Verfügbarkeit: Cytotoxic-T-lymphocytes in Theiler's virus infection

Cytotoxic-T-lymphocytes in Theiler's virus infection:

Gespeichert in:

Bibliographische Detailangaben
1. Verfasser:	Dethlefs, Sven 1968- (VerfasserIn)
Format:	Abschlussarbeit Buch
Sprache:	German
Veröffentlicht:	1997
Schlagworte:	Virusinfektion Killerzelle Hochschulschrift
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	[1], III, 108 Bl. Ill., graph. Darst.

Internformat

MARC


LEADER	00000nam a2200000 c 4500
001	BV011665539
003	DE-604
005	19980403
007	t
008	971125s1997 gw ad\|\| m\|\|\| 00\|\|\| ger d
016	7		\|a 951862057 \|2 DE-101
035			\|a (OCoLC)258637435
035			\|a (DE-599)BVBBV011665539
040			\|a DE-604 \|b ger \|e rakddb
041	0		\|a ger
044			\|a gw \|c DE
049			\|a DE-29T \|a DE-12 \|a DE-355 \|a DE-83 \|a DE-11 \|a DE-188
100	1		\|a Dethlefs, Sven \|d 1968- \|e Verfasser \|0 (DE-588)115776850 \|4 aut
245	1	0	\|a Cytotoxic-T-lymphocytes in Theiler's virus infection \|c Sven Dethlefs
264		1	\|c 1997
300			\|a [1], III, 108 Bl. \|b Ill., graph. Darst.
336			\|b txt \|2 rdacontent
337			\|b n \|2 rdamedia
338			\|b nc \|2 rdacarrier
502			\|a Berlin, Freie Univ., Diss., 1997
650	0	7	\|a Virusinfektion \|0 (DE-588)4188401-2 \|2 gnd \|9 rswk-swf
650	0	7	\|a Killerzelle \|0 (DE-588)4163776-8 \|2 gnd \|9 rswk-swf
655		7	\|0 (DE-588)4113937-9 \|a Hochschulschrift \|2 gnd-content
689	0	0	\|a Killerzelle \|0 (DE-588)4163776-8 \|D s
689	0	1	\|a Virusinfektion \|0 (DE-588)4188401-2 \|D s
689	0		\|5 DE-604
856	4	2	\|m DNB Datenaustausch \|q application/pdf \|u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007864581&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA \|3 Inhaltsverzeichnis
943	1		\|a oai:aleph.bib-bvb.de:BVB01-007864581

Datensatz im Suchindex

_version_	1812453171680772096
adam_text	TABLE OF CONTENTS I. INTRODUCTION.1 1. INNATE IMMUNITY.2 2. ADAPTIVE IMMUNITY.3 2.1. THE MAJOR HISTOCOMPATIBILITY COMPLEX (MHC).4 2.2. THE T CELL RECEPTOR.6 2.3. CYTOTOXIC T LYMPHOCYTES.7 2.4. T HELPER CELLS. 10 2.5. B CELLS.12 3. THEILER'S VIRUS.13 3.1. THE VIRUS.13 3.2. THEILER'S VIRUS INFECTION.16 3.3. VIRAL DETERMINANTS OF PERSISTENCE.19 3.4. GENETIC FACTORS DETERMINING VIRAL PERSISTENCE.20 3.5. THE IMMUNE RESPONSE TO THEILER'S VIRUS.21 II. AIM OF THE STUDY.25 III. MATERIALS AND METHODS.2 6 1. ANIMALS AND VIRUSES.2 6 2. CELL LINES.2 6 3. METHODS IN VIROLOGY.2 7 3.1. PRODUCTION OF DA VIRUS.27 3.2. PLAQUE ASSAY FOR VIRAL QUANTITATION.27 3.3. QUANTITATION OF VIRAL RNA IN THE CNS.27 3.4. HISTOLOGY.28 3.5. IMMUNOHISTOCHEMISTRY AND IN SITU HYBRIDISATION.29 4. METHODS IN IMMUNOLOGY.-3 0 4.1. GENERATION OF CTLS.30 4.2.51 QR LABELLING AND PREPARATION OF TARGET CELLS.30 4.3. CYTOXICITY ASSAYS.31 4.4. LIMITING DILUTION ASSAY.31 4.5. IN VITRO DEPLETION OF CD4 +, CD8+ T CELLS OR NK CELLS.32 4.6. ANTIBODY ELISA.32 4.7. CYTOKINE ELISA.33 4.8. ELISPOT.34 I BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/951862057 TABLE OF CONTENTS IV. RESULTS.3 6 1. CYTOTOXIC T LYMPHOCYTES IN C57BL/6 MICE.3 6 1.1. INDUCTION OF CTLS IN C57BL/6 MICE.36 1.2. CD8+ CTLS IN C57BL/6 MICE ARE H-2D B-RESTRICTED.37 2. KINETICS OF THE THEILER'S VIRUS-SPECIFIC CTL RESPONSE.4 0 2.1. KINETICS OF THE SPECIFIC CTL RESPONSE IN C57BL/6 AND SJL/J MICE.40 2.2. CTL PRECURSOR FREQUENCIES IN C57BL/6 AND SJL/J MICE.42 3. AN IMMUNODOMINANT CTL EPITOPE IN C57BL/6 MICE.4 5 3.1. DA AND MENGO VIRUS INDUCED CTLS ARE CROSS-REACTIVE.46 3.2. THE VP2122-130 EPITOPE OF DA VIRUS IS IMMUNODOMINANT.47 4. INFECTION OF H-2D B OR H-2KB DEFICIENT MICE.51 4.1. D B-/-, BUT NOT KB7- MICE ARE SUSCEPTIBLE TO DA VIRUS INFECTION.51 4.2. CYTOTOXIC ACTIVITY IN D B-/- AND KB-/- MICE~.53 4.3. VACCINATION OF D B-/- MICE.56 5. THEILER'S VIRUS INFECTION OF PERFORIN DEFICIENT MICE.5 8 5.1. INFECTION AND VACCINATION OF PERF-/- MICE.58 5.2. ANTIBODY TITERS IN PERF-/- MICE.60 5.3. CYTOTOXIC IMMUNE FUNCTIONS IN PERF-/- MICE.62 6. IN VIVO ADMINISTRATION OF LNTERLEUKIN-2 IN SUSCEPTIBLE MICE.6 5 6.1. PROTECTION BY IN VIVO ADMINISTRATION OF IL-2.65 6.2. INDUCTION OF CTLS BY IN VIVO ADMINISTRATION OF IL-2.67 6.3. CTL PRECURSOR FREQUENCIES IN IL-2 TREATED MICE.68 7. CYTOKINES INDUCED BY DA VIRUS IN C57BL/6 AND SJL/J MICE.7 0 7.1. CYTOKINE RESPONSES IN INFECTED SJL/J AND C57BL/6 MICE.70 7.3. ANTIBODY ISOTYPES IN SJL/J AND C57BL/6 MICE.73 7.4. ANTI IL-4 TREATMENT IN SJL/J MICE.75 V. DISCUSSION.7 6 1. TMEV-SPECIFIC CTL RESPONSES.7 7 2. CTL RESPONSES IN SUSCEPTIBLE AND RESISTANT MICE.7 9 3. IDENTIFICATION OF THE IMMUNODOMINANT CTL EPITOPE IN A RESISTANT MOUSE STRAIN.8 1 5. THE ROLE OF THE H-2D B AND -KB MOLECULES IN TMEV INFECTION.8 3 6. CYTOLYTIC PATHWAYS IN TMEV INFECTION.8 4 TABLE OF CONTENTS 7. IL-2 TREATMENT OF A TMEV-SUSCEPTIBLE MOUSE STRAIN.8 5 8. THE ROLE OF IL-4 AND IFN-Y IN TMEV INFECTION.8 6 VI. A SUMMARY.90 VI. B ZUSAMMENFASSUNG. 91 4 VII. REFERENCES. 94 VIII. CURRICULUM VITAE AND PUBLICATIONS, 107
any_adam_object	1
author	Dethlefs, Sven 1968-
author_GND	(DE-588)115776850
author_facet	Dethlefs, Sven 1968-
author_role	aut
author_sort	Dethlefs, Sven 1968-
author_variant	s d sd
building	Verbundindex
bvnumber	BV011665539
ctrlnum	(OCoLC)258637435 (DE-599)BVBBV011665539
format	Thesis Book
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>00000nam a2200000 c 4500</leader><controlfield tag="001">BV011665539</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">19980403</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">971125s1997 gw ad\|\| m\|\|\| 00\|\|\| ger d</controlfield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">951862057</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)258637435</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV011665539</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">ger</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">DE</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-29T</subfield><subfield code="a">DE-12</subfield><subfield code="a">DE-355</subfield><subfield code="a">DE-83</subfield><subfield code="a">DE-11</subfield><subfield code="a">DE-188</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Dethlefs, Sven</subfield><subfield code="d">1968-</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)115776850</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Cytotoxic-T-lymphocytes in Theiler's virus infection</subfield><subfield code="c">Sven Dethlefs</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1997</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">[1], III, 108 Bl.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="502" ind1=" " ind2=" "><subfield code="a">Berlin, Freie Univ., Diss., 1997</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Virusinfektion</subfield><subfield code="0">(DE-588)4188401-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Killerzelle</subfield><subfield code="0">(DE-588)4163776-8</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4113937-9</subfield><subfield code="a">Hochschulschrift</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Killerzelle</subfield><subfield code="0">(DE-588)4163776-8</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Virusinfektion</subfield><subfield code="0">(DE-588)4188401-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">DNB Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007864581&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="943" ind1="1" ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-007864581</subfield></datafield></record></collection>
genre	(DE-588)4113937-9 Hochschulschrift gnd-content
genre_facet	Hochschulschrift
id	DE-604.BV011665539
illustrated	Illustrated
indexdate	2024-10-09T16:07:18Z
institution	BVB
language	German
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-007864581
oclc_num	258637435
open_access_boolean
owner	DE-29T DE-12 DE-355 DE-BY-UBR DE-83 DE-11 DE-188
owner_facet	DE-29T DE-12 DE-355 DE-BY-UBR DE-83 DE-11 DE-188
physical	[1], III, 108 Bl. Ill., graph. Darst.
publishDate	1997
publishDateSearch	1997
publishDateSort	1997
record_format	marc
spelling	Dethlefs, Sven 1968- Verfasser (DE-588)115776850 aut Cytotoxic-T-lymphocytes in Theiler's virus infection Sven Dethlefs 1997 [1], III, 108 Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Berlin, Freie Univ., Diss., 1997 Virusinfektion (DE-588)4188401-2 gnd rswk-swf Killerzelle (DE-588)4163776-8 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Killerzelle (DE-588)4163776-8 s Virusinfektion (DE-588)4188401-2 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007864581&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Dethlefs, Sven 1968- Cytotoxic-T-lymphocytes in Theiler's virus infection Virusinfektion (DE-588)4188401-2 gnd Killerzelle (DE-588)4163776-8 gnd
subject_GND	(DE-588)4188401-2 (DE-588)4163776-8 (DE-588)4113937-9
title	Cytotoxic-T-lymphocytes in Theiler's virus infection
title_auth	Cytotoxic-T-lymphocytes in Theiler's virus infection
title_exact_search	Cytotoxic-T-lymphocytes in Theiler's virus infection
title_full	Cytotoxic-T-lymphocytes in Theiler's virus infection Sven Dethlefs
title_fullStr	Cytotoxic-T-lymphocytes in Theiler's virus infection Sven Dethlefs
title_full_unstemmed	Cytotoxic-T-lymphocytes in Theiler's virus infection Sven Dethlefs
title_short	Cytotoxic-T-lymphocytes in Theiler's virus infection
title_sort	cytotoxic t lymphocytes in theiler s virus infection
topic	Virusinfektion (DE-588)4188401-2 gnd Killerzelle (DE-588)4163776-8 gnd
topic_facet	Virusinfektion Killerzelle Hochschulschrift
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007864581&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT dethlefssven cytotoxictlymphocytesintheilersvirusinfection

Verfügbarkeit

Es ist kein Print-Exemplar vorhanden.

Fernleihe Bestellen Achtung: Nicht im THWS-Bestand! Inhaltsverzeichnis

MARC

Datensatz im Suchindex

Es ist kein Print-Exemplar vorhanden.

Ähnliche Einträge