Cell cycle regulators in cancer:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Basel ; Freiburg ; Paris [u.a.]
Karger Landes Systems
1997
|
| Schriftenreihe: | Oncology
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | IX, 162 Seiten Ill., graph. Darst. |
| ISBN: | 3805565615 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804126193012703232 |
|---|---|
| adam_text | Contents
IX Acknowledgments
1 1 Introduction
3 Cell Cycle and Cancer
4 Cell Cycle Machinery
6 Yeast Cell Cycle Genetics
7 Tumor Suppressor Genes
7 Transcriptional Control
2 8 Discovery of Cell Cycle Regulators
10 The Structure of the Cell Cycle
1 1 The First Cyclins
13 Mitosis Promoting Factor
16 Cell Division Cycle Genes
19 MPF is a Cyclin CDK Complex
21 Another Cyclin, Another CDK
21 Cyclins Regulate the Gl/S Phase Transition
23 A Paradigm of Cell Cycle Regulation
3 29 Cyclins and Cyclin Dependent Kinases
31 Mitotic Cyclins
33 Gl Cyclins
35 Miscellaneous Cyclins and CDKs
38 The Physical Interaction of Cyclins and CDKs
40 Cyclin CDK Complexes in the Cell Cycle
4 47 Cyclin CDK Regulation: Post Translational Modification
49 CDK1 is Subject to Modification During the Yeast Cell Cycle
54 Protein Kinases and Phosphatases
57 Regulatory Phosphorylation as a Model for Mitotic Control
60 A Cyclin CDK Complex Regulates MPF
61 A General Schematic for CDK Regulation by Post Translational Modification
5 70 Cyclin CDK Regulation: Checkpoints and Inhibitors
70 Two Regulatory Puzzles
75 The First of the Inhibitors
78 p21
80 p27
82 p57
83 pl6
84 Other INK4 Proteins
85 Other CDK Interacting Proteins
87 A Comprehensive Regulatory Model
6 94 Effectors of Cyclin CDK Complexes
94 The Retinoblastoma Susceptibility Gene
96 The Retinoblastoma Tumor Suppressor Protein
97 pRb as a Regulator of Cellular Growth
100 E2F and DP Transcription Factors
104 The Interaction of pRb and D Type Cyclins
106 Other Substrates of Cyclin CDK Complexes
7 116 Affectors of Cyclin CDK Complexes
117 The p53 Tumor Suppressor Protein
120 Transforming Growth Factor Beta (TGF p)
122 DNA Tumor Viruses
124 The Yin and Yang of Cell Cycle Regulation
8 130 Links to Cancer
130 Cyclins
133 CDKs
134 CKIs
138 Other Cell Cycle Related Proteins
139 A Central Pathway for Cell Cycle Deregulation?
9 151 Perspective
151 Cyclin CDK Regulation is Cell Cycle Regulation
154 The Current Model of the Cell Cycle
157 Targets for Clinical Intervention in the Treatment of Cancer
160 Subject Index
|
| any_adam_object | 1 |
| author | Musunuru, Kiran Hinds, Philip W. |
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| ctrlnum | (OCoLC)231710081 (DE-599)BVBBV011657260 |
| discipline | Medizin |
| format | Book |
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| id | DE-604.BV011657260 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:13:33Z |
| institution | BVB |
| isbn | 3805565615 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007858644 |
| oclc_num | 231710081 |
| open_access_boolean | |
| owner | DE-12 DE-29 DE-355 DE-BY-UBR DE-11 |
| owner_facet | DE-12 DE-29 DE-355 DE-BY-UBR DE-11 |
| physical | IX, 162 Seiten Ill., graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Karger Landes Systems |
| record_format | marc |
| series2 | Oncology |
| spelling | Musunuru, Kiran Verfasser (DE-588)1240242786 aut Cell cycle regulators in cancer Kiran Musunuru ; Philip W. Hinds Basel ; Freiburg ; Paris [u.a.] Karger Landes Systems 1997 IX, 162 Seiten Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Oncology Zellzyklus (DE-588)4129960-7 gnd rswk-swf Regulation (DE-588)4049075-0 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Cyclin-abhängige Kinasen (DE-588)4485596-5 gnd rswk-swf Carcinogenese (DE-588)4069853-1 gnd rswk-swf Cycline (DE-588)4313464-6 gnd rswk-swf Carcinogenese (DE-588)4069853-1 s Zellzyklus (DE-588)4129960-7 s Regulation (DE-588)4049075-0 s Cycline (DE-588)4313464-6 s DE-604 Krebs Medizin (DE-588)4073781-0 s Cyclin-abhängige Kinasen (DE-588)4485596-5 s Hinds, Philip W. Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007858644&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Musunuru, Kiran Hinds, Philip W. Cell cycle regulators in cancer Zellzyklus (DE-588)4129960-7 gnd Regulation (DE-588)4049075-0 gnd Krebs Medizin (DE-588)4073781-0 gnd Cyclin-abhängige Kinasen (DE-588)4485596-5 gnd Carcinogenese (DE-588)4069853-1 gnd Cycline (DE-588)4313464-6 gnd |
| subject_GND | (DE-588)4129960-7 (DE-588)4049075-0 (DE-588)4073781-0 (DE-588)4485596-5 (DE-588)4069853-1 (DE-588)4313464-6 |
| title | Cell cycle regulators in cancer |
| title_auth | Cell cycle regulators in cancer |
| title_exact_search | Cell cycle regulators in cancer |
| title_full | Cell cycle regulators in cancer Kiran Musunuru ; Philip W. Hinds |
| title_fullStr | Cell cycle regulators in cancer Kiran Musunuru ; Philip W. Hinds |
| title_full_unstemmed | Cell cycle regulators in cancer Kiran Musunuru ; Philip W. Hinds |
| title_short | Cell cycle regulators in cancer |
| title_sort | cell cycle regulators in cancer |
| topic | Zellzyklus (DE-588)4129960-7 gnd Regulation (DE-588)4049075-0 gnd Krebs Medizin (DE-588)4073781-0 gnd Cyclin-abhängige Kinasen (DE-588)4485596-5 gnd Carcinogenese (DE-588)4069853-1 gnd Cycline (DE-588)4313464-6 gnd |
| topic_facet | Zellzyklus Regulation Krebs Medizin Cyclin-abhängige Kinasen Carcinogenese Cycline |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007858644&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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