Receptor classification: the integration of operational, structural, and transductional information ; [this volume is the result of a conference ... held in Verona, Italy on September 21 - 22, 1995]
Gespeichert in:
| Format: | Buch |
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| Sprache: | English |
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New York, NY
New York Acad. of Sciences
1997
|
| Schriftenreihe: | Annals of the New York Academy of Sciences
812 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 244 S. Ill., graph. Darst. |
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| adam_text | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 812
May 30, 1997
RECEPTOR CLASSIFICATION
THE INTEGRATION OF OPERATIONAL, STRUCTURAL,
AND TRANSDUCTTONAL INFORMATION
Editors
D. G. Trist, P. P. A. Humphrey, P. Leff, and N. P. Shankley
Conference Organizing Committee
P. P. A. Humphrey, P. Leff, G. R. Martin, N. P. Shankley,
J. Shaw, M. Spedding, and D. G. Trist
CONTENTS
Preface and Introduction. By P. P. A. Humphrey, P. Leff, N. P.
Shankley, and D. G. Trist xi
Part I. Principles and Approaches
The Characterization and Classification of Neurotransmitter Receptors. By
Patrick P. A. Humphrey 1
Protein Structures in Receptor Classification. By Eric A. Barnard 14
Transduction Is a Major Factor Influencing Receptor Characterization. By
Michael Spedding and Catherine Dacouet 29
To What Extent Can Binding Studies Allow the Quantification of Affinity
and Efficacy? By Nigel J. M. Birdsall and Sebastian Lazareno .. 41
Part II. Current Issues and Challenges
Criteria for the Classification of Hormone Receptors with Implications for
Nomenclature: An Impossible Task? By Jon Lomasney 48
Do Recombinant Receptor Assays Provide Affinity and Potency
Estimates? By Joel Bockaert, Celine Brand, and Laurent
Journot 55
This volume is the result of a conference entitled Receptor Classification: The Integration
of Operational, Structural, and Transductional Information, supported by the International
Union of Pharmacology (IUPHAR) Committee on Receptor Nomenclature and Drug Classi¬
fication and by the Federation of European Pharmacological Societies (EPHAR) and held
in Verona, Italy on September 21 22, 1995.
v
How Receptor Mutagenesis May Confirm or Confuse Receptor
Nomenclature. By Thue W. Schwartz, Signe Perlman, Mette M.
ROSENKILDE, AND SlV A. HjORTH 71
A Genome based Receptor Nomenclature. By Paul R. Hartig 85
Part HI. Influence of Recent Theoretical Advances
Do Recent Operational Studies Indicate That a Single State Model Is No
Longer Applicable to G Protein coupled Receptors? By Richard A.
Bond 92
Agonist Efficacy and Allosteric Models of Receptor Action. By H. Ongun
Onaran and Tommaso Costa 98
Protean Agonists: Keys to Receptor Active States? By Terry Kenakin ... 116
Is Promiscuity of G Protein Interaction an Issue in the Classification of
Receptors? By Graeme Milligan 126
Kinetic Models of Ion Channels. By Barry S. Pallotta 133
Part IV. Oral Communications
The Classification of Bioamine Receptors: How Helpful are Molecular
Phytogenies? By Philippe Vernier, Bruno Cardinaud, Herve
Philippe, and Jean Didier Vincent 141
Neurokinin Receptors: Comparison of Data from Classical Pharmacology,
Binding, and Molecular Biology. By D. Regoli, K. Nguyen, and
G. Calo 144
The a and a of G Protein coupled Receptors: A Novel Method for
Classification. By Henri Moereels, Paul J. Lewi, Luc M. H.
Koymans, and Paul A. J. Janssen 147
Evolutionary Conservation of the 5 HT2B Receptors. By J. F. Colas, D. S.
Choi, J. M. Launay, and L. Maroteaux 149
General Discussion 154
Part V. Poster Presentations
Agonist Potency Ratios at ml and m3 Muscarinic Receptors Expressed in
A9L and CHO Cells. By M. H. Richards and Marion Merrell
Dow 165
[3H]5 HT Binding to 5 HTlnonA nonB Receptors in Rat Hypothalamus Is not
Representative of 5 HT7 Receptors. By Marco Gobbi, Luca
Parotti, and Tiziana Mennini 167
Working Hypothesis on the Classification of Cys Leukotriene Receptors in
Airways. By V. Capra, G. E. Rovati, and S. Nicosia 169
Cloning and Functional Expression of Guinea Pig Atrial a2 Adrenergic
Receptor Subtypes. By Samuel P. S. Svensson, Amy C. Porter, and
John W. Regan 171
Apparent Heterogeneity of 5 HT2A Receptors Observed in Functional
Studies with Antagonists May Reflect Species related Differences. By
E. J. Mylecharane, J. Lobb, L. Tyndall, and G. R. Martin 174
[3H] RS 79948 197, a High Affinity Radioligand Selective for a2
Adrenoceptor Subtypes. By C. M. Milligan, C. J. Linton,
L. Patmore, N. Gillard, G. J. Ellis, and P. Towers 176
Acylation Differentiates Two Forms of Agonist Binding to Rat 5 HT1A
Receptors: Palmitoylated G Protein Agonist States? By Catherine
Dacquet, Christelle Macia, and Michael Spedding 178
An Improved Method for Analysis of Competitive Agonist/Antagonist
Interactions by Non linear Regression. By Michael J. Lew and
James A. Angus 179
ERK Activation and Cellular Proliferation in Response to Muscarinic
Acetylcholine Receptor Agonists. By Ping Wang,
N. Dhanasekaran, and Gary R. Luthin 182
Co agonism between Glutamate and Glycine on the NMDA Receptor:
Does It Influence the Estimation of Antagonist Dissociation
Constant? By P. Fina, M. Corsi, C. Carignani, and D. G. Trist 184
Estimation of the Relative Potency of Two Glycine Antagonists on
NMDA induced Depolarizations in BRSC and ARCS. By M. Corsi,
L. Bettelini, P. Fina, and D. G. Trist 187
Functional Study of the Excitatory a Adrenoceptor in Guinea Pig Ileum,
in Relation to the Hypothesis of an Atypical Receptor. By Alice
Bricola, Neide H. Jurkiewicz, and Aron Jurkiewicz 189
Functional Change of the Balance between a1A and a1B Adrenoceptor
Populations after Transplantation of the Vas Deferens to the
Intestine. By Andre S. Pupo, Neide H. Jurkiewicz, and Aron
Jurkiewicz 193
Functional Classification of Non competitive Antagonism in Vas Deferens.
By Lucienne C. Martini, Lucia Garcez Do Carmo, and Aron
Jurkiewicz 196
M3 Receptor Mobilizes Intracellular Calcium in Rat Stomach Fundus. By
Soraya S. Smaili, Maria Etsuko Oshiro, Alice T. Ferreira, and
Aron Jurkiewicz 200
Agonist Binding Properties for Recombinant k Opioid Receptors
Expressed in CHO K1 Cells. By L. Carboni, G. Campana,
S. Cacciguerra, E. Speroni, and M. S. Pappalardo 203
The Calcitonin Gene related Peptide (CGRP) Receptor in Rat Smooth
Muscles. By F. Wisskirchen and I. Marshall 205
GR127935 Antagonizes the 5 HTl like Receptor mediated External
Carotid Vasoconstriction in Vagosympathectomized Dogs. By C. M.
Villalon, D. Centurion, and J. A. Terr6n 207
Pharmacological Analysis and Simulation of Ligand Receptor Interaction
in Microsoft Excel™. By N. S. Tilford, W. P. Bowen, and G. S.
Baxter 209
Atypical /3 Adrenoceptors in the Rat Vasculature. By S. Sooch and
I. Marshall 211
Interaction between H3 Receptors and Other Prejunctional Receptor
Systems in the Isolated Guinea Pig Duodenum. By Enzo Poli,
Cristina Pozzoli, and Giulio Bertaccini 213
Cloned and Native Guinea Pig 5 HT? Receptors: Characterization Using
an Integrated Approach. By R. M. Eglen, R. Alvarez, D. Carter,
E. Leung, L. Jakeman, Z. To, and A P. Tsou 216
Identification of a Single Residue Responsible for Agonist Selectivity in
the Oxytocin Vasopressin Receptors. By B. Chini, B. Mouillac,
Y. Ala, M. N. Balestre, S. Trumpp Kallmeyer, J. Hoflack,
J. Eland, M. Hibert, M. Manning, S. Jard, and C. Barberis 218
5 HT1D and 5 HT2B Receptors Mediate Contraction of Smooth Muscle in
Human Small Intestine. By R. A. Borman and D. E. Burleigh 222
Heterogeneity of 5 HT Receptors Mediating Secretion in the Human
Intestine. By R. A. Borman and D. E. Burleigh 224
13 Tert Butylergoline Derivatives: Assessment of Functional Serotonergic
5 HT1A Component. By M. G. Fornaretto, C. Caccia, G. Marchi,
E. Brambilla, S. Manteganni, and C. Post 226
High Level Expression of the Human 5 HT1D(1 Serotonin Receptor Using
the Semliki Forest Virus Expression System. By J. Stables, S. Rees,
K. Lundstrom, D. Livingstone, and M. G. Lee 229
Different Levels of Receptor Expression as a New Procedure to Estimate
Agonist Affinity Constant: Application to the Metabotropic
Receptors. By C. Corti, P. Cavanni, E. Caveggion, F. Ferraguti,
M. Corsi, and D. G. Trist 231
Information in Agonist Curve Shape for Receptor Classification. By D. J.
Prentice and S. M. O. Hourani 234
Sodium Dependency of Constitutive Activity at 5 HT1Da,iDfl Receptors. By
D. W. Gray, H. Giles, V. Barrett, and G. R. Martin 236
NMDA Binding Sites in Rat Hippocampus under Oxidative Stress: Effect
of Anti oxidants and NMDA Antagonists. By Z. Kvaltinova and
S. Stolc 240
Index of Contributors 243
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| spelling | Receptor classification the integration of operational, structural, and transductional information ; [this volume is the result of a conference ... held in Verona, Italy on September 21 - 22, 1995] ed. by D. G. Trist ... New York, NY New York Acad. of Sciences 1997 XII, 244 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Annals of the New York Academy of Sciences 812 Rezeptor (DE-588)4049722-7 gnd rswk-swf Membranrezeptor (DE-588)4136267-6 gnd rswk-swf Arzneimittelrezeptor (DE-588)4305233-2 gnd rswk-swf Klassifikation (DE-588)4030958-7 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1995 Verona gnd-content Rezeptor (DE-588)4049722-7 s Klassifikation (DE-588)4030958-7 s DE-604 Membranrezeptor (DE-588)4136267-6 s Arzneimittelrezeptor (DE-588)4305233-2 s Trist, D. G. Sonstige oth Annals of the New York Academy of Sciences 812 (DE-604)BV002532608 812 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007706439&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Receptor classification the integration of operational, structural, and transductional information ; [this volume is the result of a conference ... held in Verona, Italy on September 21 - 22, 1995] Annals of the New York Academy of Sciences Rezeptor (DE-588)4049722-7 gnd Membranrezeptor (DE-588)4136267-6 gnd Arzneimittelrezeptor (DE-588)4305233-2 gnd Klassifikation (DE-588)4030958-7 gnd |
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| title | Receptor classification the integration of operational, structural, and transductional information ; [this volume is the result of a conference ... held in Verona, Italy on September 21 - 22, 1995] |
| title_auth | Receptor classification the integration of operational, structural, and transductional information ; [this volume is the result of a conference ... held in Verona, Italy on September 21 - 22, 1995] |
| title_exact_search | Receptor classification the integration of operational, structural, and transductional information ; [this volume is the result of a conference ... held in Verona, Italy on September 21 - 22, 1995] |
| title_full | Receptor classification the integration of operational, structural, and transductional information ; [this volume is the result of a conference ... held in Verona, Italy on September 21 - 22, 1995] ed. by D. G. Trist ... |
| title_fullStr | Receptor classification the integration of operational, structural, and transductional information ; [this volume is the result of a conference ... held in Verona, Italy on September 21 - 22, 1995] ed. by D. G. Trist ... |
| title_full_unstemmed | Receptor classification the integration of operational, structural, and transductional information ; [this volume is the result of a conference ... held in Verona, Italy on September 21 - 22, 1995] ed. by D. G. Trist ... |
| title_short | Receptor classification |
| title_sort | receptor classification the integration of operational structural and transductional information this volume is the result of a conference held in verona italy on september 21 22 1995 |
| title_sub | the integration of operational, structural, and transductional information ; [this volume is the result of a conference ... held in Verona, Italy on September 21 - 22, 1995] |
| topic | Rezeptor (DE-588)4049722-7 gnd Membranrezeptor (DE-588)4136267-6 gnd Arzneimittelrezeptor (DE-588)4305233-2 gnd Klassifikation (DE-588)4030958-7 gnd |
| topic_facet | Rezeptor Membranrezeptor Arzneimittelrezeptor Klassifikation Konferenzschrift 1995 Verona |
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