Intracellular signal transduction:
Gespeichert in:
Format: | Buch |
---|---|
Sprache: | English |
Veröffentlicht: |
San Diego [u.a.]
Acad. Press
1996
|
Schriftenreihe: | Advances in pharmacology
36 |
Schlagworte: | |
Online-Zugang: | Inhaltsverzeichnis |
Beschreibung: | Einzelaufnahme eines Zeitschr.-Bd. |
Beschreibung: | XV, 310 S. Ill., graph. Darst. |
ISBN: | 0120329379 0125138059 |
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245 | 1 | 0 | |a Intracellular signal transduction |c ed. by Hiroyoshi Hidaka ... |
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490 | 0 | |a Advances in pharmacology |v 36 | |
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adam_text | INTRACELLULAR SIGNAL TRANSDUCTION EDITED BY HIROYOSHI HIDAKA DEPARTMENT
OF PHARMACOLOGY NAGOYA UNIVERSITY SCHOOL OF MEDICINE NAGOYA, JAPAN ANGUS
C. NAIRN LABORATORY OF MOLECULAR AND CELLULAR NEUROSCIENCE THE
ROCKEFELLER UNIVERSITY NEW YORK, NEW YORK ASSOCIATE EDITORS EDWIN G.
KREBS HOWARD HUGHES MEDICAL RESEARCH LABS UNIVERSITY OF WASHINGTON
SCHOOL OF MEDICINE SEATTLE, WASHINGTON PHILIP COHEN DEPARTMENT OF
BIOCHEMISTRY MEDICAL SCIENCE INSTITUTE UNIVERSITY OF DUNDEE DUNDEE,
SCOTLAND, UNITED KINGDOM TAMIO YAMAKAWA TOKYO COLLEGE OF PHARMACY TOKYO,
JAPAN FUMIMARO TAKAKU INTERNATIONAL MEDICAL CENTER OF JAPAN TOKYO, JAPAN
MICHIO UI THE TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE TOKYO,
JAPAN ADVANCES IN PHARMACOLOGY VOLUME 36 ACADEMIC PRESS SAN DIEGO NEW
YORK BOSTON LONDON SYDNEY TOKYO TORONTO CONTENTS CONTRIBUTORS XIII
REGULATION OF SOMATOSTATIN GENE TRANSCRIPTION BY CAMP M. MONTMINY, P.
BRINDLE, J. ARIAS, K. FERRERI, AND R. ARMSTRONG I. INTRODUCTION 1 II.
CHARACTERIZATION OF THE CAMP RESPONSE UNIT 2 III. KINETIC PROFILE OF THE
TRANSCRIPTIONAL RESPONSE TO CAMP 3 IV. MECHANISM OF
PHOSPHORYLATION-DEPENDENT INDUCTION 5 V. INTERACTIONS BETWEEN CREB AND
THE TRANSCRIPTIONAL APPARATUS 7 REFERENCES 12 DISSECTION OF PROTEIN
KINASE CASCADES THAT MEDIATE CELLULAR RESPONSE TO CYTOKINES AND CELLULAR
STRESS PHILIP COHEN I. THE FIRST TWO PROTEIN KINASE CASCADES 15 II. THE
CLASSICAL MAP KINASE PATHWAY 17 III. THE IDENTIFICATION OF MAPKAP
KINASE-2 19 IV. MAPKAP KINASE-2 IS ACTIVATED IN VIVO BY REACTIVATING
KINASE (RK), A NOVEL MAPK HOMOLOG ACTIVATED BY CELLULAR STRESS 20 V.
WHAT LIES UPSTREAM OF THE RK? 22 VI. WHAT LIES DOWNSTREAM OF THE RK? 23
REFERENCES 26 VI CONTENTS CYCLIC NUCLEOTIDE PHOSPHODIESTERASES: GENE
COMPLEXITY, REGULATION BY PHOSPHORYLATION, AND PHYSIOLOGICAL
IMPLICATIONS FIONA BURNS, ALLAN Z. ZHAO, AND JOSEPH A. BEAVO I.
INTRODUCTION 29 II. THE COMPLEXITY AND EXPRESSION OF PDE GENES 30 A.
PDE1 FAMILY (CA 2+ /CAM-ACTIVATED PDE) 30 B. PDE3 FAMILY (CGMP-INHIBITED
PDE) 34 C. PDE4 FAMILY (CAMP-SPECIFIC PDES) 35 D. PDE5 FAMILY (OR
CGMP-BINDING PDES) 36 III. REGULATION OF PDE ACTIVITY BY PHOSPHORYLATION
37 A. REGULATION OF PDE1 ACTIVITY 37 B. REGULATION OF PDE3 ACTIVITY 38
C. REGULATION OF PDE4 ACTIVITY 39 D. REGULATION OF PDE5 ACTIVITY 40 IV.
SUMMARY AND CONCLUSIONS 42 REFERENCES 43 STRUCTURAL ANALYSIS OF THE MAP
KINASE ERK2 AND STUDIES OF MAP KINASE REGULATORY PATHWAYS MELANIE H.
COBB, SHUICHAN XU, MANGENG CHENG, DOUG EBERT, DAVID ROBBINS, ELIZABETH
GOLDSMITH, AND MEGAN ROBINSON I. INTRODUCTION 49 II. REGULATION OF MAP
KINASES BY PHOSPHORYLATION 50 III. STRUCTURE-FUNCTION STUDIES OF ERK2 52
A. DESCRIPTION OF THE STRUCTURE 52 B. SUBSTRATE SPECIFICITY 52 C.
STUDIES OF MEK SPECIFICITY 53 D. PREDICTED ROLES OF THE TWO
PHOSPHORYLATED RESIDUES IN THE ACTIVE STRUCTURE 54 E. THE
PHOSPHORYLATION LIP IS AN IMPORTANT REGULATORY ELEMENT OF THE PROTEIN
KINASE FAMILY 55 F. GAIN-OF-FUNCTION MAP KINASE MUTANTS 55 IV. MAMMALIAN
MEK KINASE ACTIVITIES 56 A. ROLE OF MEKK1 IN THE MAP KINASE PATHWAY 56
B. ENDOGENOUS MEK KINASE ACTIVITIES OF CELL LYSATES 59 C. EFFECTS OF
PHOSPHORYLATION BY ERK1 ON MEK1 AND MEK2 60 V. CONCLUSIONS 62 REFERENCES
62 CONTENTS VII NOVEL PROTEIN PHOSPHATASES THAT MAY PARTICIPATE IN CELL
SIGNALING PATRICIA T. W. COHEN, MAO XIANG CHEN, AND CHRISTOPHER G.
ARMSTRONG I. PROTEIN PHOSPHATASE 5 69 II. PROTEIN PHOSPHATASE Y 76 III.
SUMMARY OF THE FUNCTIONS OF NOVEL PROTEIN PHOSPHATASES 83 REFERENCES 86
PROTEIN TYROSINE PHOSPHATASES AND THE CONTROL OF CELLULAR SIGNALING
RESPONSES N. K. TONKS I. INTRODUCTION 91 II. RECEPTOR-LIKE PTPS 93 A.
PTP/U, AND CELL-CELL ADHESION 95 B. DEP-1 AND CELL-CELL CONTACT 98 C.
PTPS AND CONTACT INHIBITION OF CELL GROWTH 98 III. NONTRANSMEMBRANE
CYTOPLASMIC PTPS 99 A. TARGETING OF PTPS 99 B. PTPS AS PHOSPHOPROTEINS
101 IV. DUAL-SPECIFICITY PHOSPHATASES 103 A. THE DUAL-SPECIFICITY
PHOSPHATASE MKP-1 DEPHOSPHORYLATES AND INACTIVATES MAP KINASES IN VIVO
104 B. CONTROVERSY OVER THE DEPHOSPHORYLATION OF MAP KINASES IN VIVO 107
C. EXPRESSION OF MKP-1 ANTAGONIZES MAP KINASE FUNCTION 109 V.
DETERMINATION OF THE CRYSTAL STRUCTURE OF PTP1B 111 VI. CONCLUSIONS 113
REFERENCES 114 ROLES OF THE MAP KINASE CASCADE IN VERTEBRATES TETSUO
MORIGUCHI, YUKIKO GOTOH, AND EISUKE NISHIDA I. INTRODUCTION 121 II.
ROLES OF THE MAP KINASE CASCADE IN MAMMALIAN CULTURED CELLS 124 A.
DIFFERENTIATION 124 B. PROLIFERATION 125 III. ROLES OF THE MAP KINASE
CASCADE IN XENOPUS 125 A. OOCYTE MATURATION 125 B. METAPHASE ARREST 126
C. EARLY DEVELOPMENT 127 VIH CONTENTS IV. MAP KINASE SUPERFAMILY 128 A.
SUBFAMILIES OF MAP KINASE*SAPK/JNK AND P38/MPK2 128 B. UPSTREAM OF THE
CASCADES 129 V. CONCLUSION AND PERSPECTIVES 130 REFERENCES 131 SIGNAL
TRANSDUCTIONS OF SH2/SH3: ASH/GRB-2 DOWNSTREAM SIGNALING TADAOMI
TAKENAWA, KENJI MIURA, HIROAKI MIKI, AND KAZUTADA WATANABE I.
INTRODUCTION 139 II. ASH DOWNSTREAM SIGNALING IN BRAIN 141 A. ISOLATION
OF ASH-BINDING PROTEINS FROM BOVINE BRAIN 141 B. TISSUE DISTRIBUTION OF
ASH, P65, AND PL50 143 C. PL50 AND P65 BIND TO THE SH3 DOMAIN OF ASH 143
D. ASH SH3 DOMAIN-BINDING PROTEINS IN VIVO 143 E. POSSIBLE FUNCTION OF
ASH IN SYNAPTOSOMES 144 III. SPLICING ISOFORMS OF RAT ASH/GRB-2 145 A.
ISOLATION AND CHARACTERIZATION OF ASH/GRB-2 SPLICING ISOFORMS 146 B.
CLONING AND ORGANIZATION OF THE ASH-1-ENCODING GENE AND GENERATION OF
ASH ISOFORMS 147 C. TISSUE DISTRIBUTION OF ASH-1 AND ASH-M 148 D.
BINDING PROTEINS TO ASH-1 AND ASH-M 148 E. BINDING PROTEINS TO THE
CARBOXY-TERMINAL SH3 DOMAIN OF ASH-M 149 F. EFFECTS OF ASH-1, ASH-M, AND
ASH-S ON PDGF-INDUCED DNA SYNTHESIS 150 G. DOWNSTREAM SIGNALING OF
ASH/GRB-2 AND ITS ISOFORMS 151 REFERENCES 152 SPHINGOLIPID-DEPENDENT
PROTEIN KINASES SEN-ITIROH HAKOMORI I. INTRODUCTION 155 II.
GANGLIOSIDE-DEPENDENT MODULATION OF GROWTH FACTOR- OR INSULIN-DEPENDENT
TYROSINE KINASE 157 III. FUNCTIONAL ROLES OF DE-N-ACETYL-GANGLIOSIDES
AND LYSO-GANGLIOSIDES 160 IV. TRANSMEMBRANE SIGNAL CONTROL BY
SPHINGOSINE AND ITS DERIVATIVES 160 V. GM3 AS A MODULATOR OF INTEGRIN
RECEPTOR FUNCTION 163 CONTENTS IX VI. PLASMALOPSYCHOSINE AS SIGNALING
MOLECULE IN NEURONAL CELLS 164 VII. APPLICATION OF SLS IN
ORTHOSIGNALING THERAPY OF INFLAMMATION 166 REFERENCES 169 G
PROTEIN-COUPLED RECEPTOR KINASE: PHOSPHORYLATION OF MUSCARINIC RECEPTORS
AND FACILITATION OF RECEPTOR SEQUESTRATION TATSUYA HAGA, KAZUKO HAGA,
KIMIHIKO KAMEYAMA, AND HIROFUMI TSUGA I. ACTIVATION OF GRK2 BY G PROTEIN
/3Y-SUBUNITS 174 A. DUAL REGULATION BY G PROTEINS OF THE
AGONIST-DEPENDENT PHOSPHORYLATION OF MUSCARINIC RECEPTORS 174 B.
INHIBITION OF AGONIST-DEPENDENT PHOSPHORYLATION OF MUSCARINIC RECEPTORS
BY GUANINE NUCLEOTIDE-FREE G PROTEIN A/3Y-TRIMER 175 C. STIMULATION BY G
PROTEIN /FY-SUBUNITS OF THE PHOSPHORYLATION OF M 2 , /3-ADRENERGIC
RECEPTORS, AND RHODOPSIN 176 D. TARGET OF G PROTEIN ^-SUBUNITS 177 II.
SYNERGISTIC ACTIVATION OF GRK2 BY /3-Y-SUBUNITS AND AGONIST-BOUND
RECEPTORS 179 A. PHOSPHORYLATION SITES IN M 2 RECEPTORS 179 B. SUBSTRATE
SPECIFICITY OF GRK2 180 C. ACTIVATION BY MASTOPARAN OF THE
PHOSPHORYLATION OF I3-GST 181 D. SYNERGISTIC ACTIVATION BY AGONIST-BOUND
RECEPTORS AND G PROTEIN /3Y-SUBUNITS 182 III. SEQUESTRATION OF
PHOSPHORYLATED M 2 RECEPTORS 184 A. INTERACTION OF PHOSPHORYLATED M 2
RECEPTORS WITH G PROTEINS 184 B. PHOSPHORYLATION BY GRK2 OF M 2
RECEPTORS IN VIVO 186 C. SEQUESTRATION OF M 2 RECEPTORS 186 IV.
CONCLUSION 188 REFERENCES 189 MOLECULAR AND CELLULAR PHARMACOLOGY OF A
CALCIUM/ CALMODULIN-DEPENDENT PROTEIN KINASE II (CAM KINASE II)
INHIBITOR, KN-62, AND PROPOSAL OF CAM KINASE PHOSPHORYLATION CASCADES
HIROYOSHI HIDAKA AND HISAYUKI YOKOKURA I. MOLECULAR PHARMACOLOGY: CAM
ANTAGONISTS TO PROTEIN KINASE INHIBITORS 195 : CONTENTS A. DEVELOPMENT
OF H-SERIES COMPOUNDS 195 B. KN-62, A CAM KINASE II INHIBITOR 197 II.
CELLULAR PHARMACOLOGY OF THE SPECIFIC CAM KINASE II INHIBITOR, KN-62 199
A. INVOLVEMENT OF CAM KINASE II IN NEURONAL ACTIVITIES 199 B.
INVOLVEMENT OF CAM KINASE II IN CARDIOVASCULAR REGULATIONS 201 C.
INVOLVEMENT OF CAM KINASE II IN SECRETORY REGULATIONS 202 D. INVOLVEMENT
OF CAM KINASE II IN REGULATION OF GENE EXPRESSION 205 E. MISCELLANEOUS
207 III. KN-62 IS NOT A SPECIFIC INHIBITOR OF CAM KINASE II BUT IS A
GROUP-SPECIFIC INHIBITOR OF CAM KINASES 209 IV. A NEW GROUP OF CAM
KINASES AND CAM KINASE PHOSPHORYLATION CASCADES 211 V. CONCLUSIONS 213
REFERENCES 215 INTRASTERIC REGULATION OF CALMODULIN-DEPENDENT PROTEIN
KINASES B. E. KEMP, J. A. BARDEN, B. KOBE, C. HOUSE, AND M. W. PARKER I.
INTRODUCTION 221 II. STRUCTURE OF AUTOINHIBITED TWITCHIN KINASE 223 A.
PROTEIN KINASE FOLD 223 B. ASSOCIATED NONCATALYTIC UNC DOMAINS 224 C.
INTRASTERIC INHIBITION: PROFILE OF CONTACTS 225 D. IMPLICATIONS FOR THE
CALMODULIN-DEPENDENT PROTEIN KINASE FAMILY 228 III. AUTOREGULATED
PROTEIN KINASES 229 A. MYOSIN LIGHT-CHAIN KINASE/TWITCHIN KINASE FAMILY
230 B. CALMODULIN-DEPENDENT PROTEIN KINASE II FAMILY 235 C.
CALMODULIN-DEPENDENT PROTEIN KINASES I AND IV 238 D. CALCIUM BINDING
AUTOREGULATED PROTEIN KINASE FAMILY 238 E. PHOSPHORYLASE KINASE 239 IV.
CHOREOGRAPHY OF ACTIVATION 240 A. MECHANISM OF ACTIVATION BY CALMODULIN
240 B. ACTIVATION HINGE IN THE AUTOINHIBITORY SEQUENCE 243 V. CONCLUSION
244 REFERENCES 244 CONTENTS XI STRUCTURE, REGULATION, AND FUNCTION OF
CALCIUM/ CALMODULIN-DEPENDENT PROTEIN KINASE I MARINA R. PICCIOTTO, KENT
L NASTIUK, AND ANGUS C. NAIRN I. INTRODUCTION 251 II. STRUCTURE OF CAM
KINASES 252 III. CHARACTERIZATION OF CAM KINASE I 258 IV. REGULATION OF
CAM KINASE I 259 V. SUBSTRATE SPECIFICITY OF CAM KINASE I AND
AUTOINHIBITION BY A PSEUDOSUBSTRATE MECHANISM 262 VI. REGULATION OF CAM
KINASE I BY A PHOSPHORYLATION CASCADE 264 VII. CELLULAR AND SUBCELLULAR
DISTRIBUTION OF CAM KINASE I 267 VIII. SUBSTRATES FOR CAM KINASE I 269
IX. CONCLUDING REMARKS 271 REFERENCES 271 GENE EXPRESSION AND CREB
PHOSPHORYLATION INDUCED BY CAMP AND CA 2+ IN NEURONAL CELLS MASATOSHI
HAGIWARA, ATSUSHI SHIMOMURA, KAZUHIKO YOSHIDA, AND JUNKO IMAKI I.
INTRODUCTION 277 II. CA 2+ -DEPENDENT ACTIVATION OF CREB 278 III.
LIGHT-INDUCED C-FOS EXPRESSION AND PHOSPHORYLATION OF CREB IN THE NEURAL
RETINA 278 IV. CA 2+ -DEPENDENT CREB ACTIVATION IN RAT RETINA 280 V.
DIFFERENTIAL ROLES OF CAM KINASES IN THE NEURAL RETINA 283 VI.
DISCUSSION AND CONCLUSION 284 REFERENCES 285 INDEX 287 CONTENTS OF
PREVIOUS VOLUMES 295
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genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content Infrazellulärraum gnd |
genre_facet | Aufsatzsammlung Infrazellulärraum |
id | DE-604.BV010948242 |
illustrated | Illustrated |
indexdate | 2024-07-09T18:01:30Z |
institution | BVB |
isbn | 0120329379 0125138059 |
language | English |
oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007322308 |
oclc_num | 35251182 |
open_access_boolean | |
owner | DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-12 DE-20 DE-11 |
owner_facet | DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-12 DE-20 DE-11 |
physical | XV, 310 S. Ill., graph. Darst. |
publishDate | 1996 |
publishDateSearch | 1996 |
publishDateSort | 1996 |
publisher | Acad. Press |
record_format | marc |
series2 | Advances in pharmacology |
spelling | Intracellular signal transduction ed. by Hiroyoshi Hidaka ... San Diego [u.a.] Acad. Press 1996 XV, 310 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in pharmacology 36 Einzelaufnahme eines Zeitschr.-Bd. Cellular signal transduction Intracellular Membranes Signal Transduction Proteinkinasen (DE-588)4175996-5 gnd rswk-swf Zelle (DE-588)4067537-3 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf Regulation (DE-588)4049075-0 gnd rswk-swf Phosphoproteinphosphatase (DE-588)4248815-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Infrazellulärraum gnd rswk-swf Signaltransduktion (DE-588)4318717-1 s Infrazellulärraum f DE-604 Phosphoproteinphosphatase (DE-588)4248815-1 s Zelle (DE-588)4067537-3 s Regulation (DE-588)4049075-0 s Proteinkinasen (DE-588)4175996-5 s Hidaka, Hiroyoshi Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007322308&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | Intracellular signal transduction Cellular signal transduction Intracellular Membranes Signal Transduction Proteinkinasen (DE-588)4175996-5 gnd Zelle (DE-588)4067537-3 gnd Signaltransduktion (DE-588)4318717-1 gnd Regulation (DE-588)4049075-0 gnd Phosphoproteinphosphatase (DE-588)4248815-1 gnd |
subject_GND | (DE-588)4175996-5 (DE-588)4067537-3 (DE-588)4318717-1 (DE-588)4049075-0 (DE-588)4248815-1 (DE-588)4143413-4 |
title | Intracellular signal transduction |
title_auth | Intracellular signal transduction |
title_exact_search | Intracellular signal transduction |
title_full | Intracellular signal transduction ed. by Hiroyoshi Hidaka ... |
title_fullStr | Intracellular signal transduction ed. by Hiroyoshi Hidaka ... |
title_full_unstemmed | Intracellular signal transduction ed. by Hiroyoshi Hidaka ... |
title_short | Intracellular signal transduction |
title_sort | intracellular signal transduction |
topic | Cellular signal transduction Intracellular Membranes Signal Transduction Proteinkinasen (DE-588)4175996-5 gnd Zelle (DE-588)4067537-3 gnd Signaltransduktion (DE-588)4318717-1 gnd Regulation (DE-588)4049075-0 gnd Phosphoproteinphosphatase (DE-588)4248815-1 gnd |
topic_facet | Cellular signal transduction Intracellular Membranes Signal Transduction Proteinkinasen Zelle Signaltransduktion Regulation Phosphoproteinphosphatase Aufsatzsammlung Infrazellulärraum |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007322308&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
work_keys_str_mv | AT hidakahiroyoshi intracellularsignaltransduction |