The many faces of RNA:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
San Diego [u.a.]
Acad. Press
1998
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVI, 228 S. Ill., graph. Darst. |
| ISBN: | 0122332105 |
Internformat
MARC
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| 245 | 1 | 0 | |a The many faces of RNA |c ed. by D. S. Eggleston ... |
| 264 | 1 | |a San Diego [u.a.] |b Acad. Press |c 1998 | |
| 300 | |a XVI, 228 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a ARN - Congrès | |
| 650 | 4 | |a ARN - Emploi en thérapeutique - Congrès | |
| 650 | 4 | |a Antibiotiques - Effets physiologiques - Congrès | |
| 650 | 4 | |a Interactions ARN-protéines | |
| 650 | 4 | |a Ribonucléases - Congrès | |
| 650 | 4 | |a Antibiotics |x Physiological effect |v Congresses | |
| 650 | 4 | |a Drug Design |v Congresses | |
| 650 | 4 | |a RNA |v Congresses | |
| 650 | 4 | |a RNA |x Therapeutic use |v Congresses | |
| 650 | 4 | |a RNA |x drug effects |v Congresses | |
| 650 | 4 | |a RNA |x physiology |v Congresses | |
| 650 | 4 | |a RNA |x therapeutic use |v Congresses | |
| 650 | 4 | |a RNA-Binding Proteins |v Congresses | |
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Datensatz im Suchindex
| _version_ | 1804126160670425088 |
|---|---|
| adam_text | Contents
Contributors xi
Introduction xiii
I OVERVIEW 1
1 RNA as a Therapeutic Target for Bleomycin 3
S. M. Hecht
Abstract 3
1 Introduction 4
2 RNAs that are cleaved by bleomycin in vitro 6
3 Cleavage of a DNA RNA heteroduplex by Fe»Bleomycin 11
4 Structural factors controlling the cleavage of DNA and
RNA 11
5 Cleavage of RNA by bleomycin in an intact cell 13
6 The case for RNA as a therapeutic target for BLM 15
7 Conclusion 15
Acknowledgement 16
References 16
II RNA: CHEMISTRY, STRUCTURE AND INTERACTIONS 19
2 Synthetic RNA Modification and Cross linking Approaches towards
the Structure of the Hairpin Ribozyme and the HIV 1 Tat Protein
Interaction with TAR RNA 21
M. J. Gait, D. J. Earnshaw, M. A. Farrow and N. A. Naryshkin
Abstract 21
1 Introduction 22
2 Chemical synthesis of oligoribonucleotides and analogues 23
3 The hairpin ribozyme 28
vi Contents
4 HIV 1 Tat protein interaction with TAR RNA 31
Acknowledgements 35
References 36
3 The Ribosome The Universal Protein synthesizing Machine 41
R. Brimacombe
Abstract 41 j
1 Introduction 42 j
2 The new era in electron microscopy 43
3 Three dimensional modelling of the ribosomal RNA 44
4 RNA protein interactions 46 ;
5 The decoding region of the 30 S subunit 47
6 Sites of interaction with antibiotics 50
7 Conclusions 51
References 51
4 tRNA Recognition by Aminoacyl tRNA Synthetases 55
5. Cusack, A. Yaremchuk and M. Tukalo
Abstract 55
1 Introduction 55
2 tRNA identity 56
3 The two classes of aminoacyl tRNA synthetases 57
4 RNA binding modules in aminoacyl tRNA synthetases 57
5 General features of tRNA recognition by aminoacyl tRNA
synthetases 59
6 Glutaminyl tRNA synthetase (GlnRS) 59
7 tRNA recognition by class lib synthetases 60
8 tRNA recognition by class Ila aminoacyl tRNA
synthetases 61
9 Seryl tRNA synthetase (SerRS) 63
Acknowledgements 64
References 64
5 RNA Protein Recognition During RNA Processing and
Maturation 67
G. Varani
Abstract 67
1 Introduction 67
Contents vii
2 RNA recognition differs from DNA recognition 68
3 a/J protein domains 70
4 The RNP domain paradigm of RNA recognition 72
5 RNP proteins recognize both the identity of single stranded
nucleotides and the unique shape and charge distribution
of the substrate RNA 73
6 Rigid docking and adaptive binding 77
7 Conformation^ flexibility at RNA protein interfaces 78
8 Do RNA and protein conformational rearrangements contribute to
specificity? 79
9 Functional implications 79
10 Conclusions and perspectives 80
Acknowledgements 80
References 80
III RNA AS A TARGET/RNA AS A TOOL 83
6 Exploiting RNA: Potential Targets, Screens and
Drug Development 85
C. D. Prescott, L. Hegg, K. Nurse, R. Gontarek, Hu Li, V. Emerick,
T. Sterner, M. Gress, G. Thorn, S. Guth and D. Rispoli
Abstract 85
1 Introduction 86
2 Validity of RNA as a target 86
3 Target selection: criteria and issues 87
4 Exploiting RNA as a target and tool 88
5 Concluding remarks 93
References 93
7 Structural Basis for Aminoglycoside Antibiotic Action 97
J. D. Puglisi
Abstract 97
1 Introduction 98
2 Aminoglycoside antibiotics 100
3 Denning a model oligonucleotide for structural studies 101
4 RNA structure determination by NMR 103
5 Conformation of the unbound A site RNA 105
6 Structure of the A site RNA paromomycin complex 105
7 Prokaryotic specificity of aminoglycoside antibiotics 107
vjjj Contents
8 Structure explains resistance mechanisms 108
9 Mechanism of aminoglycoside induced miscoding 110
10 Conclusions 110
Acknowledgements Ill
References Ill
8 Protein RNA Recognition in a Highly Conserved Ribosomal
Domain Targeted by Thiazole Antibiotics 113
D. E. Draper
Abstract 113
1 Introduction 114
2 Structure of the RNA binding domain of ribosomal
protein LI 1 115
3 An RNA tertiary structure dependent on Mg2+ and
NH4+ ions 117
4 RNA features required for protein recognition 120
5 Targeting of thiazole antibiotics to the LI 1 RNA complex .... 122
6 Conclusions 123
Acknowledgements 124
References 124
9 RNase P and Its Substrate 127
L. A. Kirsebom
Abstract 127
1 Introduction 128
2 RNase P RNA substrate interactions 129
3 RNase P RNA structure and function 137
4 Summary 140
5 Concluding remarks 141
Acknowledgements 141
References 141
10 Interfering with Gene Function at the RNA Level with
Oligozymes the Development of New Tools and Therapeutics 145
B. S. Sprout, S. T. George, M. Ma and A. R. Goldberg
Abstract 145
1 Introduction 146
2 Oligozymes 148
Contents ix
3 Oligozymes based on the hammerhead ribozyme 151
4 Choosing a target site on an RNA 153
5 Elucidating gene function in vivo 155
6 Conclusion 157
References 158
11 Progress towards Therapeutic Application of SELEX derived
Aptamers 161
B. Polisky
Abstract 161
1 Introduction 162
2 Design and construction of an oligonucleotide library 165
3 Partition 167
4 Truncation 170
5 Post SELEX modifications 171
6 Aptamer structures 171
7 Applications 172
8 Conclusion and perspective 174
Acknowledgements 175
References 175
12 Catalysis of Organic Reactions by RNA Strategies for the
Selection of Catalytic RNAs 179
A. Jaschke
Abstract 179
1 Introduction 180
2 Selection of catalytic RNA molecules 181
3 SELEX with linker coupled reactants 183
4 Future directions 187
Acknowledgement 189
References 189
Conclusions and Opportunities 191
B. W. Metcalf
Appendix: Abstracts of Posters 195
Index 223
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| spelling | The many faces of RNA ed. by D. S. Eggleston ... San Diego [u.a.] Acad. Press 1998 XVI, 228 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier ARN - Congrès ARN - Emploi en thérapeutique - Congrès Antibiotiques - Effets physiologiques - Congrès Interactions ARN-protéines Ribonucléases - Congrès Antibiotics Physiological effect Congresses Drug Design Congresses RNA Congresses RNA Therapeutic use Congresses RNA drug effects Congresses RNA physiology Congresses RNA therapeutic use Congresses RNA-Binding Proteins Congresses RNA-protein binding Congresses Ribonucleases Congresses RNS (DE-588)4076759-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content (DE-588)1071861417 Konferenzschrift gnd-content RNS (DE-588)4076759-0 s DE-604 Eggleston, Drake S. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007836452&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The many faces of RNA ARN - Congrès ARN - Emploi en thérapeutique - Congrès Antibiotiques - Effets physiologiques - Congrès Interactions ARN-protéines Ribonucléases - Congrès Antibiotics Physiological effect Congresses Drug Design Congresses RNA Congresses RNA Therapeutic use Congresses RNA drug effects Congresses RNA physiology Congresses RNA therapeutic use Congresses RNA-Binding Proteins Congresses RNA-protein binding Congresses Ribonucleases Congresses RNS (DE-588)4076759-0 gnd |
| subject_GND | (DE-588)4076759-0 (DE-588)4143413-4 (DE-588)1071861417 |
| title | The many faces of RNA |
| title_auth | The many faces of RNA |
| title_exact_search | The many faces of RNA |
| title_full | The many faces of RNA ed. by D. S. Eggleston ... |
| title_fullStr | The many faces of RNA ed. by D. S. Eggleston ... |
| title_full_unstemmed | The many faces of RNA ed. by D. S. Eggleston ... |
| title_short | The many faces of RNA |
| title_sort | the many faces of rna |
| topic | ARN - Congrès ARN - Emploi en thérapeutique - Congrès Antibiotiques - Effets physiologiques - Congrès Interactions ARN-protéines Ribonucléases - Congrès Antibiotics Physiological effect Congresses Drug Design Congresses RNA Congresses RNA Therapeutic use Congresses RNA drug effects Congresses RNA physiology Congresses RNA therapeutic use Congresses RNA-Binding Proteins Congresses RNA-protein binding Congresses Ribonucleases Congresses RNS (DE-588)4076759-0 gnd |
| topic_facet | ARN - Congrès ARN - Emploi en thérapeutique - Congrès Antibiotiques - Effets physiologiques - Congrès Interactions ARN-protéines Ribonucléases - Congrès Antibiotics Physiological effect Congresses Drug Design Congresses RNA Congresses RNA Therapeutic use Congresses RNA drug effects Congresses RNA physiology Congresses RNA therapeutic use Congresses RNA-Binding Proteins Congresses RNA-protein binding Congresses Ribonucleases Congresses RNS Aufsatzsammlung Konferenzschrift |
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