Physiology and pharmacology of biological rhythms: [with 43 tables]
Gespeichert in:
Format: | Buch |
---|---|
Sprache: | English |
Veröffentlicht: |
Berlin [u.a.]
Springer
1997
|
Schriftenreihe: | Handbook of experimental pharmacology
125 |
Schlagworte: | |
Online-Zugang: | Inhaltsverzeichnis |
Beschreibung: | XXIV, 668 S. Ill., graph. Darst. |
ISBN: | 3540615253 |
Internformat
MARC
LEADER | 00000nam a2200000 cb4500 | ||
---|---|---|---|
001 | BV011081185 | ||
003 | DE-604 | ||
005 | 20140403 | ||
007 | t | ||
008 | 961118s1997 gw ad|| |||| 00||| eng d | ||
016 | 7 | |a 948060361 |2 DE-101 | |
020 | |a 3540615253 |9 3-540-61525-3 | ||
035 | |a (OCoLC)35198557 | ||
035 | |a (DE-599)BVBBV011081185 | ||
040 | |a DE-604 |b ger |e rakwb | ||
041 | 0 | |a eng | |
044 | |a gw |c DE | ||
049 | |a DE-355 |a DE-19 |a DE-12 |a DE-20 |a DE-11 |a DE-188 |a DE-578 | ||
050 | 0 | |a QP905 | |
050 | 0 | |a RM301.3.C47 | |
082 | 0 | |a 615/.1 |2 20 | |
082 | 0 | |a 612/.022 |2 20 | |
084 | |a WD 8000 |0 (DE-625)148246: |2 rvk | ||
084 | |a XI 1701 |0 (DE-625)152977:12907 |2 rvk | ||
084 | |a QV 4 |2 nlm | ||
245 | 1 | 0 | |a Physiology and pharmacology of biological rhythms |b [with 43 tables] |c contributors F. Andreotti ... Ed. P. H. Redfern ... |
264 | 1 | |a Berlin [u.a.] |b Springer |c 1997 | |
300 | |a XXIV, 668 S. |b Ill., graph. Darst. | ||
336 | |b txt |2 rdacontent | ||
337 | |b n |2 rdamedia | ||
338 | |b nc |2 rdacarrier | ||
490 | 1 | |a Handbook of experimental pharmacology |v 125 | |
650 | 7 | |a Biological Rhythms |2 cabt | |
650 | 7 | |a Physiological Effects |2 cabt | |
650 | 7 | |a Pharmacology |2 cabt | |
650 | 7 | |a Biologisch ritme |2 gtt | |
650 | 7 | |a Circadiaans ritme |2 gtt | |
650 | 7 | |a Cronofarmacologia |2 larpcal | |
650 | 7 | |a Farmacologie |2 gtt | |
650 | 4 | |a Chronobiology | |
650 | 4 | |a Chronobiology Phenomena | |
650 | 4 | |a Chronopharmacology | |
650 | 4 | |a Circadian Rhythm |x drug effects | |
650 | 4 | |a Circadian Rhythm |x physiology | |
650 | 4 | |a Drug Therapy | |
650 | 0 | 7 | |a Chronopharmakologie |0 (DE-588)4127100-2 |2 gnd |9 rswk-swf |
650 | 0 | 7 | |a Pharmakologie |0 (DE-588)4045687-0 |2 gnd |9 rswk-swf |
650 | 0 | 7 | |a Biorhythmus |0 (DE-588)4006896-1 |2 gnd |9 rswk-swf |
650 | 0 | 7 | |a Chronobiologie |0 (DE-588)4140668-0 |2 gnd |9 rswk-swf |
655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
689 | 0 | 0 | |a Chronopharmakologie |0 (DE-588)4127100-2 |D s |
689 | 0 | |5 DE-604 | |
689 | 1 | 0 | |a Chronobiologie |0 (DE-588)4140668-0 |D s |
689 | 1 | |5 DE-604 | |
689 | 2 | 0 | |a Biorhythmus |0 (DE-588)4006896-1 |D s |
689 | 2 | 1 | |a Pharmakologie |0 (DE-588)4045687-0 |D s |
689 | 2 | |5 DE-604 | |
700 | 1 | |a Redfern, Peter H. |e Sonstige |4 oth | |
700 | 1 | |a Andreotti, Felicita |e Sonstige |4 oth | |
830 | 0 | |a Handbook of experimental pharmacology |v 125 |w (DE-604)BV002390716 |9 125 | |
856 | 4 | 2 | |m GBV Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007424041&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
999 | |a oai:aleph.bib-bvb.de:BVB01-007424041 |
Datensatz im Suchindex
_version_ | 1804125572630052864 |
---|---|
adam_text | L H PHYSIOLOGY AND PHARMACOLOGY OF BIOLOGICAL RHYTHMS CONTRIBUTORS F.
ANDREOTTI, J. ARENDT, P.M. BELANGER, G.D. BLOCK, B. BRUGUEROLLE J.
CAMBER, G.E. D ALONZO, L.N. EDMUNDS, JR., M.H. HASTINGS E. HAUS, M.
KARZAZI, G. LABRECQUE, B. LEMMER, F. LEVI, A. LLUCH K.F. MARTIN, L.
MEJEAN, H. MERKI, S. MICHEL, J.G. MOORE R.Y. MOORE, N. MROSOVSKY, G.
PATTI, M. PONS, F. PORTALUPPI P.H. REDFERN, A.E. REINBERG, L. RENSING,
A.M. ROSENWASSER R. SMAALAND, M.H. SMOLENSKY, A. STRICKER-KRONGRAD, Y.
TOUITOU M.-C. VANIER, A. WIRZ-JUSTICE, K. WITTE EDITORS P.H. REDFERN AND
B. LEMMER SPRINGER CONTENTS CHAPTER 1 THE VERTEBRATE CLOCK:
LOCALISATION, CONNECTION AND ENTRAINMENT M.H. HASTINGS. WITH 4 FIGURES 1
A. INTRODUCTION 1 I. RHYTHMS AND OUR LIVES 1 II. CIRCADIAN RHYTHMS AND
INTERNAL TEMPORAL ORDER 1 III. ENTRAINMENT AND THE PHASE RESPONSE CURVE
3 B. LOCALISATION OF THE CIRCADIAN CLOCK IN VERTEBRATES 4 I. CRITERIA
FOR IDENTIFYING THE CLOCK 4 II. THE RETINA AS A CIRCADIAN OSCILLATOR 5
III. THE PINEAL GLAND AS A CIRCADIAN OSCILLATOR 6 IV. THE
SUPRACHIASMATIC NUCLEI OF THE HYPOTHALAMUS AS A CIRCADIAN OSCILLATOR 8
C. NEUROANATOMY OF THE SCN 9 I. INTERNAL STRUCTURE AND ORGANISATION OF
THE SCN 9 II. AFFERENT CONNECTIONS OF THE SCN 11 III. OUTPUTS OF THE SCN
12 D. ENTRAINMENT OF THE SCN 13 I. LIGHT AND GLUTAMATE 13 II.
GLUTAMATERGIC SIGNALS AND GENE EXPRESSION IN THE SCN ... 14 III.
NON-PHOTIC ENTRAINMENT OF THE CIRCADIAN SYSTEM 17 IV. MELATONIN AND
ENTRAINMENT OF THE CIRCADIAN SYSTEM 18 V. CONCLUSION 20 REFERENCES 21
CHAPTER 2 REGULATION OF CELL DIVISION CYCLES BY CIRCADIAN OSCILLATORS:
SIGNAL TRANSDUCTION BETWEEN CLOCKS L.N. EDMUNDS, JR. WITH 10 FIGURES 29
A. INTRODUCTION 29 I. REGULATION OF THE CELL DIVISION CYCLE 31 II. CELL
DIVISION RHYTHMICITY IN WILD-TYPE AND MUTANT EUGLENA 32 XII CONTENTS B.
COUPLING BETWEEN OSCILLATOR AND CELL CYCLE: ROLE OF CYCLIC AMP 33 I.
PERTURBATION OF THE CELL DIVISION RHYTHM BY CYCLIC AMP 34 II. UPSTREAM
ANALYSIS: GENESIS OF THE OSCILLATION IN CYCLIC AMP 41 III. DOWNSTREAM
PATHWAY: CYCLIC AMP-DEPENDENT KINASES ... 43 IV. MODEL FOR CIRCADIAN
CONTROL OF THE CELL DIVISION CYCLE ... 47 C. PROBLEMS AND PROSPECTS:
INTERFACE WITH THE CYCLIN CLOCK 48 REFERENCES 50 CHAPTER 3 GENETICS AND
MOLECULAR BIOLOGY OF CIRCADIAN CLOCKS L. RENSING. WITH 6 FIGURES 55 A.
INTRODUCTION 55 I. OSCILLATIONS AND GENES 55 II. ANALYTICAL APPROACHES
TO THE BASIC CIRCADIAN OSCILLATOR ... 56 B. GENETICS AND MOLECULAR
BIOLOGY OF THE CLOCK 58 I. OVERVIEW AND GENERALIZATIONS 58 II.
NEUROSPORA 60 1. CIRCADIAN RHYTHM 60 2. CLOCK MUTANTS 60 3. MOLECULAR
BIOLOGY OF FRQ 62 III. DROSOPHILA 64 1. CIRCADIAN RHYTHMS 64 2. CLOCK
MUTANTS 65 3. MOLECULAR BIOLOGY OF PER 66 IV. MAMMALS 69 V. CONCLUSIONS
70 C. ZEITGEBER SIGNAL PATHWAYS TO THE CLOCK 71 I. NEUROSPORA 72 II.
MOLLUSCS 73 III. MAMMALS 73 D. OUTPUT SIGNALS FROM THE CLOCK 73
REFERENCES 75 CHAPTER 4 CHEMICAL NEUROANATOMY OF THE MAMMALIAN CIRCADIAN
SYSTEM R.Y. MOORE. WITH 7 FIGURES 79 A. INTRODUCTION 79 B. ENTRAINMENT
PATHWAYS 80 I. RETINOHYPOTHALAMIC TRACT 80 II. GENICULOHYPOTHALAMIC
TRACT 83 CONTENTS XIII III. OTHER INPUTS TO THE SUPRACHIASMATIC NUCLEUS
85 C. PACEMAKER-SUPRACHIASMATIC NUCLEUS 85 I. SUPRACHIASMATIC NUCLEUS
ORGANIZATION 85 - II. SUPRACHIASMATIC NUCLEUS EFFERENTS 87 D.
CONCLUSIONS 89 REFERENCES 90 CHAPTER 5 CHRONOBIOLOGY OF DEVELOPMENT AND
AGING E. HALTS AND Y. TOUITOU 95 A. INTRODUCTION 95 B. DEVELOPMENTAL
CHRONOBIOLOGY 97 I. BIOLOGIC RHYTHMS IN THE HUMAN FETUS 97 II. FETAL
RHYTHMS OF SUSCEPTIBILITY TO TOXIC AND TERATOGENIC AGENTS 97 III.
RHYTHMS IN THE NEWBORN AND DURING INFANCY 100 C. CHRONOBIOLOGY OF AGING
100 I. CHANGES IN SLEEP PATTERNS DURING AGING 100 II. BODY TEMPERATURE
101 III. BLOOD PRESSURE AND HEART RATE 104 IV.
HYPOTHALAMIC-PITUITARY-ADRENAL AXIS 106 1. DEHYDROEPIANDROSTERONE AND
AGING 107 V. PINEAL GLAND 109 VI. GROWTH HORMONE AND PROLACTIN 110 VII.
PITUITARY-GONADAL AXIS ILL VIII. CATECHOLAMINES 112 IX. AGE-RELATED
CHANGES IN THE PITUITARY-THYROID AXIS DURING AGING 113 X. CLINICAL
CHEMICAL VARIABLES AND AGING 113 1. PLASMA PROTEINS AND VOLEMIA 114 X.
HEMATOLOGY 115 D. CONCLUSIONS 116 REFERENCES 122 CHAPTER 6 RHYTHMS IN
SECOND MESSENGER MECHANISMS K. WITTE AND B. LEMMER. WITH 4 FIGURES 135
A. INTRODUCTION 135 B. PRINCIPLES OF TRANSMEMBRANEOUS SIGNAL
TRANSDUCTION 135 I. ADENYLYL CYCLASE PATHWAY 135 II. GUANYLYL CYCLASE
PATHWAY 137 XIV , CONTENTS III. PHOSPHOLIPASE C PATHWAY 138 C. RHYTHMS
IN SIGNAL TRANSDUCTION IN THE CARDIOVASCULAR SYSTEM 138 -I I. ADENYLYL
CYCLASE PATHWAY 138 II. GUANYLYL CYCLASE PATHWAY 145 III. PHOSPHOLIPASE
C PATHWAY 145 D. RHYTHMS IN SIGNAL TRANSDUCTION IN THE CENTRAL NERVOUS
SYSTEM 146 I. ADENYLYL CYCLASE PATHWAY 146 II. GUANYLYL CYCLASE PATHWAY
147 III. PHOSPHOLIPASE C PATHWAY 151 E. RHYTHMS IN SIGNAL TRANSDUCTION
IN OTHER TISSUES 151 I. ADENYLYL CYCLASE PATHWAY 151 II. GUANYLYL
CYCLASE PATHWAY 152 III. PHOSPHOLIPASE C PATHWAY 152 F. CONCLUSIONS AND
PERSPECTIVES 153 REFERENCES 153 CHAPTER 7 5-HYDROXYTRYPTAMINE AND
NORADRENALINE SYNTHESIS, RELEASE AND METABOLISM IN THE CENTRAL NERVOUS
SYSTEM: CIRCADIAN RHYTHMS AND CONTROL MECHANISMS K.F. MARTIN AND P.H.
REDFERN. WITH 2 FIGURES 157 A. INTRODUCTION 157 B. CIRCADIAN RHYTHMS IN
TURNOVER OF SEROTONIN 158 I. TISSUE LEVELS OF SEROTONIN 158 II.
TRYPTOPHAN HYDROXYLASE 160 III. TRYPTOPHAN AVAILABILITY 160 IV.
TRYPTOPHAN UPTAKE 161 V. 5-HYDROXYTRYPTOPHAN DECARBOXYLASE ACTIVITY 161
VI. 5-HYDROXYTRYPTAMINE RELEASE AND METABOLISM 162 VII. FIRING RATE OF
SEROTONERGIC NEURONES 165 VIII. 5-HYDROXYTRYPTAMINE AUTORECEPTOR
ACTIVITY 165 IX. WHAT IS THE FUNCTION OF THE CIRCADIAN RHYTHM IN
5-HYDROXYTRYPTAMINE TURNOVER? 168 C. CIRCADIAN RHYTHMS IN NORADRENALINE
TURNOVER 169 D. CONCLUSIONS 171 E. REFERENCES 171 CONTENTS XV CHAPTER 8
RHYTHMS IN PHARMACOKINETICS; ABSORPTION, DISTRIBUTION, METABOLISM AND
EXCRETION P.M. BELANGER, B. BRUGUEROLLE, AND G. LABRECQUE. WITH 13
FIGURES 177 A. INTRODUCTION 177 B. ABSORPTION 178 I. PARAMETERS AND
MODIFYING FACTORS 178 II. INORGANIC COMPOUNDS AND MACROMOLECULES 179
III. ORGANIC COMPOUNDS 179 IV. FACTORS MODIFYING THE TEMPORAL VARIATION
IN GASTROINTESTINAL ABSORPTION 181 1. SOLUBILITY 181 2. PHARMACEUTICAL
FORMULATION 182 3. SECRETION AND MOTILITY 182 4. BLOOD FLOW 183 C.
DISTRIBUTION 185 I. PLASMA PROTEIN BINDING 185 II. BINDING TO
ERYTHROCYTES 187 D. BIOTRANSFORMATION 188 I. OXIDATION: THE CYTOCHROME
P-450 MONOOXYGENASE 188 II. CONJUGATIONS 192 1. CONJUGATIONS TO ACETATE,
GLUCURONIC ACID AND SULFATE . 192 2. CONJUGATION TO GLUTATHIONE 193 III.
FACTORS RELATED TO BIOTRANSFORMATION 195 1. HEPATIC BLOOD FLOW 195 2.
FIRST-PASS EFFECT 196 E. EXCRETION 196 F. CONCLUSIONS AND PERSPECTIVES
197 REFERENCES 199 CHAPTER 9 PROGRESS IN THE CHRONOTHERAPY OF NOCTURNAL
ASTHMA M.H. SMOLENSKY AND G.E. D ALONZO. WITH 19 FIGURES 205 A.
INTRODUCTION 205 B. DAY-NIGHT PATTERN OF ACUTE ASTHMA 205 C. EARLY,
LATE, AND RECURRENT ASTHMA REACTIONS 207 D. THE CHRONOBIOLOGY OF ASTHMA
208 E. PHARMACOTHERAPY OF ASTHMA 211 F. THE CHRONOPHARMACOLOGY AND
CHRONOTHERAPY OF ASTHMA MEDICATIONS 212 XVI CONTENTS G. P 2 -ADRENERGIC
AGONIST MEDICATIONS 213 H. ANTICHOLINERGIC AGENTS 219 I. THEOPHYLLINE
221 J. CHRONOTHERAPY OF GLUCOCORTICOIDS 227 K. MAST CELL STABILIZERS 239
L. CONCLUSION 240 REFERENCES 241 CHAPTER 10 CHRONOPHARMACOLOGY OF
CARDIOVASCULAR DISEASES B. LEMMER AND F. PORTALUPPI. WITH 2 FIGURES 251
A. HISTORICAL BACKGROUND 251 B. CHRONOBIOLOGICAL MECHANISMS OF THE
CARDIOVASCULAR SYSTEM .... 252 I. PHYSIOLOGY AND PATHOPHYSIOLOGY OF
BLOOD PRESSURE REGULATION 252 II. CARDIOVASCULAR HAEMODYNAMICS 258 III.
ELECTRICAL PROPERTIES OF THE HEART 260 IV. PATHOPHYSIOLOGY IN CORONARY
HEART DISEASE 261 C. CHRONOPHARMACOLOGY OF HYPERTENSION 262 I.
(3-ADRENOCEPTOR ANTAGONISTS 262 1. PHARMACOLOGICAL CHARACTERIZATION 262
2. CLINICAL DATA 262 II. CALCIUM CHANNEL BLOCKERS 267 1. PHARMACOLOGICAL
CHARACTERIZATION 267 2. CLINICAL DATA 267 3. CHRONOPHARMACOKINETICS 269
III. CONVERTING ENZYME INHIBITORS 270 1. PHARMACOLOGICAL
CHARACTERIZATION 270 2. CLINICAL DATA 270 IV. OTHER ANTIHYPERTENSIVES
271 V. CHRONOPHARMACOLOGY OF BLOOD PRESSURE IN CONGESTIVE HEART FAILURE
271 VI. CONCLUSION 271 D. CHRONOPHARMACOLOGY OF CORONARY HEART DISEASE
272 I. (3-ADRENOCEPTOR ANTAGONISTS 272 II. CALCIUM CHANNEL BLOCKERS 278
III. ORGANI C NITRATES 280 1. PHARMACOLOGICAL CHARACTERIZATION 280 2.
CLINICAL DATA 280 IV. DRUGS AFFECTING COAGULATION 281 V. CONCLUSION 282
E. CONCLUDING REMARKS 282 REFERENCES 283 CONTENTS XVII CHAPTER 11
CHRONOPHARMACOLOGY OF ANTICANCER AGENTS F. LEVI. WITH 10 FIGURES 299 A.
INTRODUCTION 299 B. EXPERIMENTAL CHRONOPHARMACOLOGY 299 I. TOXICITY
RHYTHMS 299 II. CHRONOPHARMACOKINETICS 301 III. RHYTHMS IN
SUSCEPTIBILITY OF TARGET TISSUES 303 IV. CIRCADIAN RHYTHMS IN ANTITUMOR
EFFICACY 305 C. CLINICAL CHRONOPHARMACOLOGY 307 I. RHYTHMS IN TARGET
TISSUES 307 II. CHRONOPHARMACOKINETICS 309 D. CLINICAL VALIDATION OF
CHRONOTHERAPY IN ONCOLOGY 314 I. PHASE I TRIALS OF CHRONOMODULATED
CHEMOTHERAPY 315 II. PHASE II TRIALS 321 III. CHRONOTHERAPY OF
METASTATIC COLORECTAL CANCER WITH 5-FLUOROURACIL, FOLINIC ACID AND
OXALIPLATIN (CHRONO-FFL) 322 E. CONCLUSIONS AND PERSPECTIVES 324
REFERENCES 325 CHAPTER 12 THE ENDOCRINE SYSTEM AND DIABETES L. MEJEAN,
A. STRICKER-KRONGRAD, AND A. LLUCH. WITH 4 FIGURES 333 A. INTRODUCTION
333 B. CHRONOBIOLOGY OF BLOOD GLUCOSE LEVELS 334 C. CHRONOBIOLOGY OF
GLUCOSE TOLERANCE 335 D. CHRONOBIOLOGY OF PLASMA INSULIN 335 E.
CHRONOBIOLOGY OF THE CORTICOTROPIC AXIS 337 F. CHRONOBIOLOGY OF FEEDING
BEHAVIOUR 338 G. CHRONOPHARMACOLOGICAL APPROACH TO DIABETES 339
REFERENCES 345 CHAPTER 13 GASTROINTESTINAL TRACT J.G. MOORE AND H.
MERKI. WITH 21 FIGURES 351 A. INTRODUCTION 351 B. GASTROINTESTINAL
MOTILITY RHYTHMS 351 I. PHARMACOLOGICAL AND THERAPEUTIC IMPLICATIONS 354
XVIII CONTENTS II. OTHER CIRCADIAN RHYTHMS INFLUENCING DRUG
BIOAVAILABILITY 355 C. RHYTHMS IN GASTRIC ACID SECRETION 357 I.
PHARMACOLOGICAL IMPLICATIONS 361 II. THERAPEUTIC IMPLICATIONS 367 D.
RHYTHMS IN GASTRIC MUCOSAL DEFENSE 367 E. CIRCADIAN INFLUENCE IN CANCER
CHEMOTHERAPEUTIC TREATMENT REGIMENS 369 REFERENCES 371 CHAPTER 14 THE
PINEAL GLAND, CIRCADIAN RHYTHMS AND PHOTOPERIODISM J. ARENDT. WITH 10
FIGURES 375 A. INTRODUCTION 375 B. MELATONIN PRODUCTION 376 C. LIGHT
CONTROL OF MELATONIN SECRETION 380 D. CONTROL OF SEASONAL CYCLES 383 E.
MECHANISM OF ACTION OF MELATONIN IN CONTROL OF SEASONAL RHYTHMS 385 F.
HUMAN SEASONALLY 387 G. MELATONIN AS A CIRCADIAN MARKER RHYTHM 387 H.
EFFECTS OF MELATONIN ON CIRCADIAN RHYTHMS 391 I. MELATONIN AND CORE BODY
TEMPERATURE 395 J. THERAPEUTIC USES OF MELATONIN 395 K. MECHANISM OF
ACTION OF MELATONIN IN THE CONTROL OF CIRCADIAN RHYTHMS 398 L. MELATONIN
RECEPTORS 401 M. MELATONIN ANTAGONISTS AND AGONISTS 401 REFERENCES 404
CHAPTER 15 PROBLEMS IN INTERPRETING THE EFFECTS OF DRUGS ON CIRCADIAN
RHYTHMS N. MROSOVSKY. WITH 8 FIGURES 415 A. MULTIPLICITY OF SITES FOR
CHRONOTYPIC ACTION 415 B. ALTERNATIVE INTERPRETATIONS FOR MODE OF DRUG
ACTION 416 I. GONADAL STEROIDS AND CHANGES IN PERIOD 416 II.
BENZODIAZEPINES AND PHASE SHIFTS 418 III. PERIODICITY AFTER A SINGLE
TREATMENT 420 IV. MELATONIN INJECTIONS AND INFUSIONS 420 CONTENTS XIX C.
TACTICS FOR RESEARCH ON BEHAVIOURAL MEDIATION 422 I. MEASURING ACTIVITY
422 II. ALTERING OPPORTUNITIES FOR ACTIVITY 422 , III. CONFINEMENT AND
RESTRAINT 423 IV. TESTING DRUGS IN VITRO 424 D. PROBLEMS IN ASSESSING
BEHAVIOURAL MEDIATION 424 E. MIMICKING AND MODULATION OF PHOTIC EFFECTS
425 I. THE RETINOHYPOTHALAMIC TRACT TRANSMITTER 425 II. PERIOD AND
ASCHOFFS RULE 427 III. SENSITIVITY TO LIGHT AND PHASE SHIFTS 427 IV.
BEHAVIOURAL INHIBITION OF PHOTIC SHIFTS 427 F. SALINE INJECTIONS 428 I.
PERIPHERAL INJECTIONS 428 II. CENTRAL INJECTIONS 429 G. CONCLUDING
REMARKS 431 REFERENCES 431 CHAPTER 16 RHYTHMS IN RETINAL MECHANISMS G.D.
BLOCK AND S. MICHEL. WITH 7 FIGURES 435 A. INTRODUCTION 435 B. RETINAL
RHYTHMICITY IN XENOPUS 435 I. PACEMAKER LOCALIZATION 436 II. RHYTHM
GENERATION 436 III. PACEMAKER ENTRAINMENT 436 IV. RHYTHM EXPRESSION 439
C. RETINAL RHYTHMICITY IN APLYSIA CALIFORNICA 440 I. PACEMAKER
LOCALIZATION 441 II. RHYTHM GENERATION 441 III. PACEMAKER ENTRAINMENT
442 1. LIGHT-INDUCED PHASE SHIFTS 442 2. SEROTONIN-INDUCED PHASE SHIFTS
444 IV. RHYTHM EXPRESSION 446 D. RETINAL RHYTHMICITY IN BULLA GOULDIANA
446 I. PACEMAKER LOCALIZATION 447 II. RHYTHM GENERATION 447 III.
PACEMAKER ENTRAINMENT 449 IV. RHYTHM EXPRESSION 450 E. CONCLUSIONS 451
REFERENCES 451 XX CONTENTS CHAPTER 17 CIRCADIAN RHYTHMS AND DEPRESSION:
CLINICAL AND EXPERIMENTAL MODELS A.M. ROSENWASSER AND A. WIRZ-JUSTICE.
WITH 5 FIGURES 457 A. INTRODUCTION AND SCOPE 457 B. MEASUREMENT OF
CIRCADIAN RHYTHMS 458 C. CIRCADIAN RHYTHMS AND DEPRESSION: CLINICAL
RESEARCH 459 I. PHASE-ADVANCED CIRCADIAN RHYTHMS 459 II. DEPRESSION,
SLEEP, AND RHYTHMICITY 460 III. SEASONAL DEPRESSION: A CIRCADIAN RHYTHM
DISORDER? 461 IV. CIRCADIAN AMPLITUDE AND WAVEFORM 464 V. INSTABILITY
AND ZEITGEBER COUPLING 465 VI. FREE-RUNNING RHYTHMS 466 VII. ACTIVITY
FEEDBACK 466 VIII. SUMMARY 467 D. CIRCADIAN RHYTHMS AND DEPRESSION:
ANIMAL MODELS 468 I. PSYCHOPHARMACOLOGY OF CIRCADIAN RHYTHMS 468 1.
PHASE-SHIFTING AND FREE-RUNNING PERIOD 468 2. ANTIDEPRESSANTS 471 3. A
PHARMACOGENIC-DEVELOPMENTAL MODEL 472 II. STRESS-INDUCED DEPRESSION
MODELS 472 III. BEHAVIORALLY CHARACTERIZED INBRED STRAINS 473 1.
SELECTION FOR HYPERTENSION 473 2. SELECTION FOR DRUG SENSITIVITY 474 3.
INBRED MICE DIFFERING IN AFFECTIVE BEHAVIOR 474 IV. ABLATION-BASED
DEPRESSION MODELS 475 1. OLFACTORY BULBECTOMY 475 2. THYROIDECTOMY 475
V. ANIMAL MODELS OF SAD? 476 VI. BEHAVIORAL FEEDBACK EFFECTS 476 VII.
SUMMARY 477 E. CONCLUSIONS 479 REFERENCES 479 CHAPTER 18 CHRONOBIOLOGY
AND CHRONOPHARMACOLOGY OF THE HAEMOPOIETIC SYSTEM R. SMAALAND. WITH 8
FIGURES 487 A. OUTLINE OF HAEMOPOIESIS 487 B. THE HAEMOPOIETIC SYSTEM
AND THE CLINICIAN 491 C. CIRCADIAN ASPECTS OF THE HAEMOPOIETIC SYSTEM
494 I. CIRCADIAN ASPECTS OF PROLIFERATIVE ACTIVITY IN MURINE BONE MARROW
494 II. CIRCADIAN STAGE-DEPENDENT CYTOTOXICITY OF MURINE BONE MARROW 498
CONTENTS XXI III. CIRCADIAN AND CIRCANNUAL PROLIFERATIVE ACTIVITY IN
HEALTHY HUMAN BONE MARROW 499 IV. CIRCADIAN VARIATION IN BONE MARROW DNA
SYNTHESIS IN CANCER PATIENTS 504 D. REGULATION OF HAEMOPOIETIC CIRCADIAN
RHYTHMS 507 E. CHRONOPHARMACOLOGICAL ASPECTS OF THE HAEMOPOIETIC SYSTEM
. . . 508 F. DISEASE-DEPENDENT CHRONOTHERAPEUTIC EFFECTS AND
CONSEQUENCES 511 G. MARKER RHYTHMS FOR PROLIFERATIVE ACTIVITY AND
CYTOTOXICITY OF THE BONE MARROW 513 H. CHRONOBIOLOGY OF PERIPHERAL BLOOD
IN HEALTH AND DISEASE 513 I. TOTAL WHITE BLOOD CELLS 514 II. NEUTROPHIL
LEUCOCYTES 515 III. LYMPHOCYTES 515 IV. EOSINOPHIL LEUCOCYTES 516 V.
NATURAL KILLER CELLS 516 VI. PLATELETS 517 I. CYCLIC HAEMOPOIESIS 517 J.
SCIENTIFIC AND CLINICAL IMPLICATIONS 519 REFERENCES 522 CHAPTER 19
CHRONOBIOLOGY OF THE HAEMOSTATIC SYSTEM F. ANDREOTTI AND G. PATTI. WITH
2 FIGURES 533 A. THE HAEMOSTATIC SYSTEM AND ITS LABORATORY EVALUATION
533 I. THE ENDOTHELIUM 533 II. VASOMOTION 533 III. PLATELETS 534 IV.
COAGULATION AND VISCOSITY 535 V. FIBRINOLYSIS 536 B. CHRONOBIOLOGY OF
THE HAEMOSTATIC SYSTEM 537 I. CIRCADIAN VARIATION OF ENDOTHELIAL CELL
FUNCTION 537 1. ENDOTHELIUM-RELATED FACTORS IN PLASMA 537 2. EFFECT OF
ENDOTHELIAL REMOVAL 539 3. ENDOTHELIAL REACTION TO STIMULI 539 II.
CIRCADIAN VARIATION OF VASOMOTOR FUNCTION 539 1. CORONARY ARTERY TONE
539 2. FOREARM ARTERIAL TONE 539 3. RESPONSE TO CONSTRICTOR OR DILATOR
STIMULI 540 III. CIRCADIAN VARIATION OF PLATELET FUNCTION 541 1.
PLATELET ADHESIVENESS AND SEROTONIN CONTENT 541 2. IN VIVO PLATELET
ACTIVATION AND AGGREGATION 541 3. PLATELET AGGREGATION IN VITRO 542 4.
PLATELET XXII CONTENTS IV. CIRCADIAN VARIATION OF COAGULATION 544 1.
GLOBAL MEASURES OF COAGULATION 544 2. SPECIFIC COAGULATION-RELATED
FACTORS 545 3. BLOOD VISCOSITY 546 V. CIRCADIAN VARIATION OF
FIBRINOLYTIC ACTIVITY 546 1. GLOBAL ASSAYS OF FIBRINOLYSIS 546 2.
INDIVIDUAL FIBRINOLYTIC FACTORS 547 3. POSSIBLE DETERMINANTS OF THE
CIRCADIAN VARIATION OFPAI-1 548 C. CONCLUSIONS 549 REFERENCES 550
CHAPTER 20 NEW TRENDS IN CHRONOTOXICOLOGY J. CAMBAR AND M. PONS. WITH 9
FIGURES 557 A. INTRODUCTION 557 B. GENERAL CHRONOTOXICITY 558 I.
CHEMICAL TOXIC AGENTS 558 II. NONCHEMICAL TOXIC AGENTS 562 C.
CHRONOTOXICOLOGICAL EXAMPLES IN NONRODENTS 563 D. ORGAN SPECIFIC
CIRCADIAN CHRONOTOXICITY 563 I. LIVER CHRONOTOXICITY
(CHRONOHEPATOTOXICITY) 564 II. EAR CHRONOTOXICITY 565 III. GASTRIC
CHRONOTOXICITY 567 IV. RENAL CHRONOTOXICITY 568 1. HEAVY METAL
CHRONONEPHROTOXICITY 568 2. ANTIBIOTIC CHRONONEPHROTOXICITY 570 3.
CYCLOSPORINE CHRONOTOXICITY 573 E. CHRONESTHESY AS A MECHANISTIC
APPROACH TO CHRONOTOXICOLOGY . . 578 F. CIRCANNUAL CHRONOTOXICOLOGY 580
G. GENERAL CONCLUSIONS 582 REFERENCES 583 CHAPTER 21 CHRONOPHARMACOLOGY
OF HI-RECEPTOR ANTAGONISTS: EXPERIMENTAL AND CLINICAL ASPECTS (ALLERGIC
DISEASES) A.E. REINBERG. WITH 7 FIGURES .589 A. HISTAMINE AND H R
RECEPTOR ANTAGONISTS: THE CONVENTIONAL PHARMACOLOGICAL APPROACH 589 B.
SKIN REACTIVITY TO HISTAMINE AND ALLERGENS 590 C. LUNG REACTIVITY TO
HISTAMINE AND ALLERGENS 592 CONTENTS XXIII D. DOSING-TIME-DEPENDENT
CHANGES IN THE ACUTE H R RECEPTOR ANTAGONIST EFFECTS OF FOUR AGENTS 592
I. CYPROHEPTADINE 592 II. CLEMASTINE AND TERFENADINE 595 R- III.
MEQUITAZINE 596 1. SKIN TESTS 596 2. PSYCHOPHARMACOLOGIC TESTS AND
PERFORMANCE 596 IV. REMARKS 596 E. CHRONOPHARMACOKINETICS OF MEQUITAZINE
597 F. CHRONESTHESY OF MEQUITAZINE WITH REFERENCE TO CHRONIC
ADMINISTRATION 599 I. SKIN TESTS * 599 II. BRONCHIAL TESTS AND
TEMPERATURE 599 HI. PSYCHOPHARMACOLOGICAL AND PERFORMANCE TESTS 599 IV.
REMARKS 601 G. CHRONOEPIDEMIOLOGY OF A POPULATION OF 765 ALLERGIC
PATIENTS 601 I. CIRCADIAN AND CIRCANNUAL RHYTHMS IN ALLERGIC SYMPTOMS
601 H. CHRONOTHERAPY OF ALLERGIC RHINITIS WITH MEQUITAZINE 603 I.
CHRONOTOLERANCE 603 II. CHRONOEFFECTIVENESS 603 III. REMARKS 603 I.
GENERAL COMMENTS 604 REFERENCES 605 CHAPTER 22 LOCAL ANAESTHETICS B.
BRUGUEROLLE. WITH 3 FIGURES 607 A. INTRODUCTION 607 B. EXPERIMENTAL
CHRONOPHARMACOLOGY OF LOCAL ANAESTHETICS 607 I. TIME DEPENDENCY IN
TOXICITY 607 II. TIME DEPENDENCY IN KINETICS 610 C. CLINICAL
PHARMACOLOGY OF LOCAL ANAESTHETICS 611 I. BASIS FOR CLINICAL
CHRONOPHARMACOLOGY 611 II. TIME DEPENDENCY IN EFFICIENCY 611 III. TIME
DEPENDENCY OF PHARMACOKINETICS IN MAN 612 D. POSSIBLE MECHANISMS
INVOLVED 614 E. CONCLUSIONS 616 REFERENCES 616 XXIV CONTENTS CHAPTER 23
BIOLOGICAL RHYTHMS IN PAIN AND ANALGESIA G. LABRECQUE, M. KARZAZI, AND
M.-C. VANIER. WITH 2 FIGURES . . . 619 A. INTRODUCTION 619 B.
PHYSIOLOGICAL MECHANISMS OF PAIN 620 I. PAIN CONDUCTION PATHWAYS 620 II.
NEUROTRANSMITTERS AND PAIN PERCEPTION 621 III. MEASUREMENTS OF PAIN 622
1. THE PAIN QUESTIONNAIRES 622 2. THE RATING SCALES 623 C. CHRONOBIOLOGY
OF PAIN 624 I. BIOLOGICAL RHYTHMS IN PAIN CONTROL MECHANISMS 624 II.
BIOLOGICAL RHYTHMS OF PAIN 628 1. PAIN STUDIES IN EXPERIMENTAL MODELS
628 2. PAIN STUDIES IN PATIENTS 632 D. CHRONOPHARMACOLOGY OF ANALGESICS
636 I. ANIMAL STUDIES 636 II. HUMAN STUDIES 637 1. PATIENTS WITH
ARTHRITIC PAIN 638 . 2. PATIENTS WITH POSTOPERATIVE AND CANCER PAIN 640
E. CONCLUSIONS 642 REFERENCES 644 SUBJECT INDEX 651
|
any_adam_object | 1 |
building | Verbundindex |
bvnumber | BV011081185 |
callnumber-first | Q - Science |
callnumber-label | QP905 |
callnumber-raw | QP905 RM301.3.C47 |
callnumber-search | QP905 RM301.3.C47 |
callnumber-sort | QP 3905 |
callnumber-subject | QP - Physiology |
classification_rvk | WD 8000 XI 1701 |
ctrlnum | (OCoLC)35198557 (DE-599)BVBBV011081185 |
dewey-full | 615/.1 612/.022 |
dewey-hundreds | 600 - Technology (Applied sciences) |
dewey-ones | 615 - Pharmacology and therapeutics 612 - Human physiology |
dewey-raw | 615/.1 612/.022 |
dewey-search | 615/.1 612/.022 |
dewey-sort | 3615 11 |
dewey-tens | 610 - Medicine and health |
discipline | Biologie Medizin |
format | Book |
fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02659nam a2200709 cb4500</leader><controlfield tag="001">BV011081185</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20140403 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">961118s1997 gw ad|| |||| 00||| eng d</controlfield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">948060361</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3540615253</subfield><subfield code="9">3-540-61525-3</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)35198557</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV011081185</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">DE</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield><subfield code="a">DE-19</subfield><subfield code="a">DE-12</subfield><subfield code="a">DE-20</subfield><subfield code="a">DE-11</subfield><subfield code="a">DE-188</subfield><subfield code="a">DE-578</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QP905</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RM301.3.C47</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">615/.1</subfield><subfield code="2">20</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">612/.022</subfield><subfield code="2">20</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WD 8000</subfield><subfield code="0">(DE-625)148246:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">XI 1701</subfield><subfield code="0">(DE-625)152977:12907</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">QV 4</subfield><subfield code="2">nlm</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Physiology and pharmacology of biological rhythms</subfield><subfield code="b">[with 43 tables]</subfield><subfield code="c">contributors F. Andreotti ... Ed. P. H. Redfern ...</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Berlin [u.a.]</subfield><subfield code="b">Springer</subfield><subfield code="c">1997</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XXIV, 668 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Handbook of experimental pharmacology</subfield><subfield code="v">125</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Biological Rhythms</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Physiological Effects</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Pharmacology</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Biologisch ritme</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Circadiaans ritme</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Cronofarmacologia</subfield><subfield code="2">larpcal</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Farmacologie</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chronobiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chronobiology Phenomena</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chronopharmacology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Circadian Rhythm</subfield><subfield code="x">drug effects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Circadian Rhythm</subfield><subfield code="x">physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Drug Therapy</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Chronopharmakologie</subfield><subfield code="0">(DE-588)4127100-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Pharmakologie</subfield><subfield code="0">(DE-588)4045687-0</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Biorhythmus</subfield><subfield code="0">(DE-588)4006896-1</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Chronobiologie</subfield><subfield code="0">(DE-588)4140668-0</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4143413-4</subfield><subfield code="a">Aufsatzsammlung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Chronopharmakologie</subfield><subfield code="0">(DE-588)4127100-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Chronobiologie</subfield><subfield code="0">(DE-588)4140668-0</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="2" ind2="0"><subfield code="a">Biorhythmus</subfield><subfield code="0">(DE-588)4006896-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="2" ind2="1"><subfield code="a">Pharmakologie</subfield><subfield code="0">(DE-588)4045687-0</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="2" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Redfern, Peter H.</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Andreotti, Felicita</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="830" ind1=" " ind2="0"><subfield code="a">Handbook of experimental pharmacology</subfield><subfield code="v">125</subfield><subfield code="w">(DE-604)BV002390716</subfield><subfield code="9">125</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">GBV Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007424041&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-007424041</subfield></datafield></record></collection> |
genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
genre_facet | Aufsatzsammlung |
id | DE-604.BV011081185 |
illustrated | Illustrated |
indexdate | 2024-07-09T18:03:42Z |
institution | BVB |
isbn | 3540615253 |
language | English |
oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007424041 |
oclc_num | 35198557 |
open_access_boolean | |
owner | DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-12 DE-20 DE-11 DE-188 DE-578 |
owner_facet | DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-12 DE-20 DE-11 DE-188 DE-578 |
physical | XXIV, 668 S. Ill., graph. Darst. |
publishDate | 1997 |
publishDateSearch | 1997 |
publishDateSort | 1997 |
publisher | Springer |
record_format | marc |
series | Handbook of experimental pharmacology |
series2 | Handbook of experimental pharmacology |
spelling | Physiology and pharmacology of biological rhythms [with 43 tables] contributors F. Andreotti ... Ed. P. H. Redfern ... Berlin [u.a.] Springer 1997 XXIV, 668 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Handbook of experimental pharmacology 125 Biological Rhythms cabt Physiological Effects cabt Pharmacology cabt Biologisch ritme gtt Circadiaans ritme gtt Cronofarmacologia larpcal Farmacologie gtt Chronobiology Chronobiology Phenomena Chronopharmacology Circadian Rhythm drug effects Circadian Rhythm physiology Drug Therapy Chronopharmakologie (DE-588)4127100-2 gnd rswk-swf Pharmakologie (DE-588)4045687-0 gnd rswk-swf Biorhythmus (DE-588)4006896-1 gnd rswk-swf Chronobiologie (DE-588)4140668-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Chronopharmakologie (DE-588)4127100-2 s DE-604 Chronobiologie (DE-588)4140668-0 s Biorhythmus (DE-588)4006896-1 s Pharmakologie (DE-588)4045687-0 s Redfern, Peter H. Sonstige oth Andreotti, Felicita Sonstige oth Handbook of experimental pharmacology 125 (DE-604)BV002390716 125 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007424041&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | Physiology and pharmacology of biological rhythms [with 43 tables] Handbook of experimental pharmacology Biological Rhythms cabt Physiological Effects cabt Pharmacology cabt Biologisch ritme gtt Circadiaans ritme gtt Cronofarmacologia larpcal Farmacologie gtt Chronobiology Chronobiology Phenomena Chronopharmacology Circadian Rhythm drug effects Circadian Rhythm physiology Drug Therapy Chronopharmakologie (DE-588)4127100-2 gnd Pharmakologie (DE-588)4045687-0 gnd Biorhythmus (DE-588)4006896-1 gnd Chronobiologie (DE-588)4140668-0 gnd |
subject_GND | (DE-588)4127100-2 (DE-588)4045687-0 (DE-588)4006896-1 (DE-588)4140668-0 (DE-588)4143413-4 |
title | Physiology and pharmacology of biological rhythms [with 43 tables] |
title_auth | Physiology and pharmacology of biological rhythms [with 43 tables] |
title_exact_search | Physiology and pharmacology of biological rhythms [with 43 tables] |
title_full | Physiology and pharmacology of biological rhythms [with 43 tables] contributors F. Andreotti ... Ed. P. H. Redfern ... |
title_fullStr | Physiology and pharmacology of biological rhythms [with 43 tables] contributors F. Andreotti ... Ed. P. H. Redfern ... |
title_full_unstemmed | Physiology and pharmacology of biological rhythms [with 43 tables] contributors F. Andreotti ... Ed. P. H. Redfern ... |
title_short | Physiology and pharmacology of biological rhythms |
title_sort | physiology and pharmacology of biological rhythms with 43 tables |
title_sub | [with 43 tables] |
topic | Biological Rhythms cabt Physiological Effects cabt Pharmacology cabt Biologisch ritme gtt Circadiaans ritme gtt Cronofarmacologia larpcal Farmacologie gtt Chronobiology Chronobiology Phenomena Chronopharmacology Circadian Rhythm drug effects Circadian Rhythm physiology Drug Therapy Chronopharmakologie (DE-588)4127100-2 gnd Pharmakologie (DE-588)4045687-0 gnd Biorhythmus (DE-588)4006896-1 gnd Chronobiologie (DE-588)4140668-0 gnd |
topic_facet | Biological Rhythms Physiological Effects Pharmacology Biologisch ritme Circadiaans ritme Cronofarmacologia Farmacologie Chronobiology Chronobiology Phenomena Chronopharmacology Circadian Rhythm drug effects Circadian Rhythm physiology Drug Therapy Chronopharmakologie Pharmakologie Biorhythmus Chronobiologie Aufsatzsammlung |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007424041&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
volume_link | (DE-604)BV002390716 |
work_keys_str_mv | AT redfernpeterh physiologyandpharmacologyofbiologicalrhythmswith43tables AT andreottifelicita physiologyandpharmacologyofbiologicalrhythmswith43tables |