Transcriptional regulation in the interferon system:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | German |
| Veröffentlicht: |
New York [u.a.]
Springer
1997
Austin, Texas Landes |
| Schriftenreihe: | Molecular biology intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | 174 S. graph. Darst. |
| ISBN: | 3540634010 |
Internformat
MARC
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| 245 | 1 | 0 | |a Transcriptional regulation in the interferon system |c Ganes C. Sen ; Richard M. Ransohoff |
| 264 | 1 | |a New York [u.a.] |b Springer |c 1997 | |
| 264 | 1 | |a Austin, Texas |b Landes | |
| 300 | |a 174 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-007898371 | ||
Datensatz im Suchindex
| _version_ | 1804126250104520704 |
|---|---|
| adam_text | ¦ CONTENTS n
1. Introduction to the Interferon System 1
Interferon as a Prototype Cytokine 1
Discovery 2
Clinical Use 3
The IFN System 4
2. Interferon Genes and Proteins 9
Interferon Genes 9
Type I IFNs 10
Multiple IFN a Species 10
IFN y 11
3. Interferon Biosynthesis 15
General Features 15
Induction of IFN a/p Synthesis 17
Induction of IFN y Synthesis 19
4. Interferon Induced Proteins 25
General Characteristics 25
dsRNA Dependent Protein Kinase, PKR 28
The 2 5(A) Synthetase/RNase L System 34
Interferon Regulatory Factors 38
P202 Protein 39
5. Overall Design of the Interferon Signaling Pathways 55
Historical Overview 55
Isolation of Interferon Stimulated Genes (ISGs) 56
Identification of Genomic Elements that Regulate
Transcriptional Responses to IFNs 57
Protein DNA Interactions in the IFN Response;
Isolation and Characterization of the STAT Proteins
and Their Partners 58
Genetic Dissection of IFN Signaling:
JAKs Enter the Picture 60
IFN Signaling Pathway as the Prototype
JAK STAT Pathway 62
6. Sequential Steps in the Signaling Process 73
Overview of IFN y Signaling 73
Overview of IFN a/fS Signaling 79
7. Interferon Receptors 87
Interferon Receptors in the Family of Cytokine Receptors .... 87
IFN y Receptor: IFNGR 89
Type I Interferon Receptor: IFNAR 93
8. Janus Kinases 105
9. Signal Transducers and Activators of Transcription 113
STAT Proteins 113
Discovery of the STATs 116
Anatomy of a STAT 123
10. Emerging Aspects of Interferon Signaling 133
Additional Features of IFN a/p Signaling 133
MHC Class II Induction by IFN y 135
Protein Tyrosine Phosphatases in the IFN System 138
Probable Connection to the MAP Kinase Pathway 142
A JAK STAT System in Drosophila 143
Double Stranded RNA and the IFN System 145
Interference with Interferon Signaling 147
11. Future Perspectives 163
Index 171
|
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| id | DE-604.BV011712158 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:14:28Z |
| institution | BVB |
| isbn | 3540634010 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007898371 |
| oclc_num | 833243987 |
| open_access_boolean | |
| owner | DE-12 |
| owner_facet | DE-12 |
| physical | 174 S. graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Springer Landes |
| record_format | marc |
| series2 | Molecular biology intelligence unit |
| spelling | Sen, Ganes C. Verfasser aut Transcriptional regulation in the interferon system Ganes C. Sen ; Richard M. Ransohoff New York [u.a.] Springer 1997 Austin, Texas Landes 174 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit Literaturangaben Genregulation (DE-588)4122166-7 gnd rswk-swf Interferon (DE-588)4130836-0 gnd rswk-swf Interferon (DE-588)4130836-0 s Genregulation (DE-588)4122166-7 s DE-604 Ransohoff, Richard M. Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007898371&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Sen, Ganes C. Ransohoff, Richard M. Transcriptional regulation in the interferon system Genregulation (DE-588)4122166-7 gnd Interferon (DE-588)4130836-0 gnd |
| subject_GND | (DE-588)4122166-7 (DE-588)4130836-0 |
| title | Transcriptional regulation in the interferon system |
| title_auth | Transcriptional regulation in the interferon system |
| title_exact_search | Transcriptional regulation in the interferon system |
| title_full | Transcriptional regulation in the interferon system Ganes C. Sen ; Richard M. Ransohoff |
| title_fullStr | Transcriptional regulation in the interferon system Ganes C. Sen ; Richard M. Ransohoff |
| title_full_unstemmed | Transcriptional regulation in the interferon system Ganes C. Sen ; Richard M. Ransohoff |
| title_short | Transcriptional regulation in the interferon system |
| title_sort | transcriptional regulation in the interferon system |
| topic | Genregulation (DE-588)4122166-7 gnd Interferon (DE-588)4130836-0 gnd |
| topic_facet | Genregulation Interferon |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007898371&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT senganesc transcriptionalregulationintheinterferonsystem AT ransohoffrichardm transcriptionalregulationintheinterferonsystem |