Human B-cell populations: 5 tables
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Basel ; Freiburg [Breisgau] ; Paris ; London ; New York ; New Delhi ; Bangkok ; Singapore ; Tokyo ; Sydney
Karger
[1997], ©1997
|
| Schriftenreihe: | Chemical immunology
67 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | X, 137 Seiten Illustrationen, Diagramme 25 cm |
| ISBN: | 3805564600 |
Internformat
MARC
| LEADER | 00000nam a2200000 cb4500 | ||
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| 084 | |a XD 3205 |0 (DE-625)152553:12911 |2 rvk | ||
| 245 | 1 | 0 | |a Human B-cell populations |b 5 tables |c volume editors: Manlio Ferrarini, Federico Caligaris-Cappio |
| 246 | 1 | 3 | |a Human B cell populations |
| 264 | 1 | |a Basel ; Freiburg [Breisgau] ; Paris ; London ; New York ; New Delhi ; Bangkok ; Singapore ; Tokyo ; Sydney |b Karger |c [1997], ©1997 | |
| 300 | |a X, 137 Seiten |b Illustrationen, Diagramme |c 25 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Chemical immunology |v 67 | |
| 500 | |a Literaturangaben | ||
| 650 | 0 | 7 | |a Pathophysiologie |0 (DE-588)4044898-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a B-Lymphozyt |0 (DE-588)4137121-5 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 655 | 7 | |0 (DE-588)1071861417 |a Konferenzschrift |y 1995 |z Lunteren |2 gnd-content | |
| 689 | 0 | 0 | |a B-Lymphozyt |0 (DE-588)4137121-5 |D s |
| 689 | 0 | 1 | |a Pathophysiologie |0 (DE-588)4044898-8 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a B-Lymphozyt |0 (DE-588)4137121-5 |D s |
| 689 | 1 | |5 DE-604 | |
| 700 | 1 | |a Ferrarini, Manlio |d 1945- |0 (DE-588)1284582892 |4 edt | |
| 700 | 1 | |a Caligaris-Cappio, Federico |d 1948- |0 (DE-588)1284580938 |4 edt | |
| 830 | 0 | |a Chemical immunology |v 67 |w (DE-604)BV002307222 |9 67 | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007708373&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-007708373 | |
Datensatz im Suchindex
| _version_ | 1807683685330190336 |
|---|---|
| adam_text |
CONTENTS
IX
PREFACE
1
MOLECULAR
MECHANISMS
INVOLVED
IN
T-B
INTERACTIONS
P.
LANE,
BASEL
1
REQUIREMENTS
FOR
T
CELL
PRIMING
2
EFFECTIVE
T
CELL
PRIMING
REQUIRES
RECIPROCAL
COSTIMULATION
BETWEEN
T
CELLS
AND
DENDRITIC
CELLS
THAT
INVOLVES
SIGNALING
THROUGH
CD40
2
ROLE
OF
COSTIMULATION
THROUGH
CD28
AND
CTLA4
IN
THE
REGULATION
OF
T
CELL
CLONE
SIZE
2
NEGATIVE
REGULATION
OF
T
CELL
CLONES
3
A
MIXTURE
OF
TH
1
-
AND
TH2-PRIMED
T
CELLS
IN
THE
T
ZONE
ENSURES
THAT
B
CELL
RESPONSES
HERE
ARE
CAREFULLY
REGULATED
4
WHAT
DETERMINES
WHETHER
T
CELLS
EFFECTIVELY
HELP
B
CELLS
TO
FORM
GERMINAL
CENTERS?
4
EXPRESSION
OF
NEW
CD40
FAMILY
MEMBER
MOLECULES
ON
B
CELLS
ACTIVATED
THROUGH
CD40
WHICH
MIGHT
GUIDE
T
CELLS
TO
HELP
B
CELLS
5
B
CELL
PROLIFERATION
WITHIN
GERMINAL
CENTERS
AND
THE
REGULATION
OF
SOMATIC
MUTATION
6
WHAT
KIND
OF
MOLECULAR
MECHANISM
MIGHT
CAUSE
OSCILLATING
BURSTS
OF
MUTATION
AND
PROLIFERATION?
7
A
ONE
SIGNAL
MODEL
WHERE
THE
MUTATION
RATE
IS
SEPARATED
FROM
PROLIFERATION
7
THE
TWO-SIGNAL
MODEL
WHERE
PROLIFERATION
AND
MUTATION
ARE
REGULATED
BY
SEPARATE
SIGNALS
8
WHAT
CONTROLS
THE
CENTROCYTE
DECISION
POINT
WHICH
DETERMINES
WHETHER
B
CELLS
BECOME
MEMORY
B
CELLS
OR
CENTROBLASTS?
8
GENERATION
OF
ANTIBODY-PRODUCING
CELLS
9
RECALL
OF
MEMORY
B
CELL
RESPONSES
,
9
CONCLUSION
10
ACKNOWLEDGMENTS
10
REFERENCES
14
15
17
18
19
20
20
21
23
23
24
24
27
28
30
31
35
36
37
39
42
42
42
45
48
48
TRACING
ANTIGEN-DRIVEN
B
CELL
DEVELOPMENT
IN
HUMANS
Y.-J.
LIU,
DARDILLY
DEFINITION
AND
ISOLATION
OF
7
B
CELL
SUBSETS
FROM
HUMAN
TONSILS
S!GM+,
IGD+,
CD38+
GC
FOUNDER
CELLS
ARE
PRIMED
FOR
APOPTOSIS
BEFORE
THE
ONSET
OF
SOMATIC
MUTATION
OVERACTIVATED
SOMATIC
MUTATION
IN
SLGM-,
IGD+,
CD38+
B
CELLS
(BM38)
WITHIN
GC,
THE
ISOTYPE
SWITCHING
MACHINERY
IS
TRIGGERED
AFTER
THE
ONSET
OF
SOMATIC
MUTATION
HUMAN
GC
B
CELLS
ARE
PRIMED
FOR
APOPTOSIS
BY
C-MYC,
P
53
,
FAS,
BAX
IN
THE
ABSENCE
OFBCL-2
MEMORY
B
CELLS
FROM
HUMAN
TONSILS
COLONIZE
MUCOSAL
EPITHELIUM
AND
DIRECTLY
PRESENT
ANTIGEN
TO
T
CELLS
BY
RAPID
UPREGULATION
OF
B7.
1
AND
B7.
2
PLASMA
CELLS
FROM
HUMAN
TONSILS
UNDERGO
RAPID
APOPTOSIS,
UNLESS
RESCUED
BY
BONE
MARROW
STROMAL
CELLS
GENERATION
OF
MEMORY
B
CELLS
AND
PLASMA
CELLS
IN
VITRO
CONCLUSION
ACKNOWLEDGMENTS
REFERENCES
T
CELLS
IN
THE
SELECTION
OF
GERMINAL
CENTER
B
CELLS
M.
CASAMAYOR-PALLEJA,
A.
GULBRANSON-JUDGE,
I.C.M.
MACLENNAN,
BIRMINGHAM
GERMINAL
CENTER
FORMATION
SELECTION
OF
GERMINAL
CENTER
B
CELLS
CONTINUOUS
CD40
LIGATION
OF
GERMINAL
CENTER
B
CELLS
IS
UNLIKELY
TO
OCCUR
IN
VIVO
AND
DOES
NOT
RESULT
IN
THEM
ADOPTING
A
MEMORY
B
CELL
PHENOTYPE
IN
VITRO
TRANSIENT
CD40
LIGATION
IS
REQUIRED
BUT
IS
NOT
SUFFICIENT
FOR
GERMINAL
CENTER
T
CELLS
TO
PREVENT
AUTOLOGOUS
CENTROCYTES
KILLING
THEMSELVES
BY
APOPTOSIS
PREACTIVATED
GERMINAL
CENTER
T
CELLS
SELECTIVELY
FORM
CONJUGATES
WITH
THE
CENTROCYTES
FROM
AUTOLOGOUS
GERMINAL
CENTER
B
CELL
PREPARATIONS
AND
INDUCE
MOST
OF
THESE
TO
ADOPT
A
MEMORY
B
CELL
PHENOTYPE
WITHIN
24
H
A
SUBSET
OF
CENTROCYTES
REVERT
TO
A
CENTROBLAST-LIKE
PHENOTYPE
ON
COCULTURE
WITH
AUTOLOGOUS
MEMORY
T
CELLS
SIGNALLING
THROUGH
PROTEIN
KINASE
C
MIGHT
BE
INVOLVED
IN
MEMORY
B
CELL
FORMATION
CONCLUSION
ACKNOWLEDGEMENT
REFERENCES
BIASED
VH4
GENE
SEGMENT
REPERTOIRE
IN
THE
HUMAN
TONSIL
V.
PASCUAL,
P.
WILSON,
DALLAS,
TEX.;
Y.-J.
LIU,
DARDILLY;
J.
BANCHEREAU,
J.D.
CAPRA,
DALLAS,
TEX.
MATERIALS
AND
METHODS
ISOLATION
OF
TONSIL
B
CELLS
48
SEQUENCING
THE
IG
VH/VL
TRANSCRIPTS
FROM
THE
DIFFERENT
B
CELL
SUBPOPULATIONS
49
IMMUNOSTAINING
ANALYSIS
49
RESULTS
49
THE
VH4-2
1
GENE
SEGMENT
ENCODES
THE
MAJORITY
OF
VH4
GENE
PRODUCTS
IN
THE
IGM-EXPRESSING
B
CELL
SUBPOPULATIONS
OF
THE
HUMAN
TONSIL
51
SEQUENCE
ANALYSES
REVEAL
THAT
SOMATIC
DIVERSIFICATION
IN
THE
HUMAN
GC
IS
NOT
RESTRICTED
TO
POINT
MUTATION
52
DISCUSSION
55
REFERENCES
58
SUBEPITHELIAL
B
CELLS
OF
THE
HUMAN
TONSIL
M.
DONO,
S.
ZUPO,
C.E.
GROSSI,
GENOA;
N.
CHIORAZZI,
MANHASSET,
N.Y.;
M.
FERRARINI,
GENOA
59
ISOLATION
OF
A
SUBSET
OF
B
CELLS
IDENTIFIED
AS
SE
B
CELLS
61
ULTRASTRUCTURAL
AND
HISTOCHEMICAL
STUDIES
61
FUNCTIONAL
DIFFERENCES
BETWEEN
SE
B
CELLS
AND
FM
OR
GC
B
CELLS
64
ANALYSIS
OF
IG
VH4
GENES
INDICATES
THAT
SE
B
CELLS
ARE
COMPRISED
OF
BOTH
VIRGIN
AND
MEMORY
B
CELLS
65
RESPONSE
OF
SE
B
CELLS
TO
ANTIGENS
AND
MITOGENS
66
CONCLUDING
REMARKS
68
REFERENCES
70
MALIGNANT
LYMPHOMAS
STEM
FROM
DIFFERENT
B
CELL
POPULATIONS
P.M.
KLUIN,
J.HAN,
J.M.
VAN
KRIEKEN,
LEIDEN
73
MANTLE
CELL
LYMPHOMA
74
FOLLICULAR
LYMPHOMA
76
BURKITT
'
S
LYMPHOMA
78
LARGE
B
CELL
LYMPHOMA
80
CONCLUSIONS
81
REFERENCES
85
WHAT
DO
CHRONIC
B
CELL
MALIGNANCIES
TEACH
US
ABOUT
B
CELL
SUBSETS?
O.
PRITSCH,
K.
MALOUM,
C.
MAGNAC,
F.
DAVI,
J.L.
BINET,
H.
MERLE-BERAL,
G.
DIGHIERO,
PARIS
85
B
CELL
LINEAGES
88
V
GENE
EXPRESSION
IN
CHRONIC
LYMPHOID
MALIGNANCIES
89
V
GENE
EXPRESSION
IN
CD5+
AND
CD5
B
CLL
92
VH
GENE
EXPRESSION
IN
MANTLE
CELL
LYMPHOMA
93
VH
GENE
EXPRESSION
IN
SPLENIC
LYMPHOMA
WITH
VILLOUS
LYMPHOCYTES
93
VH
GENE
EXPRESSION
IN
PLL
94
96
96
102
103
103
105
106
108
109
110
110
114
114
114
116
116
117
118
119
121
122
123
124
124
125
126
127
133
134
CONCLUSION
ACKNOWLEDGMENTS
REFERENCES
B
CELL
POPULATIONS:
THE
MULTIPLE
MYELOMA
MODEL
F.
CALIGARIS-CAPPIO,
M.G.
GREGORETTI,
TURIN;
K.
NILSSON,
UPPSALA
THE
BASICS
OF
PLASMA
CELL
DEVELOPMENT
THE
HETEROGENEITY
OF
NORMAL
PLASMA
CELLS
AND
ITS
RELEVANCE
TO
UNDERSTANDING
THE
ORIGIN
OF
MM
THE
PHENOTYPE
OF
MM
PLASMA
CELLS
CIRCULATING
PLASMA
CELLS
AND
PLASMA
CELL
PRECURSORS
IN
MM
BM
MICROENVIRONMENT
AND
MM
GP
130-LINKED
CYTOKINES
AND
MM:
THE
LESSON
FROM
MM
CELL
LINES
ACKNOWLEDGEMENT
REFERENCES
REGULATION
OF
HUMAN
B
CELL
GROWTH
AND
DIFFERENTIATION:
LESSONS
FROM
THE
PRIMARY
IMMUNODEFICIENCIES
RE.
CALLARD,
S.H.
SMITH,
D.J.
MATTHEWS,
LONDON
INTRODUCTION
X-LINKED
IMMUNODEFICIENCIES
SCIDX1
AND
THE
IL-2
RECEPTOR
Y-CHAIN
THE
YC-CHAIN
AND
THE
IL-2
RECEPTOR
OTHER
CYTOKINE
RECEPTORS
THAT
USE
THE
YC-CHAIN
YC-CHAIN
MUTATIONS
IN
SCIDX1
THE
EFFECT
OF
YC-CHAIN
GENE
MUTATIONS
ON
SCIDX1
LYMPHOCYTE
FUNCTION
THE
IL-13R
DOES
NOT
INCLUDE
THE
YC-CHAIN
AND
IS
A
SECOND
RECEPTOR
FOR
IL-4
X-LINKED
HYPER-IGM
SYNDROME
CD40LAND
HIGM1
CD40:
A
MEDIATOR
OF
INTERCELLULAR
INTERACTIONS
CD40-CD40L-MEDIATED
T-B
CELL
INTERACTIONS
WHY
DO
CD40L
MUTATIONS
DISRUPT
HIGH-AFFINITY
IGG,
IGA
AND
IGE
ANTIBODY
PRODUCTION?
MULTIPLE
ROLES
FOR
CD40
REFERENCES
AUTHOR
INDEX
SUBJECT
INDEX |
| any_adam_object | 1 |
| author2 | Ferrarini, Manlio 1945- Caligaris-Cappio, Federico 1948- |
| author2_role | edt edt |
| author2_variant | m f mf f c c fcc |
| author_GND | (DE-588)1284582892 (DE-588)1284580938 |
| author_facet | Ferrarini, Manlio 1945- Caligaris-Cappio, Federico 1948- |
| building | Verbundindex |
| bvnumber | BV011459554 |
| classification_rvk | XD 3205 |
| ctrlnum | (OCoLC)845439972 (DE-599)BVBBV011459554 |
| discipline | Medizin |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content (DE-588)1071861417 Konferenzschrift 1995 Lunteren gnd-content |
| genre_facet | Aufsatzsammlung Konferenzschrift 1995 Lunteren |
| id | DE-604.BV011459554 |
| illustrated | Illustrated |
| indexdate | 2024-08-18T00:38:22Z |
| institution | BVB |
| isbn | 3805564600 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007708373 |
| oclc_num | 845439972 |
| open_access_boolean | |
| owner | DE-29 DE-12 DE-355 DE-BY-UBR DE-578 |
| owner_facet | DE-29 DE-12 DE-355 DE-BY-UBR DE-578 |
| physical | X, 137 Seiten Illustrationen, Diagramme 25 cm |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Karger |
| record_format | marc |
| series | Chemical immunology |
| series2 | Chemical immunology |
| spelling | Human B-cell populations 5 tables volume editors: Manlio Ferrarini, Federico Caligaris-Cappio Human B cell populations Basel ; Freiburg [Breisgau] ; Paris ; London ; New York ; New Delhi ; Bangkok ; Singapore ; Tokyo ; Sydney Karger [1997], ©1997 X, 137 Seiten Illustrationen, Diagramme 25 cm txt rdacontent n rdamedia nc rdacarrier Chemical immunology 67 Literaturangaben Pathophysiologie (DE-588)4044898-8 gnd rswk-swf B-Lymphozyt (DE-588)4137121-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content (DE-588)1071861417 Konferenzschrift 1995 Lunteren gnd-content B-Lymphozyt (DE-588)4137121-5 s Pathophysiologie (DE-588)4044898-8 s DE-604 Ferrarini, Manlio 1945- (DE-588)1284582892 edt Caligaris-Cappio, Federico 1948- (DE-588)1284580938 edt Chemical immunology 67 (DE-604)BV002307222 67 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007708373&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Human B-cell populations 5 tables Chemical immunology Pathophysiologie (DE-588)4044898-8 gnd B-Lymphozyt (DE-588)4137121-5 gnd |
| subject_GND | (DE-588)4044898-8 (DE-588)4137121-5 (DE-588)4143413-4 (DE-588)1071861417 |
| title | Human B-cell populations 5 tables |
| title_alt | Human B cell populations |
| title_auth | Human B-cell populations 5 tables |
| title_exact_search | Human B-cell populations 5 tables |
| title_full | Human B-cell populations 5 tables volume editors: Manlio Ferrarini, Federico Caligaris-Cappio |
| title_fullStr | Human B-cell populations 5 tables volume editors: Manlio Ferrarini, Federico Caligaris-Cappio |
| title_full_unstemmed | Human B-cell populations 5 tables volume editors: Manlio Ferrarini, Federico Caligaris-Cappio |
| title_short | Human B-cell populations |
| title_sort | human b cell populations 5 tables |
| title_sub | 5 tables |
| topic | Pathophysiologie (DE-588)4044898-8 gnd B-Lymphozyt (DE-588)4137121-5 gnd |
| topic_facet | Pathophysiologie B-Lymphozyt Aufsatzsammlung Konferenzschrift 1995 Lunteren |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007708373&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002307222 |
| work_keys_str_mv | AT ferrarinimanlio humanbcellpopulations5tables AT caligariscappiofederico humanbcellpopulations5tables AT ferrarinimanlio humanbcellpopulations AT caligariscappiofederico humanbcellpopulations |