Antibody engineering: 9 tables
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Basel [u.a.]
Karger
1997
|
| Schriftenreihe: | Chemical immunology
65 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 212 S. Ill., graph. Darst. |
| ISBN: | 3805563566 |
Internformat
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| 245 | 1 | 0 | |a Antibody engineering |b 9 tables |c vol. ed. J. Donald Capra. [Contributing authors: Billetta, R. ...] |
| 264 | 1 | |a Basel [u.a.] |b Karger |c 1997 | |
| 300 | |a XII, 212 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Chemical immunology |v 65 | |
| 650 | 0 | 7 | |a Gentechnologie |0 (DE-588)4071722-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Herstellung |0 (DE-588)4159653-5 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Antikörper |0 (DE-588)4002290-0 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
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CONTENTS
PREFACE
.
XI
ENGINEERING
MINIBODY-LIKE
LIGANDS
BY
DESIGN
AND
SELECTION
M.
SOLLAZZO,
S.
VENTURINI,
S.
LORENZETTI,
M.
PINOLA,
F.
MARTIN,
POMEZIA
.
1
THE
WHY
AND
HOW
OF
DESIGNING
PROTEINS
.
1
DESIGN
OF
THE
MINIBODY
FRAMEWORK
.
2
PHAGE
DISPLAY:
IN
VITRO
MOLECULAR
EVOLUTION
.
6
MINIBODY
REPERTOIRE
.
7
AFFINITY-SELECTION
OF
A
MINIBODY
ANTAGONIST
OF
HUMAN
IL-6
.
7
SELECTION
OF
MINIBODIES
WITH
SERINE
PROTEASE
INHIBITOR
ACTIVITY
.
10
OUTLOOK
.
12
ACKNOWLEDGMENTS
.
14
REFERENCES
.
15
ANTIBODIES
AGAINST
HIV-1
FROM
PHAGE
DISPLAY
LIBRARIES:
MAPPING
OF
AN
IMMUNE
RESPONSE
AND
PROGRESS
TOWARDS
ANTIVIRAL
IMMUNOTHERAPY
P.W.H.I.
PARREN,
D.R.
BURTON,
LA
JOLLA,
CALIF.
.
18
ANTIBODY
PHAGE
DISPLAY
LIBRARIES
.
20
EXPRESSION
OF
WHOLE
ANTIBODY
MOLECULES
.
23
ANTIBODIES
TO
VIRUSES
.
24
NEUTRALIZATION
OF
VIRUS
BY
RECOMBINANT
FAB
FRAGMENT
AND
WHOLE
IGG
.
25
ANTIBODIES
TO
HIV
1
.
27
ANTIBODIES
TO
THE
CD4-BINDING
SITE
OF
GPL20
.
29
NEUTRALIZATION
OF
UNPASSAGED
PLASMAVIRUS
.
32
PROTECTION
AGAINST
HIV-1
INFECTION
IN
HU-PBL-SCID
MICE
BY
INDUCTION
OF
PASSIVE
IMMUNITY
.
33
ANTIBODIES
TO
OTHER
EPITOPES
ON
GPL20
.
35
EPITOPE
MASKING
.
35
PANNING
ON
PEPTIDES
.
38
ANTIBODIES
TO
GP41
.
39
IN
VITRO
EVOLUTION
OF
FABS
TO
IMPROVE
AFFINITY
AND
STRAIN
CROSS-REACTIVITY
AND
INCREASE
NEUTRALIZATION
POTENCY
.
41
RECOGNITION
PROPERTIES
OF
FAB
B
12
INDICATE
EFFICIENT
BINDING
TO
NATIVE
HIV-1
ENVELOPE
OLIGOMER
.
43
ANTIBODY
PHAGE
DISPLAY
LIBRARIES
AS
TOOLS
TO
ASSESS
VACCINES
.
45
CONCLUSIONS
.
47
ACKNOWLEDGMENTS
.
48
REFERENCES
.
48
CHEMICAL
ENGINEERING
AT
THE
ANTIBODY
HINGE
G.
T
STEVENSON,
SOUTHAMPTON
.
57
ESSENTIAL
ANATOMY
OF
THE
ANTIBODY
MOLECULE
.
57
THE
IMMUNOGLOBULIN
HINGE
.
58
FUNCTIONAL
TYPES
OF
SS
BONDS
.
59
MANIPULATING
CYSTEINE
RESIDUES
.
60
SS
INTERCHANGE
.
61
ALKYLATION
BY
MALEIMIDES
.
62
OXIDATION
OF
SH
GROUPS
.
63
THE
FAB'Y
MODULE
.
64
F(AB')
2
.
64
FAB'(SH)
5
.
64
FAB'-SS-PY
.
64
FAB'-SH
AND
FAB'-MALEIMIDE
.
66
THE
FEY
MODULE
.
66
FCYL
FROM
BASIC
IGG
.
66
FC-SS-PY
.
67
FC-SH
AND
FC-MALEIMIDE
.
68
ANTIBODY
CONSTRUCTS
.
68
PLANNING
THE
CONSTRUCTS
.
68
A
SAMPLE
CONSTRUCT:
BISPECIFIC
FAB
2
FC
2
(ANTI-CD20/ANTI-CD37)
.
69
REFERENCES
.
71
VI
STRUCTURE
AND
FUNCTION
IN
IGA
IM.
HEXHAM,
L.
CARAYANNOPOULOS,
ID.
CAPRA,
DALLAS,
TEX.
73
BIOCHEMISTRY
OF
IGA
.
74
STRUCTURE
OF
IGA
.
74
POLYMERIZATION
OF
IGA
.
76
SECRETORY
IGA
.
77
EFFECTOR
FUNCTIONS
OF
IGA
.
79
IGA
COMPARATIVE
BIOLOGY
.
80
MOLECULAR
ANALYSIS
OF
IGA
.
81
FUTURE
DIRECTIONS
.
82
REFERENCES
.
83
IGG
EFFECTOR
MECHANISMS
M.
R.
CLARK,
CAMBRIDGE
.
88
IGG
ISOTYPES
.
89
IGG
FUNCTIONS
.
93
RECOMBINANT
IGG
ANTIBODIES
.
95
RESIDUES
AFFECTING
COMPLEMENT
BINDING
.
97
RESIDUES
AFFECTING
HIGH-AFFINITY
FCYRI
(CD64)
BINDING
.
99
RESIDUES
AFFECTING
LOW-AFFINITY
FCYRII
(CD32)
BINDING
.
100
RESIDUES
AFFECTING
ADCC
THROUGH
FCYRIII
(CD16)
.
101
GLYCOSYLATION
AND
EFFECTOR
FUNCTIONS
.
102
NEONATAL
TRANSPORT
AND
THE
ROLE
OF
FCRN
.
103
IS
IGG
CATABOLISM
RELATED
TO
BINDING
TO
FCRN?
.
104
ACKNOWLEDGMENTS
.
106
REFERENCES
.
106
GLYCOSYLATION
OF
ANTIBODY
MOLECULES:
STRUCTURAL
AND
FUNCTIONAL
SIGNIFICANCE
R.
JEFFERIS,
J.
LUND,
BIRMINGHAM
.
ILL
ANTIBODY
GLYCOSYLATION
.
112
STRUCTURAL
CONSEQUENCES
OF
IGG
GLYCOSYLATION
.
114
FUNCTIONAL
CONSEQUENCES
OF
ASN297
GLYCOSYLATION
.
115
FACTORS
INFLUENCING
GLYCOSYLATION
HYBRIDOMA,
AND
RECOMBINANT
IMMUNOGLOBULIN
MOLECULES
.
121
REFERENCES
.
125
VII
ENGINEERING
NOVEL
ANTIBODY
MOLECULES
M.G.
SENSEI,
M.J.
COLOMA,
E.T.
HARVILL,
S.-U.
SHIN,
R.I.F.
SMITH,
S.L.
MORRISON,
LOS
ANGELES,
CALIF.
.
129
ANTIBODY
FUSION
PROTEINS
.
131
ANTIBODY
FUSION
PROTEINS
FOR
RECEPTOR-MEDIATED
TARGETING
OF
THE
BRAIN
.
133
BINDING
OF
FUSION
PROTEINS
TO
THEIR
GF
RECEPTORS
.
135
EFFECTOR
FUNCTIONS
OF
THE
IGG3-C
H
3-GF
FUSION
PROTEINS
.
136
IN
VIVO
TARGETING
OF
THE
GF
FUSION
PROTEINS
TO
THE
BRAIN
.
137
IGG3-IL-2
FUSION
PROTEINS
.
139
THE
IGG3-IL-2
FUSION
PROTEIN
STIMULATES
BOTH
PROLIFERATION
AND
CYTOTOXICITY
.
141
THE
IGG3-IL-2
FUSION
PROTEIN
BINDS
TO
HIGH
AND
INTERMEDIATE-AFFINITY
IL-2
RECEPTORS
.
141
IGG3-IL-2
BINDS
FCYRI
AND
ACTIVATES
C'
.
142
IN
VIVO
PROPERTIES
OF
IGG3-IL-2
.
142
EFFECTIVENESS
OF
THE
IGG3-IL-2
FUSION
PROTEIN
IN
ELICITING
A
TUMOR-SPECIFIC
IMMUNE
RESPONSE
.
143
POTENTIATION
OF
HOST
ANTIBODY
RESPONSE
BY
ADNS-IGG3-IL-2-BOUND
ANTIGEN
.
145
POLYMERIC
IGG
MOLECULES
.
146
PRODUCTION
OF
IGM-LIKE
MUTANTS
OF
IGG
.
146
ANALYSIS
OF
COMPLEMENT
ACTIVATION
BY
POLYMERIC
IGG
.
148
FCYR
BINDING
BY
POLYMERIC
IGG
.
149
IN
VIVO
HALF-LIFE
OF
POLYMERIC
IGG
.
149
CONCLUSIONS
AND
FUTURE
DIRECTIONS
.
151
ACKNOWLEDGMENTS
.
154
REFERENCES
.
154
LIGAND
FUNCTION
OF
ANTIGENIZED
ANTIBODIES
EXPRESSING
THE
RGD
MOTIF
R.
BILLETTA,
P.
LANZA,
M.
ZANETTI,
LA
JOLLA,
CALIF.
.
159
THE
PROCESS
OF
ANTIGENIZATION
.
161
MATERIALS
AND
METHODS
.
161
COMPUTER-BASED
ANALYSIS
AND
SELECTION
OF
THE
ENGINEERED
SEQUENCE
.
161
ANTIGENIZATION
OF
ANTIBODIES
WITH
THE
RGD
MOTIF
.
163
IMMUNOCHEMICAL
ANALYSIS
OF
AGABS
.
165
ADHESION
AND
INHIBITION
ASSAY
.
165
STUDIES
ON
THE
ANTIGENICITY
OF
ANTIBODIES
ENGINEERED
TO
EXPRESS
ARG-GLY-ASP
.
166
DISCUSSION
.
172
CONSIDERATIONS
FOR
PEPTIDE
STRUCTURE
.
172
CONSIDERATIONS
FOR
TUMOR
AND
ANGIOGENESIS
.
173
ACKNOWLEDGMENTS
.
175
REFERENCES
.
176
VIII
IMMUNOGENICITY
OF
VIRAL
EPITOPES
EXPRESSED
ON
GENETICALLY
AND
ENZYMATICALLY
ENGINEERED
IMMUNOGLOBULINS
C.A.
BONA,
A.
BOT,
T.-D.
BRUMEANU,
NEW
YORK,
N.Y.
.
179
IMMUNOGLOBULINS
AS
DELIVERY
SYSTEMS
.
180
ANTIBODY-PEPTIDE
CONSTRUCTS
PREPARED
BY
CHEMICAL
METHODS
.
180
ANTIBODY-PEPTIDE
CONSTRUCTS
PREPARED
BY
ENZYMATICALLY-GLYCOSIDIC
MEDIATED
CONJUGATION
.
182
CHIMERIC
IMMUNOGLOBULINS
EXPRESSING
FOREIGN
PEPTIDES
OR
BIOLOGICALLY
ACTIVE
LIGANDS
.
184
CHIMERIC
IMMUNOGLOBULINS
EXPRESSING
PEPTIDES
RECOGNIZED
BY
T
CELLS
.
188
IMMUNOGENICITY
OF
PEPTIDES
EXPRESSED
IN
CHIMERIC
IMMUNOGLOBULINS
.
190
IMMUNOPOTENCY
OF
HAI
10-120
PEPTIDE
EXPRESSED
IN
CHIMERIC
MOLECULES
.
193
KINETICS
OF
GENERATION
AND
PERSISTENCE
OF
VIRAL
PEPTIDE
EXPRESSED
IN
VARIOUS
CARRIER
MOLECULES
.
193
MOLECULAR
MECHANISMS
RESPONSIBLE
FOR
THE
PRESENTATION
OF
VIRAL
EPITOPES
EXPRESSED
IN
CHIMERIC
IMMUNOGLOBULIN
MOLECULES
.
197
CONCLUSIONS
.
201
REFERENCES
.
203
SUBJECT
INDEX
.
207
IX |
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| bvnumber | BV011189046 |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV011189046 |
| illustrated | Illustrated |
| indexdate | 2024-08-14T01:14:37Z |
| institution | BVB |
| isbn | 3805563566 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007503787 |
| oclc_num | 260223952 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM DE-12 DE-29 DE-91 DE-BY-TUM DE-578 |
| owner_facet | DE-19 DE-BY-UBM DE-12 DE-29 DE-91 DE-BY-TUM DE-578 |
| physical | XII, 212 S. Ill., graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Karger |
| record_format | marc |
| series | Chemical immunology |
| series2 | Chemical immunology |
| spelling | Antibody engineering 9 tables vol. ed. J. Donald Capra. [Contributing authors: Billetta, R. ...] Basel [u.a.] Karger 1997 XII, 212 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Chemical immunology 65 Gentechnologie (DE-588)4071722-7 gnd rswk-swf Herstellung (DE-588)4159653-5 gnd rswk-swf Antikörper (DE-588)4002290-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Antikörper (DE-588)4002290-0 s Herstellung (DE-588)4159653-5 s DE-604 Gentechnologie (DE-588)4071722-7 s Capra, J. Donald 1937- Sonstige (DE-588)140425446 oth Billetta, Rosario Sonstige oth Chemical immunology 65 (DE-604)BV002307222 65 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007503787&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Antibody engineering 9 tables Chemical immunology Gentechnologie (DE-588)4071722-7 gnd Herstellung (DE-588)4159653-5 gnd Antikörper (DE-588)4002290-0 gnd |
| subject_GND | (DE-588)4071722-7 (DE-588)4159653-5 (DE-588)4002290-0 (DE-588)4143413-4 |
| title | Antibody engineering 9 tables |
| title_auth | Antibody engineering 9 tables |
| title_exact_search | Antibody engineering 9 tables |
| title_full | Antibody engineering 9 tables vol. ed. J. Donald Capra. [Contributing authors: Billetta, R. ...] |
| title_fullStr | Antibody engineering 9 tables vol. ed. J. Donald Capra. [Contributing authors: Billetta, R. ...] |
| title_full_unstemmed | Antibody engineering 9 tables vol. ed. J. Donald Capra. [Contributing authors: Billetta, R. ...] |
| title_short | Antibody engineering |
| title_sort | antibody engineering 9 tables |
| title_sub | 9 tables |
| topic | Gentechnologie (DE-588)4071722-7 gnd Herstellung (DE-588)4159653-5 gnd Antikörper (DE-588)4002290-0 gnd |
| topic_facet | Gentechnologie Herstellung Antikörper Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007503787&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002307222 |
| work_keys_str_mv | AT caprajdonald antibodyengineering9tables AT billettarosario antibodyengineering9tables |