Principles of drug therapy in neurology:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia
Davis
1992
|
| Schriftenreihe: | Contemporary neurology series
37 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVI, 358 S. Ill. |
| ISBN: | 0803650310 |
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| 650 | 4 | |a Mental Disorders |x drug therapy | |
| 650 | 4 | |a Nervous System Diseases |x drug therapy | |
| 650 | 4 | |a Nervous system |x Diseases |x Chemotherapy | |
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Datensatz im Suchindex
| _version_ | 1804125541302796288 |
|---|---|
| adam_text | PRINCIPLES OF DRUG THERAPY IN NEUROLOGY EDITORS MICHAEL V. JOHNSTON,
M.D. PROFESSOR AND HALLER SCHOLAR OF NEUROLOGY AND PEDIATRICS JOHNS
HOPKINS UNIVERSITY SCHOOL OF MEDICINE AND THE KENNEDY INSTITUTE
BALTIMORE, MARYLAND ROBERT L. MACDONALD, M.D., PH.D. PROFESSOR OF
NEUROLOGY AND PHYSIOLOGY UNIVERSITY OF MICHIGAN MEDICAL SCHOOL ANN
ARBOR, MICHIGAN ANNE B. YOUNG, M.D., PH.D. CHIEF, NEUROLOGY SERVICE
MASSACHUSETTS GENERAL HOSPITAL JULLEANNE DORN PROFESSOR OF NEUROLOGY
HARVARD MEDICAL SCHOOL BOSTON, MASSACHUSETTS F. A. DAVIS COMPANY *
PHILADELPHIA CONTENTS 1. FUNDAMENTALS OF DRUG THERAPY IN NEUROLOGY 1
MICHAEL V. JOHNSTON M.D., AND FAYE S. SILVERSTEIN, M.D. MOLECULAR
TARGETS OF DRUG ACTION IN THE NERVOUS SYSTEM 1 NEURONAL SYNAPTLC ACTION
OF DRUGS 3 NEURONAL ACTIONS ON CELL MEMBRANES AND METABOLISM 20 DRUG
ACTIONS ON NONNEURONAL ELEMENTS 21 EFFECTS ON DNA, RNA, OR PROTEIN
SYNTHESIS . 21 BARRIERS TO DRUG ACTION IN THE CNS 22 ENHANCING TRANSPORT
ACROSS THE BBB 24 POTENTIAL STRATEGIES TO PENETRATE THE BBB 25 DYNAMIC
FEATURES OF DRUG ACTION 26 DRUG DELIVERY TO THE BLOODSTREAM 26 DRUG
DISTRIBUTION 29 DRUG METABOLISM 31 DRUG ELIMINATION 31 PHARMACOKINETICS
32 THERAPEUTIC DRUG MONITORING 34 TOXICITY OF NEUROACTIVE DRUGS 34
NEUROLOGIC DISORDERS ATTRIBUTABLE TO DRUG THERAPY 35 SYSTEMIC DISORDERS
ATTRIBUTABLE TO DRUG THERAPY 39 ADVERSE DRUG INTERACTIONS 41 INFLUENCE
OF AGE ON DRUG ACTION 42 GERIATRIC NEUROPHARMACOLOGY 42 PEDIATRIC
NEUROPHARMACOLOGY 42 TERATOGENESIS 43 2. MOVEMENT DISORDERS 50 JOHN B.
PENNEY, JR., M.D., AND ANNE B. YOUNG, M.D., PH.D. NEUROCHEMICAL ANATOMY
OF THE BASAL GANGLIA 50 BASAL GANGLIA STRUCTURES 50 STRIATAL AFFERENTS
54 CLINICAL IMPLICATIONS . . . 55 PARKINSON S DISEASE 55 CLINICAL
MANIFESTATIONS 55 NEUROTRANSMITTER AND RECEPTOR CHANGES 56 SELECTIVE
VULNERABILITY 57 RATIONALE FOR THERAPY 59 HUNTINGTON S DISEASE 64
CLINICAL MANIFESTATIONS 64 NEUROTRANSMITTER AND RECEPTOR CHANGES 65
SELECTIVE VULNERABILITY . 67 RATIONALE FOR THERAPY . . 67 DYSTONIA 68
CLINICAL MANIFESTATIONS 68 NEUROCHEMICAL PATHOLOGY 69 APPROACH TO
THERAPY 69 TREMORS 70 CLINICAL MANIFESTATIONS 70 NEUROCHEMICAL PATHOLOGY
71 RATIONALE FOR THERAPY 71 TICS 71 CLINICAL MANIFESTATIONS 71
NEUROCHEMICAL PATHOLOGY 72 RATIONALE FOR THERAPY 72 HEMIBALLISMUS 72
CLINICAL MANIFESTATIONS 72 PATHOLOGY 72 RATIONALE FOR THERAPY 72
SPASTICITY 73 CLINICAL MANIFESTATIONS 73 RATIONALE FOR THERAPY 73
WILSON S DISEASE 74 CLINICAL MANIFESTATIONS 74 CLINICAL DIAGNOSIS 74
RATIONALE FOR THERAPY 75 DRUG MANIPULATION OF TRANSMITTER SYSTEMS 77
DOPAMINE SYSTEM 77 ACETYLCHOLINE SYSTEM 79 GABAERGIC SYSTEMS 80 3.
SEIZURE DISORDERS AND EPILEPSY 87 ROBERT L. MACDONALD, M.D., PH.D.
CLASSIFICATION OF SEIZURES AND THE EPILEPSIES 88 CLINICAL CLASSIFICATION
OF ANTICONVULSANT DRUGS 90 MECHANISMS OF ACTION OF ANTICONVULSANT DRUGS
91 EFFECTS OF ANTICONVULSANT DRUGS ON SODIUM CHANNELS 92 EFFECTS OF
ANTICONVULSANT DRUGS ON CALCIUM CHANNELS 94 ENHANCEMENT OF GABAERGIC
INHIBITION 95 EFFECTS OF ANTICONVULSANT DRUGS ON EXCITATORY MECHANISMS
99 MECHANISTIC CLASSIFICATION OF ANTICONVULSANT DRUGS 101 CLINICAL USE
OF ANTICONVULSANT DRUGS FOR CHRONIC THERAPY 102 DECISION TO INITIATE AND
DISCONTINUE THERAPY 102 INITIATING CHRONIC ANTICONVULSANT THERAPY 102
THERAPY FOR PREGNANT WOMEN WITH EPILEPSY 102 THERAPY FOR PARTIAL AND
GENERALIZED TONIC-CLONIC SEIZURES . 104 THERAPY FOR ABSENCE SEIZURES 108
THERAPY FOR MYOCLONIC SEIZURES 109 THERAPY FOR STATUS EPILEPTICUS 109
PHENYTOIN 110 XI BENZODIAZEPINES ILL PHENOBARBITAL ILL PENTOBARBITAL
COMA ILL 4. STROKE AND HYPOXIC-ISCHEMIC DISORDERS 118 WILLIAM A.
PULSINELLI, M.D., PH.D., MICHAEL JACEWICZ, M.D., AND ALASTAIRM. BUCHAN,
M.D., M.R.C.P. NORMAL CEREBRAL BLOOD FLOW AND METABOLISM 118 CEREBRAL
ISCHEMIA: THRESHOLDS FOR INJURY 119 MOLECULAR CHANGES DURING ISCHEMIA
121 ENERGY METABOLISM 121 LIPID METABOLISM 121 FREE RADICALS 121
NEUROTRANSMITTER CHEMISTRY 122 ION HOMEOSTASIS 122 HISTOLOGIC PATTERNS
OF ISCHEMIC BRAIN DAMAGE 124 THERAPIES TO ENHANCE BRAIN OXYGEN AND
SUBSTRATE SUPPLY 124 ANTITHROMBOTIC THERAPY 124 ANTICOAGULANTS 129
ANTIPLATELET AGENTS 134 THROMBOLYTIC THERAPY 137 HEMODILUTION AND
VISCOSITY REDUCTION 139 PERFLUOROCHEMICALS 140 VASODILATOR THERAPY 140
EXPERIMENTAL THERAPIES TO MAINTAIN CELLULAR VIABILITY 143 CALCIUM
CHANNEL ANTAGONISTS 143 EAA ANTAGONISTS 144 REDUCTION OF HYPERGLYCEMIA
AND CEREBRAL ACIDOSIS 145 ANTIOXIDANTS AND FREE-RADICAL SCAVENGERS 146
THERAPIES FOR STROKE EDEMA 146 SELECTION OF ESTABLISHED
PHARMACOTHERAPIES 146 ZII 5. MIGRAINE 161 STEPHEN J. PEROUTKA, M.D.,
PH.D. THEORIES OF MIGRAINE PATHOGENESIS 163 VASCULAR THEORY OF WOLFF 163
SPREADING DEPRESSION OF LEAO 163 SEROTONERGIC ABNORMALITIES 164 ROLE OF
THE TRIGEMINOVASCULAR SYSTEM 166 PHARMACOLOGIC APPROACHES TO MIGRAINE
166 ACUTE TREATMENTS 166 PROPHYLACTIC TREATMENTS 170 FUTURE APPROACHES
173 6. IMMUNE-MEDIATED DISORDERS 178 MARK S. FREEDMAN, M.D., JACK P.
ANTEL, M.D., AND DAVID P. RICHMAN, M.D. ORGANIZATION OF THE IMMUNE
SYSTEM 178 B-CELL-MEDIATED IMMUNITY (HUMORAL IMMUNITY) .... 179
T-CELL-MEDIATED IMMUNITY (CELL-MEDIATED IMMUNITY) 181 IMMUNE REGULATION
184 CELL-CELL INTERACTION IN THE IMMUNE SYSTEM 186 CNS-IMMUNE SYSTEM
INTERACTIONS 187 AUTOIMMUNE NEUROLOGIC DISEASES 187 IMMUNOTHERAPIES 192
NONANTIGEN-SPECIFIC DIRECTED THERAPY 192 BIOLOGIC RESPONSE MODIFIERS 196
SPECIFIC ANTIGEN- OR ANTIBODY-DIRECTED THERAPY 198 AUTOREACTIVE CELL
IMMUNOTHERAPY 199 INHIBITORS OF INFLAMMATION 201 CORTICOSTEROIDS 201 7.
PSYCHIATRIC DISORDERS 206 JOSEPH T. COYLE, M.D. CLINICAL
PSYCHOPHARMACOLOGY 206 NEUROLEPTICS 207 SCHIZOPHRENIA 207 NEUROLEPTIC
SITE OF ACTION 208 CLINICAL USE OF NEUROLEPTICS 210 XIII ACUTE
NEUROLEPTIC SIDE EFFECTS 211 TARDIVE DYSKINESIA 212 NEUROLEPTIC
MALIGNANT SYNDROME 213 OTHER USES OF NEUROLEPTICS 214 ANTIDEPRESSANTS
215 DEPRESSION 215 TRICYCLIC ANTIDEPRESSANTS 215 MAO INHIBITORS 217
ANTIDEPRESSANTS AND PANIC DISORDER 218 LITHIUM 218 BENZODIAZEPINES 220
8. COGNITIVE DISORDERS 226 MICHAEL V. JOHNSTON, M.D. MEMORY DISORDERS
226 MAJOR SYNDROMES WITH MEMORY LOSS 227 ORGANIZATION OF MEMORY 227
DRUG-INDUCED MEMORY LOSS 228 ROLES OF NEUROTRANSMITTERS IN MEMORY 229
THERAPY FOR MEMORY DISORDERS 232 DEMENTIA 232 TYPES OF DEMENTIA * 232
SYNAPTIC ABNORMALITIES IN AD 233 OTHER NEUROCHEMICAL ABNORMALITIES IN AD
238 ABNORMALITIES IN VASCULAR DEMENTIA AND OTHER DEMENTING DISORDERS 240
THERAPY FOR DEMENTIA 241 APPROACH TO ASSESSMENT 241 SYMPTOMATIC
TREATMENT OF BEHAVIOR PROBLEMS 242 CHOLINERGIC AUGMENTATION THERAPY 242
THERAPIES DIRECTED TOWARD OTHER NEUROTRANSMITTER TARGETS 250
COGNITION-ACTIVATING DRUGS 250 NEUROPROTECTION: STRATEGIES FOR
PROMOTING NEURON SURVIVAL OR RESTORING NEURON FUNCTION 255 COGNITIVE
DISORDERS IN YOUNG PEOPLE 256 DYSLEXIA AND LEARNING DISABILITIES 256
ATTENTION DEFICIT DISORDER 257 ZIV 9. PAIN 268 RICHARD PAYNE, M.D., AND
GAVRIL W. PASTERNAK, M.D., PH.D. TYPES OF PAIN 268 SOMATIC PAIN 268
VISCERAL PAIN 268 DEAFFERENTATION PAIN 269 ACUTE VERSUS CHRONIC PAIN 269
ANATOMY AND PHYSIOLOGY OF CENTRAL NOCICEPTIVE SYSTEMS 270 NOCICEPTORS
270 DORSAL HORN AND SPINOTHALAMIC TRACTS 271 MECHANISMS OF FACIAL
SENSATION 273 THE CORTEX AND PAIN 273 ANTINOCICEPTIVE SYSTEMS IN THE CNS
273 ENDOGENOUS OPIOID SYSTEMS 274 OPIATE ACTIONS 277 PHARMACOLOGIC
MANAGEMENT OF PAIN 279 CLINICAL USE OF NSAIDS 279 CLINICAL USE OF OPIOID
ANALGESICS 280 ADJUVANT ANALGESICS 290 AGENTS TO BE AVOIDED IN THE
PHARMACOLOGIC MANAGEMENT OF PAIN 292 PLACEBO RESPONSE 293 PAIN IN
CHILDREN . 293 ANALGESICS IN THE ELDERLY . 293 10. ACUTE DRUG
INTOXICATION 302 DANIEL H. LOWENSTEIN, M.D., AND ROGER P. SIMON, M.D.
ALTERATIONS IN CONSCIOUSNESS CAUSED BY DRUGS AND TOXINS 302 MECHANISMS
OF ALTERATIONS IN CONSCIOUSNESS 303 DISTINGUISHING INTOXICATION FROM
OTHER CAUSES OF COMA 304 SPECIFIC AGENTS THAT PRODUCE ALTERATIONS IN
CONSCIOUSNESS 311 SEIZURES CAUSED BY DRUG INTOXICATION 321 OPIOIDS 322
ETHANOL 323 XV HETEROCYCLIC ANTIDEPRESSANTS 324 ANTIPSYCHOTICS 324
HALLUCINOGENS AND STIMULANTS 325 APPENDIX: SOURCES OF DRUG INFORMATION
335 INDEX 337 CVI
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| id | DE-604.BV011051224 |
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| indexdate | 2024-07-09T18:03:12Z |
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| isbn | 0803650310 |
| language | English |
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| physical | XVI, 358 S. Ill. |
| publishDate | 1992 |
| publishDateSearch | 1992 |
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| publisher | Davis |
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| series | Contemporary neurology series |
| series2 | Contemporary neurology series |
| spelling | Principles of drug therapy in neurology eds. Michael V. Johnston ... Philadelphia Davis 1992 XVI, 358 S. Ill. txt rdacontent n rdamedia nc rdacarrier Contemporary neurology series 37 Geneesmiddelen gtt Neurologie gtt Neuropharmacologie Système nerveux - Maladies - Chimiothérapie Cognition Disorders drug therapy Mental Disorders drug therapy Nervous System Diseases drug therapy Nervous system Diseases Chemotherapy Neuropharmacology Psychotropic Drugs Neurologie (DE-588)4041888-1 gnd rswk-swf Pharmakotherapie (DE-588)4076066-2 gnd rswk-swf Neurologie (DE-588)4041888-1 s Pharmakotherapie (DE-588)4076066-2 s DE-604 Johnston, Michael V. Sonstige oth Contemporary neurology series 37 (DE-604)BV000898796 37 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007401486&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Principles of drug therapy in neurology Contemporary neurology series Geneesmiddelen gtt Neurologie gtt Neuropharmacologie Système nerveux - Maladies - Chimiothérapie Cognition Disorders drug therapy Mental Disorders drug therapy Nervous System Diseases drug therapy Nervous system Diseases Chemotherapy Neuropharmacology Psychotropic Drugs Neurologie (DE-588)4041888-1 gnd Pharmakotherapie (DE-588)4076066-2 gnd |
| subject_GND | (DE-588)4041888-1 (DE-588)4076066-2 |
| title | Principles of drug therapy in neurology |
| title_auth | Principles of drug therapy in neurology |
| title_exact_search | Principles of drug therapy in neurology |
| title_full | Principles of drug therapy in neurology eds. Michael V. Johnston ... |
| title_fullStr | Principles of drug therapy in neurology eds. Michael V. Johnston ... |
| title_full_unstemmed | Principles of drug therapy in neurology eds. Michael V. Johnston ... |
| title_short | Principles of drug therapy in neurology |
| title_sort | principles of drug therapy in neurology |
| topic | Geneesmiddelen gtt Neurologie gtt Neuropharmacologie Système nerveux - Maladies - Chimiothérapie Cognition Disorders drug therapy Mental Disorders drug therapy Nervous System Diseases drug therapy Nervous system Diseases Chemotherapy Neuropharmacology Psychotropic Drugs Neurologie (DE-588)4041888-1 gnd Pharmakotherapie (DE-588)4076066-2 gnd |
| topic_facet | Geneesmiddelen Neurologie Neuropharmacologie Système nerveux - Maladies - Chimiothérapie Cognition Disorders drug therapy Mental Disorders drug therapy Nervous System Diseases drug therapy Nervous system Diseases Chemotherapy Neuropharmacology Psychotropic Drugs Pharmakotherapie |
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