Membrane protein assembly:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Springer [u.a.]
1997
|
| Schriftenreihe: | Molecular biology intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 270 S. Ill., graph. Darst. |
| ISBN: | 3540620419 |
Internformat
MARC
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Datensatz im Suchindex
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|---|---|
| adam_text | I CONTENTS ——j|
Parti
STRUCTURAL ASPECTS OF INTEGRAL
MEMBRANE PROTEINS
1. Transmembrane a Helix Interactions in Folding
and Oligomerization of Integral Membrane Proteins 3
Mark A. Lemmon, Kevin R. MacKenzie, Isiah T. Arkin and
Donald M. Engelman
Introduction 3
Why Transmembrane a Helices? 4
Membrane Protein Folding and Oligomerization in Two Stages 4
How do Transmembrane a Helices Associate? 6
Views of Transmembrane Helix Interactions from Crystal Structures ... 7
Other Views of Helix Helix Interfaces 9
Mutational Analyses of Polytopic Membrane Proteins 10
Highly Specific Interactions between Transmembrane a Helices 12
A Brief Survey of Other Single Transmembrane Helices That
Oligomerize 17
General Conclusions on Transmembrane a Helix Interactions 19
Promiscuity and Its Possible Functional Role 20
2. Conformation^ Properties of Amino Acids in
Transmembrane Helices 25
Charles M. Deber and Natalie K Goto
Introduction 25
Sequence and Composition of Transmembrane (TM) Segments 26
The TM Helix as a Structural Unit 27
The Role of the Bilayer 28
Design and Synthesis of Membrane Interactive Peptides 28
Role of Proline and Glycine in TM Helices 30
Peptide Design with Amphipathicity Normalized 32
Toward an Algorithm for Helical Propensity of Residues in
Membrane Environments 34
3. Assembly Properties of Model Transmembrane Channel
Peptides 39
M. Montal and S.J. Opella
Introduction and Scope 39
Designed Channel Peptides 40
Structure and Transmembrane Orientation of the M2 Segment of the
AChR and the GlyR Determined by NMR Spectroscopy 43
Concluding Remarks 48
Part II
ASSEMBLY OF PROKARYOTIC MEMBRANE PROTEINS
4. Assembly of Bacterial Inner Membrane Proteins 55
Gunnar von Heijne
Introduction 55
The Secretory Apparatus 56
Sec Dependent and Sec Independent Membrane Protein Insertion .... 57
Transmembrane Segments: Signal Anchor Sequences,
Stop Transfer Sequences, and Helical Hairpins 57
The Positive Inside Rule 58
Inner Membrane Protein Assembly: Hydrophobicity and
Positive Charge 59
5. Assembly of Bacterial Outer Membrane Proteins 63
Patrick Van Gelder, Hans de Cock and Jan Tommassen
Introduction 63
Assembly of OMPs In Vivo 66
Assembly of OMPs In Vitro 72
Conclusions and Future Aspects 75
6. Folding and Insertion of Proteins into Membranes In Vitro 83
Fritz Jdhnig and Thomas Surrey
The Problem of Unfolding Membrane Proteins 83
Structural and Functional Characterization of OmpA and OmpF 85
Unfolded, Partially Folded and Refolded OmpA 85
Yield of Refolding and Membrane Insertion of OmpA 88
Kinetics of Refolding and Membrane Insertion of OmpA 90
Refolding and Membrane Insertion of OmpF 92
Conclusions 96
7. Membrane Insertion of Toxins 99
Claire Lesieur, Beatrix Vecsey Semjen, Monika Kruse and
Gisou van der Goot
Introduction 99
Background 100
Toxins with a Hydrophilic Primary Sequence 100
Toxins Having Stretches of Hydrophobic Sequence 106
Conclusions Ill
Part III
ASSEMBLY OF EUKARYOTIC MEMBRANE PROTEINS
8. The Biosynthesis of Membrane Proteins at the
Endoplasmic Reticulum 119
Stephen High, Vivienne Laird and Jason D. Oliver
Introduction 119
ER Targeting Signals and Membrane Topology 120
The Integration of Proteins into the ER Membrane 121
Molecular Chaperones 128
Conclusion 130
9. Mutational Analysis of Signal Anchor and Stop Transfer
Sequences in Membrane Proteins 135
Masao Sakaguchi
Introduction 135
Topology and Topogenic Sequences 135
Functional Dissection of Signal Sequences 140
Conclusion 148
10. Assembly of Mitochondrial Membrane Proteins 151
Douglas G. Millar and Gordon C. Shore
Introduction 151
Overview 152
Outer Membrane Protein Insertion and Assembly 153
Inner Membrane Protein Assembly 163
Protein Sorting Between the Outer and Inner Membranes 165
Concluding Remarks 166
11. Oligomerization and Maturation of Eukaryotic Membrane
Proteins 173
Ka thi Geering
Introduction 173
The Endoplasmic Reticulum: The Compartment of Protein
Folding and Assembly 174
Initial Folding of Proteins: A Prerequisite for Oligomerization 174
Oligomerization and Structural Maturation 178
Oligomerization and Functional Maturation 182
12. Intracellular Sorting of Membrane Proteins:
Oligomerization as a General Sorting Mechanism 189
Tommy Nilsson
Introduction 189
The Membrane Spanning Domain as a Sorting Domain 190
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| genre_facet | Aufsatzsammlung |
| id | DE-604.BV011285291 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:07:09Z |
| institution | BVB |
| isbn | 3540620419 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007578809 |
| oclc_num | 75947413 |
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| owner_facet | DE-355 DE-BY-UBR DE-703 DE-20 DE-634 DE-11 |
| physical | 270 S. Ill., graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Springer [u.a.] |
| record_format | marc |
| series2 | Molecular biology intelligence unit |
| spelling | Membrane protein assembly Gunnar von Heijne New York [u.a.] Springer [u.a.] 1997 270 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit Membranproteine (DE-588)4130026-9 gnd rswk-swf Assembly (DE-588)4378786-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Membranproteine (DE-588)4130026-9 s DE-604 Assembly (DE-588)4378786-1 s Heijne, Gunnar von Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007578809&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Membrane protein assembly Membranproteine (DE-588)4130026-9 gnd Assembly (DE-588)4378786-1 gnd |
| subject_GND | (DE-588)4130026-9 (DE-588)4378786-1 (DE-588)4143413-4 |
| title | Membrane protein assembly |
| title_auth | Membrane protein assembly |
| title_exact_search | Membrane protein assembly |
| title_full | Membrane protein assembly Gunnar von Heijne |
| title_fullStr | Membrane protein assembly Gunnar von Heijne |
| title_full_unstemmed | Membrane protein assembly Gunnar von Heijne |
| title_short | Membrane protein assembly |
| title_sort | membrane protein assembly |
| topic | Membranproteine (DE-588)4130026-9 gnd Assembly (DE-588)4378786-1 gnd |
| topic_facet | Membranproteine Assembly Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007578809&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT heijnegunnarvon membraneproteinassembly |