Cerebrovascular pathology in Alzheimer's disease: [this volume is the result of a conference ... held by the New York Academy of Sciences on November 12 - 15, 1996 in East Rutherford, New Jersey]
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| Format: | Buch |
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| Sprache: | English |
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New York, NY
New York Acad. of Sciences
1997
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| Schriftenreihe: | Annals of the New York Academy of Sciences
826 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV, 523 S. Ill., graph. Darst. |
| ISBN: | 1573310867 1573310875 |
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| adam_text | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 826
September 26,1997
CEREBROVASCULAR PATHOLOGY
IN ALZHEIMER S DISEASE0
Editors and Conference Organizers
Jack C. de la Torre and Vladimir Hachinski
CONTENTS
The Long Search: Preface to the Volume. By Jack de la Torre and
Vladimir Hachinski xiii
Part L Structural and Functional Pathology of Mkrovessels
Cerebrovascular Pathology in Alzheimer s Disease: Cause, Effect, or
Epiphenomenon? By Vladimir Hachinski and David G. Munoz 1
Brain Microvascular Changes in Alzheimer s Disease and Other
Dementias. By Luc Buee, Patrick R. Hof, and Andre
Delacourte 7
Electron Microscopy of Amyloid Fibrils and Microvessels. By Taihei
Miyakawa 25
The Vasoactivity of Aj3 Peptides. By Fiona Crawford, Zhiming Suo,
Chunhong Fang, Asad Sawar, George Su, Gary Arendash, and
Mike Mullan 35
Production of Neurotoxic Factors by Brain Endothelium in Alzheimer s
Disease. By Paula Grammas, Toya R. Botchlet, Pete Moore,
and Paul H. Weigel 47
Cerebrovascular Hypoperfusion: A Risk Factor for Alzheimer s
Disease?—Animal Model and Postmortem Human Studies. By
G. I. De Jong, R. A. I. De Vos, E. N. H. Jansen Steur, and
P. G. M. Luiten 56
Tins volume is the result of a conference entitled Cerebtoroariar Patitoiogy in Abtvtimet *
Disease held by the New York Academy of Sciences on November 12 15, 1996 in East
Rutherford, New Jersey.
v
Part n. Physiology of Cerebrovasculature in Alzheimer s Disease
Hemodynamic Consequences of Deformed Microvessels in the Brain in
Alzheimer s Disease. By J. C. de la Torre 75
Cognitive Impairment and Cellular/Vascular Changes in the Cerebral
White Matter. By Leonardo Pantoni and Julio H. Garcia 92
Cerebral Microvascular Alterations in Aging, Leukoaraiosis, and
Alzheimer s Disease. By Dixon M. Moody, William R. Brown,
Venkata R. Challa, Hani S. Ghazi Birry, and David
M. Reboussin 103
Can Deposition of Amyloid Be Prevented in Alzheimer s Disease? By
Robert Kisilevsky 117
Coronary Artery Disease, Hypertension, ApoE, and Cholesterol: A Link
to Alzheimer s Disease? By D. Larry Sparks 128
Part HI. Blood Brain Barrier Pathology
Vascular Basement Membrane Pathology and Alzheimer s Disease. By
Chris Zarow, Ernesto Barron, Helena Chang Chui, and Lynn
S. Perlmutter 147
Amyloid Angiopathy and Blood Brain Barrier Changes in Alzheimer s
Disease. By Henryk M. Wisniewski, Andrzej W. Vorbrodt, and
Jerzy Wegiel 161
Serum Protein Leakage in Alzheimer s Disease Revisited. By David G.
Munoz, Timo Erkinjuntti, Sylvia Gaytan Garcia, and Vladimir
Hachinski 173
Interactions of B Amyloids with the Blood Brain Barrier. By William A.
Banks, Abba J. Kastin, Lawrence M. Maness, Marian F. Banks,
Marcos Shayo, and Robert N. McLay 190
ApoE, Alzheimer s Disease, and Recovery from Brain Stress. By Allen
D. Roses and Ann M. Saunders 200
Notch3 Mutations in Cerebral Autosomal Dominant Arteriopathy with
Subcortical Infarcts and Leukoencephalopathy (CADASIL), a
Mendelian Condition Causing Stroke and Vascular Dementia. By
Anne Joutel, Christophe Corpechot, Anne Ducros, Katayoun
Vahedi, Huges Chabriat, Philippe Mouton, Sonia Alamowitch,
Valerie Domenga, Michaelle Cecillion, Emmanuelle
Marechal, Jacqueline Maciazek, Celine Vayssiere, Corinne
Cruaud, Emmanuel Alain Cabanis, Marie Madeleine Ruchoux,
Jean Weissenbach, Jean Francois Bach, Marie Germaine
Bousser, and Elisabeth Tournier Lasserve 213
Part Y. Cerebral Blood Flow and Metabolism
Brain Energy Metabolizing Enzymes in Alzheimer s Disease:
a Ketoglutarate Dehydrogenase Complex and Cytochrome Oxidase.
By Stephen J. Kish 218
Pathogenesis of Decreased Glucose Turnover and Oxidative
Phosphorylation in Ischemic and Trauma Induced Dementia of the
Alzheimer Type. By W. A. Meier Ruge and C. Bertoni Freddari .. 229
Neuroimaging of Vessel Amyloid in Alzheimer s Disease.
By Robert P. Friedland, Rajesh Kalaria, Marc Berridge,
Floro Miraldi, Peter Hedera, John Reno, Leon Lyle, and
Charles A. Marotta 242
Decreased Brain Glucose Metabolism in Microvessels from Patients with
Alzheimer s Disease. By David L. Marcus and Michael
L. Freedman 248
Clinical Studies of Cerebral Blood Flow in Alzheimer s Disease. By
William J. Jagust, Jamie L. Eberling, Bruce R. Reed, Chester
A. Mathis, and Thomas F. Budinger 254
Cerebrovascular Degeneration Is Related to Amyloid /? Protein
Deposition in Alzheimer s Disease. By Rajesh N. Kalaria 263
Misery Perfusion with Preserved Vascular Reactivity in Alzheimer s
Disease. By Ken Nagata, Robert J. Buchan, Eriko Yokoyama,
Yasushi Kondoh, Mika Sato, Hiroo Terashi, Yuichi Sato,
Yasuhito Watahiki, Melis Senova, Yutaka Hirata, and Jun
Hatazawa 272
Magnetic Resonance Spectroscopic Changes in Alzheimer s Disease. By
J. W. Pettegrew, W. E. Klunk, K. Panchalingam, R. J. McClure,
and J. A. Stanley 282
Part VI. Therapeutic Approaches
Clinical Trials in Dementia with Propentofylline. By Barbara Kittner,
Martin ROssner, and Matthias Rother 307
Combined Tacrine and Estrogen Replacement Therapy in Patients with
Alzheimer s Disease. By Lon S. Schneider and Martin Farlow 317
Omental Transposition to the Brain for Alzheimer s Disease. By Harry
S. Goldsmith 323
Support of Homeostatic Glial Cell Signaling: A Novel Therapeutic
Approach by Propentofylline. By Peter Schubert,
Tadanori Ogata, Karl Rudolphi, Cristina Marchini,
Amanda McRae, and Stefano Ferroni 337
Review and Summary
Amyloid Is Not a Tombstone —A Summation. The Primary Role for
Cerebrovascular and CSF Dynamics as Factors in Alzheimer s
Disease: DMSO, Fluorocarbon Oxygen Carriers, Thyroid Hormonal,
and Other Suggested Therapeutic Measures. By William Regelson
and S. W. Harkins 348
Extended Abstracts
Cerebrovascular Changes Associated with Interleukin 1/3 (IL 1/6) and
Histamine (HA) Levels in Alzheimer s Disease. By X. A. Alvarez,
L. Fernandez Novoa, J. Caamano, L. Corzo, R. Zas, K. Beyer,
J. I. Lao, and R. Cacabelos 375
Causes and Consequences of Neuronal Energy Deficit in Sporadic
Alzheimer s Disease. By J. Bauer, K. Plaschke, E. Martin,
H. J. Bardenheuer, and S. Hoyer 379
Inherent Abnormalities in Oxidative Metabolism in Alzheimer s Disease:
Interaction with Vascular Abnormalities. By John P. Blass,
Kwan Fu R. Sheu, Silvia Piacentini, and Sandro Sorbi 382
Microembolic Brain Injuries from Cardiac Surgery: Are They Seeds of
Future Alzheimer s Disease? By William R. Brown, Dixon
M. Moody, Michael Tytell, Hani S. Ghazi Birry, and
Venkata R. Challa 386
Amyloid /? Protein Angiopathies Masquerading as Alzheimer s Disease?
By D. L. Cohen, P. Hedera, D. R. D. Premkumar,
R. P. Friedland, and R. N. Kalaria : 390
Global Deterioration Scale Related Brain Hemodynamics and Histamine
Levels in Alzheimer s Disease and Vascular Dementia. By
L. Fernandez Novoa, L. Corzo, R. Zas, X. A. Alvarez, and
R. Cacabelos 396
Amyloid /3 Peptide and Precursor Protein (APP) in Mild and Severe Brain
Ischemia. By K. Jendroska, O. M. Hoffmann, and S. Patt 401
Dynamic FDG PET Study in Probable Alzheimer s Disease. By Yasushi
Kondoh, Ken Nagata, Hiroshi Sasaki, and Jun Hatazawa 406
Reduced Cortical Vasodilatory Response to Stimulation of the Nucleus
Basalis of Meynert in the Aged Rat and Evidence for a Control of
the Cerebral Circulation. By Pierre Lacombe, Richard Sercombe,
Elvire Vaucher, and Jacques Seylaz 410
Effects of Cholinesterase Inhibitors on the Secretion of Beta Amyloid
Precursor Protein in Cell Cultures. By D. K. Lahiri, M. R. Farlow,
J. I. Nurnberger, Jr., and N. H. Grieg 416
The Risk of Dementia among Persons with Diabetes Mellitus: A
Population Based Cohort Study. By C. L. Leibson, W. A. Rocca,
V. A. Hanson, R. Cha, E. Kokmen, P. C. O Brien, and P. J.
Palumbo 422
Changes of Microvessels in the Brain with Alzheimer s Disease. By
T. Miyakawa, S. Katsuragi, Y. Higuchi, K. Yamashita,
T. Kimura, K. Teraoka, T. Ono, and K. Ishizuka 428
Cerebral Hypoxia and Ischemia in the Pathogenesis of Dementia after
Stroke. By J. T. Moroney, E. Bagiella, D. W. Desmond, M. C.
Paik, Y. Stern, and T. K. Tatemichi 433
Cerebral Microischemia as a Potential Precipitant of the
Neurodegenerative Cascade of Alzheimer s Disease. By J. Steven
Richardson 437
Long Term Venous AB^_m Infusion in Rats Causes Lung Hemorrhage and
Brain Perivascular Gliosis. By George C. Su, Gary W. Arendash,
Rajesh N. Kalaria, and Michael J. Mullan 440
/3 Amyloid Induced Cerebrovascular Endothelial Dysfunction. By Tom
Thomas, Chris McLendon, E. Truitt Sutton, and George
Thomas 447
APOE e4 Allele Frequency in Alzheimer s Disease and Vascular
Dementia in the Spanish Population. By Katrin Beyer, Josfi
Ignacio Lao, Lucia Fernandez Novoa, Xose Ant6n Alvarez,
Maria Angeles Sellers, and Ramon Cacabelos 452
Inhibition of Glutamine Synthetase Induces Critical Energy Threshold for
Neuronal Survival. By David M. Cohen 456
;8 Amyloid Peptides and Enhancement of Vasoconstriction by
Endothelin 1. By Fiona Crawford, Zhiming Suo, Chunhong Fang,
and Mike Mullan 461
Amyloid Deposition in Cerebrovascular Angiopathy. By Rui J. P. de
Figueiredo, Remzi Oten, Joseph Su, and Carl W. Cotman 463
Tacrine Treatment in Alzheimer s Disease Enhances Cerebral Blood Flow
and Mental Status and Decreases Caregiver Suffering. By S. W.
Harkins, J. R. Taylor, V. Mattay, and W. Regelson 472
/3 Amyloid (Aj81 40) Evoked Changes in Vascular Reactivity Are
Mediated via an Endothelium Specific Mechanism: Studies Using
Rabbit Isolated Aorta. By T. Giokarini, L. Bonafini, M. S.
Shearman, R. G. Hill, and J. Longmore 475
Impaired Dynamic Morphology of Cerebellar Mitochondria in
Physiological Aging and Alzheimer s Disease. By Carlo
Bertoni Freddari, Patrizia Fattoretti, Roberta Paoloni,
Ugo Caselli, and William Meier Ruge 479
Human Aging: Risk Factors for Cerebral Atrophy. By John Stirling
Meyer, Hisanao Akiyama, Karl F. Mortel, Shizuko Konno, and
Gaiane M. Margishvili 483
Misclassification of Dementia Subtype Using the Hachinski Ischemic
Score: Results of a Meta Analysis of Patients with Pathologically
Verified Dementia. By J. T. Moroney, E. Bagiella, V. C.
Hachinski, P. K. MolsA, L. Gustafson, A. Brun, P. Fischer,
T. Erkinjuntti, W. Rosen, M. C. Paik, T. K. Tatemichi, and
D. W. Desmond 490
Types of Cerebrovascular Lesions Associated with Severe Cerebral
Amyloid Angiopathy in Alzheimer s Disease. By John M. Olichney,
Ronald J. Ellis, Robert Katzman, Marwan N. Sabbagh, and
Larry Hansen 493
Chronic Ischemia: Memory Impairment and Neural Pathology in the Rat.
By B. A. Pappas, C. M. Davidson, S. A. L. Bennett, J. C. de la
Torre, T. Fortin, and M. P. R. Tenniswood 498
The Effect of Stepwise Cerebral Hypoperfusion on Energy Metabolism
and Amyloid Precursor Protein (APP) in Cerebral Cortex and
Hippocampus in the Adult Rat. By Konstanze Plaschke, Tina
Ranneberg, Jens Bauer, Markus Weigand, Siegfried Hoyer,
and Hubert J. Bardenheuer 502
Altered Choroid Plexus Basement Membrane and Epithelium in
Late Onset Alzheimer s Disease: An Ultrastructural Study. By
J. M. Serot, M. C. Bene, B. Foliguet, and G. C. Faure 507
Accumulation of Aluminum and Silicon in Lipofuscin Granules Suggests
Retardation of Blood Brain Barrier Function by Aging. By
S. TOKUTAKE 510
Altered Phosphoglycerides and PLA2 Activity in Aging Mouse Brain
Microvessel Membrane. By W. M. Williams, M. C. J. Chang,
E. Grange, and S. I. Rapoport 513
Importance of Vascular Changes in Selective Neurodegeneration with
Thiamine Deficiency. By G. E. Gibson, N. Y. Calingasan,
H. Baker, S. Gandy, and K. F. R. Sheu 516
Index of Contributors 521
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| spellingShingle | Cerebrovascular pathology in Alzheimer's disease [this volume is the result of a conference ... held by the New York Academy of Sciences on November 12 - 15, 1996 in East Rutherford, New Jersey] Annals of the New York Academy of Sciences Alzheimerkrankheit (DE-588)4112510-1 gnd Hirngefäßkrankheit (DE-588)4025015-5 gnd Pathophysiologie (DE-588)4044898-8 gnd |
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| title | Cerebrovascular pathology in Alzheimer's disease [this volume is the result of a conference ... held by the New York Academy of Sciences on November 12 - 15, 1996 in East Rutherford, New Jersey] |
| title_auth | Cerebrovascular pathology in Alzheimer's disease [this volume is the result of a conference ... held by the New York Academy of Sciences on November 12 - 15, 1996 in East Rutherford, New Jersey] |
| title_exact_search | Cerebrovascular pathology in Alzheimer's disease [this volume is the result of a conference ... held by the New York Academy of Sciences on November 12 - 15, 1996 in East Rutherford, New Jersey] |
| title_full | Cerebrovascular pathology in Alzheimer's disease [this volume is the result of a conference ... held by the New York Academy of Sciences on November 12 - 15, 1996 in East Rutherford, New Jersey] ed. by Jack C. DeLaTorre ... |
| title_fullStr | Cerebrovascular pathology in Alzheimer's disease [this volume is the result of a conference ... held by the New York Academy of Sciences on November 12 - 15, 1996 in East Rutherford, New Jersey] ed. by Jack C. DeLaTorre ... |
| title_full_unstemmed | Cerebrovascular pathology in Alzheimer's disease [this volume is the result of a conference ... held by the New York Academy of Sciences on November 12 - 15, 1996 in East Rutherford, New Jersey] ed. by Jack C. DeLaTorre ... |
| title_short | Cerebrovascular pathology in Alzheimer's disease |
| title_sort | cerebrovascular pathology in alzheimer s disease this volume is the result of a conference held by the new york academy of sciences on november 12 15 1996 in east rutherford new jersey |
| title_sub | [this volume is the result of a conference ... held by the New York Academy of Sciences on November 12 - 15, 1996 in East Rutherford, New Jersey] |
| topic | Alzheimerkrankheit (DE-588)4112510-1 gnd Hirngefäßkrankheit (DE-588)4025015-5 gnd Pathophysiologie (DE-588)4044898-8 gnd |
| topic_facet | Alzheimerkrankheit Hirngefäßkrankheit Pathophysiologie Konferenzschrift 1996 East Rutherford NJ |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007883683&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002532608 |
| work_keys_str_mv | AT delatorrejackc cerebrovascularpathologyinalzheimersdiseasethisvolumeistheresultofaconferenceheldbythenewyorkacademyofsciencesonnovember12151996ineastrutherfordnewjersey |