Mitosenes and related antitumor drugs: rational design of cytostatic agents
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | German |
| Veröffentlicht: |
New York [u.a.]
Springer [u.a.]
1996
|
| Schriftenreihe: | Medical intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 126 S. graph. Darst. |
| ISBN: | 3540609997 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV010980233 | ||
| 003 | DE-604 | ||
| 005 | 19961113 | ||
| 007 | t | ||
| 008 | 960923s1996 gw d||| |||| 00||| ger d | ||
| 016 | 7 | |a 948456655 |2 DE-101 | |
| 020 | |a 3540609997 |c Pp. : DM 154.00 |9 3-540-60999-7 | ||
| 035 | |a (OCoLC)34116393 | ||
| 035 | |a (DE-599)BVBBV010980233 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a ger | |
| 044 | |a gw |c DE | ||
| 049 | |a DE-355 | ||
| 050 | 0 | |a RC271.M53 | |
| 082 | 0 | |a 616.99/2061 |2 20 | |
| 084 | |a XI 7000 |0 (DE-625)153024:12905 |2 rvk | ||
| 245 | 1 | 0 | |a Mitosenes and related antitumor drugs |b rational design of cytostatic agents |c Marc Maliepaard |
| 264 | 1 | |a New York [u.a.] |b Springer [u.a.] |c 1996 | |
| 300 | |a 126 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Medical intelligence unit | |
| 650 | 4 | |a Antineoplastic Agents | |
| 650 | 4 | |a Mitomycin C |x Derivatives |x Structure-activity relationships | |
| 650 | 4 | |a Mitomycin |x therapeutic use | |
| 650 | 4 | |a Mitomycins | |
| 650 | 4 | |a Structure-Activity Relationship | |
| 650 | 0 | 7 | |a Mitomycinanaloga |0 (DE-588)4396971-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Mitomycin C |0 (DE-588)4122286-6 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Mitomycin C |0 (DE-588)4122286-6 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Mitomycinanaloga |0 (DE-588)4396971-9 |D s |
| 689 | 1 | |5 DE-604 | |
| 700 | 1 | |a Maliepaard, Marc |e Sonstige |4 oth | |
| 856 | 4 | 2 | |m GBV Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007348223&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-007348223 | ||
Datensatz im Suchindex
| _version_ | 1804125469212147712 |
|---|---|
| adam_text | MEDICAL INTELLIGENCE UNIT MLTOSENES AND RELATED ANTITUMOR DRUGS:
RATIONAL DESIGN OF CYTOSTATIC AGENTS MARC MALIEPAARD, PH.D. DEPARTMENT
OF MEDICAL ONCOLOGY ROTTERDAM CANCER INSTITUTE/DANIEL DEN HOED KLINIEK
ROTTERDAM, THE NETHERLANDS SPRINGER NEW YORK BERLIN HEIDELBERG LONDON
PARIS LG. LANDES COMPANY TOKYO HONG KONG BARCELONA BUDAPEST AUSTIN
CONTENTS 1. INTRODUCTION 1 CANCER AND CHEMOTHERAPEUTIC TREATMENT 1
MITOMYCIN C 3 MECHANISM OF ACTION OF MITOMYCIN C 4 MITOSANE ANALOGUES OF
MITOMYCIN C 8 MITOSENES AND OTHER BIOREDUCTIVELY-ACTIVATED COMPOUNDS 11
SCOPE OF THIS BOOK 13 2. SYNTHESIS OF MITOSENE DERIVATIVES 23 WILLEM
VERBOOM INTRODUCTION 23 MITOSENES STARTING FROM NATURAL PRODUCTS 23
SYNTHETIC MITOSENES 24 SUMMARY 33 3. REDUCTIVE ACTIVATION 37
INTRODUCTION: REDUCTIVE ACTIVATION 37 REDUCTIVE ACTIVATION OF MITOSENES
39 IMPORTANT ENZYMES FOR REDUCTIVE ACTIVATION OF MITOSENES 42
DIFFERENCES BETWEEN NORMAL AND (SOLID) TUMOR TISSUE 46 SUMMARY 55 4.
PHYSICO-CHEMICAL PARAMETERS AFFECTING ANTITUMOR ACTIVITY OF MITOSENES 63
INTRODUCTION 63 LIPOPHILICITY 64 REDUCTION POTENTIAL 70 STEREOCHEMICAL
CONFIGURATION OF MITOSENES 75 SUMMARY 79 5. REDUCTIVE ACTIVATION AND
MITOSENE REACTIVITY 83 INTRODUCTION 83 ACTIVATION OF THE MITOSENE
BACKBONE 84 MECHANISM OF ACTION OF MITOSENES AND RELATED ANTITUMOR
COMPOUNDS 86 MITOSENES 89 AZAMITOSENES 90 EO9 93 AZIRIDINE FUNCTION 94
SUMMARY 96 6. ANTITUMOR ACTIVITY OF MITOSENE COMPOUNDS 101 INTRODUCTION:
ANTITUMOR ACTIVITY 101 CHOOSING THE RIGHT MODEL 102 IN VITRO AND IN VIVO
ANTITUMOR ACTIVITY 103 TOXICITY STUDIES IN ANIMALS 119 PHASE I CLINICAL
STUDIES 119 SUMMARY 120 INDEX 125
|
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV010980233 |
| callnumber-first | R - Medicine |
| callnumber-label | RC271 |
| callnumber-raw | RC271.M53 |
| callnumber-search | RC271.M53 |
| callnumber-sort | RC 3271 M53 |
| callnumber-subject | RC - Internal Medicine |
| classification_rvk | XI 7000 |
| ctrlnum | (OCoLC)34116393 (DE-599)BVBBV010980233 |
| dewey-full | 616.99/2061 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.99/2061 |
| dewey-search | 616.99/2061 |
| dewey-sort | 3616.99 42061 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01732nam a2200469 c 4500</leader><controlfield tag="001">BV010980233</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">19961113 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">960923s1996 gw d||| |||| 00||| ger d</controlfield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">948456655</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3540609997</subfield><subfield code="c">Pp. : DM 154.00</subfield><subfield code="9">3-540-60999-7</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)34116393</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV010980233</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">ger</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">DE</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC271.M53</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">616.99/2061</subfield><subfield code="2">20</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">XI 7000</subfield><subfield code="0">(DE-625)153024:12905</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Mitosenes and related antitumor drugs</subfield><subfield code="b">rational design of cytostatic agents</subfield><subfield code="c">Marc Maliepaard</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">New York [u.a.]</subfield><subfield code="b">Springer [u.a.]</subfield><subfield code="c">1996</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">126 S.</subfield><subfield code="b">graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Medical intelligence unit</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Antineoplastic Agents</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitomycin C</subfield><subfield code="x">Derivatives</subfield><subfield code="x">Structure-activity relationships</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitomycin</subfield><subfield code="x">therapeutic use</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitomycins</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Structure-Activity Relationship</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Mitomycinanaloga</subfield><subfield code="0">(DE-588)4396971-9</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Mitomycin C</subfield><subfield code="0">(DE-588)4122286-6</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Mitomycin C</subfield><subfield code="0">(DE-588)4122286-6</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Mitomycinanaloga</subfield><subfield code="0">(DE-588)4396971-9</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Maliepaard, Marc</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">GBV Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007348223&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-007348223</subfield></datafield></record></collection> |
| id | DE-604.BV010980233 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:02:03Z |
| institution | BVB |
| isbn | 3540609997 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007348223 |
| oclc_num | 34116393 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 126 S. graph. Darst. |
| publishDate | 1996 |
| publishDateSearch | 1996 |
| publishDateSort | 1996 |
| publisher | Springer [u.a.] |
| record_format | marc |
| series2 | Medical intelligence unit |
| spelling | Mitosenes and related antitumor drugs rational design of cytostatic agents Marc Maliepaard New York [u.a.] Springer [u.a.] 1996 126 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Medical intelligence unit Antineoplastic Agents Mitomycin C Derivatives Structure-activity relationships Mitomycin therapeutic use Mitomycins Structure-Activity Relationship Mitomycinanaloga (DE-588)4396971-9 gnd rswk-swf Mitomycin C (DE-588)4122286-6 gnd rswk-swf Mitomycin C (DE-588)4122286-6 s DE-604 Mitomycinanaloga (DE-588)4396971-9 s Maliepaard, Marc Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007348223&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Mitosenes and related antitumor drugs rational design of cytostatic agents Antineoplastic Agents Mitomycin C Derivatives Structure-activity relationships Mitomycin therapeutic use Mitomycins Structure-Activity Relationship Mitomycinanaloga (DE-588)4396971-9 gnd Mitomycin C (DE-588)4122286-6 gnd |
| subject_GND | (DE-588)4396971-9 (DE-588)4122286-6 |
| title | Mitosenes and related antitumor drugs rational design of cytostatic agents |
| title_auth | Mitosenes and related antitumor drugs rational design of cytostatic agents |
| title_exact_search | Mitosenes and related antitumor drugs rational design of cytostatic agents |
| title_full | Mitosenes and related antitumor drugs rational design of cytostatic agents Marc Maliepaard |
| title_fullStr | Mitosenes and related antitumor drugs rational design of cytostatic agents Marc Maliepaard |
| title_full_unstemmed | Mitosenes and related antitumor drugs rational design of cytostatic agents Marc Maliepaard |
| title_short | Mitosenes and related antitumor drugs |
| title_sort | mitosenes and related antitumor drugs rational design of cytostatic agents |
| title_sub | rational design of cytostatic agents |
| topic | Antineoplastic Agents Mitomycin C Derivatives Structure-activity relationships Mitomycin therapeutic use Mitomycins Structure-Activity Relationship Mitomycinanaloga (DE-588)4396971-9 gnd Mitomycin C (DE-588)4122286-6 gnd |
| topic_facet | Antineoplastic Agents Mitomycin C Derivatives Structure-activity relationships Mitomycin therapeutic use Mitomycins Structure-Activity Relationship Mitomycinanaloga Mitomycin C |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007348223&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT maliepaardmarc mitosenesandrelatedantitumordrugsrationaldesignofcytostaticagents |