Facilitative glucose transporters:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Springer [u.a.]
1997
|
| Schriftenreihe: | Molecular biology intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | 235 S. Ill., graph. Darst. |
| ISBN: | 354062578X |
Internformat
MARC
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| 245 | 1 | 0 | |a Facilitative glucose transporters |c Gwyn W. Gould |
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| 300 | |a 235 S. |b Ill., graph. Darst. | ||
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Datensatz im Suchindex
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| adam_text | h = CONTENTS =n
1. Introduction to the Facilitative Glucose Transporter Family 1
Gtuyn W. Gould and Michael J. Seatter
Synopsis of the Chapter 1
Glucose Transport Before Molecular Biology:
An Historical Perspective 1
The Glucose Transporters:
An Introduction to the Family 2
GLUT Chromosomal Localization and Gene Structure 27
Summary 29
2. Glucose Transport: Probing the Structure/Function
Relationship 39
E.G. SaravokcandG.D. Holman
Synopsis of the Chapter 39
Binding—The Two Conformation Model 40
Side Specific Affinity Labels 40
Sequence, Spectroscopy and Structure 43
Mutagenesis 47
Summary 60
Future Directions: A Possible Structure? 60
3. Trafficking, Targeting and Translocation
of the Insulin Regulatable Glucose Transporter, GLUT4 67
Gwyn W. Gould
Synopsis of the Chapter 67
Insulin Stimulated Glucose Transport:
The Discovery of Translocation 67
Evidence in Favor of Translocation 68
GLUT4 Trafficking 74
How is GLUT4 Targeted? 82
Insulin Stimulated GLUT4 Translocation in Real Time:
Is the Future Green? 93
Trafficking, Targeting and Translocation in Skeletal Muscle 94
Synopsis and Future Directions 98
4. Signaling Pathways Mediating Insulin Activated
Glucose Transport 105
Sharon F. Hausdorff, Diane C. Fingar and Morris J. Birnbaum
Synopsis of the Chapter 105
Introduction 105
The Insulin Receptor 109
Insulin Receptor and GLUT4 Translocation 110
Insulin Receptor and Other Actions of Insulin 110
Insulin Receptor Substrates 1 and 2 (IRS 1 and IRS 2) Ill
IRS 1 and Insulin Action 112
IRS 1 and the Metabolic and Mitogenic Actions of Insulin 113
IRS 1 and GLUT4 Translocation 114
Studies with IRS 1 Knock Out Transgenic Mice 114
Other Signaling Events 116
Ras 116
Raf 117
MEK/MAP Kinase/pp90RSK 117
SH PTP2 118
Phosphatidylinositol 3 Kinase 119
IRS 1 and PI 3 Kinase 120
Down Stream Targets of PI 3 Kinase 124
C AKT 124
C AKT and Insulin Signaling 125
C AKT and Insulin Stimulated Glucose Transport 125
5. GLUT4 in Insulin Resistance 137
Antonio Zorzano andMarta Camps
Synopsis of the Chapter 137
Introduction 137
Obesity 139
Non Insulin Dependent Diabetes Mellitus 142
Muscle Inactivity and Chronic Exercise 146
Insulin Resistance Can Be Ameliorated in Insulin Resistant
States by Overexpressing GLUT4 Glucose Transporters 147
Pregnancy and Lactation 149
Summary and Future Prospects 154
6. GLUT2 Function, Expression and Transcriptional Regulation in
Liver and Pancreatic P Cells 167
Bernard Thorens and Gerard Waeber
Synopsis of the Chapter 167
Introduction 167
GLUT2 Function in Liver and Pancreatic p Cells 168
GLUT2 Regulated Expression 169
GLUT2 Gene Structure and Regulation 173
P cell Specific Transcriptional Control of GLUT2
Gene Expression 174
Conclusions and Future Directions 178
7. Nutrient Regulation of Facilitative Hexose Transporters 183
Edith Brot Laroche andArmelle Leturque
Synopsis of the Chapter 183
Studies in the Small Intestine 184
Studies in Kidney 188
Studies in the Liver 189
Studies in Skeletal Muscle 191
Summary and Future Prospects 192
8. Regulation of Glucose Transport by Growth
Factors and Oncogenes 197
Fiona J. Thomson and Gwyn W. Gould
Synopsis of the Chapter 197
Cellular Proliferation and the Mechanism of Activation of Glucose
Transport 198
Growth Factors Induce a Biphasic Stimulation
of Glucose Transport 198
Growth Factor Receptor Signal Transduction 198
Receptor Tyrosine Kinase Signaling 198
G Protein Coupled Receptor Signaling 200
Growth Factor Signaling and the Acute Glucose
Transport Response 200
Phospholipid Hydrolysis and Protein Kinase C Activation 200
Mitogen Activated Protein Kinase (MAP Kinase) Cascades
and the Regulation of Glucose Transport 202
The Involvement of Phosphatidylinositol 3 Kinase Activation
in the Early Glucose Transport Response to Growth Factors 205
Involvement of the Rab and Rho Families of GTP Binding
Proteins in the Acute Phase of Growth Factor Stimulated
Glucose Transport 208
Oncogenes and the Late Phase Stimulation of Glucose Transport 209
Activated Cellular Oncogenes Stimulate Glucose Transport
and GLUT1 Gene Expression 209
Summary and Future Perspectives 210
9. Transgenic Animals—Lessons for Glucose Transport 219
E. Michael Gibbs
Synopsis of the Chapter 219
Introduction 219
GLUTl Overexpression 220
GLUT4 Overexpression 222
GLUT4 Knockout Mice 226
Future Directions 227
Index 231
|
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| genre_facet | Aufsatzsammlung |
| id | DE-604.BV011386938 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:08:53Z |
| institution | BVB |
| isbn | 354062578X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007653302 |
| oclc_num | 75737290 |
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| owner_facet | DE-355 DE-BY-UBR DE-11 |
| physical | 235 S. Ill., graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Springer [u.a.] |
| record_format | marc |
| series2 | Molecular biology intelligence unit |
| spelling | Facilitative glucose transporters Gwyn W. Gould New York [u.a.] Springer [u.a.] 1997 235 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit Literaturangaben Carrier-Proteine (DE-588)4213127-3 gnd rswk-swf Glucosetransport (DE-588)4157684-6 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Glucosetransport (DE-588)4157684-6 s Carrier-Proteine (DE-588)4213127-3 s DE-604 Gould, Gwyn W. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007653302&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Facilitative glucose transporters Carrier-Proteine (DE-588)4213127-3 gnd Glucosetransport (DE-588)4157684-6 gnd |
| subject_GND | (DE-588)4213127-3 (DE-588)4157684-6 (DE-588)4143413-4 |
| title | Facilitative glucose transporters |
| title_auth | Facilitative glucose transporters |
| title_exact_search | Facilitative glucose transporters |
| title_full | Facilitative glucose transporters Gwyn W. Gould |
| title_fullStr | Facilitative glucose transporters Gwyn W. Gould |
| title_full_unstemmed | Facilitative glucose transporters Gwyn W. Gould |
| title_short | Facilitative glucose transporters |
| title_sort | facilitative glucose transporters |
| topic | Carrier-Proteine (DE-588)4213127-3 gnd Glucosetransport (DE-588)4157684-6 gnd |
| topic_facet | Carrier-Proteine Glucosetransport Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007653302&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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