The meaning of nucleocytoplasmic transport:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Springer [u.a.]
1996
|
| Schriftenreihe: | Molecular biology intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 200 S. graph. Darst. |
| ISBN: | 354061351X |
Internformat
MARC
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| 100 | 1 | |a Agutter, Paul S. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a The meaning of nucleocytoplasmic transport |c Paul S. Agutter ; Philip L. Taylor |
| 264 | 1 | |a New York [u.a.] |b Springer [u.a.] |c 1996 | |
| 300 | |a 200 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
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Datensatz im Suchindex
| _version_ | 1808227710802067456 |
|---|---|
| adam_text |
CONTENTS
1.
PERSPECTIVES
IN
TRANSPORT
.
1
'
TRANSPORT
'
IS
USED
IN
SEVERAL
DIFFERENT
WAYS
IN
CELL
BIOLOGY
.
1
'
NUCLEOCYTOPLASMIC
TRANSPORT
'
AND
'
GLUCOSE
TRANSPORT
'
HAVE
SOME
COMMON
CHARACTERISTICS,
BUT
SOME
MAJOR
DIFFERENCES
.
5
THE
GLUCOSE
TRANSPORT
ANALOGY
PERSISTS,
BUT
THE
REASONS
FOR
ITS
PERSISTENCE
ARE
LARGELY
UNSOUND
.
8
NO
ALTERNATIVE
PERSPECTIVE
IS
JUSTIFIABLE
A
PRIORI
.
10
A
METHODOLOGICAL
PARADOX
.
12
OVERVIEW
AND
PROSPECTS
.
17
2.
THE
VAGARIES
OF
DIFFUSION
.21
INTRODUCTION
.
21
THE
DESCRIPTIVE
AND
EXPLANATORY
USES
OF
'
DIFFUSION
'
ARE
NOT
SHARPLY
DISTINCT
.
21
CLASSICAL
DIFFUSION
THEORY
INVOLVES
AT
LEAST
TEN
ASSUMPTIONS
AND
IS
STRICTLY
APPLICABLE
ONLY
TO
IDEAL
SOLUTIONS
.
24
LONG
RANGE
MACROMOLECULE MOVEMENTS
IN
CELLS
ARE
NOT
DOMINATED
BY BROWNIAN
MOTION
.
30
MEASUREMENTS
OF
INTRACELLULAR
'
DIFFUSIVITIES
'
REQUIRE
RADICALLY
NEW
INTERPRETATIONS
.
34
A
MODEL
FOR
MACROMOLECULE
MOVEMENT
WITHIN
COMPARTMENTS
MIGHT
ALSO
BE
APPLICABLE
TO
NUCLEOCYTOPLASMIC
TRANSPORT
.
37
VIABLE
MODELS
FOR
MACROMOLECULE
TRANSPORT
MUST
INVOLVE
INTRACELLULAR
STRUCTURES
OR
FLUID
MOVEMENT
.
42
OVERVIEW
.
48
3.
CELLULAR
STRUCTURES
AND
NUCLEOCYTOPLASMIC
TRANSPORT
.
53
INTRODUCTION
.53
MORPHOLOGY
AND
BIOCHEMISTRY
.54
WHEN
IS
A
STRUCTURE
WELL-CHARACTERIZED?
.56
CYTOSKELETAL
ELEMENTS
.58
PORE-COMPLEXES
.
59
NUCLEOSKELETON
.
67
CHARACTERIZATION
AND
TRANSPORT
FUNCTION
.
71
4.
EVENTS
AT
THE
PORE-COMPLEX
.
81
INTRODUCTION
.
81
SOME
EXPERIMENTAL
APPROACHES
.
82
PRESUMPTION
AND
INTERPRETATION
.
84
FUNCTIONAL
ORGANIZATION
OF
THE
PORE-COMPLEX
.
86
TRANSPORT
SIGNALS:
SUBSTRATE
RECOGNITION
.88
NUCLEAR
LOCATION
SIGNALS
AND
PROTEIN
IMPORT
.
89
INTERACTIONS
BETWEEN
PROTEIN
TRANSPORTANTS
AND
LOCATION
SIGNAL
BINDING
FACTORS
.
92
LSBS
INVOLVED
IN
RNA
EXPORT
.
96
RAN/TC4
AND
ITS
ANCILLARIES
.
97
THE
TRANSLOCATION
PROCESS
.
101
OVERVIEW
.
107
5.
EVENTS
INVOLVING
THE
NUCLEOSKELETON
AND
CYTOSKELETON
.
119
INTRODUCTION
.119
MRNA
AND
THE
CYTOSKELETON
.
120
THE
NATURE
AND
FUNCTION
OF
MESSENGER
BINDING
TO
MICROFILAMENTS.
122
OTHER
CYTOSKELETAL
ATTACHMENTS
AND
THE
SIGNIFICANCE
OF
THE
'
FREE
MESSENGER
POOL
'
.
124
MRNA,
MRNA
PRECURSORS
AND
THE
NUCLEOSKELETON
.
127
SPLICING
AND
THE
NUCLEOSKELETON
.
130
PROTEIN
TRANSPORT
AND
THE
CELL
SKELETONS
.
132
TRANSPORT
AND
THE
MAINTENANCE
OF
STRUCTURE
.
135
THE
FUNCTIONS
OF
RAN
AND
RCC1
.
138
NUCLEOLIN:
IS
IT
IDENTICAL
WITH
PL
10?
.
141
OVERVIEW
.
141
6.
REGULATION
AND
PATHOLOGIES
OF
NUCLEOCYTOPLASMIC
TRANSPORT
.
153
INTRODUCTION
.
153
CONTROL
OF
PROTEIN
IMPORT:
PHOSPHORYLATION
AND
CYTOPLASMIC
ANCHORING
.
156
EXTRACELLULAR
PROTEINS
CAN
ENTER
THE
NUCLEUS
.
158
SIGNALING
FROM
THE
EXTRACELLULAR
MATRIX
TO
THE
NUCLEUS
.159
THE
SPECIFICITY
PROBLEM
.160
INSULIN
AND
EPIDERMAL
GROWTH
FACTOR
.
162
MRNA
TRANSPORT
IN
ADENOVIRUS
AND
INFLUENZA
VIRUS
INFECTED
CELLS
.
163
MESSENGER
TRANSPORT
IN
HIV-INFECTED
CELLS
.
165
EFFECTS
OF
CARCINOGENS
ON
MESSENGER
TRANSPORT
.
166
AGE-RELATED
CHANGES
IN
MESSENGER
TRANSPORT
.
168
OVERVIEW
.
169
7.
EVALUATION
OF
A
MODEL
.
181
INTRODUCTION
.
181
SOLID-STATE
TRANSPORT:
ARGUMENTS
AND
MODELS
.
182
MOTOR
DRIVEN
AND
ASSEMBLY
DRIVEN
MODELS:
PRO
AND
CONTRA
.184
TESTING
A
'
CONSENSUS
MODEL
'
OF
NUCLEOCYTOPLASMIC
TRANSPORT
.
187
REFLECTIONS
ON
KINETICS
AND
TOPOLOGY
.
188
MAKING
TRANSPORT
VECTORIAL
OR
REVERSIBLE
.
190
GENERALIZING
THE
MODEL
.192
INDEX
.
199 |
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| author | Agutter, Paul S. Taylor, Philip L. |
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| bvnumber | BV010992368 |
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| ctrlnum | (OCoLC)68691586 (DE-599)BVBBV010992368 |
| discipline | Biologie |
| format | Book |
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| language | English |
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| publisher | Springer [u.a.] |
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| series2 | Molecular biology intelligence unit |
| spelling | Agutter, Paul S. Verfasser aut The meaning of nucleocytoplasmic transport Paul S. Agutter ; Philip L. Taylor New York [u.a.] Springer [u.a.] 1996 200 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit Zellkern (DE-588)4067544-0 gnd rswk-swf Proteintransport (DE-588)4273577-4 gnd rswk-swf Kernhülle (DE-588)4309987-7 gnd rswk-swf Transport (DE-588)4060680-6 gnd rswk-swf Cytoplasma (DE-588)4129692-8 gnd rswk-swf Zellkern (DE-588)4067544-0 s Cytoplasma (DE-588)4129692-8 s Transport (DE-588)4060680-6 s DE-604 Kernhülle (DE-588)4309987-7 s Proteintransport (DE-588)4273577-4 s Taylor, Philip L. Verfasser aut DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007357420&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Agutter, Paul S. Taylor, Philip L. The meaning of nucleocytoplasmic transport Zellkern (DE-588)4067544-0 gnd Proteintransport (DE-588)4273577-4 gnd Kernhülle (DE-588)4309987-7 gnd Transport (DE-588)4060680-6 gnd Cytoplasma (DE-588)4129692-8 gnd |
| subject_GND | (DE-588)4067544-0 (DE-588)4273577-4 (DE-588)4309987-7 (DE-588)4060680-6 (DE-588)4129692-8 |
| title | The meaning of nucleocytoplasmic transport |
| title_auth | The meaning of nucleocytoplasmic transport |
| title_exact_search | The meaning of nucleocytoplasmic transport |
| title_full | The meaning of nucleocytoplasmic transport Paul S. Agutter ; Philip L. Taylor |
| title_fullStr | The meaning of nucleocytoplasmic transport Paul S. Agutter ; Philip L. Taylor |
| title_full_unstemmed | The meaning of nucleocytoplasmic transport Paul S. Agutter ; Philip L. Taylor |
| title_short | The meaning of nucleocytoplasmic transport |
| title_sort | the meaning of nucleocytoplasmic transport |
| topic | Zellkern (DE-588)4067544-0 gnd Proteintransport (DE-588)4273577-4 gnd Kernhülle (DE-588)4309987-7 gnd Transport (DE-588)4060680-6 gnd Cytoplasma (DE-588)4129692-8 gnd |
| topic_facet | Zellkern Proteintransport Kernhülle Transport Cytoplasma |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007357420&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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