Platelets and their factors: [with 39 tables]
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | German |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1997
|
| Schriftenreihe: | Handbook of experimental pharmacology
126 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXVIII, 753 S. Ill., graph. Darst. |
| ISBN: | 3540619976 |
Internformat
MARC
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| 245 | 1 | 0 | |a Platelets and their factors |b [with 39 tables] |c contributors K. S. Authi ... Ed. F. von Bruchhausen ... |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 1997 | |
| 300 | |a XXVIII, 753 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Handbook of experimental pharmacology |v 126 | |
| 650 | 7 | |a Blood Platelets |2 cabt | |
| 650 | 7 | |a Bloedplaatjes |2 gtt | |
| 650 | 7 | |a Farmacologia |2 larpcal | |
| 650 | 7 | |a Stollingsfactoren |2 gtt | |
| 650 | 4 | |a Blood Platelets | |
| 650 | 4 | |a Blood platelet disorders | |
| 650 | 4 | |a Blood platelets | |
| 650 | 4 | |a Blood platelets |x Receptors | |
| 650 | 4 | |a Cellular signal transduction | |
| 650 | 4 | |a Platelet activating factor | |
| 650 | 0 | 7 | |a Platelet activating Factor |0 (DE-588)4192717-5 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Thrombozyt |0 (DE-588)4059964-4 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Thrombozytenfaktor |0 (DE-588)4192718-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Platelet-derived Growth Factor |0 (DE-588)4301727-7 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
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| 689 | 3 | 0 | |a Platelet activating Factor |0 (DE-588)4192717-5 |D s |
| 689 | 3 | |5 DE-604 | |
| 689 | 4 | 0 | |a Platelet-derived Growth Factor |0 (DE-588)4301727-7 |D s |
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| 700 | 1 | |a Authi, Kalwant S. |e Sonstige |4 oth | |
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Datensatz im Suchindex
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| adam_text | IS, 2~ ?H- H - LOO PLATELETS AND THEIR FACTORS CONTRIBUTORS K.S. AUTHI,
Y. BANNO, E.M. BEVERS, A.S. BROWN, E. BUTT F. CATELLA-LAWSON, J.-P.
CAZENAVE, J.D. CHANG, KJ. CLEMETSON P.G. DE GROOT, Y. DENIZOT, T.F.
DEUEL, J.D. ERUSALIMSKY G.A. FITZGERALD, M.M. FROJMOVIC, M.H. FUKAMI, C.
GACHET P.V. HALUSHKA, D. HANDLEY, R. HELLER, M. HIRATA, H. HOLMSEN D.
KOESLING, J.F. MARTIN, M.L. MARTIN, E.A. MARTINSON L.M. MCMANUS, H.
MISZTA-LANE, E. MORGENSTERN, S. NAKASHIMA S. NARUMIYA, Y. NOZAWA, B.
NURNBERG, H. PATSCHEKE, S. PAWATE R.N. PINCKARD, J. POLGAR, P. PRESEK,
M.W. RADOMSKI M. RODRIGUES, G. RUDNICK, A. RUF, E. SALAS, B. SCHWIPPERT
W. SIESS, H. SINZINGER, JJ. SIXMA, D. TSCHOEPE, F. USHIKUBI G.H. VAN
ZANTEN, F. VON BRUCHHAUSEN, U. WALTER, J.A. WARE S.P. WATSON, S.T.
WEINTRAUB, D.S. WOODARD EDITORS F. VON BRUCHHAUSEN AND U. WALTER
SPRINGER CONTENTS SECTION I: PLATELET DEVELOPMENT, MORPHOLOGY AND
PHYSIOLOGY CHAPTER 1 MEGAKARYOCYTOPOIESIS: THE MEGAKARYOCYTE/PLATELET
HAEMOSTATIC AXIS A.S. BROWN, J.D. ERUSALIMSKY, AND J.F. MARTIN. WITH 1
FIGURE 3 A. INTRODUCTION 3 B. MEGAKARYOCYTE ANATOMY 4 I. STRUCTURE 4 II.
SITE OF PLATELET PRODUCTION 4 III. PLOIDY 7 C. MEGAKARYOCYTOPOIESIS AND
THROMBOPOIESIS 8 I. PERTURBATIONS OF THE STEADY STATE 8 II.
MEGAKARYOCYTE PROGENITOR CELLS 9 III. MEGAKARYOCYTE GROWTH FACTORS 9 IV.
THROMBOPOIETIN/CMPL LIGAND 13 V. NEGATIVE REGULATION OF
MEGAKARYOCYTOPOIESIS 15 D. SIGNAL TRANSDUCTION EVENTS AND MECHANISMS OF
POLYPLOIDISATION.. 16 I. INVOLVEMENT OF PROTEIN KINASE C IN
MEGAKARYOCYTE DIFFERENTIATION 16 II. INDUCTION OF TYROSINE
PHOSPHORYLATION BY TPO 16 III. CELL CYCLE CONTROL AND POLYPLOIDISATION
17 E. MEGAKARYOCYTES IN ATHEROSCLEROSIS 17 F. CONCLUSION 19 REFERENCES
19 CHAPTER 2 HUMAN PLATELET MORPHOLOGY/ULTRASTRUCTURE E. MORGENSTERN.
WITH 16 FIGURES 27 A. GENERAL MORPHOLOGY: SHAPE AND PROPERTIES OF
PLATELETS 27 B. ELECTRON-MICROSCOPIC TECHNIQUES 29 XII CONTENTS C.
MORPHOMETRIC DATA 31 D. ULTRASTRUCTURE OF PLATELETS 32 I. CYTOSOL AND
CYTOSKELETON 32 1. CYTOSOL 32 2. SUBMEMBRANOUS CYTOSKELETON 34 3.
CONTRACTILE GEL 34 II. PLASMALEMMA AND SURFACE 35 III. SURFACE-CONNECTED
MEMBRANES 36 1. SURFACE-CONNECTED (OPEN CANALICULAR) SYSTEM 36 2. COATED
MEMBRANES 38 IV. CELL ORGANELLES 38 1. MITOCHONDRIA 38 2. DENSE TUBULAR
SYSTEM 38 3. ALPHA-GRANULES 39 4. DENSE GRANULES 40 5. LYSOSOMES AND
PEROXISOMES 40 E. FUNCTIONAL MORPHOLOGY 41 I. FOCAL ADHESION CONTACTS 41
II. INTERNALIZATION AND ENDOCYTOSIS 43 1. RECEPTOR TRANSPORT AND
MEMBRANE RECYCLING 43 2. INTERNALIZATION OF LIGANDS BY THE CONTRACTILE
GEL 46 III. EXOCYTOSIS 47 1. SECRETORY PATHWAY 47 2. SHEDDING OF
MICROPARTICLES 48 F. SYNOPSIS AND CONCLUSIONS 50 REFERENCES T 52
CHAPTER 3 PLATELET ADHESION G.H. VAN ZANTEN, P.G. DE GROOT, AND J.J.
SIXMA. WITH 1 FIGURE 61 A. INTRODUCTION 61 B. THE VESSEL WALL 62 C.
PLATELET ADHESION UNDER FLOW CONDITIONS 63 D. PLATELET ADHESION TO THE
ADHESIVE PROTEINS 64 I. VON WILLEBRAND FACTOR 64 II. COLLAGEN 66 III.
FIBRONECTIN 68 IV. FIBRIN(OGEN) 69 V. OTHER PROTEINS 70 1. LAMININ 70 2.
THROMBOSPONDIN 71 3. PROTEOGLYCANS 71 E. CONCLUSION 72 REFERENCES 72
CONTENTS XIII CHAPTER 4 PLATELET AGGREGATION A. RUF, M.M. FROJMOVIC, AND
H. PATSCHEKE. WITH 1 FIGURE 83 A. INTRODUCTION 83 B. MECHANISM OF
PLATELET AGGREGATION 83 I. THE GLYCOPROTEIN ILB-IIIA COMPLEX 83 II.
ADHESIVE LIGANDS OF THE GPIIB-IIIA COMPLEX 85 III. REDISTRIBUTION OF THE
GPIIB-IIIA COMPLEX AND INTERNALIZATION OF THE LIGANDS 86 C. PLATELET
AGGREGATION TESTING 86 I. SAMPLE PREPARATION 86 II. OPTICAL AGGREGOMETRY
88 III. LUMI-AGGREGOMETRY 89 IV. DETERMINATION OF PLATELET AGGREGATION
BY PARTICLE COUNTING . 90 V. POTENTIAL AND LIMITATIONS OF PLATELET
AGGREGATION TESTING ... 90 D. INHIBITION OF PLATELET AGGREGATION AS A
THERAPEUTIC PRINCIPLE 92 E. CONCLUSIONS 93 REFERENCES 94 SECTION II:
PLATELET BIOCHEMISTRY, SIGNAL TRANSDUCTION CHAPTER 5 PLATELET RECEPTORS:
THE THROMBIN RECEPTOR W. SIESS. WITH 3 FIGURES 101 A. INTRODUCTION 101
B. THE SEVEN-TRANSMEMBRANE DOMAIN RECEPTOR 102 I. STRUCTURE AND
ACTIVATION MECHANISM 102 II. RECEPTOR DESENSITIZATION AND
RESENSITIZATION 105 C. GLYCOPROTEIN IB 107 D. RECEPTOR SIGNALING AND
PLATELET RESPONSES 109 E. THROMBIN RECEPTOR INHIBITORS ILL REFERENCES
112 CHAPTER 6 PLATELET ADP/PURINERGIC RECEPTORS C. GACHET AND J.-P.
CAZENAVE. WITH 2 FIGURES 117 A. INTRODUCTION 117 B. PLATELET RESPONSES
TO ADP 118 I. PLATELET FUNCTIONS 118 1. SHAPE CHANGE 118 XIV CONTENTS 2.
BINDING OF FIBRINOGEN 118 3. ADP-INDUCED PLATELET AGGREGATION 119 4.
DESENSITIZATION 121 II. SIGNAL TRANSDUCTION 121 1. CHANGES IN CYTOSOLIC
FREE CALCIUM CONCENTRATION 121 2. CHANGES IN INOSITOL PHOSPHOLIPIDS 122
3. INHIBITION OF ADENYLYL CYCLASE 122 4. INVOLVEMENT OF G PROTEINS 123
C. PLATELET ADP RECEPTORS 124 I. BINDING STUDIES 124 II. ADP-BINDING
PROTEINS 125 III. THE P2 PURINOCEPTOR FAMILY 125 IV. CURRENT HYPOTHESIS
OF A TWO-RECEPTOR MODEL 126 V. FUTURE PERSPECTIVES 129 D. CONCLUSIONS
129 REFERENCES 130 CHAPTER 7 PLATELET PROSTAGLANDIN RECEPTORS F.
USHIKUBI, M. HIRATA, AND S. NARUMIYA. WITH 5 FIGURES 135 A. INTRODUCTION
135 B. THROMBOXANE A 2 RECEPTOR 136 I. STRUCTURE AND LIGAND BINDING
SPECIFICITY 136 II. SIGNAL TRANSDUCTION 141 III. REGULATION 142 C.
PROSTACYCLIN RECEPTOR 143 I. STRUCTURE AND LIGAND BINDING SPECIFICITY
143 II. SIGNAL TRANSDUCTION 144 III. REGULATION 144 D. PROSTAGLANDIN D
RECEPTOR 145 I. STRUCTURE 145 II. LIGAND BINDING SPECIFICITY AND SIGNAL
TRANSDUCTION 145 E. PROSTAGLANDIN E RECEPTOR SUBTYPE; THE EP 3 RECEPTOR
147 REFERENCES 149 CHAPTER 8 PLATELET ADHESION AND AGGREGATION RECEPTORS
K.J. CLEMETSON AND J. POLGAR. WITH 3 FIGURES 155 A. INTRODUCTION 155 B.
PLATELET SURFACE GLYCOPROTEINS 156 CONTENTS XV C. THE GLYCOPROTEIN
IB-V-IX COMPLEX 156 I. INTRODUCTION 156 1. GLYCOPROTEIN IBA 157 2.
GLYCOPROTEIN IB/3 158 3. GLYCOPROTEIN IX 158 4. GLYCOPROTEIN V 159 5.
POLYMORPHISM WITHIN GPIBA 159 II. FUNCTION OF THE GLYCOPROTEIN IB-V-IX
COMPLEX 159 1. BLEEDING DISORDERS 159 A) BERNARD-SOULIER SYNDROME 159 B)
PLATELET-TYPE VON WILLEBRAND S DISEASE 160 2. GPIB-VWF BINDING 161 3.
NON-PHYSIOLOGICAL ACTIVATORS OF THE GPIB/VWF AXIS 161 III. EXPRESSION OF
GPIB-V-IX 163 D. GPIIB-IIIA 163 E. GPIA-IIA 166 F. GPIC-IIA 167 G.
GPIC -IIA 167 H. CD36 (GPIIIB OR GPIV) 167 I. P-SELECTIN (CD62, GMP-140,
PADGEM) 168 J. PECAM-1 (CD31) 169 K. INHIBITION OF PLATELET
ADHESION/AGGREGATION AS A PROPHYLACTIC TOOL OR FOR TREATMENT OF ACUTE
THROMBOTIC EVENTS 169 REFERENCES 170 CHAPTER 9 PLATELET G PROTEINS AND
ADENYLYL AND GUANYLYL CYCLASES D. KOESLING AND B. NURNBERG. WITH 2
FIGURES 181 A. INTRODUCTION 181 B. G PROTEINS 182 I. GENERAL
CONSIDERATIONS 182 1. ACTIVATION OF G PROTEINS 182 2. DIVERSITY OF G
PROTEINS 184 3. STRUCTURE OF G PROTEINS 186 4. CO- AND POSTTRANSLATIONAL
MODIFICATIONS OF PLATELET G PROTEINS 188 II. G PROTEINS EXPRESSED IN
PLATELETS 189 III. G PROTEINS AS MODULATORS OF PLATELET ACTIVATION 190
1. PLATELET-ACTIVATING G PROTEINS 190 2. PLATELET-INHIBITING G PROTEINS
193 C. ADENYLYL CYCLASES 193 XVI CONTENTS D. GUANYLYL CYCLASES 195 I.
MEMBRANE-BOUND GUANYLYL CYCLASES 195 II. SOLUBLE GUANYLYL CYCLASES 196
1. REGULATION OF SOLUBLE GUANYLYL CYCLASES 197 2. BIOSYNTHESIS OF NITRIC
OXIDE 199 III. CGMP RECEPTOR PROTEINS 200 1. CGMP-DEPENDENT PROTEIN
KINASES 200 2. CGMP-GATED CHANNELS 202 E. PHYSIOLOGICAL ROLE OF CYCLIC
NUCLEOTIDES IN PLATELETS 203 I. CGMP-FORMATION IN PLATELETS 204 II.
CGMP- AND CAMP-DEPENDENT PROTEIN KINASES IN PLATELETS 205 III.
SUBSTRATES FOR CAMP- AND CGMP-DEPENDENT PROTEIN KINASES IN PLATELETS 206
IV. CELLULAR RESPONSES LEADING TO PLATELET INHIBITION 207 REFERENCES 208
CHAPTER 10 PLATELET PHOSPHODIESTERASES E. BUTT AND U. WALTER. WITH 3
FIGURES 219 A. INTRODUCTION 219 B. CATALYTIC ARID REGULATORY PROPERTIES
OF HUMAN PLATELET PHOSPHODIESTERASES 219 I. CGMP-STIMULATED
PHOSPHODIESTERASE 219 II. CGMP-INHIBITED PHOSPHODIESTERASE 221 III.
CGMP-SPECIFIC PHOSPHODIESTERASE 221 C. SYNERGISTIC INHIBITION OF
PLATELET FUNCTION BY CYCLIC NUCLEOTIDE ELEVATING AGENTS 222 D.
REGULATION OF PLATELET PHOSPHODIESTERASES BY INSULIN 223 E. EFFECT OF
PHOSPHODIESTERASE INHIBITORS ON PLATELET FUNCTION 224 I. GENERAL ASPECTS
224 II. SPECIFICITY 225 F. CONCLUDING REMARKS 226 REFERENCES 227 CHAPTER
11 PLATELET PHOSPHOLIPASES C AND D S. NAKASHIMA, Y. BANNO, AND Y.
NOZAWA. WITH 4 FIGURES 231 A. INTRODUCTION 231 B. RECEPTOR-MEDIATED
ACTIVATION OF PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C 231 CONTENTS
XVII I. ACTIVATION OF PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C IN
PLATELETS 231 II. FORMATION OF SECOND MESSENGERS 232 1. INOSITOL
1,4,5-TRISPHOSPHATE 232 2. 1,2-DIACYLGLYCEROL 233 3. PHOSPHATIDIC ACID
AND LYSOPHOSPHATIDIC ACID 234 III. MODULATION OF
PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C 234 C. REGULATION OF
PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C 235 I. MULTIPLICITY OF
PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C 235 II. G-PROTEIN-MEDIATED
PHOSPHOLIPASE C-/3 ACTIVATION 237 III. TYROSINE KINASE-MEDIATED
PHOSPHOLIPASE C-Y ACTIVATION 239 D. ROLES AND REGULATION OF
PHOSPHOLIPASE D IN PLATELET ACTIVATION 240 I. ACTIVATION OF
PHOSPHOLIPASE D IN PLATELETS 240 II. REGULATION OF PHOSPHOLIPASE D
ACTIVITY 242 E. REMARKS 244 REFERENCES 244 CHAPTER 12 PROTEIN KINASE C
AND ITS INTERACTIONS WITH OTHER SERINE-THREONINE KINASES J.A. WARE AND
J.D. CHANG. WITH 2 FIGURES 247 A. INTRODUCTION AND DEFINITION 247 B.
MOLECULAR STRUCTURE AND HETEROGENEITY 248 C. PKC ACTIVATION BY LIPID
MEDIATORS IN PLATELETS 251 D. PKC SUBSTRATES, BINDING PROTEINS, AND
TRANSLOCATION 254 E. FUNCTIONAL ROLES FOR PKC IN PLATELETS 255 F.
RELATION OF PKC ACTIVATION TO OTHER PLATELET SERINE-THREONINE KINASES
AND THEIR EFFECTORS .. 257 G. ABNORMALITIES OF PLATELET PKC IN DISEASE
258 H. SUMMARY AND FUTURE AREAS OF RESEARCH 258 REFERENCES 259 CHAPTER
13 PLATELET PROTEIN TYROSINE KINASES P. PRESEK AND E.A. MARTINSON. WITH
4 FIGURES 263 A. BACKGROUND 263 B. PROTEIN TYROSINE KINASES IN PLATELETS
266 XVIII CONTENTS I. SRC FAMILY KINASES 266 1. SRC 268 2. OTHER SRC
FAMILY MEMBERS 270 II. SYK 271 III. JAK FAMILY KINASES 273 IV. FOCAL
ADHESION KINASE (FAK) 273 V. RECEPTOR PROTEIN TYROSINE KINASES 275 C.
POTENTIAL ROLES OF PROTEIN TYROSINE KINASES IN PLATELET FUNCTIONS 276 I.
SECOND MESSENGER PATHWAYS 277 1. PHOSPHOLIPASES 277 2. PHOSPHOINOSITIDE
3-KINASE 279 3. GTP-BINDING PROTEINS 280 4. CALCIUM 280 5. CYCLIC
NUCLEOTIDES 281 II. PLATELET RESPONSES 281 1. SHAPE CHANGE 281 2.
AGGREGATION 282 3. ADHESION 285 REFERENCES 286 CHAPTER 14 PROTEIN
PHOSPHATASES IN PLATELET FUNCTION S.P. WATSON. WITH 1 FIGURE 297 A.
INTRODUCTION 297 B. PROTEIN SERINE/THREONINE PHOSPHATASES IN PLATELETS
299 I. CLASSIFICATION OF SERINE/THREONINE PROTEIN PHOSPHATASES 299 II.
INHIBITORS OF PROTEIN SERINE/THREONINE PHOSPHATASES 300 III. THE
PRESENCE OF PROTEIN SERINE/THREONINE PHOSPHATASES IN PLATELETS 300 IV.
EFFECT OF OKADAIC ACID AND CALYCULIN A IN PLATELETS 301 V.
DEPHOSPHORYLATION OF COFILIN IN PLATELETS 304 VI. PROTEIN
SERINE/THREONINE PHOSPHATASES IN PLATELETS: CONCLUDING REMARKS 305 C.
PROTEIN TYROSINE PHOSPHATASES 305 I. CLASSIFICATION OF PROTEIN TYROSINE
PHOSPHATASES 306 II. DISTRIBUTION OF PROTEIN TYROSINE PHOSPHATASES IN
PLATELETS : 307 III. REGULATION OF TYROSINE PHOSPHORYLATION BY
IRREVERSIBLE PLATELET AGGREGATION 308 IV. EFFECT OF VANADATE AND ITS
DERIVATIVES IN PLATELETS 311 CONTENTS XIX V. EFFECT OF PHENYLARSINE
OXIDE IN PLATELETS 314 VI. POSSIBLE ROLE OF PROTEIN TYROSINE
PHOSPHATASES IN CA 2+ ENTRY 316 VII. REGULATION OF PROTEIN TYROSINE
PHOSPHATASES BY SERINE/THREONINE PHOSPHORYLATION 316 VIII. PROTEIN
TYROSINE PHOSPHATASES IN PLATELETS: CONCLUDING REMARKS 317 D. DUAL
SPECIFICITY PROTEIN PHOSPHATASES 317 E. CONCLUDING REMARKS 318
REFERENCES 318 CHAPTER 15 CA 2+ HOMEOSTASIS IN HUMAN PLATELETS K.S.
AUTHI. WITH 6 FIGURES 325 A. INTRODUCTION ; 325 I. CA 2+ HOMEOSTASIS 325
B. MAINTENANCE OF LOW CYTOSOLIC CA 2+ CONCENTRATIONS 327 I. PLATELET
SERCAS 328 II. MEMBRANE ORGANISATION, PROPERTIES AND REGULATION OF
PLATELET SERCAS 330 III. ORGANELLAR DISTRIBUTION OF PLATELET SERCA PUMPS
334 IV. PLASMA MEMBRANE CALCIUM ATPASES 336 V. PLATELET PMCAS 337 VI.
NA7CA 2+ EXCHANGER 339 C. MECHANISMS OF CA 2+ ELEVATION IN PLATELETS 340
I. CA 2+ RELEASE FROM INTRACELLULAR STORES 340 1. INOSITOL (1,4,5)
TRISPHOSPHATE 340 2. GENERAL PROPERTIES OF IP 3 RS 340 3. PLATELET IP 3
RS 341 4. IN(L,4,5)P 3 -INDUCED CA 2+ RELEASE . FROM PLATELET
INTRACELLULAR STORES 344 II. NATURE OF CA 2+ RELEASE FROM INTRACELLULAR
STORES 344 III. CA 2+ OSCILLATIONS IN PLATELETS 346 IV. CA 2+ INFLUX
MECHANISMS 347 V. CAPACITATIVE OR STORE-REGULATED CA 2+ ENTRY 347 VI.
POSSIBLE DIRECT INVOLVEMENT OF SECOND MESSENGERS IN CA 2+ ENTRY 351 VII.
INTEGRIN-ASSOCIATED PLASMA MEMBRANE CA 2+ FLUX 355 VIII. CA 2+ INFLUX
VIA RECEPTOR-OPERATED CA 2+ CHANNEL (ROC)... 356 IX. CYCLIC NUCLEOTIDE
EFFECTS ON CA 2+ INFLUX 356 REFERENCES 357 XX CONTENTS CHAPTER 16
REGULATION OF PLATELET FUNCTION BY NITRIC OXIDE AND OTHER NITROGEN- AND
OXYGEN-DERIVED REACTIVE SPECIES E. SALAS, H. MISZTA-LANE, AND M.W.
RADOMSKI. WITH 3 FIGURES .... 371 A. INTRODUCTION 371 B. A HISTORICAL
PERSPECTIVE 371 C. NITRIC OXIDE SYNTHASE ISOENZYMES 372 I. GENERAL
CHARACTERISTICS 372 II. PLATELET NITRIC OXIDE SYNTHASE 372 III. THE
ENDOTHELIAL NOS 374 IV. NITRIC OXIDE SYNTHASE REACTION 375 V. METABOLIC
FATE OF NO 375 VI. INTERACTIONS OF NO WITH BIOMOLECULES 376 VII. NITRIC
OXIDE - PHYSIOLOGICAL REGULATOR OF PLATELET FUNCTION 379 VIII. ROLE OF
NO IN THE PATHOGENESIS OF VASCULAR DISORDERS 380 IX. PHARMACOLOGICAL
REGULATION OF PLATELET FUNCTION BY NO GAS AND NO DONOR DRUGS 382 D.
OTHER OXYGEN- AND NITROGEN-DERIVED REACTIVE SPECIES 385 I. MECHANISMS OF
ACTION OF OXYGEN-DERIVED RADICALS ON PLATELETS 386 1. THROMBOXANE
GENERATION 386 2. CYCLIC NUCLEOTIDES 386 3. STIMULATION OF PLATELET
SEROTONIN TRANSPORT 387 4. ACTIVATION OF PLATELET RECEPTORS 387 5.
FORMATION OF NITRIC OXIDE DONORS 387 E. CONCLUSIONS 387 REFERENCES 388
CHAPTER 17 PLATELET 5-HYDROXYTRYPTAMINE TRANSPORTERS G. RUDNICK. WITH 4
FIGURES 399 A. INTRODUCTION 399 B. THE PLASMA MEMBRANE
5-HYDROXYTRYPTAMINE TRANSPORTER (SERT) 400 I. IONIC REQUIREMENTS 401 1.
COUPLING TO NA + 401 2. COUPLING TO CL~ 402 3. COUPLING TO K + 402 II.
REVERSAL OF TRANSPORT 402 CONTENTS XXI III. MECHANISM 404 IV.
PURIFICATION 406 V. CLONING 406 VI. REGULATION 408 C. DENSE GRANULE
MEMBRANE VESICLES 410 I. DRIVING FORCES 410 II. PURIFICATION 411 III.
CLONING 411 REFERENCES 412 SECTION III: PLATELET-DERIVED FACTORS CHAPTER
18 DENSE GRANULE FACTORS M.H. FUKAMI 419 A. INTRODUCTION 419 B. CONTENTS
OF PLATELETS 420 I. NUCLEOTIDES 420 II. DIVALENT CATIONS 422 III. AMINES
423 IV. OTHER 424 C. STORAGE MECHANISMS *-.- : 424 D. SPECIES
DIFFERENCES 426 E. MEMBRANE PROTEINS 427 F. DISCUSSION AND COMMENTS 429
REFERENCES 429 CHAPTER 19 PROTEIN GRANULE FACTORS T.F. DEUEL 433 A.
INTRODUCTION 433 B. PLATELET PROTEINS 434 C. PLATELET-DERIVED GROWTH
FACTORS 436 D. THROMBOSPONDIN 437 E. PROTEINS SIMILAR OR IDENTICAL TO
PLASMA PROTEINS 437 F. ENZYMES 438 G. SUMMARY AND CONCLUSIONS 439
REFERENCES 439 XXII CONTENTS CHAPTER 20 LYSOSOMAL STORAGE M.H. FUKAMI
AND H. HOLMSEN 447 A. INTRODUCTION 447 I. LYSOSOMES IN GENERAL 447 II.
PLATELET LYSOSOMES 447 B. LYSOSOMAL HYDROLASES IN PLATELETS 448 I.
GLYCOSIDASES 448 1. SECRETION 448 2. SUBCELLULAR LOCALIZATION 450 II.
PROTEINASES 451 III. PHOSPHOLIPASES 452 IV. OTHER 452 C. LYSOSOMAL
MEMBRANE PROTEINS 454 D. DISCUSSION AND COMMENTS 455 REFERENCES 456
CHAPTER 21 THROMBOXANE A, AND OTHER EICOSANOIDS P.V. HALUSHKA, S. PAW
ATE, AND M.L. MARTIN 459 A. INTRODUCTION 459 B. PLATELET ARACHIDONIC
ACID METABOLISM 459 I. METABOLITES 459 II. SOURCES OF ARACHIDONIC ACID
460 III. RELEASE OF ARACHIDONIC ACID 461 1. PHOSPHOLIPASE A 2 461 2.
OTHER ROUTES OF ARACHIDONIC ACID LIBERATION 462 C. EICOSANOIDS AFFECTING
PLATELET FUNCTION 463 I. THROMBOXANE A 2 463 1. INTRODUCTION 463 A)
THROMBOXANE A 2 RECEPTORS 463 B) SIGNAL TRANSDUCTION ; 464 A)
INTRACELLULAR CALCIUM ; 464 P) ALKALINIZATION OF INTRAPLATELET PH 464 Y)
PROTEIN KINASE C ACTIVATION 464 8) TYROSINE PHOSPHORYLATION 465 E)
MYOSIN LIGHT CHAIN KINASE 465 II. PROSTACYCLIN (PGI 2 , EPOPROSTANOL)
465 III. 8-EPI-PROSTAGLANDIN F 2A 466 IV. PROSTAGLANDIN D 2 (PGD 2 ) 466
V. 12-HETE (12-HYDROXYEICOSATETRAENOIC ACID) 466 D. ALTERATIONS IN
THROMBOXANE A 2 SYNTHESIS IN DISEASE STATES 467 CONTENTS XXIII I.
DIABETES MELLITUS 467 II. ACUTE CORONARY ARTERY SYNDROMES 468 III.
PREGNANCY-INDUCED HYPERTENSION 469 IV. CEREBRAL ISCHEMIA 470 V.
HOMOCYSTINURIA 470 VI. SICKLE CELL DISEASE 470 VII. EFFECTS OF FISH OILS
471 E. ALTERATIONS IN THROMBOXANE A 2 RECEPTORS IN DISEASE STATES 471 I.
ACUTE CORONARY ARTERY SYNDROMES 471 II. PREGNANCY-INDUCED HYPERTENSION
472 III. DIABETES MELLITUS 472 IV. REGULATION BY ANDROGENIC STEROIDS 473
F. ASPIRIN, THROMBOXANE SYNTHASE INHIBITORS, AND THROMBOXANE A 2
RECEPTOR ANTAGONISTS IN CORONARY ARTERY DISEASE 473 REFERENCES 474
CHAPTER 22 PLATELET-ACTIVATING FACTOR: BIOSYNTHESIS, BIODEGRADATION,
ACTIONS Y. DENIZOT. WITH 3 FIGURES 483 A. INTRODUCTION 483 B.
BIOSYNTHESIS OF PAF IN MAMMALIAN CELLS 483 C. CATABOLISM OF PAF IN
MAMMALIAN CELLS 486 D. PAF AND BACTERIA 488 E. PAF AND YEAST CELLS,
PROTOZOANS, AMOEBAS, AND PARASITES 490 F. EFFECTS OF PAF ON CELL
PROLIFERATION 491 G. SOME EFFECTS OF PAF ON SEVERAL CELL FUNCTIONS AND
TISSUE STRUCTURES 492 H. CONCLUSION 495 REFERENCES 496 CHAPTER 23
QUALITATIVE AND QUANTITATIVE ASSESSMENT OF PLATELET ACTIVATING FACTORS
R.N. PINCKARD, D.S. WOODARD, S.T. WEINTRAUB, AND L.M. MCMANUS WITH 4
FIGURES 507 A. PAF MOLECULAR DIVERSITY 507 B. ESTIMATION OF PAF ACTIVITY
BY BIOASSAY 509 I. PLATELET BIOASSAY 509 1. RABBIT PLATELET BIOASSAY 510
2. PLATELET DESENSITIZATION 511 3. PAF CARRIERS IN PLATELET BIOASSAY 512
4. PAF MOLECULAR DIVERSITY IN PLATELET BIOASSAY 512 XXIV CONTENTS II.
OTHER 512 C. ESTIMATION OF PAF ACTIVITY BY RADIOIMMUNOASSAY (RIA) 513 I.
RIA DEVELOPMENT AND USE 513 II. PAF MOLECULAR DIVERSITY IN RIA 513 D.
ESTIMATION OF PAF BY RADIORECEPTOR ASSAY 514 E. ESTIMATION OF PAF BASED
ON [ 3 H]ACETATE INCORPORATION 514 F. ANALYSIS OF PAF BY MASS
SPECTROMETRY 518 I. ANALYSIS OF INTACT PAF 518 II. ANALYSIS OF PAF AFTER
DERIVATIZATION 519 G. CONCLUDING COMMENTS 522 REFERENCES 522 CHAPTER 24
BIOSYNTHETIC INHIBITORS AND RECEPTOR ANTAGONISTS TO PLATELET ACTIVATING
FACTOR D. HANDLEY. WITH 11 FIGURES : 529 A. PAF: HISTORICAL PERSPECTIVE
AND PATHOLOGY 529 B. BIOSYNTHESIS INHIBITORS 531 I. PHOSPHOLIPASE PLA 2
INHIBITORS 532 II. LYSO-PAF-TRANSFERASE INHIBITORS 533 C. PRECLINICAL
AND CLINICAL PAF RECEPTOR ANTAGONISTS 533 I. ABBOTT LABORATORIES 534 II.
ALTER S.A 534 III. BOEHRINGER INGELHEIM KG 534 IV. BRITISH BIOTECHNOLOGY
LTD 536 V. EISAI CO., LTD 536 VI. FUJISAWA PHARMACEUTICAL CO 537 VII.
HOFFMANN-LA ROCHE AND CO., LTD 537 VIII. LEO PHARMACEUTICAL PRODUCTS LTD
538 IX. MERCK SHARP AND DOHME RESEARCH LABORATORIES 538 X. ONO
PHARMACEUTICAL CO., LTD 539 XI. PFIZER LABORATORIES 539 XII.
RHONE-POULENC SANTE LABORATORIES 539 XIII. SANDOZ RESEARCH INSTITUTE 540
XIV. SANOFI RESEARCH 543 XV. SCHERING-PLOUGH RESEARCH INSTITUTE 544 XVI.
SOLVAY PHARMA LABORATORIES 544 XVII. SUMITOMO PHARMACEUTICALS CO., LTD
544 XVIII. TAKEDA CHEMICAL CO., LTD 545 XIX. URIACH S.A 547 XX.
YAMANOUCHI PHARMACEUTICAL COMPANY V 547 XXI. YOSHITOMI PHARMACEUTICAL
INDUSTRIES LTD 547 CONTENTS XXV D. CONCLUSIONS :... 547 REFERENCES 548
SECTION IV: CLINICAL ASPECTS OF PLATELETS AND THEIR FACTORS CHAPTER 25
PLATELETS AND THE VASCULAR SYSTEM: ATHEROSCLEROSIS, THROMBOSIS,
MYOCARDIAL INFARCTION H. SINZINGER AND M. RODRIGUES. WITH 1 FIGURE 563
A. INTRODUCTION 563 B. ATHEROSCLEROSIS : 563 C. THROMBOSIS 566 D.
MYOCARDIAL INFARCTION 568 E. METHODOLOGY OF RADIOLABELING OF PLATELETS
569 F. STUDIES WITH RADIOLABELED PLATELETS 571 I. PLATELET KINETICS 572
II. IMAGING 573 1. ATHEROSCLEROSIS 573 2. THROMBOSIS 576 3. MYOCARDIAL
INFARCTION 577 G. PLATELET AGGREGATION 577 H. CONCLUSIONS 578 REFERENCES
578 CHAPTER 26 PLATELETS, VESSEL WALL, AND THE COAGULATION SYSTEM R.
HELLER AND E.M. BEVERS. WITH 3 FIGURES 585 A. PLATELET-ENDOTHELIUM
INTERACTION 585 I. ROLE OF PLATELETS IN MAINTAINING VASCULAR INTEGRITY
585 II. CONTROL OF PLATELET REACTIVITY BY ENDOTHELIAL CELLS 587 1.
13-HYDROXY-OCTADECADIENOIC ACID (13-HODE) - AN ANTIADHESIVE FATTY ACID
METABOLITE 587 2. ENDOTHELIUM-DERIVED PLATELET INHIBITORS 588 3.
PLATELET EFFECTS ON PGI 2 AND EDRF/NO SYNTHESIS 589 4. MECHANISMS OF
PLATELET INHIBITION BY PGI 2 AND EDRF/NO 590 5. ENDOTHELIAL-BOUND
ANTIPLATELET FACTORS 591 6. PLATELET ADHESION TO ENDOTHELIAL CELLS :...
592 III. PLATELET-MEDIATED INFLAMMATORY AND PROCOAGULANT ALTERATIONS OF
ENDOTHELIAL CELLS 595 XXVI CONTENTS B. PLATELETS AND COAGULATION 596 I.
MEMBRANE-DEPENDENT REACTIONS IN BLOOD COAGULATION 597 II. PLATELET
PROCOAGULANT ACTIVITY 598 III. MECHANISMS INVOLVED IN THE MAINTENANCE OF
MEMBRANE LIPID ASYMMETRY *. 599 IV. MECHANISMS INVOLVED IN THE
EXPRESSION OF PROCOAGULANT ACTIVITY 601 V. PLATELET MICROVESICLES 603
VI. PLATELETS AND COAGULATION DISORDERS 603 1. SCOTT SYNDROME 603 2.
ANTIPHOSPHOLIPID SYNDROME 604 3. FACTOR V QUEBEC 604 VII. ANTICOAGULANT
ACTIVITIES OF PLATELETS AND MICROVESICLES 605 VIII. ROLE OF PLATELETS IN
FIBRINOLYSIS 606 REFERENCES 607 CHAPTER 27 PLATELET FLOW CYTOMETRY -
ADHESIVE PROTEINS D. TSCHOEPE AND B. SCHWIPPERT. WITH 5 FIGURES 619 A.
INTRODUCTION 619 I. PROCEDURES FOR THE DIAGNOSIS OF PLATELET DISEASE
STATES 619 1. PROBLEMS 619 2. REQUIREMENTS 620 B. SINGLE PLATELET FLOW
CYTOMETRY (SPFC) 620 I. PRINCIPLE 620 II. PITFALLS AND STANDARDIZATION
REQUIREMENTS 621 III. ASSAY SYSTEMS 623 C. PLATELET ADHESION MOLECULES
AS DIAGNOSTIC TARGETS 624 I. MEGAKARYOCYTIC CONDITIONING 625 II.
PLATELET MEMBRANE PROCESSING 626 III. DEFINING DIAGNOSTIC EPITOPES 627
1. THE CONSTITUTIVE STAIN 627 2. THE FUNCTIONAL STAIN 627 IV.
PLATELET-LEUKOCYTE COAGGREGATES 628 D. APPLICATIONS IN PLATELET
PATHOLOGY 630 I. HEMORRHAGIC DIATHESIS 630 II. THROMBOTIC DIATHESIS 631
III. INFLAMMATION 633 E. PHARMACOLOGY 634 REFERENCES 637 CONTENTS XXVII
CHAPTER 28 PATHOLOGICAL ASPECTS OF PLATELET-ACTIVATING FACTOR (PAF) F.
VON BRUCHHAUSEN 645 A. INTRODUCTION 645 B. INVOLVEMENT OF PAF IN
INFLAMMATORY AND ALLERGIC RESPONSES .... 645 I. INFLAMMATORY CELLULAR
RESPONSES BY PAF 647 II. INVOLVEMENT OF PAF IN ALLERGIC REACTIONS 647 C.
INVOLVEMENT OF PAF IN CARDIOVASCULAR DISEASES 649 I. PAF IN VASCULAR
DISTURBANCES 649 II. PAF IN ENDOTOXIN-INDUCED SHOCK 650 III.
THROMBOVASCULAR DISEASES 652 IV. MYOCARDIAL INFARCTION AND STROKE 654 D.
INVOLVEMENT OF PAF IN CEREBRAL DISTURBANCES 655 E. PAF IN RESPIRATORY
DISEASES 657 I. BRONCHIAL HYPERRESPONSIVENESS 657 II. PAF IN ASTHMA
BRONCHIALE 658 III. PULMONARY EDEMA 660 IV. ADULT RESPIRATORY DISTRESS
SYNDROME (ARDS) 661 V. LUNG FIBROSIS 662 F. INVOLVEMENT OF PAF IN
GASTROINTESTINAL DISEASES 662 I. GASTRIC DISEASES 662 II. INTESTINAL
DISEASES 664 G. INVOLVEMENT OF PAF IN FUNCTION AND DISTURBANCES OF
REPRODUCTION 667 I. OVULATION 667 II. GAMETOCYTES (OOCYTES, SPERM) 667
III. FERTILIZATION 668 IV. OVIDUCT PASSAGE AND PREIMPLANTATION STATE 668
V. NIDATION 669 VI. EMBRYONIC DEVELOPMENT 669 H. INVOLVEMENT OF PAF IN
SKIN DISEASES 670 I. INVOLVEMENT OF PAF IN DISEASES OF OTHER ORGANS 672
I. RENAL DISEASES 672 II. HEPATIC DISTURBANCES 673 III. ACUTE
PANCREATITIS 673 IV. TRANSPLANT REJECTION 674 V. TUMOR GROWTH 674 J.
CONCLUSION 675 REFERENCES 675 XXVIII CONTENTS CHAPTER 29 THERAPEUTIC
ASPECTS OF PLATELET PHARMACOLOGY F. CATELLA-LAWSON AND G.A. FITZGERALD.
WITH 1 FIGURE 719 ASPIRIN 719 SELECTIVE THROMBOXANE BLOCKADE 722
TICLOPIDINE AND CLOPIDOGREL 723 FIBRINOGEN RECEPTOR ANTAGONISM 726
REFERENCES 730 SUBJECT INDEX 737
|
| any_adam_object | 1 |
| author_GND | (DE-588)115197443 |
| building | Verbundindex |
| bvnumber | BV011217459 |
| callnumber-first | Q - Science |
| callnumber-label | QP905 |
| callnumber-raw | QP905 |
| callnumber-search | QP905 |
| callnumber-sort | QP 3905 |
| callnumber-subject | QP - Physiology |
| classification_rvk | XI 1701 YC 2900 |
| ctrlnum | (OCoLC)35927656 (DE-599)BVBBV011217459 |
| dewey-full | 612.1/17 615/.1 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology 615 - Pharmacology and therapeutics |
| dewey-raw | 612.1/17 615/.1 |
| dewey-search | 612.1/17 615/.1 |
| dewey-sort | 3612.1 217 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV011217459 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:05:58Z |
| institution | BVB |
| isbn | 3540619976 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007525652 |
| oclc_num | 35927656 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-12 DE-20 DE-11 DE-188 DE-578 |
| owner_facet | DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-12 DE-20 DE-11 DE-188 DE-578 |
| physical | XXVIII, 753 S. Ill., graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Springer |
| record_format | marc |
| series | Handbook of experimental pharmacology |
| series2 | Handbook of experimental pharmacology |
| spelling | Platelets and their factors [with 39 tables] contributors K. S. Authi ... Ed. F. von Bruchhausen ... Berlin [u.a.] Springer 1997 XXVIII, 753 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Handbook of experimental pharmacology 126 Blood Platelets cabt Bloedplaatjes gtt Farmacologia larpcal Stollingsfactoren gtt Blood Platelets Blood platelet disorders Blood platelets Blood platelets Receptors Cellular signal transduction Platelet activating factor Platelet activating Factor (DE-588)4192717-5 gnd rswk-swf Thrombozyt (DE-588)4059964-4 gnd rswk-swf Thrombozytenfaktor (DE-588)4192718-7 gnd rswk-swf Platelet-derived Growth Factor (DE-588)4301727-7 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Thrombozyt (DE-588)4059964-4 s Thrombozytenfaktor (DE-588)4192718-7 s DE-604 Platelet activating Factor (DE-588)4192717-5 s Platelet-derived Growth Factor (DE-588)4301727-7 s Bruchhausen, Franz von 1929- Sonstige (DE-588)115197443 oth Authi, Kalwant S. Sonstige oth Handbook of experimental pharmacology 126 (DE-604)BV002390716 126 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007525652&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Platelets and their factors [with 39 tables] Handbook of experimental pharmacology Blood Platelets cabt Bloedplaatjes gtt Farmacologia larpcal Stollingsfactoren gtt Blood Platelets Blood platelet disorders Blood platelets Blood platelets Receptors Cellular signal transduction Platelet activating factor Platelet activating Factor (DE-588)4192717-5 gnd Thrombozyt (DE-588)4059964-4 gnd Thrombozytenfaktor (DE-588)4192718-7 gnd Platelet-derived Growth Factor (DE-588)4301727-7 gnd |
| subject_GND | (DE-588)4192717-5 (DE-588)4059964-4 (DE-588)4192718-7 (DE-588)4301727-7 (DE-588)4143413-4 |
| title | Platelets and their factors [with 39 tables] |
| title_auth | Platelets and their factors [with 39 tables] |
| title_exact_search | Platelets and their factors [with 39 tables] |
| title_full | Platelets and their factors [with 39 tables] contributors K. S. Authi ... Ed. F. von Bruchhausen ... |
| title_fullStr | Platelets and their factors [with 39 tables] contributors K. S. Authi ... Ed. F. von Bruchhausen ... |
| title_full_unstemmed | Platelets and their factors [with 39 tables] contributors K. S. Authi ... Ed. F. von Bruchhausen ... |
| title_short | Platelets and their factors |
| title_sort | platelets and their factors with 39 tables |
| title_sub | [with 39 tables] |
| topic | Blood Platelets cabt Bloedplaatjes gtt Farmacologia larpcal Stollingsfactoren gtt Blood Platelets Blood platelet disorders Blood platelets Blood platelets Receptors Cellular signal transduction Platelet activating factor Platelet activating Factor (DE-588)4192717-5 gnd Thrombozyt (DE-588)4059964-4 gnd Thrombozytenfaktor (DE-588)4192718-7 gnd Platelet-derived Growth Factor (DE-588)4301727-7 gnd |
| topic_facet | Blood Platelets Bloedplaatjes Farmacologia Stollingsfactoren Blood platelet disorders Blood platelets Blood platelets Receptors Cellular signal transduction Platelet activating factor Platelet activating Factor Thrombozyt Thrombozytenfaktor Platelet-derived Growth Factor Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007525652&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002390716 |
| work_keys_str_mv | AT bruchhausenfranzvon plateletsandtheirfactorswith39tables AT authikalwants plateletsandtheirfactorswith39tables |