Human B cell superantigens:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Springer [u.a.]
1996
|
| Schriftenreihe: | Molecular biology intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 270 S. Ill., graph. Darst. |
| ISBN: | 157059385X 3540614494 |
Internformat
MARC
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| 084 | |a XD 3100 |0 (DE-625)152552:12905 |2 rvk | ||
| 245 | 1 | 0 | |a Human B cell superantigens |c Moncef Zouali |
| 264 | 1 | |a New York [u.a.] |b Springer [u.a.] |c 1996 | |
| 300 | |a 270 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Molecular biology intelligence unit | |
| 650 | 0 | 7 | |a B-Lymphozyt |0 (DE-588)4137121-5 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Superantigen |0 (DE-588)4312998-5 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 655 | 7 | |a Lymphozytantigen |2 gnd |9 rswk-swf | |
| 689 | 0 | 0 | |a B-Lymphozyt |0 (DE-588)4137121-5 |D s |
| 689 | 0 | 1 | |a Superantigen |0 (DE-588)4312998-5 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Lymphozytantigen |A f |
| 689 | 1 | 1 | |a Superantigen |0 (DE-588)4312998-5 |D s |
| 689 | 1 | |5 DE-604 | |
| 700 | 1 | |a Zouali, Moncef |d 1952- |e Sonstige |0 (DE-588)113811780 |4 oth | |
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Datensatz im Suchindex
| _version_ | 1808137242802126848 |
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| adam_text |
CONTENTS
1.
ORGANIZATION
OF
THE
HUMAN
VH
LOCUS
AND
REARRANGEMENT
PATTERNS
OF
THE
VH3
GENE
FAMILY
.
1
ERIC
C.
B.
MILNER
INTRODUCTION
.
1
POLYMORPHISM
OF
VH3
GENES
.
2
HAPLOTYPE
STRUCTURE
.
4
PATTERNS
OF
VH3
EXPRESSION
.
5
DISCUSSION
.
7
2.
FRAMEWORK
STRUCTURES
OF
IMMUNOGLOBULIN
VARIABLE
DOMAINS:
IMPLICATIONS
FOR
ANTIGEN
AND
SUPERANTIGEN
BINDING
.
11
ALFONSO
TRAMONTANE
INTRODUCTION
.
11
FR
CONTRIBUTIONS
TO
AG
BINDING
.
12
FUNCTIONAL
CORRELATES
FOR
FR
STRUCTURES
OF
V
DOMAINS
.
14
UNCONVENTIONAL
V
DOMAIN
BINDING
.
15
VH
FAMILY
HOMOLOGIES
AND
FR
.
16
CONSERVED
STRUCTURES
AND
SURFACE
TOPOLOGY
.
17
IMPLICATIONS
FOR
SAG
RECOGNITION
.
19
IG
AND
TCR
V
REGION
ANALOGY
AND
SAG
RECOGNITION
.
23
3.
FUNCTIONAL
IMPLICATIONS
OF
IMMUNOGLOBULIN
VH
GERMLINE
GENES
-
VH3
SUPERANTIGEN
STAPHYLOCOCCAL
PROTEIN
A
AND
VH
GENE
POLYMORPHISM
.
31
ERIC
H.
SASSO
INTRODUCTION
-
IMMUNOGLOBULIN
VH
GENES
.
31
STAPHYLOCOCCAL
PROTEIN
A
-
THE
PROTOTYPE
B
CELL
SUPERANTIGEN
.
32
POLYMORPHISM
OF
IG
VH
GENES
-
IMPLICATIONS
FOR
SUPERANTIGEN
EFFECTS
.
40
4.
MOLECULAR
CHARACTERIZATION
OF
THE
INTERACTION
OF
IMMUNO
GLOBULIN
VARIABLE
REGION
WITH
STAPHYLOCOCCAL
PROTEIN
A
.53
SALEH
M.
IBRAHIM
INTRODUCTION
.
53
KEY
IMMUNOGLOBULIN
GENE
SEGMENTS
DETERMINING
THE
FAB-SPA
BINDING
.54
SPA-BINDING
AS
A
MARKER
OF
A
HUMAN
IMMUNOGLOBULIN
SUBSET
.
62
FREQUENCY
OF
SPA-BINDERS
IN
IMMUNOGLOBULIN
ISOTYPES
.
63
FREQUENCY
OF
SPA
BINDING
AS
A
FUNCTION
OF
AGE
.
63
FREQUENCY
OF
SPA-BINDERS
IN
AG-SPECIFIC
ANTIBODY
POPULATIONS
.
63
DISCUSSION
.
64
5.
B
CELL
SUPERANTIGENS
AND
THE
SOMATIC
DIVERSIFICATION
OF
IMMUNE
REPERTOIRES:
MOLECULAR
AND
CELLULAR
IMPLICATIONS
.
67
GREGG
J.
SILVERMAN
INTRODUCTION
.
67
SPECIFICITY
AND
AFFINITY
OF
AB
BINDING
TO
SPA
.69
THE
GERMLINE
GENE
VH3-23
APPEARS
TO
ENCODE
FOR
OPTIMAL
SPA
BINDING
ACTIVITY
.
72
LOCALIZATION
OF
THE
VH
REGION
BINDING
SITE
FOR
STAPHYLOCOCCAL
PROTEIN
A
.
73
CHARACTERIZATION
OF
THE
SITE(S)
ON
SPA
THAT
BIND
ABS
.
75
SPA
BINDING
AMONGST
HUMAN
B
CELL
SUBSETS
.
76
CHARACTERIZATION
OF
THE
AB
SITE
RESPONSIBLE
FOR
PROTEIN
FV
BINDING
.
79
PROTEIN
FV
AND
SPA
BIND
TO
SIMILAR
VH
FAB
SITES
.
82
DISCUSSION
.
83
6.
STAPHYLOCOCCAL
PROTEIN
A
AND
STAPHYLOCOCCAL
ENTEROTOXINS:
TWO
MODEL
B
CELL
SUPERANTIGENS
.89
RANA
DOMIATI-SAAD
AND
PETER
E.
LIPSKY
INTRODUCTION
.
89
STAPHYLOCOCCAL
PROTEIN
A
.
91
STAPHYLOCOCCAL
ENTEROTOXINS
.
93
DISCUSSION
.
94
7.
STAPHYLOCOCCAL
PROTEIN
A:
FUNCTIONAL
PROPERTIES
OF
A
MODEL
B
CELL
SUPERANTIGEN
.
99
ARNOLD
I.
LEVINSON
AND
LISA
M.
KOZLOWSKI
INTRODUCTION
.
99
BINDING
OF
SPA
TO
B
CELLS
EXPRESSING
VH3+
IGS
.
100
INDUCTION
OF
AUTOANTIBODY
PRODUCTION
BY
SPA
.
101
ACTIVATION
OF
COMPLEMENT
BY
SPA
.
104
DISCUSSION
.
106
8.
LOW-AFFINITY
BINDING
OF
HUMAN
IMMUNOGLOBULIN
VARIABLE
DOMAINS:
A
NEW
SUPERANTIGEN
IN
ESCHERICHIA
COIP.
.113
MATS
OHLIN,
CHRISTINA
FUREBRING
AND
CARL
A.
K
BORREBAECK
INTRODUCTION
.
113
IDENTIFICATION
OF
AN
E.
COLI
IG-BINDING
SAG
COMPONENT
.
114
DISCUSSION
.
115
9.
GENETIC
BASIS
AND
SOMATIC
EVOLUTION
OF
A
HUMAN
POLYSACCHARIDE-SPECIFIC
ANTIBODY
REPERTOIRE
.
121
ALEXANDER
H.
LUCAS
INTRODUCTION
.
121
GENETIC
BASIS
OF
THE
ANTI-HIB
REPERTOIRE
.
122
SPECIFICITY
.
124
AGE-RELATED
V
EXPRESSION
.
126
OLIGOCLONALITY
AND
PREDOMINANCE
OF
KII-A2
ABS
.
128
IMMUNOGEN
STRUCTURE
AFFECTS
V
REGION
EXPRESSION
AND
AB
FUNCTION
.
129
POSSIBLE
MECHANISMS
OFVH
RESTRICTION
.
129
VL
RESTRICTION
AND
CLONAL
DOMINANCE
.
132
SOMATIC
MUTATION
.
134
EVOLUTIONARY
CONSIDERATIONS
.
135
SUMMARY
.
136
10.
THE
HIV-1
GPL20
SUPERANTIGEN:
STRUCTURAL
FEATURES
AND
ROLE
IN
VIRAL
HOST-PATHOGEN
INTERACTION
.
145
LEE
GOODGLICK,
JANET
TOWNSLEY-FUCHS,
RICK
M.
FAIRHURST,
MEHRAN
NESHAT,
DENISE
MARCELO,
DONALD.
E.
MOSIER
AND
JONATHAN
BRAUN
HIV
INFECTION
CAUSES
DYSFUNCTION
OF
B
CELLS
AND
HUMORAL
IMMUNITY
.
145
SELECTIVE
BINDING
OF
HIV
1
GPL20
BY
VH3
IG
.
147
RELATIONSHIP
OFVH3
BINDING
TO
GPL20,
SPA,
AND
POLYREACTIVITY
.
149
DEFINING
THE
INTERACTION
DOMAINS
.
150
IMMUNOBIOLOGY
OF
THE
GPL20-VH3
INTERACTION:
GPL20-BINDING
AS
A
STABLE
POLYMORPHIC
TRAIT
.
153
ROLE
OF
NATURAL
VH3
ANTI-GPL20
ANTIBODIES
IN
RESISTANCE
TO
HIV
INFECTION
.
154
DISCUSSION
.
155
11.
SUPERANTIGENS
AND
THE
VERSATILITY
OF
HIV-MEDIATED
B
CELL
INTERACTIONS
.
161
SAOUSSEN
KARRAY,
LAURE
JUOMPAN
AND
MONCEFZOUALI
INTERSPERSION,
POLYMORPHISM
AND
SHUFFLING
OF
HUMAN
VH
GENES.
162
PHYLOGENETIC
CONSERVATION
OFVH3-LIKE
GENES
.
163
OVER-EXPRESSION
OF
VH3
GENE
MEMBERS
.
163
ANTIBODIES
TO
PATHOGENS
USE
PREDOMINANTLY
VH3
GENES
.
163
B
CELL
ABNORMALITIES
IN
HIV
INFECTION
.
164
PROBING
THE
ANTI-HIV
ANTIBODY
REPERTOIRE
BY
COMBINATORIAL
LIBRARIES
.
164
SKEWED
VH
GENE-FAMILY
UTILIZATION
IN
MONOCLONAL
ANTIBODIES
TO
HIV
.
165
LACK
OF
CONTINUED
DIVERSIFICATION
OF
THE
ANTI-HIV
ANTIBODY
RESPONSE
.
167
B
CELL
SUPERANTIGENS
AND
REPERTOIRE
BIAS
IN
HIV
INFECTION
.
167
SUPERANTIGENS
FOR
T
CELLS
DURING
HIV
INFECTION
.
168
THE
POWER
OF
MICROBIAL
ADAPTATION
.
171
12.
PROTEIN
FV
(FV
FRAGMENT
BINDING
PROTEIN):
A
MUCOSAL
HUMAN
SUPERANTIGEN
REACTING
WITH
NORMAL
IMMUNOGLOBULINS
.179
JEAN-PIERRE
BOUVET,
RENE
PIRES
AND
CANH
P.
QUAN
DETECTION
OF
PFV
IN
PATIENTS
WITH
HEPATITIS
.
179
MOLECULAR
CHARACTERISTICS
.
181
BINDING
SPECIFICITY
.
181
PRESENCE
IN
NORMAL
SUBJECTS
AND
IN
OTHER
ANIMAL
SPECIES
.
183
VALENCY
AND
STRUCTURE
OF
PFV
.
184
ATTEMPTS
TO
PURIFY
PFV
.
184
SEMI-QUANTITATIVE
MEASUREMENT
.
185
TISSUE
ORIGIN
OF
PFV
.
185
"
IMMUNE
FORTRESSES
"
IN
THE
DIGESTIVE
LUMEN
.
185
COMPLEMENT
ACTIVATION
AND
SUPERALLERGEN
PROPERTIES
.
186
RELATIONSHIP
WITH
B
CELL
SUPERANTIGENS
.
186
CONCLUDING
REMARKS
.
186
13.
IMMUNOGLOBULIN
NUCLEOTIDE
BINDING
SITE:
A
POSSIBLE
SUPERANTIGEN
RECEPTOR
.189
HEINZ
KOHLER,
GABRIELA
PAVLINKOVA
AND
BOYD
HALEY
INTRODUCTION
.
189
THE
DISCOVERY
OF
A
NUCLEOTIDE
BINDING
SITE
IN
ANTIBODIES
.
190
CHARACTERIZATION
OF
THE
ATP-BINDING
SITE
.
191
THE
UTILITY
OF
THE
SITE
FOR
CHEMICAL
ANTIBODY
ENGINEERING
.
193
CONCLUSION
.
193
14.
SUPERANTIGEN-INDUCED
STIMULATION
OF
RHEUMATOID
FACTOR
PRODUCING
B
CELLS
.
195
JORG
J.
GORONZY,
XIAOWEN
HE
AND
CORNELIA
M.
WEYAND
INTRODUCTION
.
195
STIMULATION
WITH
THE
BACTERIAL
SUPERANTIGEN
SED
PREFERENTIALLY
INDUCES
RF
PRODUCTION
.
196
MOLECULAR
CHARACTERIZATION
OF
IMMUNOGLOBULIN
HEAVY
CHAIN
SEQUENCES
OF
SED
STIMULATED
B
CELLS
.
198
COMPARISON
OF
RFS
PRODUCED
BY
RA
AND
PSS
PATIENTS
AND
SED
INDUCED
RFS
FROM
NORMAL
CONTROLS
.
200
DISCUSSION
.
202
15.
SUPERANTIGEN-DEPENDENT
T
H
CELL/B
CELL
INTERACTION:
A
MODEL
FOR
TYY
CELL-MEDIATED
B
CELL
ACTIVATION
RI
AND
APOPTOSIS
.
209
ELAINE
J.
SCHATTNER,
DAE-HYUN
YOO,
MARY
K.
CROW
AND
STEVEN
M.
FRIEDMAN
INTRODUCTION
.
209
SAGS
MEDIATE
PRODUCTIVE
T
H
/B
CELL
INTERACTION
.
210
SAG-DEPENDENT
T
H
/B
CELL
INTERACTION
CAN
RESULT
IN
B
CELL
APOPTOSIS
.
213
POTENTIAL
ROLE
FOR
SAG
IN
AUTOIMMUNE
DISEASE
PATHOGENESIS
.
217
SAG
AND
SAG-T
CD4+
T
CELLS
INDUCE
FAS-MEDIATED
APOPTOSIS
OF
MALIGNANT
HUMAN
B
CELLS
.
218
DISCUSSION
.
220
16.
VARIABLE
REGION
GENES
OF
HUMAN
ANTIBODIES
TO
RED
BLOOD
CELLS:
POTENTIAL
TARGETS
FOR
SUPERANTIGEN
INTERACTION
.
225
KATHLEEN
N
POTTER,
J.
DONALD
CAPRA
AND
VIRGINIA
PASCUAL
INTRODUCTION
.
225
RED
BLOOD
CELL
ANTIGENS
.
226
ANTI-I/I
ANTIBODIES
.
226
ANTI-RH
D,
C,
C,
E,
E
ANTIBODIES
.
232
ANTI-PR2
ANTIBODIES
.
233
ANTI-MN
ANTIBODIES
.
233
ANTI-SA,
LUD,
FL,
VO,
LI,
AND
GD
ANTIBODIES
.
234
DISCUSSION
.
243
17.
CD4-IMMUNOGLOBULIN
INTERACTION:
A
PROPOSAL
FOR
A
NOVEL
SELF-REGULATORY
CIRCUIT
.
253
PETAR
LENERT
AND
MAURIZIO
ZANETTI
INTRODUCTION
.
253
CD4
-
K
MULTIFUNCTIONAL
RECEPTOR
MOLECULE
.
254
CD4
AND
ITS
LIGANDS
.
254
CD4/IMMUNOGLOBULIN
INTERACTION
.
254
CD4
BINDING
IS
MEDIATED
BY
THE
VH
DOMAIN
OF
THE
IG
MOLECULE
.
257
IMMUNOCHEMISTRY
OF
THE
CD4-IG
INTERACTION
.
258
SUPERANTIGEN
FUNCTION
OF
CD4
.
259
HYPOTHESIS
AND
CONCLUSIONS
.
261
INDEX
.
267 |
| any_adam_object | 1 |
| author_GND | (DE-588)113811780 |
| building | Verbundindex |
| bvnumber | BV011077193 |
| classification_rvk | XD 3100 |
| ctrlnum | (OCoLC)260222364 (DE-599)BVBBV011077193 |
| discipline | Medizin |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content Lymphozytantigen gnd |
| genre_facet | Aufsatzsammlung Lymphozytantigen |
| id | DE-604.BV011077193 |
| illustrated | Illustrated |
| indexdate | 2024-08-23T00:47:27Z |
| institution | BVB |
| isbn | 157059385X 3540614494 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007420829 |
| oclc_num | 260222364 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-12 |
| owner_facet | DE-355 DE-BY-UBR DE-12 |
| physical | 270 S. Ill., graph. Darst. |
| publishDate | 1996 |
| publishDateSearch | 1996 |
| publishDateSort | 1996 |
| publisher | Springer [u.a.] |
| record_format | marc |
| series2 | Molecular biology intelligence unit |
| spelling | Human B cell superantigens Moncef Zouali New York [u.a.] Springer [u.a.] 1996 270 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit B-Lymphozyt (DE-588)4137121-5 gnd rswk-swf Superantigen (DE-588)4312998-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Lymphozytantigen gnd rswk-swf B-Lymphozyt (DE-588)4137121-5 s Superantigen (DE-588)4312998-5 s DE-604 Lymphozytantigen f Zouali, Moncef 1952- Sonstige (DE-588)113811780 oth DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007420829&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Human B cell superantigens B-Lymphozyt (DE-588)4137121-5 gnd Superantigen (DE-588)4312998-5 gnd |
| subject_GND | (DE-588)4137121-5 (DE-588)4312998-5 (DE-588)4143413-4 |
| title | Human B cell superantigens |
| title_auth | Human B cell superantigens |
| title_exact_search | Human B cell superantigens |
| title_full | Human B cell superantigens Moncef Zouali |
| title_fullStr | Human B cell superantigens Moncef Zouali |
| title_full_unstemmed | Human B cell superantigens Moncef Zouali |
| title_short | Human B cell superantigens |
| title_sort | human b cell superantigens |
| topic | B-Lymphozyt (DE-588)4137121-5 gnd Superantigen (DE-588)4312998-5 gnd |
| topic_facet | B-Lymphozyt Superantigen Aufsatzsammlung Lymphozytantigen |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007420829&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT zoualimoncef humanbcellsuperantigens |