Clinical applications of neurotrophic factors:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Philadelphia [u.a.]
Lippincott-Raven
1997
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIII, 209 S. Ill., graph. Darst. |
| ISBN: | 0397517823 |
Internformat
MARC
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| 245 | 1 | 0 | |a Clinical applications of neurotrophic factors |c Stuart C. Apfel |
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| 650 | 4 | |a Growth factors |x Therapeutic use | |
| 650 | 4 | |a Nerve Growth Factors |x therapeutic use | |
| 650 | 4 | |a Nerve growth factor |x Therapeutic use | |
| 650 | 4 | |a Nervous system |x Diseases |x Chemotherapy | |
| 650 | 4 | |a Neurotropin |x Therapeutic use | |
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Datensatz im Suchindex
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| adam_text | Contents
Preface xi
Acknowledgments xiii
Glossary of Abbreviations xiv
1 What Are Neurotrophic Factors? 1
Early History / Concept of Neurotropism / Discovery of Nerve
Growth Factor / Physiologic Role / Mechanisms of Action /
Regulation of Gene Expression / Neuronal Populations Responsive
to Nerve Growth Factor / Early Conclusions / Responsive Neurons
in the Peripheral Nervous System / Nerve Growth Factor in the
Central Nervous System / The Nerve Growth Factor Receptor /
High and Low Affinity Receptors / The TRK Oncogene / Discovery
of Other Neurotrophins / Neumtrophin Receptors / Cell
Populations Responsive to Brain Derived Neurotrophic Factor, NT 3,
and NT 4/5 / Ciliary Neurotrophic Factor / Discovery / Structure
and Receptor / Responsive Cell Populations / Is Ciliary
Neurotrophic Factor an Injury Factor? / Other Growth Factors With
Neurotrophic Activity / Insulin and Its Related Peptides /
Fibroblast Growth Factor / Epidermal Growth Factor and
Transforming Growth Factor / Discovery of Epidermal Growth
Factor / Discovery of Transforming Growth Factor a / Effects on
the Nervous System / Glial Cell Line Derived Neurotrophic Factor /
Adenocorticotrophic Hormone and Melanocyte Stimulating Hormone
Peptides / Summary
2 Introduction to the Clinical Applications of Neurotrophic Factors 55
Choosing a Neurotrophic Factor / The Goal of Therapy / Adverse
Effects of Neurotrophic Factor Therapy / Future Directions /
Summary
3 Treatment of Peripheral Nervous System Disorders 63
Organization of the Peripheral Nervous System / Sensory Neurons /
Motor Neurons / Sympathetic Neurons / Parasympathetic Neurons /
Do Neurotrophic Factors Play a Role in the Pathogenesis of
vii
viii / CONTENTS
Peripheral Nerve Disease? / Treatment of Peripheral Nervous
System Disorders / Neurotrophic Factors in the Treatment of Toxic
Neuropathy / Diabetic Neuropathy / Treatment of Neuropathic
Pain / Neurotrophic Factors in the Treatment of Motor Neuropathy /
Adverse Effects of Neurotrophic Factor Therapy / Clinical Trials /
Summary
4 Traumatic Injury to the Peripheral Nerve and Regeneration 82
What Happens to a Nerve When It Is Injured? / Nerve
Degeneration / Nerve Regeneration / Initiating Axonal Outgrowth
/ Axonal Growth Across a Gap / Forming Precise Connections /
Improving the Process / Mechanical Repair / Neurotrophic
Factors in Regeneration / Nerve Growth Factor / Ciliary
Neurotrophic Factor / Insulin Like Growth Factors I and II /
Summary
5 Neurotrophic Factors for Specialized Sense Organs 101
Stuart C. Apfel and Thomas Van De Water
Optic Nerve / Visual System Anatomy Review / Physiologic
Sources of Neurotrophic Activity for the Retina / Characterized
Neurotrophic Factors That May Promote the Survival of the Retina
and Optic Nerve / Brain derived Neurotrophic Factor / Nerve
Growth Factor / Other Neurotrophins / Fibroblast Growth Factor /
Other Trophic Factors / Extracellular Matrix Molecules in the Optic
Nerve / Regenerative Capacity of the Retina / Effects of Growth
Factors on the Visual Cortex / Other Preclinical Studies /
Summary / Vestibular—Cochlear Nerve / Review of Vestibular
Cochlear Anatomy / Responses to Neurotrophic Factors /
Neurotrophins / Other Neurotrophic Factors / Preclinical Studies /
Summary
6 Treatment of Motor Neuron Disease 128
Etiologies of Motor Neuron Disease / Role of Neurotrophic Factors
in the Therapy of Motor Neuron Disease / Ciliary Neurotrophic
Factor (CNTF) / Neurotrophins / Insulin Like Growth Factors /
Glial Derived Neurotrophic Factor / Other Growth Factors /
Combination Therapy / Summary
7 Treatment of Parkinson s Disease 142
Do Abnormalities of Neurotrophic Factors Play a Pathogenic Role? /
Neural Transplantation and Tissue Grafts / Adrenal Medulla
Grafts / Fetal Neuron Transplants / Direct Applications of
Neurotrophic Factors to the Dopaminergic System /
CONTENTS / ix
Neurotrophins / Glial Cell Line Derived Neurotrophic Factor /
Other Potentially Useful Neurotrophic Factors / Summary
8 Treatment of Alzheimer s Disease 156
Affected Cell Populations / Pathogenesis / Does Loss of
Neurotrophic Support Contribute to the Pathogenesis of Alzheimer s
Disease? / Nerve Growth Factor / Other Neurotrophic Factors /
The Goal of Therapy in Alzheimer s Disease / Effects of Nerve
Growth Factor on the Septal Cholinergic Pathways / Behavioral
Effects of Nerve Growth Factor Infusion / Human Trials of Nerve
Growth Factor in the Treatment of Alzheimer s Disease / Possible
Adverse Effects / Summary
9 Seizures, Neurotrophins, and TRK Receptors 176
Samuel Koszer
Review of Hippocampal Functional Anatomy / Seizure Induced
Morphologic and Functional Changes in the Hippocampus /
Seizure Models and Neurotrophins / Summary and Conclusions
10 Administration to the Central Nervous System 185
The Blood Brain Barrier / Intraventricular Infusions / Carrier
Drugs / Implantable Polymers / Nanoparticles / Cell
Transplantation / Direct Cell Grafting / Fetal Cells /
Transformed Cell Lines / Neuronal Progenitor Cells /
Encapsulated Cells / Summary
Subject Index 201
|
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| id | DE-604.BV011403537 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:09:10Z |
| institution | BVB |
| isbn | 0397517823 |
| language | English |
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| physical | XIII, 209 S. Ill., graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Lippincott-Raven |
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| spelling | Apfel, Stuart C. Verfasser aut Clinical applications of neurotrophic factors Stuart C. Apfel Philadelphia [u.a.] Lippincott-Raven 1997 XIII, 209 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Groeifactoren (biowetenschappen) gtt Neuronen gtt Growth factors Therapeutic use Nerve Growth Factors therapeutic use Nerve growth factor Therapeutic use Nervous system Diseases Chemotherapy Neurotropin Therapeutic use Neurotropher Faktor (DE-588)4317638-0 gnd rswk-swf Therapie (DE-588)4059798-2 gnd rswk-swf Neurotropher Faktor (DE-588)4317638-0 s Therapie (DE-588)4059798-2 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007666244&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Apfel, Stuart C. Clinical applications of neurotrophic factors Groeifactoren (biowetenschappen) gtt Neuronen gtt Growth factors Therapeutic use Nerve Growth Factors therapeutic use Nerve growth factor Therapeutic use Nervous system Diseases Chemotherapy Neurotropin Therapeutic use Neurotropher Faktor (DE-588)4317638-0 gnd Therapie (DE-588)4059798-2 gnd |
| subject_GND | (DE-588)4317638-0 (DE-588)4059798-2 |
| title | Clinical applications of neurotrophic factors |
| title_auth | Clinical applications of neurotrophic factors |
| title_exact_search | Clinical applications of neurotrophic factors |
| title_full | Clinical applications of neurotrophic factors Stuart C. Apfel |
| title_fullStr | Clinical applications of neurotrophic factors Stuart C. Apfel |
| title_full_unstemmed | Clinical applications of neurotrophic factors Stuart C. Apfel |
| title_short | Clinical applications of neurotrophic factors |
| title_sort | clinical applications of neurotrophic factors |
| topic | Groeifactoren (biowetenschappen) gtt Neuronen gtt Growth factors Therapeutic use Nerve Growth Factors therapeutic use Nerve growth factor Therapeutic use Nervous system Diseases Chemotherapy Neurotropin Therapeutic use Neurotropher Faktor (DE-588)4317638-0 gnd Therapie (DE-588)4059798-2 gnd |
| topic_facet | Groeifactoren (biowetenschappen) Neuronen Growth factors Therapeutic use Nerve Growth Factors therapeutic use Nerve growth factor Therapeutic use Nervous system Diseases Chemotherapy Neurotropin Therapeutic use Neurotropher Faktor Therapie |
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