Antioxidants in disease mechanisms and therapy:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
San Diego [u.a.]
Acad. Press
1997
|
| Schriftenreihe: | Advances in pharmacology
38 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Einzelaufnahme eines Zeitschr.-Bd. |
| Beschreibung: | XXIII, 707 S. Ill., graph. Darst. |
| ISBN: | 0120329395 |
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| adam_text | ANTIOXIDANTS IN DISEASE MECHANISMS AND THERAPY EDITED BY HELMUT SIES
INSTITUTE OF PHYSIOLOGICAL CHEMISTRY HEINRICH-HEINE-UNIVERSITAT
DIISSELDORF DUSSELDORF, GERMANY ADVANCES IN PHARMACOLOGY VOLUME 38
ACADEMIC PRESS SAN DIEGO LONDON BOSTON NEW YORK SYDNEY TOKYO TORONTO
CONTENTS CONTRIBUTORS XVII PREFACE XXIII PART I NATURAL ANTIOXIDANTS
ANTIOXIDANTS: THE BASICS*WHAT THEY ARE AND HOW TO EVALUATE THEM BARRY
HALLIWELL I. INTRODUCTION 3 II. BIOLOGICALLY RELEVANT ROS/RNS 6 III.
PROVING THAT A PUTATIVE ANTIOXIDANT IS IMPORTANT IN VIVO 16 REFERENCES
17 METABOLISM OF VITAMIN C IN HEALTH AND DISEASE ANN M. BODE I.
INTRODUCTION AND OVERVIEW 21 II. CHANGES IN VITAMIN C STATUS ASSOCIATED
WITH DISEASE 22 III. MECHANISM OF CHANGES IN VITAMIN C STATUS ASSOCIATED
WITH DISEASE 24 IV. EVIDENCE FOR THERAPEUTIC EFFECTIVENESS OF VITAMIN C
35 V. SIGNIFICANCE AND CONCLUSIONS 39 REFERENCES 40 VII VIII CONTENTS
REGULATION OF HUMAN PLASMA VITAMIN E MARET G. TRABER I. INTRODUCTION 49
II. PLASMA KINETICS 50 III. DISCRIMINATION BETWEEN TOCOPHEROLS 52 IV.
GENETIC STUDIES 54 V. CONCLUSIONS 58 REFERENCES 59 GLUTATHIONE AND
GLUTATHIONE DELIVERY COMPOUNDS MARY E. ANDERSON I. GLUTATHIONE 65 II.
GLUTATHIONE DELIVERY COMPOUNDS 70 III. SUMMARY 74 REFERENCES 74 A-LIPOIC
ACID: A METABOLIC ANTIOXIDANT AND POTENTIAL REDOX MODULATOR OF
TRANSCRIPTION LESTER PACKER, SASHWATI ROY, AND CHANDAN K. SEN I.
INTRODUCTION 79 II. ROLE OF LIPOATE IN METABOLISM 80 III. ANTIOXIDANT
PROPERTIES 85 IV. NF-KB ROLE IN NORMAL AND ABNORMAL CELL FUNCTION 91
REFERENCES 96 ANTIOXIDANT ACTIONS OF MELATONIN RUSSEL J. REITER I.
INTRODUCTION 103 II. MELATONIN AS A FREE RADICAL SCAVENGER 104 III.
MELATONIN AS AN ANTIOXIDANT 107 IV. EFFECT OF MELATONIN ON ENZYMES
RELATED TO THE ANTIOXIDATIVE DEFENSE SYSTEM 113 V. CONCLUDING REMARKS
114 REFERENCES 115 CONTENTS IX ANTIOXIDATIVE AND METAL-CHELATING EFFECTS
OF POLYAMINES ERIK LOVAAS I. INTRODUCTION 119 II. CHEMISTRY AND TYPE
REACTIONS OF POLYAMINES 121 III. ANTIOXIDATIVE EFFECTS OF POLYAMINES 128
IV. CONCLUSIONS 140 REFERENCES 141 ANTIOXIDANT AND CHELATING PROPERTIES
OF FLAVONOIDS LUDMILA G. KORKINA AND IGOR B. AFANAS EV I. INTRODUCTION
151 II. FREE RADICAL-SCAVENGING, ANTIOXIDANT, AND CHELATORY ACTIVITIES
OF FLAVONOIDS 152 III. PROOXIDANT ACTIVITY OF FLAVONOIDS 156 IV.
CYTOTOXIC EFFECTS OF FLAVONOIDS AGAINST TUMOR CELLS 157 V. MUTAGENIC AND
ANTIMUTAGENIC PROPERTIES OF FLAVONOIDS 159 REFERENCES 159 PART II
SYNTHETIC ANTIOXIDANTS AND ENZYME MIMICS POTENTIAL USE OF IRON CHELATORS
AGAINST OXIDATIVE DAMAGE JEAN-BAPTISTE GALEY I. INTRODUCTION 167 II.
IRON HOMEOSTASIS 169 III. IRON RELEASE DURING OXIDATIVE STRESS 172 IV.
IRON CHELATORS 176 V. PROTECTIVE EFFECT OF IRON CHELATORS AGAINST
OXIDATIVE DAMAGE 191 VI. CONCLUDING REMARKS 195 REFERENCES 196 X
CONTENTS N-ACETYLCYSTEINE: PHARMACOLOGICAL CONSIDERATIONS AND
EXPERIMENTAL AND CLINICAL APPLICATIONS IAN A. COTGREAVE I. INTRODUCTION
205 II. BIOPHARMACEUTICAL AND PHARMACOLOGICAL ASPECTS 206 III. GENERAL
BIOCHEMICAL AND CELLULAR EFFECTS 209 IV. SPECIFIC THERAPEUTIC EFFECTS OF
NAC IN ANIMALS AND HUMANS 213 V. SUMMARY 221 REFERENCES 221 EBSELEN AS A
GLUTATHIONE PEROXIDASE MIMIC AND AS A SCAVENGER OF PEROXYNITRITE HELMUT
SIES AND HIROSHI MASUMOTO I. INTRODUCTION 229 II. SYNTHESIS OF EBSELEN
230 III. MOLECULAR ACTIVITIES OF EBSELEN 230 FV. ACTIVITY IN BIOLOGICAL
MODEL SYSTEMS 236 V. METABOLISM 238 VI. CLINICAL ASSESSMENT 239 VII.
OTHER SELENOORGANIC COMPOUNDS 240 VIII. CONCLUDING REMARKS 240
REFERENCES 241 SALEN-MANGANESE COMPLEXES: COMBINED SUPEROXIDE
DISMUTASE/CATALASE MIMICS WITH BROAD PHARMACOLOGICAL EFFICACY SUSAN R.
DOCTROW, KARL HUFFMAN, CATHERINE B. MARCUS, WAEL MUSLEH, ANNADORA BRUCE,
MICHEL BAUDRY, AND BERNARD MALFROY I. INTRODUCTION 247 II. MULTIPLE
CATALYTIC ACTIVITIES OF EUK-8, A PROTOTYPE SOD/CATALASE MIMIC 249 III.
EFFICACY OF EUK-8 IN EXPERIMENTAL MODELS FOR DISEASE 256 FV. CONCLUSIONS
AND FUTURE DIRECTIONS 264 REFERENCES 265 CONTENTS XI PART III
ANTIOXIDANT ENZYME INDUCTION AND PATHOPHYSIOLOGY ANTIOXIDANT DRUG
TARGETING ANTHONY C. ALLISON I. INTRODUCTION 273 II. DELIVERING
ANTIOXIDANTS TO ORGANS OR TISSUES 274 III. TARGETING ANTIOXIDANTS TO
PARTICULAR CELL TYPES 276 IV. EFFECTS OF ANTIOXIDANTS ON ENZYMES 277 V.
REACTIVE OXYGEN INTERMEDIATES AS SIGNAL TRANSDUCERS 279 VI. EFFECTS OF
ANTIOXIDANTS ON TRANSCRIPTION FACTORS 281 VII. EFFECTS OF ANTIOXIDANTS
ON GENE EXPRESSION 284 VIII. DISCUSSION 288 REFERENCES 289
ANTIOXIDANT-LNDUCIBLE GENES THOMAS PRIMIANO, THOMAS R. SUTTER, AND
THOMAS W. KENSLER I. INTRODUCTION 293 II. GENES INDUCED BY ANTIOXIDANTS
294 III. MECHANISMS OF GENE INDUCTION BY ANTIOXIDANTS 307 IV.
CONSEQUENCES OF ANTIOXIDANT GENE INDUCTION 315 V. FUTURE PERSPECTIVES
317 REFERENCES 317 REDOX SIGNALING AND THE CONTROL OF CELL GROWTH AND
DEATH GARTH POWIS, JOHN R. GASDASKA, AND AMANDA BAKER I. INTRODUCTION
329 II. CELLULAR REDOX SYSTEMS 330 III. REDOX TARGETS 335 IV. CELLULAR
RESPONSES TO REDOX CHANGES 340 V. CONCLUSION 349 REFERENCES 349 XII
CONTENTS PROTECTIVE ACTION OF NITRONE-BASED FREE RADICAL TRAPS AGAINST
OXIDATIVE DAMAGE TO THE CENTRAL NERVOUS SYSTEM ROBERT A. FLOYD I.
INTRODUCTION 361 II. CNS IS SENSITIVE TO OXIDATIVE DAMAGE 362 III.
SPIN-TRAPPING REACTIONS OF NITRONE-BASED FREE RADICAL TRAPS 363 IV.
ANTIOXIDANT ACTIVITY OF PBN 364 V. PBN EXHIBITS PROTECTIVE ACTIVITY IN
SEPTIC SHOCK MODELS 365 VI. PBN AND RELATED COMPOUNDS ARE
NEUROPROTECTIVE 365 VII. PHARMACOLOGY STUDIES OF PBN AND RELATED
COMPOUNDS 366 VIII. PBN PREVENTS LPS-MEDIATED NO FORMATION IN LIVER 367
IX. NO CHEMISTRY AND ITS POTENTIAL NEUROTOXIC ACTION 368 X. HYPOTHESIS
TO EXPLAIN THE NEUROPROTECTIVE ACTION OF PBN 370 REFERENCES 374 REACTIVE
OXYGEN SPECIES AND THEIR CONTRIBUTION TO PATHOLOGY IN DOWN SYNDROME JUDY
B. DE HAAN, ERNST J. WOLVETANG, FRANCESCA CRISTIANO, ROCCO LANNELLO,
CECILE BLADIER, MICHAEL J. KELNER, AND ISMAIL KOLA I. INTRODUCTION 379
II. SODL AND GPXL EXPRESSION LEVELS IN DOWN SYNDROME 381 III. PREMATURE
AGING OF DOWN SYNDROME INDIVIDUALS 383 IV. APOPTOSIS AND DOWN SYNDROME
391 V. CONCLUSION AND DISCUSSION 397 REFERENCES 398 ANTIOXIDANTS,
REDOX-REGULATED TRANSCRIPTION FACTORS, AND INFLAMMATION PAUL G. WINYARD
AND DAVID R. BLAKE I. BACKGROUND 403 II. TWO REDOX-CONTROLLED
TRANSCRIPTION FACTORS: AP-IANDNF-KB 406 III. ROI/RNI AND NF-KB IN HUMAN
DISEASES 409 IV. ISCHEMIC-REPERFUSION INJURY, RHEUMATOID ARTHRITIS, AND
REDOX-REGULATED TRANSCRIPTION FACTORS 410 V. NF-/ CONTENTS XIII VI. WHAT
IS THE CELLULAR SOURCE OF ROI INVOLVED IN NF-/CB ACTIVATION? 412 VII.
CONCLUSION 416 REFERENCES 416 PART IV DISEASE PROCESSES RELATIONSHIPS
AMONG OXIDATION OF LOW-DENSITY LIPOPROTEIN, ANTIOXIDANT PROTECTION, AND
ATHEROSCLEROSIS HERMANN ESTERBAUER, REINHOLD SCHMIDT, AND MARIANNE HAYN
I. INTRODUCTION 425 II. THE LOW-DENSITY LIPOPROTEIN OXIDATION HYPOTHESIS
427 III. ASSESSMENT OF OXIDATION RESISTANCE OF LOW-DENSITY LIPOPROTEIN
431 IV. VITAMIN E SUPPLEMENTATION INCREASES OXIDATION RESISTANCE OF
LOW-DENSITY LIPOPROTEIN AS JUDGED BY THE CONJUGATED DIENE METHOD 434 V.
PLASMA LOW-DENSITY LIPOPROTEIN ANTIOXIDANT LEVELS 437 VI.
EPIDEMIOLOGICAL STUDIES 440 VII. CONCLUSION 447 REFERENCES 448 ADULT
RESPIRATORY DISTRESS SYNDROME: A RADICAL PERSPECTIVE SAMUEL LOUIE, BARRY
HALLIWELL, AND CARROLL EDWARD CROSS I. INTRODUCTION 457 II.
PATHOBIOLOGIC CONSIDERATIONS 460 III. THERAPEUTIC STRATEGIES 472 IV.
CONCLUSION 480 REFERENCES 481 OXIDATIVE STRESS IN CYSTIC FIBROSIS: DOES
IT OCCUR AND DOES IT MATTER? ALBERT VAN DER VLIET, JASON P. EISERICH,
GREGORY P. MARELICH, BARRY HALLIWELL, AND CARROLL E. CROSS I.
INTRODUCTION 491 II. ROLE OF OXYGEN-DERIVED SPECIES 492 XIV CONTENTS
III. OXIDATIVE STRESS AND LUNG DISEASE 494 FV. EVIDENCE FOR OXIDATIVE
STRESS IN CYSTIC FIBROSIS 494 V. THE SPECIAL CASE OF /3-CAROTENE
DEFICIENCY 497 VI. OXIDATIVE STRESS AT THE AIRWAY SURFACE 498 VII.
POTENTIAL ROLE OF NITRIC OXIDE AND RELATED SPECIES IN CYSTIC FIBROSIS
500 VIII. OTHER CONSIDERATIONS 503 IX. POTENTIAL FOR ANTIOXIDANT THERAPY
503 X. DILEMMA OF ADMINISTERING AEROSOLIZED THIOLS OR ASCORBIC ACID 504
XI. CONCLUSION 505 REFERENCES 505 OXIDATIVE STRESS AND ANTIOXIDANT
FUNCTION IN RELATION TO RISK FOR CATARACT ALLEN TAYLOR AND THOMAS NOWELL
I. INTRODUCTION 516 II. PUBLIC HEALTH ISSUES REGARDING CATARACT 517 III.
CLINICAL FEATURES OF CATARACT 518 IV. OXIDATION, SMOKING, AND CATARACT
FORMATION 518 V. ASSOCIATIONS BETWEEN ANTIOXIDANTS AND CATARACT 519 VI.
CONCLUSIONS 531 REFERENCES 532 THE MACULAR PIGMENT: A POSSIBLE ROLE IN
PROTECTION FROM AGE-RELATED MACULAR DEGENERATION JOHN T. LANDRUM,
RICHARD A. BONE, AND MARK D. KILBURN I. INTRODUCTION 537 II. THE MACULAR
PIGMENT 538 III. AGE-RELATED MACULAR DEGENERATION 541 IV. METHODS 542 V.
RESULTS 547 VI. DISCUSSION AND CONCLUSIONS 551 REFERENCES 553
NEUROLOGICAL DISEASE DAVID P. R. MULLER I. INTRODUCTION 557 II.
ANTIOXIDANT DEFICIENCY 558 CONTENTS XV III. INCREASED CONCENTRATIONS OF
REACTIVE OXYGEN SPECIES 563 IV. CONCLUSIONS 572 REFERENCES 572 ROLE OF
CYSTEINE AND GLUTATHIONE IN HIV INFECTION AND CANCER CACHEXIA:
THERAPEUTIC INTERVENTION WITH N-ACETYLCYSTEINE WULF DROGE, ANDREA GROSS,
VOLKER HACK, RALF KINSCHERF, MICHAEL SCHYKOWSKI, MICHAEL BOCKSTETTE,
SABINE MIHM, AND DAGMAR GAITER I. INTRODUCTION 581 II. ELEVATED VENOUS
PLASMA GLUTAMATE LEVELS AS AN EARLY AND POSSIBLY UNIVERSAL MARKER FOR
CATABOLIC AND PRECATABOLIC CONDITIONS 583 III. PUSH AND PULL
MECHANISMS IN CATABOLIC AND PRECATABOLIC PROCESSES 585 IV. IMMUNOLOGICAL
IMPLICATIONS 589 V. THERAPEUTIC INTERVENTION WITH A CYSTEINE DERIVATIVE:
EFFECTS OF LONG-TERM TREATMENT WITH N-ACETYLCYSTEINE 592 VI. CONCLUDING
REMARKS 595 REFERENCES 596 ROLE OF OXIDATIVE STRESS AND ANTIOXIDANT
THERAPY IN ALCOHOLIC AND NONALCOHOLIC LIVER DISEASES CHARLES S. LIEBER
I. METABOLISM OF ETHANOL 601 II. ACETALDEHYDE: ITS METABOLISM AND
TOXICITY, INCLUDING PEROXIDATION 610 III. ANTIOXIDANT THERAPY 611 IV.
SUMMARY 618 REFERENCES 619 ANTIOXIDANT THERAPY FOR THE PREVENTION OF
TYPE I DIABETES BIRGIT HELLER, VOLKER BURKART, EBERHARD LAMPETER, AND
HUBERT KOLB I. INTRODUCTION 629 II. MECHANISM OF REACTIVE OXYGEN
INTERMEDIATES AND NITRIC OXIDE TOXICITY 630 III. INTERVENTION STUDIES IN
ANIMALS 632 XVI CONTENTS FV. INTERVENTION STUDIES IN HUMANS 634 V.
CONCLUDING REMARKS 635 REFERENCES 635 PHOTOAGING OF THE CONNECTIVE
TISSUE OF SKIN: ITS PREVENTION AND THERAPY KARIN SCHARFFETTER-KOCHANEK
I. INTRODUCTION 639 II. THE NATURE OF PHOTOAGING 640 III. ROLE OF
ULTRAVIOLET-GENERATED OXYGEN SPECIES IN CUTANEOUS PHOTOAGING 642 IV.
PREVENTION AND THERAPY OF CONNECTIVE TISSUE DAMAGE 647 REFERENCES 650
ANTIOXIDANT NUTRIENTS AND CANCER INCIDENCE AND MORTALITY: AN
EPIDEMIOLOGIC PERSPECTIVE SUSAN T. MAYNE I. INTRODUCTION 657 II.
ANTIOXIDANT NUTRIENTS AND CANCER PREVENTION 659 III. ANTIOXIDANT
NUTRIENTS AND CANCER SURVIVAL 666 IV. ANTIOXIDANTS AND CANCER: EMERGING
ISSUES 668 V. CONCLUSIONS AND POLICY IMPLICATIONS 670 REFERENCES 671
INDEX 677 CONTENTS OF PREVIOUS VOLUMES 693
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV011161163 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:04:59Z |
| institution | BVB |
| isbn | 0120329395 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007481398 |
| oclc_num | 35842283 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-12 DE-19 DE-BY-UBM DE-20 DE-M49 DE-BY-TUM |
| owner_facet | DE-355 DE-BY-UBR DE-12 DE-19 DE-BY-UBM DE-20 DE-M49 DE-BY-TUM |
| physical | XXIII, 707 S. Ill., graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Acad. Press |
| record_format | marc |
| series2 | Advances in pharmacology |
| spelling | Antioxidants in disease mechanisms and therapy ed. by Helmut Sies San Diego [u.a.] Acad. Press 1997 XXIII, 707 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in pharmacology 38 Einzelaufnahme eines Zeitschr.-Bd. Antioxidanten gtt Antioxydants - Aspect sanitaire Antioxydants - Emploi en thérapeutique Radicaux libres (Chimie) - Physiopathologie Antioxidants Health aspects Antioxidants Therapeutic use Antioxidants pharmacology Antioxidants therapeutic use Free radicals (Chemistry) Pathophysiology Antioxidans (DE-588)4142729-4 gnd rswk-swf Pharmakologie (DE-588)4045687-0 gnd rswk-swf Pharmakotherapie (DE-588)4076066-2 gnd rswk-swf Sauerstoffradikal (DE-588)4179211-7 gnd rswk-swf Pathobiochemie (DE-588)4044888-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Antioxidans (DE-588)4142729-4 s Pharmakologie (DE-588)4045687-0 s DE-604 Pharmakotherapie (DE-588)4076066-2 s Sauerstoffradikal (DE-588)4179211-7 s Pathobiochemie (DE-588)4044888-5 s Sies, Helmut 1942- Sonstige (DE-588)1202544282 oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007481398&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Antioxidants in disease mechanisms and therapy Antioxidanten gtt Antioxydants - Aspect sanitaire Antioxydants - Emploi en thérapeutique Radicaux libres (Chimie) - Physiopathologie Antioxidants Health aspects Antioxidants Therapeutic use Antioxidants pharmacology Antioxidants therapeutic use Free radicals (Chemistry) Pathophysiology Antioxidans (DE-588)4142729-4 gnd Pharmakologie (DE-588)4045687-0 gnd Pharmakotherapie (DE-588)4076066-2 gnd Sauerstoffradikal (DE-588)4179211-7 gnd Pathobiochemie (DE-588)4044888-5 gnd |
| subject_GND | (DE-588)4142729-4 (DE-588)4045687-0 (DE-588)4076066-2 (DE-588)4179211-7 (DE-588)4044888-5 (DE-588)4143413-4 |
| title | Antioxidants in disease mechanisms and therapy |
| title_auth | Antioxidants in disease mechanisms and therapy |
| title_exact_search | Antioxidants in disease mechanisms and therapy |
| title_full | Antioxidants in disease mechanisms and therapy ed. by Helmut Sies |
| title_fullStr | Antioxidants in disease mechanisms and therapy ed. by Helmut Sies |
| title_full_unstemmed | Antioxidants in disease mechanisms and therapy ed. by Helmut Sies |
| title_short | Antioxidants in disease mechanisms and therapy |
| title_sort | antioxidants in disease mechanisms and therapy |
| topic | Antioxidanten gtt Antioxydants - Aspect sanitaire Antioxydants - Emploi en thérapeutique Radicaux libres (Chimie) - Physiopathologie Antioxidants Health aspects Antioxidants Therapeutic use Antioxidants pharmacology Antioxidants therapeutic use Free radicals (Chemistry) Pathophysiology Antioxidans (DE-588)4142729-4 gnd Pharmakologie (DE-588)4045687-0 gnd Pharmakotherapie (DE-588)4076066-2 gnd Sauerstoffradikal (DE-588)4179211-7 gnd Pathobiochemie (DE-588)4044888-5 gnd |
| topic_facet | Antioxidanten Antioxydants - Aspect sanitaire Antioxydants - Emploi en thérapeutique Radicaux libres (Chimie) - Physiopathologie Antioxidants Health aspects Antioxidants Therapeutic use Antioxidants pharmacology Antioxidants therapeutic use Free radicals (Chemistry) Pathophysiology Antioxidans Pharmakologie Pharmakotherapie Sauerstoffradikal Pathobiochemie Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007481398&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT sieshelmut antioxidantsindiseasemechanismsandtherapy |