Update on hair disorders:
Gespeichert in:
Format: | Buch |
---|---|
Sprache: | English |
Veröffentlicht: |
Philadelphia [u.a.]
Saunders
1996
|
Schriftenreihe: | Dermatologic clinics
14,4 |
Schlagworte: | |
Online-Zugang: | Inhaltsverzeichnis |
Beschreibung: | XVI S., S. 543 - 826 Ill., graph. Darst. |
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adam_text | I UPDATE ON HAIR DISORDERS
CONTENTS
Preface xv
David A. Whiting
Basic Science Aspects of Hair Disorders
Hair Follicle Growth Controls 543
Kurt S. Stenn, Nickolas J. Combates, Kenneth J. Eilertsen, Joel S. Gordon,
Jose R. Pardinas, Satish Parimoo, and Stephen M. Prouty
Research in hair biology has embarked in the pursuit for molecules that
control hair growth. Many molecules already have been associated with
the controls of hair patterning, hair maturation, and hair cycling and
differentiation. Knowing how these molecules work gives us the tools for
understanding and treating patients with hair disorders.
Growth Factors in Hair Organ Development and The Hair Growth Cycle 559
Dominik Peus and Mark R. Pittelkow
Growth factors are polypeptides that regulate growth and differentiation
of many cell types. Different growth factor families including the epider¬
mal growth factor (EGF) related ligands, fibroblast growth factors (FGF),
transforming growth factor (3 (TGF p), insulin like growth factor (IGF),
hepatocyte growth factor/scatter factor (HGF/SF), and platelet derived
growth factor (PDGF) have been shown to be crucial for the regulation of
the hair cycle and hair growth. Growth factors and their receptors have
been localized to the skin and hair follicles. Their biological activities on
cells comprising the hair follicle have been tested in vitro and increasingly
in transgenic mice. Herein we review selected important aspects of growth
factors with regard to the hair organ, its development, and the hair
growth cycle.
Dermal Epidermal Interactions: Adult Follicle Derived Cell
Populations and Hair Growth 573
Colin A. B. Jahoda and Amanda J. Reynolds
Intrinsic dermal epidermal interactions are central to the development
and growth of hair. This article describes investigations into the inductive
DERMATQLOGIC CLINICS
properties of specific dermal and epidermal cell populations from adult
follicles by means of cell culture and in vivo implantation. It highlights
the inductive powers of cultured dermal papilla cells and the more recent
finding that the germinative epidermal cells of the lower follicle also can
stimulate hair growth. How the reconstruction of a hair follicle from its
constituent parts has been achieved is described. The significance of these
findings is considered with reference to human hair growth, tissue engi¬
neering, and the prospects for elucidating the molecular signalling mecha¬
nisms that underpin dermal epidermal interplay.
The Use of Dermal Papilla Cells in Studies of Normal and Abnormal
Hair Follicle Biology 585
Valerie Anne Randall
The mesenchyme derived dermal papilla plays a major regulatory role in
the complex cell biology of the hair follicle. The ability to culture dermal
papilla cells from a range of species and particularly a range of normal
and disordered human hair follicles has enabled the development of a
powerful new model system for investigating hair follicle biology. Already
these studies have reinforced the importance of dermal papilla cells in
initiating new follicle growth and in androgen action in human hair
follicles. The retention of hair growth inducing capabilities and characteris¬
tics that reflect their in vivo responsiveness to androgens in culture means
that they offer a potentially useful approach despite significant drawbacks
in working with the cells themselves. Further studies using dermal papilla
cells may well elucidate key molecules involved in hair biology in health
and disease and, thereby, lead to better therapeutic regimens.
Whole Hair Follicle Culture 595
Michael P. Philpott, Deborah A. Sanders, and Terence Kealey
In this article the authors have reviewed the historical background behind
the organ culture of whole hair follicles. The methods developed by the
authors and others for the isolation and whole organ maintenance of hair
follicles from both human and other species are described. How whole
organ models have been used to further understanding of the biology of
the hair follicle and how they may be used in the future are discussed.
The Growth of Human Hair in Nude Mice 609
Dominique Van Neste
The author reviews published papers on human hair growth in nude mice.
There is evidence from various sources indicating that grafting of human
scalp onto nude mice does not modify significantly morphogenesis, hair
follicle structure and function, and composition of the newly grown hair
fiber. On the basis of personal observations, the author further highlights
the results obtained in genetic hair defects. Hints are given as to the
potential use of the model for drug discovery programs as the product
can be used on the human target at early stages of drug development.
Mouse Models for the Study of Human Hair Loss 619
John P. Sundberg and Lloyd E. King, Jr
This article provides an overview of the advantages and disadvantages of
laboratory mice as models for studying hair biology. Comparisons are
provided of normal skin and hair between the two species as well as an
overview of models for hirsutism, hair cycle, inflammatory and nonin¬
flammatory nonscarring alopecia, scarring alopecia without inflammation,
and scarring alopecia with inflammation. Examples are provided to illus¬
trate how skin and bone marrow grafting techniques can be used to
address fundamental dermatologic questions.
Hair Keratinization in Health and Disease 633
Leslie N. Jones and Peter M. Steinert
The cells of the epidermis and its derivative, the hair follicle, undergo
processes of terminal differentiation that involves the synthesis and assem¬
bly of classes of protein and enzymes to form the stratum corneum of the
epidermis, and the hair fiber and its cuticle. Using genetic linkage and
DNA sequencing methods, we now know that mutations in several genes
encoding epidermal keratins or a transglutaminase enzyme cause ichthyo
sis related diseases. Similar methods have now suggested that mutations
in hair keratin genes underlie some cases of monilethrix, and a deficiency
in a cuticle lipid metabolizing enzyme causes maple syrup urine disease.
It is to be expected that further application of these methods will elucidate
the molecular bases of other genetic hair diseases.
Relationship Between Follicular Nerve Supply and Alopecia 651
Maria K. Hordinsky and Marna E. Ericson
The peripheral cutaneous nervous system is associated with the delivery
of neuropeptides that modulate inflammatory and proliferative processes.
The focus of this article is on the network of nerves associated with
the normal human hair follicle and those affected by alopecia areata or
androgenetic alopecia. Methods used to study nerves and current concepts
about the innervation of the human scalp hair follicle are reviewed.
The Pathogenesis of Alopecia Areata 661
A. J. G. McDonagh and A. G. Messenger
Knowledge of the disease mechanisms in alopecia areata is discussed in
the light of progress in hair biology, immunology, and genetics. A disease
model is presented incorporating polygenic determination of disease se¬
verity and susceptibility with largely unknown trigger factors responsible
for initiating clinical disease expression. Experimental systems including
animal models for alopecia areata offer new opportunities for investigation
of alopecia areata and developing novel therapies.
Genetic Control of Cytokines: Cytokine Gene Polymorphisms in
Alopecia Areata 671
Michael J. Cork, Alison M. Crane, and Gordon W. Duff
It is likely that alopecia areata is a multifactorial disease determined by
a combination of genetic and environmental factors. The interaction of
susceptibility genes with environmental factors gives rise to the disease
phenotype, and then genetic modifying factors determine the extent of the
inflammatory response and thereby the clinical outcome. Cytokines regu¬
late the inflammatory response. Polymorphisms in these genes may there¬
fore determine the amount of a cytokine that is produced in response to
an environmental trigger such as a bacterial or viral infection.
Heritable Factors Distinguish Two Types of Alopecia Areata 679
Vera H. Price and Beth W. Colombe
Alopecia areata (AA) has been shown to be associated with the inheritance
of HLA class II alleles. HLA DQ3 appears to be the general susceptibility
allele for AA. Patients with long standing disease patterns, namely, long
term patchy AA and long term alopecia totalis and alopecia universalis
(AT/AU), can be differentiated by their particular HLA associations. Long¬
standing AT/AU patients have unique and highly significant associations
with HLA antigens DR4, DR11, and DQ7. A complex of early onset,
disease severity, family incidence, and associations with HLA DR antigens
are characteristic of long standing AT/AU as distinct from long standing
patchy AA.
Clinical Aspects of Hair Disorders
A Simplified Approach to the Diagnosis of Alopecia 691
Robert L. Rietschel
Two elements of the medical history—age and duration of alopecia—
coupled with four elements of the physical examination—scalp status,
pattern of hair loss, pull test, and units—can be used to determine the
major pathologic conditions causing alopecia. This method assumes a
working knowledge of the major diseases that cause alopecia.
Androgen Metabolism as it Affects Hair Growth in
Androgenetic Alopecia 697
Keith D. Kaufman
Androgens, in combination with a genetic susceptibility, have been dem¬
onstrated to be required for the development of androgenetic alopecia.
Disturbances in androgen metabolism or target organ sensitivity are
thought to underlie the pathophysiology of the condition. Observations of
patients with disorders of androgen metabolism or function have deter¬
mined the basic physiology involved in regulation of hair growth by
androgens at selective body sites. More recently, in vitro studies of scalp
skin and hair follicles have begun to define specific alterations in androgen
metabolism at the local level that may play a key role in pathogenesis.
The prominent role of 5 reductase in these studies suggests that inhibitors
of this enzyme may provide new therapeutic opportunities for patients
with androgenetic alopecia.
Photographic Documentation of Hair Growth in
Androgenetic Alopecia 713
Douglas Canfield
The ability to photodocument the outcomes of patients with androgenetic
alopecia allows for better assessment of therapy efficacy. The photogra¬
pher s challenge is to control the variables inherent with photography to
allow for reproducible serial photographs to be taken. The physician
and patient will benefit from better quality photographic documentation.
Examples of serial photographs and technical methods are reviewed.
Chronic Telogen Effluvium 723
David A. Whiting
Some patients with idiopathic diffuse hair loss present with chronic telo¬
gen effluvium. Most of these cases are women aged 30 to 60 years who
complain of severe hair shedding. Many describe unusually dense hair
prior to an abrupt onset of hair loss. The subsequent shedding fluctuates
in severity and may persist for years. Distinctive clinical and histologic
criteria for the diagnosis of chronic telogen effluvium are described.
Treatment of Alopecia Areata 733
Virginia C. Fiedler and Samer Alaiti
Studies suggest that several agents may be useful treatments for alopecia
areata. Alopecia areata that is extensive or is associated with atopy is the
hardest to treat and may require long term therapy to establish and main
tain cosmetic hair growth. Efficacy, long term safety, and cost are all
significant considerations in choosing a treatment.
Topical Immunotherapy in Alopecia Areata: What, How, and Why? 739
Rolf Hoffmann and Rudolf Happle
At present, the induction and elicitation of an allergic contact dermatitis
(ACD) with potent contact allergens such as diphenylcyclopropenone ap¬
pears to be the most effective, but still not definitively curative, approach
to treat extensive forms of alopecia areata (AA). Experimental data suggest
that cytokines and growth factors such as IL lp are involved in the
pathogenesis of AA as well as the therapeutic effect mediated by contact
sensitizers. It seems reasonable to assume that factors inherent in the late
phase of ACD modulate a T cell mediated mechanism responsible for AA,
thus inducing hair regrowth. Such counteracting activities are most likely
mediated by promflammatory cytokines such as TNF a, IL 10, or TGF fil.
This hypothesis may oversimplify the underlying immunological mecha¬
nisms, but the effectiveness of topical immunotherapy in AA would be
compatible with this concept. This mode of treatment is, however, a rather
rough approach and recurrences are possible. Hopefully, advances in basic
science will eventually allow us to find a more specific mode of treatment.
Loose Anagen Syndrome and Loose Anagen Hair 745
Vincent W. Li, Howard P. Baden, and Joseph C. Kvedar
Loose anagen syndrome, or loose anagen hair, is a recently described
condition of unknown etiology that may be under recognized. The typical
patient is a child with sparse fine hair that can easily be pulled out. The
diagnosis is confirmed by microscopic examination of firmly pulled hairs,
many of which are in the anagen phase but lacking an inner and outer
root sheath and demonstrating a ruffled cuticle. Some presentations of
alopecia areata may be confused with this condition, but the pull test
analysis serves to differentiate them. A variety of theories have been
postulated to explain the pathophysiology of loose anagen syndrome. In
some cases, there is an autosomal dominant pattern of inheritance. In most
cases, this condition spontaneously improves with age.
An Update of Hair Shaft Disorders 753
R. P. R. Dawber
This article discusses the up to date clinical and laboratory diagnostic
criteria in well known conditions of hair disorders.
Cicatricial Alopecia 773
John T. Headington
Scarring alopecias are of diverse etiology and pathogenesis. They may be
histologically classified as primary or secondary, depending on involve¬
ment of reticular dermis. The most important primary scarring alopecias
include pseudopelade, lichen planopilaris, and diffuse scarring of the
vertex in African Americans. The most important secondary scarring alo¬
pecias include folliculitis decalvans and late stage lupus erythematosus.
What s New in Hair Replacement Surgery 783
Walter P. Unger
The isolated frontal forelock, bridge over troubled waters, and lighter
density coverage of larger areas are new options for hair transplant pa¬
tients. Alopecia reductions are playing an increasingly important role in
overall planning after a period in which they had at least appeared to be
losing popularity. Tumescent anesthesia in the donor or recipient area
results in safer, more comfortable, and effective anesthesia. Total excision
techniques in the donor area as well as improvements in minigrafting
represent important advances that are being utilized by an increasing
number of practitioners. Carbon dioxide lasers are likely to play an im¬
portant role in hair replacement surgery.
Current Therapy
Antiandrogen and Hormonal Treatment of Acne 803
James C. Shaw
In the treatment of acne in women, the use of antiandrogens and other
hormonal approaches is a valuable alternative to standard therapy. These
treatments that are based on physiologically sound principles produce
gratifying results in selected women with acne, and are the primary
treatment for women with hirsutism. The drugs discussed in this article
include spironolactone, cyproterone acetate, flutamide, oral contraceptives,
corticosteroids, finasteride, and gonadotropin releasing hormone agonists.
Patient selection, pretreatment evaluation, and case studies also are dis¬
cussed with an emphasis on practical applications.
Cumulative Index 1996 813
Subscription Information Inside back cover
Erratum
In the January 1996 issue of Dermatologic Clinics (volume 14, number 1), there
was an incorrect statement in the article Recent Developments in Antifungal
Therapy by Jack L. Lesher, Jr, MD. On page 164, the last sentence at the
bottom of the left hand column should read The main drug interactions with
griseofulvin are warfarin (griseofulvin causing decreased levels). ...
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spelling | Update on hair disorders David A. Whiting, guest ed. Philadelphia [u.a.] Saunders 1996 XVI S., S. 543 - 826 Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Dermatologic clinics 14,4 Maladies du système pileux Hair Diseases Hair Physiology Haarkrankheit (DE-588)4128071-4 gnd rswk-swf Alopecia (DE-588)4141988-1 gnd rswk-swf Haarausfall (DE-588)4158629-3 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Haarkrankheit (DE-588)4128071-4 s DE-604 Haarausfall (DE-588)4158629-3 s Alopecia (DE-588)4141988-1 s Whiting, David A. Sonstige oth Dermatologic clinics 14,4 (DE-604)BV000004924 14,4 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007409309&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | Update on hair disorders Dermatologic clinics Maladies du système pileux Hair Diseases Hair Physiology Haarkrankheit (DE-588)4128071-4 gnd Alopecia (DE-588)4141988-1 gnd Haarausfall (DE-588)4158629-3 gnd |
subject_GND | (DE-588)4128071-4 (DE-588)4141988-1 (DE-588)4158629-3 (DE-588)4143413-4 |
title | Update on hair disorders |
title_auth | Update on hair disorders |
title_exact_search | Update on hair disorders |
title_full | Update on hair disorders David A. Whiting, guest ed. |
title_fullStr | Update on hair disorders David A. Whiting, guest ed. |
title_full_unstemmed | Update on hair disorders David A. Whiting, guest ed. |
title_short | Update on hair disorders |
title_sort | update on hair disorders |
topic | Maladies du système pileux Hair Diseases Hair Physiology Haarkrankheit (DE-588)4128071-4 gnd Alopecia (DE-588)4141988-1 gnd Haarausfall (DE-588)4158629-3 gnd |
topic_facet | Maladies du système pileux Hair Diseases Hair Physiology Haarkrankheit Alopecia Haarausfall Aufsatzsammlung |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007409309&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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