Apolipoprotein E genotyping in Alzheimer's disease: [this volume is the result of a conference ... held in Chicago, Illinois on October 21 through 22, 1995]
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
New York Acad. of Sciences
1996
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| Schriftenreihe: | Annals of the New York Academy of Sciences
802 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | IX, 225 S. Ill., graph. Darst. |
| ISBN: | 1573310484 1573310492 |
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Datensatz im Suchindex
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| adam_text | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 802
December 16, 1996
APOLIPOPROTEIN E GENOTYPING IN
ALZHEIMER S DISEASE
Editors and Conference Organizers
Norman R. Relkin, Zaven Khachaturian, and Samuel Gandy
Advisory Board
Leonard Berg, John Blass, John Breitner,
John Fletcher, Robert Hegele, Fred Plum,
Dennis Selkoe, Leon Thal, and
Peter Whitehouse
CONTENTS
Preface. By Norman R. Relkin, Zaven Khachaturian, and
Samuel Gandy ix
Part I. The Relationship of Apolipoprotein E to Alzheimer s Disease
Epidemiological, Clinical, and Neuropathological Study of
Apolipoprotein E Genotype in Alzheimer s Disease.
By Bradley T. Hyman, Teresa Gomez Isla, G. William
Rebeck, Megan Briggs, Haeyong Chung, Howard L.
West, Steven Greenberg, Stina Mui, Susan Nichols,
Robert Wallace and John H. Growdon 1
Effect of Age, Ethnicity, and Head Injury on the Association
between APOE Genotypes and Alzheimer s Disease. By
Min Xin Tang, Gladys Maestre, Wei Yann Tsai,
Xin Hua Liu, Lin Feng, Wai Yee Chung, Michael Chun,
Peter Schofield, Yaakov Stern, Benjamin Tycko, and
Richard Mayeux 6
a This volume is the result of a conference, entitled Apolipoprotein E Genotyping in Alzheimer s
Disease, sponsored by the National Institute on Aging and the Alzheimer s Association, and held
in Chicago, Illinois on October 21 through 22, 1995.
. Familial and Population Based Studies of Apolipoprotein and
Alzheimer s Disease. By Michael Mullan, Paul Scibelli,
Ranjan Duara, Danielle Fallin, Michael Gold, John
Schinka, Jonathan Hoyne, Aaron Osborne, Steven
Sevush, and Fiona Crawford 16
Polygenic Determinants of Alzheimer s Disease: Modulation of the
Risk of Alzheimer s Disease by al Antichymotrypsin. By
Steven T. DeKosky, Christopher E. Aston, and M. Ilyas
Kamboh 27
No Association between al Antichymotrypsin and Familial
Alzheimer s Disease. By Jonathan L. Haines, Meredyth L.
Pritchard, Ann M. Saunders, Joellen M. Schildkraut,
John H. Growdon, Peter C. Gaskell, Lindsay A. Farrer,
Sanford A. Auerbach, James F. Gusella, Patricia A.
Locke, Barbara L. Rosi, Larry Yamaoka, Gary W.
Small, P. Michael Conneally, Allen D. Roses, and
Margaret Pericak Vance 35
Apolipoprotein E, A(3 Amyloid, and the Molecular Pathology of
Alzheimer s Disease: Therapeutic Implications. By Michael
Kaplitt, Gunnar K. Gouras, Hideo Makimura, Jasmina
Jovanovic, David Sweeney, Paul Greengard, Norman R.
Relkin, and Samuel Gandy 42
Part II. Diagnostic and Predictive Use of APOE Genotyping
Apolipoprotein E and Alzheimer s Disease: A Rapidly Expanding
Field with Medical and Epidemiological Consequences. By
Allen D. Roses 50
Predictive Value of APOE Genotyping in Incipient Alzheimer s
Disease. By Ronald C. Petersen, Stephen C. Waring,
Glenn E. Smith, Eric G. Tangalos, and Stephen N.
Thibodeau 58
Early Detection of Alzheimer s Disease by Combining
Apolipoprotein E and Neuroimaging. By Gary W. Small,
Scott Komo, Asenath La Rue, Sanjaya Saxena, Michael
E. Phelps, John C. Mazziota, Ann M. Saunders,
Jonathan L. Haines, Margaret A. Pericak Vance, and
Allen D. Roses 70
The Use of Apolipoprotein E Genotyping as a Diagnostic Test in
Suspected Alzheimer s Disease. By W. A. van Gool 79
The Effect of Apolipoprotein E Genotype on Biochemical Markers
of Alzheimer s Disease. By Dale Schenk, Ivan Lieberburg,
Ruth Motter, and Peter Seubert 92
Apolipoprotein E Genotype and Gender Influence Response to
Tacrine Therapy. By Martin R. Farlow, Debomoy K.
Lahiri, Judes Poirier, Jean Davignon, and Siu Hui 101
Part III. Ethical, Medicolegal, and Counseling Issues Raised by
APOE and Alzheimer s Disease
On Not Jumping the Gun: Ethical Aspects of APOE Gene Testing
for Alzheimer s Disease. By Stephen G. Post Ill
A Pilot Experience in Genetic Counseling for Alzheimer s Disease:
Findings Relevant to the Potential Use of APOE Genotyping
in Cognitively Impaired Individuals. By H. Karlinsky, Odie
Geiger, Anne MacDougall, Maurice Bloch, Dessa
Shadovnick and Michael Burgess 120
Just Caring: The Moral and Economic Costs of APOE Genotyping
for Alzheimer s Disease. By Leonard M. Fleck 128
Medicolegal, Employment, and Insurance Issues in APOE
Genotyping and Alzheimer s Disease. By Marshall B. Kapp . 139
Part IV. Epilogue
The National Institute on Aging/Alzheimer s Association
Recommendations on the Application of Apolipoprotein E
Genotyping to Alzheimer s Disease. By Norman R. Relkin,
Younga J. Kwon, Julia Tsai, and Samuel Gandy 149
Bibliography. Compiled by Younga J. Kwon, Julia Tsai, and
Norman R. Relkin 177
Index of Contributors 225
Financial assistance was received from:
• ALZHEIMER S ASSOCIATION (USA)
• PARKE DAVIS
• C. V. STARR FOUNDATION
• ZACHARY ELIZABETH M. FISHER CENTER FOR RESEARCH ON
ALZHEIMER S DISEASE AT ROCKEFELLER UNIVERSITY
The New York Academy of Sciences believes it has a responsibility to provide an open forum for discussion
of scientific questions. The positions taken by the participants in the reported conferences are their own
and not necessarily those of the Academy. The Academy has no intent to influence legislation by providing
such forums.
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| illustrated | Illustrated |
| indexdate | 2024-07-09T18:07:17Z |
| institution | BVB |
| isbn | 1573310484 1573310492 |
| language | English |
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| publishDate | 1996 |
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| series | Annals of the New York Academy of Sciences |
| series2 | Annals of the New York Academy of Sciences |
| spelling | Apolipoprotein E genotyping in Alzheimer's disease [this volume is the result of a conference ... held in Chicago, Illinois on October 21 through 22, 1995] ed. by Norman R. Relkin ... New York, NY New York Acad. of Sciences 1996 IX, 225 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Annals of the New York Academy of Sciences 802 Alzheimerkrankheit (DE-588)4112510-1 gnd rswk-swf Genanalyse (DE-588)4200230-8 gnd rswk-swf Polymorphismus (DE-588)4130554-1 gnd rswk-swf Apolipoprotein E (DE-588)4244358-1 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1995 Chicago Ill. gnd-content Alzheimerkrankheit (DE-588)4112510-1 s Apolipoprotein E (DE-588)4244358-1 s Polymorphismus (DE-588)4130554-1 s DE-604 Genanalyse (DE-588)4200230-8 s Relkin, Norman R. Sonstige oth Annals of the New York Academy of Sciences 802 (DE-604)BV002532608 802 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007584523&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Apolipoprotein E genotyping in Alzheimer's disease [this volume is the result of a conference ... held in Chicago, Illinois on October 21 through 22, 1995] Annals of the New York Academy of Sciences Alzheimerkrankheit (DE-588)4112510-1 gnd Genanalyse (DE-588)4200230-8 gnd Polymorphismus (DE-588)4130554-1 gnd Apolipoprotein E (DE-588)4244358-1 gnd |
| subject_GND | (DE-588)4112510-1 (DE-588)4200230-8 (DE-588)4130554-1 (DE-588)4244358-1 (DE-588)1071861417 |
| title | Apolipoprotein E genotyping in Alzheimer's disease [this volume is the result of a conference ... held in Chicago, Illinois on October 21 through 22, 1995] |
| title_auth | Apolipoprotein E genotyping in Alzheimer's disease [this volume is the result of a conference ... held in Chicago, Illinois on October 21 through 22, 1995] |
| title_exact_search | Apolipoprotein E genotyping in Alzheimer's disease [this volume is the result of a conference ... held in Chicago, Illinois on October 21 through 22, 1995] |
| title_full | Apolipoprotein E genotyping in Alzheimer's disease [this volume is the result of a conference ... held in Chicago, Illinois on October 21 through 22, 1995] ed. by Norman R. Relkin ... |
| title_fullStr | Apolipoprotein E genotyping in Alzheimer's disease [this volume is the result of a conference ... held in Chicago, Illinois on October 21 through 22, 1995] ed. by Norman R. Relkin ... |
| title_full_unstemmed | Apolipoprotein E genotyping in Alzheimer's disease [this volume is the result of a conference ... held in Chicago, Illinois on October 21 through 22, 1995] ed. by Norman R. Relkin ... |
| title_short | Apolipoprotein E genotyping in Alzheimer's disease |
| title_sort | apolipoprotein e genotyping in alzheimer s disease this volume is the result of a conference held in chicago illinois on october 21 through 22 1995 |
| title_sub | [this volume is the result of a conference ... held in Chicago, Illinois on October 21 through 22, 1995] |
| topic | Alzheimerkrankheit (DE-588)4112510-1 gnd Genanalyse (DE-588)4200230-8 gnd Polymorphismus (DE-588)4130554-1 gnd Apolipoprotein E (DE-588)4244358-1 gnd |
| topic_facet | Alzheimerkrankheit Genanalyse Polymorphismus Apolipoprotein E Konferenzschrift 1995 Chicago Ill. |
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