES / 98 HAPTENS AND THE STUDY OF ANTIGENICITY 100 MITOGENS 101
IMMUNOGENICITY VERSUS ANTIGENICITY FACTORS THAT INFLUENCE IMMUNOGENICITY
CONTRIBUTION OF THE IMMUNOGEN TO IMMUNOGENICITY / 88 FOREIGNNESS / 88
MOLECULAR SIZE / 88 CHEMICAL COMPOSITION AND HETEROGENEITY / 89
SUSCEPTIBILITY TO ANTIGEN PROCESSING AND PRESENTATION /90 CONTENTS IX
SUMMARY REFERENCES STUDY QUESTIONS 104 105 105 C H A P T E R
ANTIGEN-ANTIBODY INTERACTIONS/143 C H A P T E R IMMUNOGLOBULINS:
STRUCTURE AND FUNCTION / 107 BASIC STRUCTURE OF IMMUNOGLOBULINS 108
IMMUNOGLOBULIN SEQUENCING STUDIES 109 ROLE OF MULTIPLE MYELOMA /109
LIGHT-CHAIN SEQUENCING /110 HEAVY-CHAIN SEQUENCING /110 IMMUNOGLOBULIN
FINE STRUCTURE 111 IMMUNOGLOBULIN DOMAINS /111 VARIABLE-REGION DOMAINS
/113 CDRS AND ANTIGEN BINDING /115 CONFORMATIONAL CHANGES INDUCED BY
ANTIGEN BINDING/117 CONSTANT-REGION DOMAINS/118 C H 1 AND C L DOMAINS /
118 HINGE REGION/119 OTHER CONSTANT-REGION DOMAINS / 120 B-CELL RECEPTOR
121 ANTIGENIC DETERMINANTS ON IMMUNOGLOBULINS 122 JSOTYPIC DETERMINANTS
/122 ALLOTYPIC DETERMINANTS /122 IDIOTYPIC DETERMINANTS /123
IMMUNOGLOBULIN CLASSES 123 IMMUNOGLOBULIN G (IGC) /123 IMMUNOGLOBULIN M
(IGM) /123 IMMUNOGLOBULIN A (IGA) /125 IMMUNOGLOBULIN E (IGE) /127
IMMUNOGLOBULIN D (IGD) /129 THE IMMUNOGLOBULIN SUPERFAMILY 129
MONOCLONAL ANTIBODIES 131 FORMATION AND SELECTION OF HYBRID CELLS /132
PRODUCTION OF MONOCLONAL ANTIBODIES /132 CLINICAL USES FOR MONOCLONAL
ANTIBODIES /133 ENGINEERED MONOCLONAL ANTIBODIES /135 CHIMERIC AND
HYBRID MONOCLONAL ANTIBODIES / 136 MONOCLONAL ANTIBODIES CONSTRUCTED
FROM IC-GENE LIBRARIES/138 CATALYTIC MONOCLONAL ANTIBODIES (ABZYMES)
/138 SUMMARY 139 REFERENCES 140 STUDY QUESTIONS 140 STRENGTH OF
ANTIGEN-ANTIBODY INTERACTIONS ANTIBODY AFFINITY /144 ANTIBODY
AVIDITY/146 CROSS-REACTIVITY PRECIPITATION REACTIONS PRECIPITATION
REACTIONS IN FLUIDS /148 PRECIPITATION REACTIONS IN GELS /150 RADIAL
IMMUNODIFFUSION (MANCINI METHOD) / 150 DOUBLE IMMUNODIFFUSION
(OUCHTERLONY METHOD)/150 IMMUNOELECTROPHORESIS / 152 AGGLUTINATION
REACTIONS HEMAGGLUTINATION /154 BACTERIAL AGGLUTINATION /155 PASSIVE
AGGLUTINATION /155 AGGLUTINATION INHIBITION /155 RADIOIMMUNOASSAY
ENZYME-LINKED IMMUNOSORBENT ASSAY INDIRECT ELISA/157 SANDWICH ELISA/157
COMPETITIVE ELISA/157 WESTERN BLOTTING IMMUNOFLUORESCENCE IMMUNOELECTRON
MICROSCOPY SUMMARY REFERENCES STUDY QUESTIONS 144 147 148 154 156 156
158 159 160 162 162 162 C H P T ORGANIZATION AND EXPRESSION OF
IMMUNOGLOBULIN GENES/165 GENETIC MODEL COMPATIBLE WITH IG STRUCTURE 166
GERM-LINE AND SOMATIC-VARIATION MODELS /166 DRYER AND BENNETT TWO-GENE
MODEL /166 EARLY VERIFICATION OF THE DRYER AND BENNETT HYPOTHESIS/168
MULTIGENE ORGANIZATION OF IG GENES 169 X-CHAIN MULTIGENE FAMILY /169
K-CHAIN MULTIGENE FAMILY /169 HEAVY-CHAIN MULTIGENE FAMILY /170
VARIABLE-REGION GENE REARRANGEMENTS 171 V-J REARRANGEMENTS IN
LIGHT-CHAIN DNA /171 V-D-J REARRANGEMENTS IN HEAVY-CHAIN DNA/171
CONTENTS MECHANISM OF VARIABLE-REGION DNA REARRANGEMENTS /172
RECOMBINATION SIGNAL SEQUENCES / 172 ENZYMATIC JOINING OF GENE SEGMENTS
/ 173 EXPERIMENTAL IDENTIFICATION OF RAG-1 AND RAG-2 GENES/175. DEFECTS
IN IC-GENE REARRANGEMENT/ 176 PRODUCTIVE AND NONPRODUCTIVE
REARRANGEMENTS / 176 ALLELIC EXCLUSION /177 GENERATION OF ANTIBODY
DIVERSITY 178 MULTIPLE GERM-LINE V, D, AND J GENE SEGMENTS /179
COMBINATORIAL V-J AND V-D-J JOINING /179 JUNCTIONAL FLEXIBILITY /180
P-NUCLEOTIDE ADDITION /181 N-REGION NUCLEOTIDE ADDITION /181 SOMATIC
HYPERMUTATION /182 ASSOCIATION OF HEAVY AND LIGHT CHAINS /184 CLASS
SWITCHING AMONG CONSTANT-REGION GENES 184 EXPRESSION OF IG GENES 184
DIFFERENTIAL RNA PROCESSING OF HEAVY-CHAIN PRIMARY TRANSCRIPTS/184
EXPRESSION OF MEMBRANE-BOUND OR SECRETED IMMUNOGLOBULIN /185
SIMULTANEOUS EXPRESSION OF IGM AND IGD / 187 SYNTHESIS, ASSEMBLY, AND
SECRETION OF IMMUNOGLOBULINS/188 REGULATION OF IG-GENE TRANSCRIPTION ,
189 EFFECT OF DNA REARRANGEMENT ON TRANSCRIPTION/190 INHIBITION OF
IG-GENE EXPRESSION IN T CELLS /190 SUMMARY 190 REFERENCES 191 STUDY
QUESTIONS 192 C H A P T E R 8 B-CELL MATURATION, ACTIVATION, AND
DIFFERENTIATION /195 B-CELL MATURATION 196 BONE MARROW ENVIRONMENT /197
IG-CENE REARRANGEMENTS /197 PRE-B CELL RECEPTOR /198 SELECTION OF
IMMATURE SELF-REACTIVE B CELLS /199 NEGATIVE SELECTION /199 RESCUE BY
EDITING OF LIGHT-CHAIN GENES / 200 B-CELL ACTIVATION AND PROLIFERATION
200 THYMUS-DEPENDENT AND THYMUS-LNDEPENDENT ANTIGENS / 200 ORIGIN OF
ACTIVATING SIGNALS / 202 TRANSDUCTION OF ACTIVATING SIGNALS / 203 B-CELL
CORECEPTOR COMPLEX / 205 ROLE OF T H CELLS IN HUMORAL RESPONSE / 205
FORMATION OF T-B CONJUGATE / 206 CONTACT-DEPENDENT HELP MEDIATED BY
CD40/CD40L INTERACTION / 207 PROGRESSION SIGNALS INDUCED BY TH-CELL
CYTOKINES / 207 NEGATIVE SELECTION OF MATURE, SELF-REACTIVE B CELLS /
208 IN VIVO SITES FOR INDUCTION OF HUMORAL RESPONSE 211 B-CELL
DIFFERENTIATION 213 AFFINITY MATURATION / 213 ROLE OF SOMATIC
HYPERMUTATION / 213 ANTIGEN SELECTION OF HIGH-AFFINITY CENTROCYTES / 214
CLASS SWITCHING/215 GENERATION OF PLASMA CELLS AND MEMORY B CELLS / 216
REGULATION OF B-CELL DEVELOPMENT , 218 SUMMARY 219 REFERENCES 220 STUDY
QUESTIONS . 221 C H A P T E R 9 MAJOR HISTOCOMPATIBILITY COMPLEX/223
GENERAL ORGANIZATION AND INHERITANCE OF THE MHC 224 LOCATION AND
FUNCTION OF MHC REGIONS / 224 MHC HAPLOTYPES / 225 CONGENIC MHC MOUSE
STRAINS / 226 MHC MOLECULES AND GENES 227 STRUCTURE OF CLASS I MOLECULES
/ 228 STRUCTURE OF CLASS II MOLECULES / 229 ORGANIZATION OF CLASS I AND
II GENES / 231 PEPTIDE BINDING BY MHC MOLECULES / 231 CLASS I
MHC-PEPTIDE INTERACTION / 233 CLASS II MHC-PEPTIDE INTERACTION / 234
POLYMORPHISM OF CLASS I AND II MOLECULES / 235 CLASS III MOLECULES / 236
DETAILED GENOMIC MAP OF MHC GENES 238 MAP OF CLASS I MHC / 239 MAP OF
CLASS II MHC / 239 MAP OF CLASS III MHC/239 CELLULAR DISTRIBUTION OF MHC
MOLECULES 240 REGULATION OF MHC EXPRESSION 241 MHC AND IMMUNE
RESPONSIVENESS * 241 DETERMINANT-SELECTION MODEL / 243
HOLES-IN-THE-REPERTOIRE MODEL / 244 MHC AND SUSCEPTIBILITY TO INFECTIOUS
DISEASE 244 SUMMARY 245 REFERENCES 246 STUDY QUESTIONS 246 CONTENTS XI C
H A P T E R 1 0 ANTIGEN PROCESSING AND PRESENTATION /249 250 251
SELF-MHC RESTRICTION OF T CELLS ROLE OF ANTIGEN-PRESENTING CELLS EARLY
EVIDENCE FOR THE NECESSITY OF ANTIGEN PROCESSING / 251 CELLS THAT
FUNCTION IN ANTIGEN PRESENTATION / 252 EVIDENCE FOR TWO PROCESSING AND
PRESENTATION PATHWAYS 253 ENDOGENOUS ANTIGENS: THE CYTOSOLIC PATHWAY 255
PEPTIDE GENERATION BY CYTOSOLIC PROTEASOMES / 255 PEPTIDE TRANSPORT FROM
THE CYTOSOL TO THE RER / 256 ASSEMBLY OF PEPTIDES WITH CLASS I MHC
MOLECULES /257 OVERVIEW OF CLASS I ENDOGENOUS PATHWAY / 257 EXOGENOUS
ANTIGENS: THE ENDOCYTIC PATHWAY 258 PEPTIDE GENERATION IN ENDOCYTIC
VESICLES / 258 TRANSPORT OF CLASS II MHC MOLECULES TO ENDOCYTIC VESICLES
/ 258 ASSEMBLY OF PEPTIDES WITH CLASS II MHC MOLECULES / 259 OVERVIEW OF
CLASS II EXOGENOUS PATHWAY / 259 CLINICAL APPLICATIONS 259 SUMMARY 260
REFERENCES 260 STUDY QUESTIONS 261 C H A P T E R 1 1 T-CELL RECEPTOR/263
EARLY STUDIES OF THE T-CELL RECEPTOR 264 SELF-MHC RESTRICTION OF THE
T-CELL RECEPTOR / 264 ISOLATION OF T-CELL RECEPTORS / 264 STRUCTURE OF
T-CELL RECEPTORS 265 ORGANIZATION AND REARRANGEMENT OF TCR GENES 266
IDENTIFYING AND CLONING THE TCR GENES / 266 TCR MULTIGENE FAMILIES / 267
VARIABLE-REGION GENE REARRANGEMENTS / 268 MECHANISM OF TCR DNA
REARRANGEMENTS / 269 ALLELIC EXCLUSION OF TCR GENES / 270 STRUCTURE OF
REARRANGED TCR GENES / 270 GENERATION OF TCR DIVERSITY / 271 T-CELL
RECEPTOR COMPLEX: TCR-CD3 273 T-CELL ACCESSORY MEMBRANE MOLECULES 274
CD4 AND CD8 CORECEPTORS / 275 OTHER ACCESSORY MEMBRANE MOLECULES / 276
TERNARY TCR-PEPTIDE-MHC COMPLEX 277 EVIDENCE THAT TCR ALONE RECOGNIZES
PEPTIDE-MHC COMPLEX / 277 INTERACTIONS INVOLVED IN FORMING TERNARY
COMPLEX / 278 AFFINITY OF TCR FOR PEPTIDE-MHC COMPLEXES / 279 INFLUENCE
OF PEPTIDE ON TOPOLOGY OF TERNARY COMPLEX /280 ALLOREACTIVITY OF T CELLS
280 SUMMARY 281 REFERENCES 282 STUDY QUESTIONS 282 C H A P T E R 1 2
T-CELL MATURATION, ACTIVATION, AND DIFFERENTIATION / 285 T-CELL
MATURATION 285 PRE-T CELL RECEPTOR / 286 T-CELL DEVELOPMENTAL PATHWAYS /
286 THYMIC SELECTION OF THE T-CELL REPERTOIRE / 288 POSITIVE SELECTION /
289 NEGATIVE SELECTION / 289 EXPERIMENTAL EVIDENCE FOR POSITIVE
SELECTION / 290 EXPERIMENTAL EVIDENCE FOR NEGATIVE SELECTION / 291
UNSOLVED QUESTIONS REGARDING THYMIC SELECTION / 292 T H -CELL ACTIVATION
295 TCR-COUPLED SIGNALING PATHWAYS / 297 THE CO-STIMULATORY SIGNAL / 299
ALTERED PEPTIDE LIGANDS AS ANTAGONISTS OR PARTIAL AGONISTS / 300 CLONAL
EXPANSION VERSUS CLONAL ANERGY / 300 SUPERANTIGEN-LNDUCED T-CELL
ACTIVATION / 300 T-CELL DIFFERENTIATION 304 GENERATION OF EFFECTOR AND
MEMORY CELLS / 304 CO-STIMULATORY DIFFERENCES AMONG ANTIGEN- PRESENTING
CELLS / 305 PERIPHERAL YD! CELLS ,306 DISTRIBUTION OF YD T CELLS / 306
LIGANDS RECOGNIZED BY YD T CELLS / 306 FUNCTIONS OF YD T CELLS / 306
SUMMARY 307 REFERENCES 308 STUDY QUESTIONS 309 XII CONTENTS P A R T I I
I MMUNE EFFECTOR MECHANISMS / 311 C H A P T E R 1 3 CYTOKINES/313
PROPERTIES OF CYTOKINES GENERAL STRUCTURE OF CYTOKINES / 316 FUNCTION OF
CYTOKINES / 316 CYTOKINE RECEPTORS GENERAL STRUCTURE OF CYTOKINE
RECEPTORS / 321 SUBFAMILIES OF CLASS I CYTOKINE RECEPTORS / 321 IL-2
RECEPTOR / 323 SIGNAL TRANSDUCTION MEDIATED BY CYTOKINE RECEPTORS / 324
* CYTOKINE ANTAGONISTS CYTOKINE SECRETION BY T H 1 AND T H 2 SUBSETS
DEVELOPMENT OF T H 1 AND T H 2 SUBSETS / 327 CYTOKINE CROSS-REGULATION /
327 ROLE OF T H 1/T H 2 BALANCE IN DETERMINING DISEASE OUTCOMES / 327
CYTOKINE-RELATED DISEASES BACTERIAL SEPTIC SHOCK / 329 BACTERIAL TOXIC
SHOCK AND SIMILAR DISEASES / 329 LYMPHOID AND MYELOID CANCERS / 330
CHAGAS DISEASE / 330 THERAPEUTIC USES OF CYTOKINES AND THEIR RECEPTORS
SUMMARY REFERENCES STUDY QUESTIONS C H A P T E R 1 4 313 321 325 326 329
331 332 333 333 THE COMPLEMENT SYSTEM /335 THE COMPLEMENT COMPONENTS 335
COMPLEMENT ACTIVATION 336 CLASSICAL PATHWAY / 336 ALTERNATIVE PATHWAY /
339 TERMINAL SEQUENCE: FORMATION OF MEMBRANE-ATTACK COMPLEX / 342
REGULATION OF THE COMPLEMENT SYSTEM 345 BIOLOGICAL CONSEQUENCES OF
COMPLEMENT ACTIVATION CELL LYSIS / 349 INFLAMMATORY RESPONSE / 351
OPSONIZATION OF ANTIGEN / 352 VIRAL NEUTRALIZATION / 352 SOLUBILIZATION
OF IMMUNE COMPLEXES / 353 COMPLEMENT DEFICIENCIES SUMMARY REFERENCES
STUDY QUESTIONS 349 353 354 355 355 C H A P T E R 1 5 LEUKOCYTE
MIGRATION AND INFLAMMATION / 357 LYMPHOCYTE RECIRCULATION 357
CELL-ADHESION MOLECULES 358 SELECTIN FAMILY / 358 MUCIN-LIKE FAMILY /
358 INTEGRIN FAMILY / 358 IMMUNOGLOBULIN SUPERFAMILY / 359 NEUTROPHIL
EXTRAVASATION 359 LYMPHOCYTE EXTRAVASATION 361 HIGH-ENDOTHELIAL VENULES
(HEVS) / 361 HOMING OF LYMPHOCYTES / 361 NAIVE LYMPHOCYTES / 362
EFFECTOR AND MEMORY LYMPHOCYTES / 363 ADHESION-MOLECULE INTERACTIONS /
364 MEDIATORS OF INFLAMMATION 365 CHEMOKINES / 365 PLASMA ENZYME
MEDIATORS / 367 KININ SYSTEM / 367 CLOTTING SYSTEM / 367 FLBRINOLYTIC
SYSTEM / 367 COMPLEMENT SYSTEM / 367 LIPID INFLAMMATORY MEDIATORS / 368
CYTOKINE INFLAMMATORY MEDIATORS / 368 THE INFLAMMATORY PROCESS . 369
CENTRAL ROLE OF NEUTROPHILS IN INFLAMMATION / 369 CONTENTS XIII ACUTE
INFLAMMATORY RESPONSE / 370 LOCALIZED RESPONSE / 370 SYSTEMIC
ACUTE-PHASE RESPONSE / 370 CHRONIC INFLAMMATORY RESPONSE / 373 ROLE OF
IFN-/AND TNF-A/373 CHRONIC INFLAMMATORY DISEASES / 375 ANTI-INFLAMMATORY
AGENTS AGENTS THAT REDUCE LEUKOCYTE EXTRAVASATION / 375 CORTICOSTEROIDS
/ 376 NONSTEROIDAL ANTI-INFLAMMATORY DRUGS / 376 SUMMARY REFERENCES
STUDY QUESTIONS 375 376 377 378 C H P T 1 CELL-MEDIATED AND HUMORAL
EFFECTOR RESPONSES / 379 EFFECTOR RESPONSES IN THE CELL-MEDIATED BRANCH
380 GENERAL PROPERTIES OF EFFECTOR T CELLS / 380 ACTIVATION REQUIREMENTS
/ 380 CELL-ADHESION MOLECULES / 380 EFFECTOR MOLECULES / 381 DIRECT
CYTOTOXIC RESPONSES / 381 CTL-MEDIATED CYTOTOXICITY / 381 NK
CELL-MEDIATED CYTOTOXICITY / 387 ANTIBODY-DEPENDENT CELL-MEDIATED
CYTOTOXICITY / 390 EXPERIMENTAL ASSESSMENT OF CELL-MEDIATED CYTOTOXICITY
/ 391 DELAYED-TYPE HYPERSENSITIVITY / 393 PHASES OF THE DTH RESPONSE /
393 CYTOKINES INVOLVED IN THE DTH REACTION / 395 PROTECTIVE ROLE OF THE
DTH RESPONSE / 395 DETECTION OF THE DTH REACTION / 396 PATHOLOGIC DTH
RESPONSES / 397 EFFECTOR RESPONSES IN THE HUMORAL BRANCH 397 PRIMARY AND
SECONDARY RESPONSES / 397 EXPERIMENTAL ASSESSMENT OF HUMORAL
IMMUNITY/398 HEMOLYTIC PLAQUE ASSAYS / 399 ELISPOT ASSAY / 399 HUMORAL
RESPONSE TO HAPTEN-CARRIER CONJUGATES / 400 REGULATION OF THE IMMUNE
EFFECTOR RESPONSE 402 ANTIGEN-MEDIATED REGULATION / 403
ANTIBODY-MEDIATED SUPPRESSION / 403 IMMUNE COMPLEXES AS REGULATORS / 404
IDIOTYPE REGULATION: THE NETWORK THEORY / 404 NEUROENDOCRINE REGULATION
(NEUROIMMUNOMODULATION) / 406 SUMMARY REFERENCES STUDY QUESTIONS - 408
409 410 C H A P T E R 1 7 HYPERSENSITIVE REACTIONS/413 CELL AND COOMBS
CLASSIFICATION 414 IGE-MEDIATED (TYPE I) HYPERSENSITIVITY 415 COMPONENTS
OF TYPE I REACTIONS / 415 ALLERGENS/415 REAGINIC ANTIBODY (IGE) / 416
MAST CELLS AND BASOPHILS / 417 IGE-BINDING FC RECEPTORS / 417 MECHANISM
OF IGE-MEDIATED DEGRANULATION / 418 RECEPTOR CROSS-LINKAGE / 419
INTRACELLULAR EVENTS LEADING TO MAST CELL DEGRANULATION /419 MEDIATORS
OF TYPE I REACTIONS / 420 HLSTAMINE / 421 LEUKOTRIENES AND
PROSTACLANDINS / 422 CYTOKINES / 422 CONSEQUENCES OF TYPE I REACTIONS /
423 SYSTEMIC ANAPHYLAXIS / 423 LOCALIZED ANAPHYLAXIS (ATOPY) / 424
LATE-PHASE REACTION / 426 REGULATION OF THE TYPE I RESPONSE / 426
DETECTION OF TYPE I HYPERSENSITIVITY / 427 THERAPY FOR TYPE I
HYPERSENSITIVITIES / 428 ANTIBODY-MEDIATED CYTOTOXIC (TYPE II)
HYPERSENSITIVITY 430 TRANSFUSION REACTIONS / 430 HEMOLYTIC DISEASE OF
THE NEWBORN / 432 DRUG-INDUCED HEMOLYTIC ANEMIA / 433 IMMUNE
COMPLEX-MEDIATED (TYPE III) HYPERSENSITIVITY 430 LOCALIZED TYPE III
REACTIONS / 434 GENERALIZED TYPE III REACTIONS / 434 T D TH-MEDIATED
(TYPE IV) HYPERSENSITIVITY 436 SUMMARY 437 REFERENCES 438 STUDY
QUESTIONS 438 XIV CONTENTS P A R T I V THE IMMUNE SYSTEM IN HEALTH AND
DISEASE/441 C H A P T E R VACCINES/443 ACTIVE AND PASSIVE IMMUNIZATION
PASSIVE IMMUNIZATION / 444 ACTIVE IMMUNIZATION / 445 DESIGNING VACCINES
FOR ACTIVE IMMUNIZATION WHOLE-ORGANISM VACCINES ATTENUATED VIRAL OR
BACTERIAL VACCINES / 448 INACTIVATED VIRAL OR BACTERIAL VACCINES / 450
PURIFIED MACROMOLECULES AS VACCINES / 450 POLYSACCHARIDE VACCINES / 450
TOXOID VACCINES / 451 RECOMBINANT ANTIGEN VACCINES / 451 RECOMBINANT
VECTOR VACCINES DNA VACCINES SYNTHETIC PEPTIDE VACCINES MULTIVALENT
SUBUNIT VACCINES ANTI-LDIOTYPE VACCINES SUMMARY REFERENCES STUDY
QUESTIONS C H P T 444 446 448 451 452 453 454 455 456 457 457 IMMUNE
RESPONSE TO INFECTIOUS DISEASES/459 VIRAL INFECTIONS 460 VIRAL
NEUTRALIZATION BY HUMORAL ANTIBODY / 460 CELL-MEDIATED ANTIVIRAL
MECHANISMS / 460 VIRAL EVASION OF HOST-DEFENSE MECHANISMS / 461
INFLUENZA / 462 PROPERTIES OF INFLUENZA VIRUS / 462 HOST RESPONSE TO
INFLUENZA INFECTION / 465 BACTERIAL INFECTIONS 467 IMMUNE RESPONSE TO
EXTRACELLULAR AND INTRACELLULAR BACTERIA / 467 BACTERIAL EVASION OF
HOST-DEFENSE MECHANISMS / 467 CONTRIBUTION OF THE IMMUNE RESPONSE TO
BACTERIAL PATHOGENESIS / 470 DIPTHERIA (CORYNEBACTERIUM DIPHTHERIAE) 1
470 TUBERCULOSIS (MYCOBACTEHUM TUBERCULOSIS) 1 471 LYME DISEASE
(BORRELIA BURGDORFERI) 1 473 PROTOZOAN DISEASES MALARIA {PLASMODIUM
SPECIES) / 474 PLASMODIUM LIFE CYCLE AND PATHOGENESIS OF MALARIA / 474
HOST RESPONSE TO PLASMODIUM INFECTION / 475 DESIGN OF MALARIA VACCINES /
476 AFRICAN SLEEPING SICKNESS (TRYPANOSOMA SPECIES) / 476 DISEASES
CAUSED BY PARASITIC WORMS (HELMINTHS) SUMMARY REFERENCES STUDY QUESTIONS
474 478 480 481 482 C H A P T E R 2 0 AUTOIMMUNITY/485 ORGAN-SPECIFIC
AUTOIMMUNE DISEASES 485 DISEASES MEDIATED BY DIRECT CELLULAR DAMAGE /
486 HASHIMOTO S THYROIDITIS / 486 AUTOIMMUNE ANEMIAS / 487 GOODPASTURE S
SYNDROME / 487 INSULIN-DEPENDENT DIABETES MELLITUS / 487 DISEASES
MEDIATED BY STIMULATING OR BLOCKING ANTIBODIES / 488 GRAVES DISEASE /
488 MYASTHENIA GRAVIS / 489 SYSTEMIC AUTOIMMUNE DISEASES 489 SYSTEMIC
LUPUS ERYTHEMATOSUS / 489 MULTIPLE SCLEROSIS / 490 RHEUMATOID ARTHRITIS
/ 490 ANIMAL MODELS FOR AUTOIMMUNE DISEASE 490 SPONTANEOUS AUTOIMMUNITY
IN ANIMALS / 490 EXPERIMENTALLY INDUCED AUTOIMMUNITY IN ANIMALS / 492
EVIDENCE IMPLICATING THE CD4 + T CELL, MHC, AND TCR IN AUTOIMMUNITY 492
ROLE OF CD4+ T-CELLS AND T H 1/T H 2 BALANCE / 492 ASSOCIATION WITH THE
MHC / 493 ASSOCIATION WITH THE T-CELL RECEPTOR / 495 PROPOSED MECHANISMS
FOR INDUCTION OF AUTOIMMUNITY 495 CONTENTS XV RELEASE OF SEQUESTERED
ANTIGENS / 495 MOLECULAR MIMICRY / 495 MIMICRY BETWEEN MBP AND VIRAL
PEPTIDES / 496 MIMICRY INVOLVING HEAT-SHOCK PROTEINS / 497 INAPPROPRIATE
EXPRESSION OF CLASS II MHC MOLECULES / 499 POLYCLONAL B-CELL ACTIVATION
/ 500 TREATMENT OF AUTOIMMUNE DISEASES CURRENT THERAPIES / 500
EXPERIMENTAL THERAPEUTIC APPROACHES / 500 T-CELL VACCINATION / 500
PEPTIDE BLOCKADE OF MHC MOLECULES / 501 MONOCLONAL-ANTIBODY TREATMENT /
501 TOLERANCE INDUCTION BY ORAL ANTIGENS / 502 SUMMARY REFERENCES STUDY
QUESTIONS C H A P T E R 2 2 500 503 503 504 C H A P T E R 2 1
IMMUNODEFICIENCY DISEASES/507 PHAGOCYTIC DEFICIENCIES 507 REDUCTION IN
NEUTROPHIL COUNT/ 508 DEFECTIVE PHAGOCYTIC FUNCTION / 508 -ADHERENCE
DEFECTS / 508 CHEMOTACTIC DEFECTS / 510 KILLING DEFECTS/ 510 HUMORAL
DEFICIENCIES 511 X-LINKED AGAMMAGLOBULINEMIA / 511 X-LINKED HYPER-IGM
SYNDROME / 512 COMMON VARIABLE HYPOGAMMAGLOBULINEMIA / 513 SELECTIVE
IMMUNOGLOBULIN DEFICIENCIES / 514 CELL-MEDIATED DEFICIENCIES 514
DIGEORGE SYNDROME (CONGENITAL THYMIC APLASIA)/515 NUDE MICE/515 COMBINED
IMMUNODEFICIENCIES 516 RETICULAR DYSGENESIS / 516 BARE-LYMPHOCYTE
SYNDROME / 516 SEVERE COMBINED IMMUNODEFICIENCY DISEASE (SCID)/517 ADA
DEFICIENCY AND PNP-DEFICIENCY (SCID) / 518 SCID MICE AND SCID-HUMAN MICE
/ 518 WISKOTT-ALDRICH SYNDROME / 519 COMPLEMENT DEFICIENCIES 519 SUMMARY
519 REFERENCES 520 STUDY QUESTIONS 520 THE IMMUNE SYSTEM IN AIDS/523
DISCOVERY OF AIDS AND ITS CAUSATIVE AGENT 523 HUMAN IMMUNODEFICIENCY
VIRUS (HIV) 524 RELATION BETWEEN HIV AND OTHER RETROVIRUSES / 524
STRUCTURE OF HIV / 526 HIV INFECTION OF TARGET CELLS / 526 ENTRY OF HIV
INTO CELLS / 527 INTEGRATION OF HIV INTO HOST GENOME / 530 ACTIVATION OF
HIV PROVIRUS / 530 TRANSMISSION OF HIV / 530 HIV GENOME / 531 FACTORS
THAT PROMOTE ACTIVATION OF HIV PROVIRUS / 531 EXPRESSION OF HIV PROVIRAL
DNA / 533 GENETIC VARIATION IN HIV / 533 ROLE OF IMMUNE RESPONSE IN
EMERGENCE OF HIV VARIANTS / 534 VARIATION IN THE ENVELOPE GLYCOPROTEINS
/ 534 DIAGNOSIS OF HIV INFECTION AND AIDS , 536 SEROLOGIC PROFILE OF HIV
INFECTION / 536 SCREENING TESTS FOR HIV INFECTION / 537 CLINICAL
DIAGNOSIS OF AIDS / 537 DESTRUCTION OF CD4+ T CELLS 538 DEPLETION OF
HIV-LNFECTED CD4 + T CELLS / 538 DEPLETION OF UNINFECTED CD4+ T CELLS /
540 DESTRUCTION MEDIATED BY ANTI-GP120 ANTIBODY / 540 GP120-INDUCED
DISRUPTION OF T-CELL ACTIVATION / 541 GP120-STIMULATED SYNCYTIA
FORMATION / 542 INTERFERENCE WITH T-CELL MATURATION BY GP120/543
IMMUNOLOGIC ABNORMALITIES IN AIDS 543 PATHOLOGIC CHANGES IN LYMPH NODES
/ 543 REDUCED ANTIGEN-SPECIFIC RESPONSES BY T H CELLS / 543 INEFFECTIVE
ANTIBODY RESPONSE / 545 CYTOKINE IMBALANCE / 545 DECREASED DTH RESPONSE
/ 546 IMPAIRED CTL ACTIVITY / 547 DEVELOPMENT OF AN AIDS VACCINE 547
OBSTACLES TO DEVELOPMENT OF AN AIDS VACCINE / 548 EXPERIMENTAL AIDS
VACCINES / 549 INACTIVATED WHOLE VIRUSES / 549 CLONED ENVELOPE
GLYCOPROTEINS / 549 XVI CONTENTS ATTENUATED VIRUSES / 550 RECOMBINANT
VIRUSES CARRYING HIV GENES / 551 SYNTHETIC CROWN-SEQUENCE PEPTIDES / 551
SUMMARY REFERENCES STUDY QUESTIONS C H A P T E R 2 4 C H A P T E R 2 3
TRANSPLANTATION IMMUNOLOGY/555 552 552 553 IMMUNOLOGIC BASIS OF GRAFT
REJECTION 556 SPECIFICITY AND MEMORY OF THE REJECTION RESPONSE / 556
ROLE OF CELL-MEDIATED RESPONSES / 556 TRANSPLANTATION ANTIGENS / 557
MECHANISMS INVOLVED IN GRAFT REJECTION / 558 SENSITIZATION STAGE / 559
EFFECTOR STAGE / 560 CLINICAL MANIFESTATIONS OF GRAFT REJECTION 560
HYPERACUTE REJECTION / 560 ACUTE REJECTION / 562 CHRONIC REJECTION / 562
TISSUE TYPING 562 GENERAL IMMUNOSUPPRESSIVE THERAPY 563 MITOTIC
INHIBITORS / 563 CORTICOSTEROIDS / 564 CYCLOSPORIN A, FK506, AND
RAPAMYCIN / 564 TOTAL LYMPHOID IRRADIATION / 564 SPECIFIC
IMMUNOSUPPRESSIVE THERAPY 565 MONOCLONAL ANTIBODIES TO T-CELL COMPONENTS
OR CYTOKINES / 565 AGENTS THAT BLOCK THE CO-STIMULATORY SIGNAL / 566
DONOR-CELL MICROCHIMERISM / 566 CLINICAL TRANSPLANTATION BONE MARROW
TRANSPLANTS / 567 ORGAN TRANSPLANTS / 567 XENOTRANSPLANTS / 568
TRANSPLANTS TO IMMUNOLOGICALLY PRIVILEGED SITES / 569 SUMMARY REFERENCES
STUDY QUESTIONS 567 570 570 571 TUMOR-CELL VACCINES / 594 SUMMARY
REFERENCES STUDY QUESTIONS GLOSSARY ANSWERS TO STUDY QUESTIONS CREDITS
INDEX CANCER AND THE IMMUNE SYSTEM /573 CANCER: ORIGIN AND TERMINOLOGY
573 MALIGNANT TRANSFORMATION OF CELLS 574 ONCOGENES AND CANCER INDUCTION
574 FUNCTION OF ONCOGENES / 576 INDUCTION OF CELLULAR PROLIFERATION /
576 INHIBITION OF CELLULAR. PROLIFERATION / 576 REGULATION OF PROGRAMMED
CELL DEATH / 577 CONVERSION OF PROTO-ONCOGENES TO ONCOGENES / 577
INDUCTION OF CANCER: A MULTISTEP PROCESS / 578 TUMORS OF THE IMMUNE
SYSTEM 579 TUMOR ANTIGENS 580 TUMOR-SPECIFIC ANTIGENS / 580 CHEMICALLY
OR PHYSICALLY INDUCED TUMOR ANTIGENS / 580 VIRALLY INDUCED TUMOR
ANTIGENS / 583 TUMOR-ASSOCIATED ANTIGENS / 584 ONCOFETAL TUMOR ANTIGENS
/ 584 ONCOGENE PROTEINS AS TUMOR ANTIGENS / 585 TATAS ON HUMAN MELANOMAS
/ 586 IMMUNE RESPONSE TO TUMORS 586 ROLE OF NK CELLS AND MACROPHAGES /
586 IMMUNE SURVEILLANCE THEORY / 586 TUMOR EVASION OF THE IMMUNE SYSTEM
587 IMMUNOLOGIC ENHANCEMENT OF TUMOR GROWTH / 587 MODULATION OF TUMOR
ANTIGENS / 587 REDUCTION IN CLASS I MHC MOLECULES / 587 LACK OF
CO-STIMULATORY SIGNAL / 587 CANCER IMMUNOTHERAPY 588 MANIPULATION OF
CO-STIMULATORY SIGNAL / 588 ENHANCEMENT OF APC ACTIVITY / 589 CYTOKINE
THERAPY / 590 INTERFERONS / 590 TUMOR NECROSIS FACTORS / 591 IN
VITRO-ACTIVATED LAK AND TIL CELLS / 592 MONOCLONAL ANTIBODIES / 592 594
595 595 597 611 633 641
|
| any_adam_object | 1 |
| author | Kuby, Janis |
| author_facet | Kuby, Janis |
| author_role | aut |
| author_sort | Kuby, Janis |
| author_variant | j k jk |
| building | Verbundindex |
| bvnumber | BV011745893 |
| callnumber-first | Q - Science |
| callnumber-label | QR181 |
| callnumber-raw | QR181 |
| callnumber-search | QR181 |
| callnumber-sort | QR 3181 |
| callnumber-subject | QR - Microbiology |
| classification_rvk | WF 9800 |
| ctrlnum | (OCoLC)36127172 (DE-599)BVBBV011745893 |
| dewey-full | 616.07/9 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.07/9 |
| dewey-search | 616.07/9 |
| dewey-sort | 3616.07 19 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| edition | 3. ed. |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02081nam a2200625 c 4500</leader><controlfield tag="001">BV011745893</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">980202s1997 ad|| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0716728680</subfield><subfield code="9">0-7167-2868-0</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)36127172</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV011745893</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-91</subfield><subfield code="a">DE-19</subfield><subfield code="a">DE-188</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QR181</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">616.07/9</subfield><subfield code="2">21</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WF 9800</subfield><subfield code="0">(DE-625)148471:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Kuby, Janis</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Immunology</subfield><subfield code="c">Janis Kuby</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">3. ed.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">New York</subfield><subfield code="b">Freeman</subfield><subfield code="c">1997</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XXIV, 664 S.</subfield><subfield code="b">Ill., zahlr. graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Immunology</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Immune system</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">B Lymphocytes</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Immune Response</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Immunoglobulins</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Immunological Diseases</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Antigenen</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Cytochemie</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Cytokinen</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Histocompatibiliteit</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Immunoglobulinen</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunologie</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Immunologie</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Imunologia</subfield><subfield code="2">larpcal</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Leukocyten</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Recombinant DNA</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immune System</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunology</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Immunsystem</subfield><subfield code="0">(DE-588)4026643-6</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Immunologie</subfield><subfield code="0">(DE-588)4026637-0</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Immunologie</subfield><subfield code="0">(DE-588)4026637-0</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Immunsystem</subfield><subfield code="0">(DE-588)4026643-6</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="8">1\p</subfield><subfield code="5">DE-604</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HEBIS Datenaustausch Darmstadt</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007924906&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-007924906</subfield></datafield><datafield tag="883" ind1="1" ind2=" "><subfield code="8">1\p</subfield><subfield code="a">cgwrk</subfield><subfield code="d">20201028</subfield><subfield code="q">DE-101</subfield><subfield code="u">https://d-nb.info/provenance/plan#cgwrk</subfield></datafield></record></collection> |
| id | DE-604.BV011745893 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:15:04Z |
| institution | BVB |
| isbn | 0716728680 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007924906 |
| oclc_num | 36127172 |
| open_access_boolean | |
| owner | DE-91 DE-BY-TUM DE-19 DE-BY-UBM DE-188 |
| owner_facet | DE-91 DE-BY-TUM DE-19 DE-BY-UBM DE-188 |
| physical | XXIV, 664 S. Ill., zahlr. graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Freeman |
| record_format | marc |
| spelling | Kuby, Janis Verfasser aut Immunology Janis Kuby 3. ed. New York Freeman 1997 XXIV, 664 S. Ill., zahlr. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Immunology cabt Immune system cabt B Lymphocytes cabt Immune Response cabt Immunoglobulins cabt Immunological Diseases cabt Antigenen gtt Cytochemie gtt Cytokinen gtt Histocompatibiliteit gtt Immunoglobulinen gtt Immunologie Immunologie gtt Imunologia larpcal Leukocyten gtt Recombinant DNA gtt Immune System Immunity Immunology Immunsystem (DE-588)4026643-6 gnd rswk-swf Immunologie (DE-588)4026637-0 gnd rswk-swf Immunologie (DE-588)4026637-0 s DE-604 Immunsystem (DE-588)4026643-6 s 1\p DE-604 HEBIS Datenaustausch Darmstadt application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007924906&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Kuby, Janis Immunology Immunology cabt Immune system cabt B Lymphocytes cabt Immune Response cabt Immunoglobulins cabt Immunological Diseases cabt Antigenen gtt Cytochemie gtt Cytokinen gtt Histocompatibiliteit gtt Immunoglobulinen gtt Immunologie Immunologie gtt Imunologia larpcal Leukocyten gtt Recombinant DNA gtt Immune System Immunity Immunology Immunsystem (DE-588)4026643-6 gnd Immunologie (DE-588)4026637-0 gnd |
| subject_GND | (DE-588)4026643-6 (DE-588)4026637-0 |
| title | Immunology |
| title_auth | Immunology |
| title_exact_search | Immunology |
| title_full | Immunology Janis Kuby |
| title_fullStr | Immunology Janis Kuby |
| title_full_unstemmed | Immunology Janis Kuby |
| title_short | Immunology |
| title_sort | immunology |
| topic | Immunology cabt Immune system cabt B Lymphocytes cabt Immune Response cabt Immunoglobulins cabt Immunological Diseases cabt Antigenen gtt Cytochemie gtt Cytokinen gtt Histocompatibiliteit gtt Immunoglobulinen gtt Immunologie Immunologie gtt Imunologia larpcal Leukocyten gtt Recombinant DNA gtt Immune System Immunity Immunology Immunsystem (DE-588)4026643-6 gnd Immunologie (DE-588)4026637-0 gnd |
| topic_facet | Immunology Immune system B Lymphocytes Immune Response Immunoglobulins Immunological Diseases Antigenen Cytochemie Cytokinen Histocompatibiliteit Immunoglobulinen Immunologie Imunologia Leukocyten Recombinant DNA Immune System Immunity Immunsystem |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007924906&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT kubyjanis immunology |