Serotoninergic neurons and 5-HT receptors in the CNS: [with 35 tables]
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1997
|
| Schriftenreihe: | Handbook of experimental pharmacology
129 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXX, 767 S. Ill., graph. Darst. |
| ISBN: | 3540626662 |
Internformat
MARC
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| 245 | 1 | 0 | |a Serotoninergic neurons and 5-HT receptors in the CNS |b [with 35 tables] |c contributors G. K. Aghajanian ... Eds. H. G. Baumgarten ... |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 1997 | |
| 300 | |a XXX, 767 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Handbook of experimental pharmacology |v 129 | |
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| 650 | 7 | |a Neurons |2 cabt | |
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Datensatz im Suchindex
| _version_ | 1804125989494587392 |
|---|---|
| adam_text | Contents
CHAPTER 1
Development and Adult Plasticity of Serotoninergic Neurons
and Their Target Cells
E.C. Azmitia and P.M. Whitaker Azmitia. With 7 Figures 1
A. Introduction 1
B. Serotonin Growth 2
I. Immature Brain 2
1. Neurons 2
2. Receptors 3
II. Mature Brain 4
1. Regeneration 6
2. Homotypic Collateral Sprouting 7
3. Heterotypic Collateral Sprouting 7
III. Transplantation: Mature and Immature Interactions 8
C. Trophic Factors 9
I. Neurotransmitters 9
1. Serotonin 9
2. Dopamine 10
II. Protein Growth Factors 10
1. S 100/3 11
2. Brain Derived Neuronotrophic Factor 12
3. Other Factors 12
III. Neuropeptides 12
IV. Steroids 14
V. Attachment Factors 14
VI. Summary 14
D. Serotoninergic Influences on Target Tissue Maturation 15
I. Introduction 15
II. Immature Brain 16
III. Mature Brain 19
E. Neuronal Dynamic Instability 22
I. Model 22
II. Clinical Implications 25
1. Psychiatric Implications 26
XIV Contents i
2. Alzheimer s Disease 26
References 27
Chapter 2
Anatomy of Central Serotoninergic Projection Systems
H.G. Baumgarten and Z. Grozdanovic. With 1 Figure 41
A. Introduction 41
B. Historical Perspective 41
C. Nuclei of Origin of Serotoninergic Projections 43
D. Coexistence of Serotonin, Peptides, GABA and
Nitric Oxide Synthase in 5 HT Neurons 49
E. Projections to the Spinal Cord, Brainstem and Cerebellum 51
F. Projections to the Forebrain 54
G. Afferent Connections of the Raphe Nuclei 58
H. Terminal Axon Innervation Patterns and Target
Relationship 60
References 71
CHAPTER 3
Physiology and Pharmacology of Brain Serotoninergic Neurons
B.L. Jacobs and C.A. Fornal 91
A. General Introduction 91
B. Anatomical Perspective 91
C. Activity of Serotoninergic Neurons in Behaving Cats 92
I. Introduction 92
II. Sleep Wake Arousal Cycle 92
III. Afferent Control of Neuronal Activity 94
IV. Response to Challenges/Stressors 95
V. Relation to Motor Activity 96
VI. Conclusions 98
D. Release of Serotonin in Forebrain Sites 99
I. Introduction 99
II. Sleep Wake Arousal Cycle 99
III. Response to Challenges/Stressors 100
IV. Conclusions 101
E. Pharmacological Studies of Serotonin
Somatodendritic Autoreceptors 101
I. Introduction 101
II. Effects of Agonist and Antagonist Drugs 101
III. Role in the Regulation of Neuronal Activity 105
IV. Role in Therapeutic Action of Antidepressant Drugs 108
1
Contents XV
V. Conclusions 110
References Ill
CHAPTER 4
Tryptophan Hydroxylase: Molecular Biology and Regulation
T.H. Joh. With 4 Figures 117
A. Introduction 117
B. Structure 118
C. Neurochemistry 119
D. Gene Expression and Regulation 121
E. Immortalized Serotoninergic Cell Lines 123
F. TPH Regulation at mRNA Levels 123
G. Conclusion 125
References 126
CHAPTER 5
Molecular Analysis of Serotonin Packaging into Secretory Vesicles
D. Peter, J.P. Finn III, A. Merickel, Y. Liu, and R.H. Edwards ... 131
A. Introduction 131
I. Bioenergetics 131
II. Pharmacology 132
B. Biochemical Analysis and Molecular Cloning 135
I. Vesicular Monoamine Transport Suppresses
MPP + Toxicity 136
II. Two Genes Encode Vesicular Amine Transport 137
1. RNA Analysis 137
2. Sequence Relationship to Bacterial
Antibiotic Resistance Proteins 138
3. Implications for Parkinson s Disease 139
4. Chromosomal Localization 139
C. Functional Properties 140
I. Transport 140
II. Drug Binding 140
III. Flux Reversal 141
D. Distribution 142
E. Subcellular Localization 143
F. Structure/Function Studies of Vesicular Amine Transport 145
References 148
CHAPTER 6
Regulation of the Environment of the Interior of
Serotonin Storing Vesicles
XVI Contents
M.D. Gershon and H. Tamir. With 3 Figures 153
A. Introduction 153
B. Secretory Pathways and the Vesicles Found at Synapses 155
I. Secretory Vesicles of Parafollicular Cells 156
II. Contents of Parafollicular Secretory Vesicles
and Serotoninergic Neurons 158
III. Vesicle Recycling 158
IV. Induction of Secretion 159
V. Stimulus Coupled Acidification of Vesicles
and Its Study 160
VI. Plasmalemmal Calcium Receptor of
the Parafollicular Cell 161 :
VII. Dissociation of Acidification of Parafollicular
Secretory Vesicles from Secretion 163
C. Evoking of Vesicle Acidification by the Parafollicular
Calcium Receptor 163
I. Induction of Binding of [^SJGTP/S to Gcri and Gaq
by Stimulation of Parafollicular Cells by
the Calcium Receptor Agonists Ca2+ or Gd3+ 165
II. Release of Ca2+ from Internal Stores and
Increase in Cytosolic [Ca2+]; by Activation of
the Calcium Receptor 166
III. Electropysiological Characterization of Plasmalemmal
Ca2+ Channels of Parafollicular Cells 169
IV. Real Time Measurement of 5 HT Secretion
from Single Parafollicular Vesicles 170
References 171
CHAPTER 7
Molecular Biology and Transductional Characteristics of
5 HT Receptors
P.R. Hartig. With 1 Figure 175
A. Serotonin, the Largest 7TM Neuroreceptor Family? 175
B. Receptor Families and Subtypes 176
C. Properties of Each Subtype: Clones, Genes,
and Transduction Pathways 184
I. 5 HT,A Receptor 184
II. 5 HTIB Receptor 186
III. 5 HT1D Receptor 188
IV. 5 HT1E Receptor 190
V. 5 HT1F Receptor 191
VI. 5 HT2A Receptor 192
VII. 5 HT2B Receptor 193
Contents XVII
VIII. 5 HT2C Receptor 194
IX. 5 HT3 Receptor 195
X. 5 HT4 Receptor 196
XI. 5 HT5A Receptor 197
XII. 5 HT5B Receptor 198
XIII. 5 HT6 Receptor 198
XIV. 5 HT7 Receptor 199
D. Ligand and Drug Binding Sites: Mutagenesis
and Chimeric Receptor Studies 200
E. Gene Knockout and Antisense Approaches to Function 202
References 205
CHAPTER 8
5 Hydroxytryptamine Receptor Histochemistry: Comparison of
Receptor niRNA Distribution and Radioligand Autoradiography
in the Brain
G. Mengod, J.M. Palacios, K.H. Wiederhold,
and D. Hoyer. With 5 Figures 213
A. Introduction 213
B. Methodology 216
C. Distribution of 5 HT Receptor mRNA and Binding Sites
in Brain (Mainly Rat) 217
I. 5 HT, Receptors 217
1. 5 HT1A Receptors 217
2. 5 HT1B/1D Receptors 217
3. 5 HT1E Receptors 221
4. 5 HTIF Receptors 222
II. 5 HT2 Receptors 223
1. 5 HT2A Receptors 223
2. 5 HT2B Receptors 223
3. 5 HT2r Receptors 224
III. 5 HT, Receptors 225
IV. 5 HT4 Receptors 226
V. 5 HT, Receptors 226
VI. 5 HT6 Receptors 228
VII. 5 HT7 Receptors 228
D. Conclusion 229
Appendix: Glossary of Drug Names 230
References 232
CHAPTER 9
The Main Features of Central 5 HT1A Receptor
M. Hamon. With 5 Figures 239
XVIII Contents
A. Introduction 239
B. Molecular Organisation of the 5 HT1A Receptor 241
C. Cellular Responses to 5 HT1A Receptor Activation 243
D. Localisation of 5 HT,A Receptors 244
I. Regional and Cellular Distributions
of 5 HT1A Receptors 244
II. Addressing of 5 HT1A Receptors 247
E. Pharmacological Properties of 5 HT1A Receptors 248
F. Functional Roles of 5 HT1A Receptors 252
G. Regulation of 5 HT1A Receptors 255
H. Clinical Perspectives 257
References 260
CHAPTER 10
Functional Neuropharmacology of Compounds Acting at
5 HT1B/D Receptors
M. Briley, P. Chopin, M. Marien, and C. Moret. With 1 Figure 269
A. Introduction 269
B. Biochemical Neuropharmacology 270
I. Regulation of Serotonin Release 270
1. In Vitro 270
2. In Vivo 271
a) Rat 271
b) Guinea Pig 272
3. Effects of Repeated Antidepressant
Administration on Autoreceptor Sensitivity 273
II. Regulation of 5 HT Synthesis 275
C. Behavioural Neuropharmacology 276
I. Locomotor Activity 276
II. Feeding Behaviour 277
III. Sexual Behaviour 278
IV. Aggressive Behaviour 279
V. Isolation Induced Social Behavioural Deficit in Mice 280
VI. Animal Models of Anxiety 281
VII. Animal Models of Depression 281
D. Clinical Neuropharmacology 282
E. Conclusion 283
References 284
CHAPTER 11
5 HT Moduline, an Endogenous Peptide Modulating Serotoninergic
Activity via a Direct Interaction at 5 HT,B/ID Receptors
Contents XIX
G. Fillion, O. Massot, J.C. Rousselle, M.P. Fillion,
and N. Prudhomme. With 6 Figures 293
A. Introduction 293
B. Isolation, Purification and Characterization
of 5 HT Moduline 295
C. Molecular Interactions of 5 HT Moduline with
5 HT1B/1D Receptors 295
D. Functional Interactions of 5 HT Moduline with
5 HT1B/iD Receptors 300
E. In Vivo Activity of 5 HT Moduline 301
F. Release of 5 HT Moduline 302
G. Conclusion 302
References 305
CHAPTER 12
Regulation of 5 HT Release in the CNS by Presynaptic 5 HT
Autoreceptors and by 5 HT Heteroreceptors
M. Gothert and E. Schlicker. With 4 Figures 307
A. Introduction: Definitions and Scope 307
B. Methodological Approaches 309
I. In Vitro Studies 309
II. In Vivo Studies 310
C. Identification, Location and Physiological Role of 5 HT
Receptors Mediating Inhibition or Facilitation
of 5 HT Release 311
I. Inhibitory Presynaptic 5 HT Autoreceptors 311
1. Identification and Location 311
2. Physiological Role 318
II. 5 HT Receptors Mediating Facilitation
of 5 HT Release 318
1. Identification and Location 318
2. Physiological Role 319
D. Classification 320
I. Inhibitory Presynaptic 5 HT Autoreceptors 320
1. Classification in Terms of 5 HT, B
and 5 HT]D Receptors 320
2. Subclassification of 5 HT,,, Receptors 321
3. Revised Nomenclature of 5 HT1BIO Receptors on the
Basis of the Primacy of the Human Genome 324
4. Subclassification and Nomenclature in Terms
of the Revised Nomenclature 325
II. 5 HT Receptors Mediating Faciliation of 5 HT Release 328
XX Contents
E. Site and Mechanism of Action 329
I. Inhibitory Presynaptic 5 HT Autoreceptors 329
II. 5 HT Receptors Mediating Facilitation
of 5 HT Release 330
F. Plasticity of Inhibitory Presynaptic 5 HT Autoreceptors 331
I. Lack of Circadian Variations 331
II. Age Dependent Variations 331
III. Changes by Drugs and Electroconvulsive Shocks 332
G. Potential Pathophysiological and Therapeutic Roles
of Inhibitory Presynaptic 5 HT Autoreceptors 337
H. Concluding Remarks 341
References 342
CHAPTER 13
Behavioral Consequences of 5 HT1B Receptor Gene Deletion
N. Castanon, S. Ramboz, F. Saudou, and R. Hen. With 7 Figures ... 351
A. Introduction 351
B. 5 HT1B Receptor Gene Targeting 352
C. Effectiveness of 5 HT1B Receptor Ablation 355
D. Locomotion 356
E. Anxiety 357
F. Aggression 358
G. Discussion and Conclusions 360
References 363
CHAPTER 14
Pharmacology of 5 HT2 Receptors
B.L. Roth and E.G. Hyde. With 12 Figures 367
A. Introduction 367
B. Structure Activity Studies of 5 HT2 Receptor Ligands 367
I. Introduction 367
II. Indolealkylamines 368
III. Tryptamines 369
IV. Ergolines 372
V. N Alkylpiperidines 373
VI. Piperazines 375
VII. Tricyclic Compounds 377
VIII. Phenylisopropylamines 379
IX. Miscellaneous Agents 380
C. Structure Activity Studies of 5 HT2 Receptors 381
I. Molecular Modelling Overview 381
Contents XXI
II. Bacteriorhodopsin and Rhodopsin Based Models 382
1. Dahl Model 382
2. Holtje and Jendretski Model 385
3. Weinstein Model 385
4. Westkaemper, Glennon and Roth Models 386
5. Other 5 HT2A Receptor Models 387
III. Mutations Involving Aromatic Residues 387
IV. Mutations of Non Conserved Residues 388
V. Mutagenesis Overview 389
VI. Mutations Involving Charged Residues 390
References 390
CHAPTER 15
Regulation of 5 HT2A Receptor at the Molecular Level
M. Toth and D. Benjamin 395
A. Introduction 395
B. Cell Type Specific Regulation of the 5 HT2A Receptor 395
I. Cells Expressing 5 HT2A Receptor
in the Nervous System 395
II. Reconstruction of Cell Type Specific Expression
in Cultured Cells 396
III. Transgenic Strategy to Study the Regulation
of the 5 HT2A Promoter 398
C. Regulation of 5 HT2A Receptor by Agonists and Antagonists .... 398
I. Regulation by Agonists 398
II. Receptor Downregulation by Antagonists 400
III. Antidepressant Induced Downregulation
of the 5 HT2A Receptor 400
D. Glucocorticoid Regulation of 5 HT2A Receptor Expression 401
I. Glucocorticoids Upregulate 5 HT2A Receptor In Vivo 401
II. Glucocorticoid Regulation of the 5 HT2A Receptor
in Cultured Cells 401
E. Clinical Relevance 402
I. Upregulation of the 5 HT2A Receptor in
a Group of Depressed Patients 402
II. Upregulation of the 5 HT2A Receptor in Depression
May Be Related to Stress 402
References 403
CHAPTER 16
Neuropharmacology of 5 HT3 Receptor Ligands
B. Costall and R.J. Naylor 409
XXII Contents
A. Introduction 409
B. Electrophysiological Studies of the 5 HT, Receptors 409
I. The 5 HT, Receptor as a Member of the Ligand Gated
Ion Channel Superfamily 409
II. Agonist Pharmacology 410
III. Antagonist Pharmacology 410
C. Molecular Characterisation of 5 HT, Receptors 411
I. Biochemical Characterisation of 5 HT, Receptors 411
II. Cloning of the 5 HT, Receptor 412
III. Splice Variant of 5 HT, R A 412
D. Distribution of 5 HT, Receptors 413
E. 5 HT, Receptor Heterogeneity 414
F. Involvement of 5 HT3 Receptors in Neurotransmitter
Release 417
G. Behavioural Effects of 5 HT, Agonists and Antagonists 418
I. Reversal of Behavioural Suppression 419
II. 5 HT, Receptor Involvement in the Interaction Between
Limbic Serotoninergic and Dopaminergic Systems 420
III. 5 HT, Receptors and Cognition 422
H. Role of 5 HT, Receptors in Nociception and Migraine 425
I. Role of 5 HT, Receptors in Emesis 426
References 427
CHAPTER 17
5 HT4 Receptors: An Update
J. Bockaert, L. Fagni, and A. Dumuis. With 8 Figures 439
A. Introduction: A Review 439
B. Structure of 5 HT4 Receptors 443
C. Pharmacological Characterization 448
I. Agonists and Antagonists 448
1. 5 HT4 Agonists 448
2. 5 HT4 Antagonists 451
II. Are There 5 HT4 Receptor Subtypes? 451
D. Transduction Mechanisms 452
I. cAMP as the Second Messenger Mediating
5 HT, Receptor Action 452
II. Control of K+ Channels 453
III. Control of Ca2+ Channels 455
IV. Desensitization 457
E. 5 HT4 Receptor Distribution and Functions 459
I. Central Nervous System 459
II. Peripheral Nervous System 461
Contents XXIII
III. Alimentary Tract 461
1. Excitatory Responses 462
2. Inhibitory Responses 462
3. Secretory Responses in the Alimentary Tract 462
IV. Urinary Bladder 463
V. Adrenal Gland 463
VI. Heart 463
F. Present and Future Therapeutic Drugs Acting
at 5 HT4 Receptors 464
I. Alimentary Tract 464
II. Central Nervous System 465
III. Cardiovascular System 465
IV. Urinary System 465
G. Conclusion 465
References 465
CHAPTER 18
Molecular Biology and Potential Functional Role of 5 HT5, 5 HT6,
and 5 HT7 Receptors
T.A. Branchek and J.M. Zgombick. With 3 Figures 475
A. Introduction 475
B. Molecular Biology of the 5 HT,, 5 HT6,
and 5 HT7 Receptors 475
I. 5 HT, Receptors 475
II. 5 HT6 Receptors 478
III. 5 HT7 Receptors 479
C. Molecular Pharmacology of the 5 HT,, 5 HT6.
and 5 HT7 Receptors 481
I. 5 HT, Receptors 481
II. 5 HT6 Receptors 481
III. 5 HT7 Receptors 483
D. Distribution of 5 HT,, 5 HT,,, and 5 HT7 Receptors 483
I. 5 HT, Receptors 483
II. 5 HT, Receptors 485
III. 5 HT7 Receptors 486
E. Potential Functional Roles of the 5 HT,, 5 HT,,
and 5 HT7 Receptors 488
I. 5 HT, Receptors 488
II. 5 HTf) Receptors 489
III. 5 HT7 Receptors 490
F. Summary and Conclusions 492
References 493
XXIV Contents
CHAPTER 19
Electrophysiology of 5 HT Receptors
G.K. Aghajanian and R. Andrade. With 7 Figures 499
A. Introduction 499
B. 5 HT, Receptors 499
I. Raphe Nuclei 500
1. Physiology and Pharmacology 500
2. Signal Transduction Pathways 502
II. Other Subcortical Regions 503
III. Hippocampus 503
1. Physiology and Pharmacology 503
2. Signal Transduction Pathways 504
IV. Cerebral Cortex 507
C. 5 HT2 Receptors 508
I. Motoneurons 509
1. Physiology and Pharmacology 509
2. Signal Transduction Pathways 511
II. Locus Coeruleus 512
III. Other Subcortical Regions 512
IV. Cerebral Cortex 513
1. Piriform Cortex 514
2. Prefrontal Cortex 517
D. 5 HT3 Receptors 518
E. Gs Coupled Serotonin Receptors: the 5 HT4, 5 HT6
and 5 HT7 Subtypes 519
I. 5 HT4 Receptors 519
II. 5 HT7 Receptors 522
F. Summary and Conclusions 523
I. 5 HT Receptor Subtypes, Ion Channels, and Second
Messenger Systems 523
II. Role of 5 HT in Neuronal Networks 524
III. Integrative Action of 5 HT 524
References 526
CHAPTER 20
5 HT Receptors Involved in the Regulation of
Hormone Secretion
L.D. Van de Kar. With 2 Figures 537
A. Organization of the Neuroendocrine System 537
B. 5 HT Receptor Subtypes 538
C. Neuroendocrine Effects of 5 HT1A Agonists 538
I. Hypothalamic Pituitary Adrenal Axis 538
Contents XXV
II. Oxytocin 540
III. Prolactin 541
IV. Inhibition by 5 HT1A Agonists of the Neuroendocrine
Responses to Stress 543
D. Neuroendocrine Effects of 5 HT1B/1D Agonists 544
E. Neuroendocrine Effects of 5 HT2 Agonists 545
I. Hypothalamic Pituitary Adrenal Axis 545
II. Oxytocin 545
III. Prolactin 546
IV. Renin and Vasopressin 547
V. Location of the 5 HT2 Receptors Involved 548
F. Neuroendocrine Effects of 5 HT, Agonists 549
G. Neuroendocrine Effects of 5 HT4 Agonists 549
I. Hormones as Markers of Serotoninergic Function
( Neuroendocrine Challenge Tests ) 550
H. Effects of 5 HT Uptake Blockers on 5 HT1A
and 5 HT2 Receptor Mediated Hormone Secretion 551
I. Concluding Remarks 552
References 553
CHAPTER 21
Role of Serotoninergic Neurons and 5 HT Receptors in the Action
of Hallucinogens
D.E. Nichols. With 2 Figures 563
A. Introduction 563
B. Chemical Classes of Hallucinogens 566
C. Historical Relationship Between Serotonin
and Hallucinogen Action 568
D. Early Hypothesis for a Presynaptic Agonist
Mechanism of Action 569
E. Evidence for Agonist Activity at the 5 HT2A Serotonin
Receptor Subtype 569
I. Mechanistic Basis for Rapid Tolerance
to the Hallucinogens 572
II. Possible Species Differences? 572
F. Evidence for Involvement of the 5 HT2( Receptor Subtype 573
G. Evidence for 5 HT1A Receptor Involvement 574
H. Potentiating Effects of Interactions at Other
Receptor Subtypes 577
I. Conclusions 579
References 579
XXVI Contents
CHAPTER 22
The Interaction of the Serotoninergic and Other Neuroregulatory
Systems in Alcohol Dependence
E.M. Sellers, M.K. Romach, and A.D. Le 587
A. Introduction 587
B. Role of the 5 HT System in Regulating Alcohol Consumption ... 587
I. Anatomical Pathways 587
II. Role of Serotonin in Regulating Ethanol
Consumption 588
1. Preclinical Studies 588
2. Human Experimental and Clinical Studies 588
a) Serotonin Uptake Inhibitors (SSRIs) 589
b) Dexfenfluramine 589
c) Role of General Serotoninergic Agents 590
C. Involvement of Selective 5 HT Receptor Types and
Subtypes in Alcohol Consumption 590
I. 5 HT Receptor Types and Subtypes 590
II. 5 HT, Receptor Type and Subtypes 590
1. 5 HT1A Receptors 590
a) Preclinical Studies 590
b) Human Experimental and Clinical Studies 592
2. 5 HT,B Receptors 593
a) Preclinical Studies 593
b) Human Experimental and Clinical Studies 594
III. 5 HT2A Receptors 594
1. Preclinical Studies 594
2. Human Experimental and Clinical Studies 596
IV. 5 HT , Receptors 597
1. Preclinical Studies 597
2. Clinical Studies 598
V. 5 HT4 Receptors 599
1. Preclinical Studies 599
D. Interaction Between 5 HT and Other
Neurotransmitters in the Regulation of Alcohol Intake 599
I. 5 HT and Opioid Systems 599
1. Preclinical Studies 599
2. Clinical Studies 600
II. 5 HT and GABA Systems 601
1. Preclinical Studies 601
III. Alcohol, 5 HT and Mood Disorders 602
IV. Alcohol and Craving 603
V. Alcohol, 5 HT and Impulsivity 604
1. Preclinical Studies 604
Contents XXVII
E. Conclusions 604
References 605
CHAPTER 23
Neuronal Pathophysiology of Migraine as a Basis for Acute
Treatment with 5 HT Receptor Ligands
M.A. Moskowitz and C. Waeber. With 2 Figures 613
A. Introduction 613
B. In Vivo Animal Models 614
I. Dural Plasma Extravasation 614
1. Studies Using Agonists 615
2. Studies Using Antagonists 617
3. Studies in Mice Lacking 5 HT,B Receptors 618
II. Neuropeptide Release 619
III. c Fos Expression in the Trigeminal Nucleus Caudalis 620
C. Data from In Vitro Experiments 623
I. Autoradiographic Data 623
II. Detection of the mRNA for Different 5 HT
Receptor Subtypes 626
III. Antimigraine Drugs and Vasoconstriction 627
D. Conclusion 628
References 629
CHAPTER 24
Modulation of Nociception by Descending Serotoninergic
Projections
J. Sawynok 637
A. Introduction 637
B. Raphe Spinal Serotoninergic Projections 637
C. 5 HT Receptors in the Spinal Cord 638
D. Tonic Regulation of Nociceptive Transmission 639
E. 5 HT Agonists and Spinal Antinociception 640
I. 5 HT1A Receptors 641
II. 5 HT,,, Receptors 642
III. 5 HT2 Receptors 642
IV. 5 HT, Receptors 643
V. 5 HT]S Receptors 643
VI. Receptor Subtypes Activated by 5 HT 644
F. Interactions with Endogenous Systems 644
I. Noradrenaline 645
II. GABA and Glycine 645
III. Enkephalin 646
IV. Adenosine 646
XXVIII Contents
V. Peptides 646
G. Conclusion 647
References 647
CHAPTER 25
Molecular Biology of Monoamine Oxidase A and B: Their Role
in the Degradation of Serotonin
J.C. Shih, J. Grimsby, and K. Chen. With 2 Figures 655
A. Introduction 655
B. Molecular Biology of MAO 655
I. MAOA and B cDNAs and Genomic Structure 655
1. Allelic Associations 657
2. Heterologous Expression 659
a) Site Directed Mutagenesis 660
b) Chimeric MAO Forms 660
C. Serotonin Oxidation by MAO 661
I. Effect of MAO Deficiencies on 5 HT Levels 662
1. MAOA Deficient Humans and Mice 662
2. Deletion of the MAOA and MAOB Genes
in Norrie Disease 664
D. Conclusions 665
References 665
CHAPTER 26
Molecular Biology, Pharmacology, and Genetics of the Serotonin
Transporter: Psychobiological and Clinical Implications
K. P. Lesch. With 12 Figures 671
A. Introduction 671
B. Molecular Biology 673
I. Gene Family of Na+/Cr Dependent Transporters 673
II. Molecular Structure 673
III. Electrogenicity 675
C. Developmental Biology and Anatomical Distribution 675
I. Autoradiography, Immunohistochemistry, and mRNA
Expression 676
II. In Vivo Imaging 676
D. Pharmacological Properties 677
I. Drug Interaction 677
II. Toxins and Neurodegeneration 679
III. Structure Function Relationships 680
Contents XXIX
E. Gene Organization: Of Mice and Men 682
I. Chromosomal Mapping and Gene Organization 682
II. Regulation of Gene Expression 684
III. 5 HTT Linked Polymorphic Region 684
IV. Allelic Variation of Functional 5 HTT Expression 685
F. Genetics: Listening to the Gene 685
I. Mutation Screening 685
II. 5 HTT Linked Polymorphic Region and Personality
Traits: A Susceptibility Locus? 686
III. Affective Disorders 687
IV. Alcoholism 689
V. Neurodevelopmental and Neurodegenerative
Disorders 691
G. Talking Back to the Gene: Target or Tool? 692
I. Glucocorticoids 692
II. 5 HT Reuptake Inhibitors 693
III. Other Compounds and Environmental Factors 694
IV. Targeted Gene Disruption 695
V. Promoter and Regulatory Elements of the 5 HTT Gene: Therapeutic Relevance? 697
VI. Developing Drugs that Target 5 HTT
Gene Expression 699
H. Future Directions 700
References 701
CHAPTER 27
Animal Models of Integrated Serotoninergic Functions:
Their Predictive Value for the Clinical Applicability of Drugs
Interfering with Serotoninergic Transmission
P.E. Keane and P. Soubrie 707
A. Introduction 707
B. Anxiety 710
C. Depression 710
D. Schizophrenia 712
E. Obsessive Compulsive Disorders 713
F. Aggressive Behaviour 714
G. Sexual Dysfunction 714
H. Eating Disorders 715
I. Predictive Value of Animal Models
for Clinical Applicability 716
References 719
XXX Contents
CHAPTER 28
Current Psychiatric Uses of Drugs Acting on the Serotonin System
P. Blier and C. de Montigny. With 7 Figures 727
A. Introduction 727
B. Depression 729
I. Mechanisms of Action of Antidepressant Treatments 729
II. An Accelerating Strategy: 5 HTIA Autoreceptor
Antagonism 732
III. Potentiation Strategies 734
C. Obsessive Compulsive Disorder 736
D. Anxiety Disorders 741
I. Panic Disorder 741
II. Generalized Anxiety Disorder 743
III. Social Phobia 744
E. Schizophrenia 744
F. Conclusion 746
References 746
Subject Index 751
|
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| dewey-search | 612.8 615/.1 |
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| genre_facet | Aufsatzsammlung |
| id | DE-604.BV011469862 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:10:19Z |
| institution | BVB |
| isbn | 3540626662 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007716763 |
| oclc_num | 36989362 |
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| owner_facet | DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-12 DE-20 DE-11 DE-188 DE-578 |
| physical | XXX, 767 S. Ill., graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Springer |
| record_format | marc |
| series | Handbook of experimental pharmacology |
| series2 | Handbook of experimental pharmacology |
| spelling | Serotoninergic neurons and 5-HT receptors in the CNS [with 35 tables] contributors G. K. Aghajanian ... Eds. H. G. Baumgarten ... Berlin [u.a.] Springer 1997 XXX, 767 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Handbook of experimental pharmacology 129 Serotonin cabt Neurons cabt Receptors cabt Central Nervous System cabt Centraal zenuwstelsel gtt Neuronen gtt Receptoren gtt Serotonine gtt Central Nervous System Neurons Receptors, Serotonin Serotonin Serotonin Receptors Serotoninergic mechanisms Serotoninrezeptor (DE-588)4181047-8 gnd rswk-swf Serotonerge Nervenzelle (DE-588)4316017-7 gnd rswk-swf Serotonin (DE-588)4054614-7 gnd rswk-swf Neurochemie (DE-588)4041872-8 gnd rswk-swf Zentralnervensystem (DE-588)4067637-7 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Zentralnervensystem (DE-588)4067637-7 s Serotoninrezeptor (DE-588)4181047-8 s DE-604 Serotonerge Nervenzelle (DE-588)4316017-7 s Serotonin (DE-588)4054614-7 s Neurochemie (DE-588)4041872-8 s Baumgarten, Hans G. 1936- Sonstige (DE-588)115361472 oth Aghajanian, George K. Sonstige oth Handbook of experimental pharmacology 129 (DE-604)BV002390716 129 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007716763&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Serotoninergic neurons and 5-HT receptors in the CNS [with 35 tables] Handbook of experimental pharmacology Serotonin cabt Neurons cabt Receptors cabt Central Nervous System cabt Centraal zenuwstelsel gtt Neuronen gtt Receptoren gtt Serotonine gtt Central Nervous System Neurons Receptors, Serotonin Serotonin Serotonin Receptors Serotoninergic mechanisms Serotoninrezeptor (DE-588)4181047-8 gnd Serotonerge Nervenzelle (DE-588)4316017-7 gnd Serotonin (DE-588)4054614-7 gnd Neurochemie (DE-588)4041872-8 gnd Zentralnervensystem (DE-588)4067637-7 gnd |
| subject_GND | (DE-588)4181047-8 (DE-588)4316017-7 (DE-588)4054614-7 (DE-588)4041872-8 (DE-588)4067637-7 (DE-588)4143413-4 |
| title | Serotoninergic neurons and 5-HT receptors in the CNS [with 35 tables] |
| title_auth | Serotoninergic neurons and 5-HT receptors in the CNS [with 35 tables] |
| title_exact_search | Serotoninergic neurons and 5-HT receptors in the CNS [with 35 tables] |
| title_full | Serotoninergic neurons and 5-HT receptors in the CNS [with 35 tables] contributors G. K. Aghajanian ... Eds. H. G. Baumgarten ... |
| title_fullStr | Serotoninergic neurons and 5-HT receptors in the CNS [with 35 tables] contributors G. K. Aghajanian ... Eds. H. G. Baumgarten ... |
| title_full_unstemmed | Serotoninergic neurons and 5-HT receptors in the CNS [with 35 tables] contributors G. K. Aghajanian ... Eds. H. G. Baumgarten ... |
| title_short | Serotoninergic neurons and 5-HT receptors in the CNS |
| title_sort | serotoninergic neurons and 5 ht receptors in the cns with 35 tables |
| title_sub | [with 35 tables] |
| topic | Serotonin cabt Neurons cabt Receptors cabt Central Nervous System cabt Centraal zenuwstelsel gtt Neuronen gtt Receptoren gtt Serotonine gtt Central Nervous System Neurons Receptors, Serotonin Serotonin Serotonin Receptors Serotoninergic mechanisms Serotoninrezeptor (DE-588)4181047-8 gnd Serotonerge Nervenzelle (DE-588)4316017-7 gnd Serotonin (DE-588)4054614-7 gnd Neurochemie (DE-588)4041872-8 gnd Zentralnervensystem (DE-588)4067637-7 gnd |
| topic_facet | Serotonin Neurons Receptors Central Nervous System Centraal zenuwstelsel Neuronen Receptoren Serotonine Receptors, Serotonin Serotonin Receptors Serotoninergic mechanisms Serotoninrezeptor Serotonerge Nervenzelle Neurochemie Zentralnervensystem Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007716763&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002390716 |
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