Evaluation of the appropriateness of the extended subacute (28 day-) toxicity test to detect adverse effects on the immune system: a report
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English German |
| Veröffentlicht: |
Berlin
1996
|
| Schriftenreihe: | Bundesinstitut für Gesundheitlichen Verbraucherschutz und Veterinärmedizin <Berlin>: BgVV-Hefte
1996,4 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Zsfassung in dt. Sprache |
| Beschreibung: | 187 S. |
| ISBN: | 3931675068 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804125835735597056 |
|---|---|
| adam_text | Contents
page
1. Zusammenfassung/Summary 7
2. Introduction 14
3. Methods 17
3.1 General information 17
3.2 Test substance 19
3.3 Test system 21
3.3.1 Animal species 21
3.3.2 Husbandry 22
3.3.3 Allocation and identification of the
animals . 23
3.3.4 Acclimatization time 24
3.4 Study design 24
3.4.1 Dose finding 24
3.4.2 Dose regimen 25
3.5 Investigations and parameters examined 26
3.5.1 Clinical investigations 26
3.5.2 Clinical pathology 27
3.5.2.1 Hematology 27
3.5.2.2 Clinical chemistry 28
3.5.3 Pathology 29
3.5.3.1 Necropsy 29
3.5.3.2 Organ weights 30
3.5.3.3 Histopathology 31
3.5.4 Immune parameters 34
3.5.4.1 Serum level of immunoglobulins 34
3.5.4.2 Preparation of single cell suspensions 35
3.5.4.3 Sensitity of spleen and lymph node
cells to mitogens and alloantigens 36
3.5.4.4 Activation status of macrophages and
natural killer cells 37
3.5.4.5 Analysis of cell subpopulations in spleen
and lymph node cells (surface markers) 37
3.5.4.6 Plaque forming cell assay (PFCA) 38
3.5.5 Statistical methods 38
4. Results 41
4.1 In life findings 41
4.1.1 Clinical investigations 41
4.1.1.1 Clinical signs 41
4.1.1.2 Food consumption and food efficiency 41
4.1.1.3 Body weights 43
4.1.2. Clinical pathology 44
4.1.2.1 Hematology 44
4.1.2.2 Clinical chemistry 46
4.2 Pathology 48
4.2.1 Organ weights 48
4.2.2 Gross necropsy 50
4.2.3 Histopathology 50
4.3 Immune parameters 60
4.3.1 Serum level of immunoglobulins 60
4.3.2 Cell count determinations in bone marrow 60
4.3.3 Sensitity of spleen and lymph node cells
to mitogens and alloantigens 61
4.3.4 Activation status of macrophages and
natural killer cells 62
4.3.5 Analysis of subpopulations in spleen and
lymph node cells (surface markers) 63
4.3.6 Plaque forming cell assay (PFCA) 64
5. Discussion 66
6. Conclusions 75
7. Appendices 77
7.1 Abbreviation list 78
7.2 Certificates of analysis 79
7.3 List of parameters for interlaboratory
comparison 81
7.4 In life findings 84
7.4.1 Summary tables Food consumption and food
efficiency 84
7.4.2 Summary tables Body weight and body weight
changes 89
7.5 Clinical pathology 94
7.5.1 Summary tables Hematology and
differential blood counts 94
7.5.2 Summary tables Clinical chemistry 99
7.6 Pathology 105
7.6.1 Summary tables Organ weights
and organ/body weight ratios 105
7.6.2 Summary tables Microscopic pathology 110
7.7 Immune parameters 167
7.7.1 Summary tables Immunoglobulins 167
7.7.2 Summary table Bone marrow cellularity 170
7.7.3 Summary tables Immune parameters from
sections 4.3.3 to 4.3.6 170
8. References 184
|
| any_adam_object | 1 |
| author | Richter-Reichhelm, Hans-Bernhard Schulte, Agnes |
| author_facet | Richter-Reichhelm, Hans-Bernhard Schulte, Agnes |
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| author_sort | Richter-Reichhelm, Hans-Bernhard |
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| building | Verbundindex |
| bvnumber | BV011327422 |
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| id | DE-604.BV011327422 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-09T18:07:53Z |
| institution | BVB |
| isbn | 3931675068 |
| language | English German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007610820 |
| oclc_num | 643626135 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-12 |
| owner_facet | DE-355 DE-BY-UBR DE-12 |
| physical | 187 S. |
| publishDate | 1996 |
| publishDateSearch | 1996 |
| publishDateSort | 1996 |
| record_format | marc |
| series | Bundesinstitut für Gesundheitlichen Verbraucherschutz und Veterinärmedizin <Berlin>: BgVV-Hefte |
| series2 | Bundesinstitut für Gesundheitlichen Verbraucherschutz und Veterinärmedizin <Berlin>: BgVV-Hefte |
| spelling | Richter-Reichhelm, Hans-Bernhard Verfasser aut Evaluation of the appropriateness of the extended subacute (28 day-) toxicity test to detect adverse effects on the immune system a report H.-B. Richter-Reichhelm ; A. E. Schulte Berlin 1996 187 S. txt rdacontent n rdamedia nc rdacarrier Bundesinstitut für Gesundheitlichen Verbraucherschutz und Veterinärmedizin <Berlin>: BgVV-Hefte 1996,4 Zsfassung in dt. Sprache Toxizitätstest (DE-588)4060540-1 gnd rswk-swf Immunotoxin (DE-588)4209677-7 gnd rswk-swf Immunsystem (DE-588)4026643-6 gnd rswk-swf Toxizitätstest (DE-588)4060540-1 s Immunsystem (DE-588)4026643-6 s DE-604 Immunotoxin (DE-588)4209677-7 s Schulte, Agnes Verfasser aut Bundesinstitut für Gesundheitlichen Verbraucherschutz und Veterinärmedizin <Berlin>: BgVV-Hefte 1996,4 (DE-604)BV010349012 1996,4 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007610820&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Richter-Reichhelm, Hans-Bernhard Schulte, Agnes Evaluation of the appropriateness of the extended subacute (28 day-) toxicity test to detect adverse effects on the immune system a report Bundesinstitut für Gesundheitlichen Verbraucherschutz und Veterinärmedizin <Berlin>: BgVV-Hefte Toxizitätstest (DE-588)4060540-1 gnd Immunotoxin (DE-588)4209677-7 gnd Immunsystem (DE-588)4026643-6 gnd |
| subject_GND | (DE-588)4060540-1 (DE-588)4209677-7 (DE-588)4026643-6 |
| title | Evaluation of the appropriateness of the extended subacute (28 day-) toxicity test to detect adverse effects on the immune system a report |
| title_auth | Evaluation of the appropriateness of the extended subacute (28 day-) toxicity test to detect adverse effects on the immune system a report |
| title_exact_search | Evaluation of the appropriateness of the extended subacute (28 day-) toxicity test to detect adverse effects on the immune system a report |
| title_full | Evaluation of the appropriateness of the extended subacute (28 day-) toxicity test to detect adverse effects on the immune system a report H.-B. Richter-Reichhelm ; A. E. Schulte |
| title_fullStr | Evaluation of the appropriateness of the extended subacute (28 day-) toxicity test to detect adverse effects on the immune system a report H.-B. Richter-Reichhelm ; A. E. Schulte |
| title_full_unstemmed | Evaluation of the appropriateness of the extended subacute (28 day-) toxicity test to detect adverse effects on the immune system a report H.-B. Richter-Reichhelm ; A. E. Schulte |
| title_short | Evaluation of the appropriateness of the extended subacute (28 day-) toxicity test to detect adverse effects on the immune system |
| title_sort | evaluation of the appropriateness of the extended subacute 28 day toxicity test to detect adverse effects on the immune system a report |
| title_sub | a report |
| topic | Toxizitätstest (DE-588)4060540-1 gnd Immunotoxin (DE-588)4209677-7 gnd Immunsystem (DE-588)4026643-6 gnd |
| topic_facet | Toxizitätstest Immunotoxin Immunsystem |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007610820&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV010349012 |
| work_keys_str_mv | AT richterreichhelmhansbernhard evaluationoftheappropriatenessoftheextendedsubacute28daytoxicitytesttodetectadverseeffectsontheimmunesystemareport AT schulteagnes evaluationoftheappropriatenessoftheextendedsubacute28daytoxicitytesttodetectadverseeffectsontheimmunesystemareport |