HIV and the pathogenesis of AIDS:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Washington, D.C
ASM Press
1998
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXII, 588 S. Ill., graph. Darst. |
| ISBN: | 1555811221 |
Internformat
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| 100 | 1 | |a Levy, Jay A. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a HIV and the pathogenesis of AIDS |c Jay A. Levy |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a Washington, D.C |b ASM Press |c 1998 | |
| 300 | |a XXII, 588 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Infections à VIH - Pathogenèse | |
| 650 | 4 | |a Virus de l'immunodéficience humaine | |
| 650 | 4 | |a Acquired Immunodeficiency Syndrome |x etiology | |
| 650 | 4 | |a Acquired Immunodeficiency Syndrome |x physiopathology | |
| 650 | 4 | |a HIV (Viruses) | |
| 650 | 4 | |a HIV infections |x Pathogenesis | |
| 650 | 4 | |a HIV |x pathogenicity | |
| 650 | 0 | 7 | |a HIV |0 (DE-588)4200792-6 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Pathogenese |0 (DE-588)4115512-9 |2 gnd |9 rswk-swf |
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Datensatz im Suchindex
| _version_ | 1804126175047450624 |
|---|---|
| adam_text | Contents
Preface
Preface to the First Edition
1 Discovery and Orgin of HIV 1
I. Discovery of the AIDS Virus 3
II. TheHIVVirion 7
III. Origin of HIV 11
3 Features of HIV Transmission 15
I. HIV in Blood 16
II. HIV in Genital Fluids 22
III. HIV in Saliva and Other Body Fluids 26
IV. HIV Transmission by Blood and Blood Products 27
V. Sexual Transmission of HIV 28
VI. Mother Child Transmission of HIV 36
3 Steps Involved in HIV:Cell Interaction and Virus Entry 43
I. CD4 Receptor 43
II. Postbinding Steps in Virus Entry 47
III. Virus:Cell Fusion 56
IV. HIV:Cell Surface Interactions Possibly Involved in Virus Entry 58
V. Down Modulation of the CD4 Protein 59
VI. Infection of Cells Lacking CD4 Expression 61
vii
VII. Other Possible HIV:Cell Surface Interactions 64
VIII. Overview of Early Steps in HIV Infection 64
IX. Cell to Cell Transfer of HIV 66
X. Additional Mechanisms Involved in Virus Entry 68
XI. Recombination 72
z| Acute HIV Infection and Cells Susceptible to HIV Infection 75
I. Acute HIV Infection 75
II. Cells and Tissues Infected by HIV 83
III. Number of CD4+ Lymphocytes Infected by HIV 91
IV. Interference and Superinfection 92
fj Intracellular Control of HIV Replication 97
I. Early Intracelullar Events in HIV Infection 97
II. Differences in Virus Production: Role of Intracellular Factors 100
III. Effect of Other Viruses on HIV Replication 105
IV. Virus Infection of Quiescent Cells 106
V. Latency 111
ft Cytopathic Properties of HIV 121
I. HIV Induction of Cell Fusion 121
II. Accumulation of Extrachromosomal Viral DNA and Cell Death 125
III. Toxicity of the Virus and Viral Proteins 125
IV. Apoptosis 128
V. Role of Superantigens 133
^ Heterogeneity of HIV and Its Relation to Pathogenesis 137
I. HIV 2 138
II. Differences in Cellular Host Range among HIV 1 Strains 141
III. Modulation of CD4 Protein Expression 149
IV. Cytopathology 149
V. Latency 150
VI. Molecular Features of HIV Strains 151
VII. Serologic Properties of HIV Strains 159
VIII. Sensitivity to Cell Mediated Immune Responses 165
IX. Relation of HIV Heterogeneity to Pathogenesis 165
Q Viral Regions Determining Biologic Features of HIV 175
I. Envelope Region and Cell Tropism 175
II. Regulatory Proteins and Virus Replication 184
III. Envelope Region and Cytopathicity, CD4 Protein Modulation, and sCD4
Neutralization 185
IV. Conclusions 187
Q Effect of HIV on Various Tissues and Organ Systems
in the Host 189
I. Hematopoietic System: Immune Function 189
II. Central Nervous System 206
III. Gastrointestinal System 224
IV. Other Organ Systems 226
4 Q Humoral Immune Responses to HIV Infection 229
I. Detection of Anti HIV Antibodies 229
II. Neutralizing Antibodies 231
III. Enhancing Antibodies 237
IV. Antibody Dependent Cellular Cytotoxicity and Antibody Dependent
Cytotoxicity 242
V. Complement Fixing Antiviral Antibodies 243
VI. Complement 243
VII. Autoimmunity 244
4 ? Cell Mediated Immune Responses in HIV Infection 253
I. Natural Killer Cells 254
II. Cytotoxic T Lymphocytes 256
III. CD8+ Cell Noncytotoxic Anti HIV Activity 270
IV. Cell Mediated Antiviral Immune Responses in Uninfected, HIV Exposed
High Risk Individuals 281
V. Antiviral Responses at Mucosal Surfaces 282
jM? HIV Infection and Development of Cancer 285
I. Introduction 285
II. Kaposi s Sarcoma 287
III. B Cell Lymphomas 297
IV. Anal Carcinoma 303
V. Cervical Carcinoma 306
VI. Other Lymphomas 306
VII. Summary 308
J ^2 Overall Features of HIV Pathogenesis: Prognosis for Long Term
1%J Survival 311
I. Cofactors in HIV Infection and Disease Progression 311
II. Features of HIV Pathogenesis 317
III. Prognosis 325
IV. Differences in Clinical Outcome 329
V. Factors Involved in Long Term Survival 332
VI. High Risk Exposed Seronegative Individuals 335
VII. Conclusions: Viral and Immunologic Features of HIV Pathogenesis 336
jj^£ Antiviral Therapies 339
I. Anti HIV Therapies 339
II. Effects of Antiretroviral Therapy on the Immune System 354
III. Immune System Based Therapies 356
IV. Immune Restoration 358
V. Postinfection Immunization 360
VI. Passive Immunotherapy and Use of Antibody Based Approaches 361
VII. Summary 362
jH*jr Vaccine Development 365
I. Introduction 366
II. Inactivated and Attenuated Viruses 369
III. Vaccines Containing Purified Envelope gp120 Alone or in Association
with an Expression Vector 372
IV. Viral Cores as Vaccines 377
V. Viral DNA Inoculation 377
VI. Cytokine Enhancement 380
VII. Induction of Mucosal Immunity 381
VIII. Human Vaccine Trials 382
IX. Other Anti HIV Prevention Approaches 390
Conclusions 393
Appendix 1:1993 Revised Classification System for HIV
Infection and Expanded AIDS Surveillance Case Definition for
Adolescents and Adults 397
Appendix II: Clinical Categories 399
Appendix III: Conditions Included in the 1993 AIDS
Surveillance Case Definition 401
Appendix IV: Other Definitions in HIV Infection: CD4+
T Lymphocyte Categories 403
References 405
Index 579
|
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| discipline | Medizin |
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| spelling | Levy, Jay A. Verfasser aut HIV and the pathogenesis of AIDS Jay A. Levy 2. ed. Washington, D.C ASM Press 1998 XXII, 588 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Infections à VIH - Pathogenèse Virus de l'immunodéficience humaine Acquired Immunodeficiency Syndrome etiology Acquired Immunodeficiency Syndrome physiopathology HIV (Viruses) HIV infections Pathogenesis HIV pathogenicity HIV (DE-588)4200792-6 gnd rswk-swf Pathogenese (DE-588)4115512-9 gnd rswk-swf Aids (DE-588)4112470-4 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content HIV (DE-588)4200792-6 s Aids (DE-588)4112470-4 s Pathogenese (DE-588)4115512-9 s 1\p DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007846339&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Levy, Jay A. HIV and the pathogenesis of AIDS Infections à VIH - Pathogenèse Virus de l'immunodéficience humaine Acquired Immunodeficiency Syndrome etiology Acquired Immunodeficiency Syndrome physiopathology HIV (Viruses) HIV infections Pathogenesis HIV pathogenicity HIV (DE-588)4200792-6 gnd Pathogenese (DE-588)4115512-9 gnd Aids (DE-588)4112470-4 gnd |
| subject_GND | (DE-588)4200792-6 (DE-588)4115512-9 (DE-588)4112470-4 (DE-588)4143413-4 |
| title | HIV and the pathogenesis of AIDS |
| title_auth | HIV and the pathogenesis of AIDS |
| title_exact_search | HIV and the pathogenesis of AIDS |
| title_full | HIV and the pathogenesis of AIDS Jay A. Levy |
| title_fullStr | HIV and the pathogenesis of AIDS Jay A. Levy |
| title_full_unstemmed | HIV and the pathogenesis of AIDS Jay A. Levy |
| title_short | HIV and the pathogenesis of AIDS |
| title_sort | hiv and the pathogenesis of aids |
| topic | Infections à VIH - Pathogenèse Virus de l'immunodéficience humaine Acquired Immunodeficiency Syndrome etiology Acquired Immunodeficiency Syndrome physiopathology HIV (Viruses) HIV infections Pathogenesis HIV pathogenicity HIV (DE-588)4200792-6 gnd Pathogenese (DE-588)4115512-9 gnd Aids (DE-588)4112470-4 gnd |
| topic_facet | Infections à VIH - Pathogenèse Virus de l'immunodéficience humaine Acquired Immunodeficiency Syndrome etiology Acquired Immunodeficiency Syndrome physiopathology HIV (Viruses) HIV infections Pathogenesis HIV pathogenicity HIV Pathogenese Aids Aufsatzsammlung |
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