Cellular and molecular mechanisms of ischemic brain damage:
This volume provides an in-depth review of the cellular and molecular mechanisms involved in ischemic brain damage. The book features contributions from more than 100 leading international authorities in all relevant clinical and basic science disciplines. These experts synthesize the latest finding...
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia [u.a.]
Lippincott-Raven
1996
|
| Schriftenreihe: | Advances in neurology
71 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Zusammenfassung: | This volume provides an in-depth review of the cellular and molecular mechanisms involved in ischemic brain damage. The book features contributions from more than 100 leading international authorities in all relevant clinical and basic science disciplines. These experts synthesize the latest findings on molecular events that play a key role in neuronal cell death or in neuroprotection after ischemia. This volume is an essential resource for all physicians treating stroke and for researchers investigating the molecular pathology of ischemic brain damage. The book is also a valuable source of promising new ideas of pharmacologists developing anti-ischemic drugs for treatment of stroke. |
| Beschreibung: | XXI, 527 S. zahlr. Ill. und graph. Darst. |
| ISBN: | 0781702771 |
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| 490 | 1 | |a Advances in neurology |v 71 | |
| 520 | 3 | |a This volume provides an in-depth review of the cellular and molecular mechanisms involved in ischemic brain damage. The book features contributions from more than 100 leading international authorities in all relevant clinical and basic science disciplines. These experts synthesize the latest findings on molecular events that play a key role in neuronal cell death or in neuroprotection after ischemia. This volume is an essential resource for all physicians treating stroke and for researchers investigating the molecular pathology of ischemic brain damage. The book is also a valuable source of promising new ideas of pharmacologists developing anti-ischemic drugs for treatment of stroke. | |
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Datensatz im Suchindex
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| adam_text | Contents
Contributors xi
Preface xxi
Acknowledgments xxii
I. Excitotoxic Mechanisms
1. Excitotoxicity and Excitoprotection In Vitro 1
Mark P. Mattson and Robert J. Mark
2. Effects of Glutamate on Calcium Influx and Sequestration/Extrusion
Mechanisms in Hippocampal Neurons 37
Robert J. DeLorenzo and David D. Limbrick, Jr.
3. Metabotropic Glutamate Receptors and Neuronal Degeneration in Culture 47
V. Bruno, A. Copani, G. Battaglia, P. Dell Albani, D. F. Condorelli, and
Ferdinando Nicoletti
4. Glutamate, Arachidonic Acid, and Calcium Regulation in Cultured
Hippocampal Astrocytes: Involvement in Ischemia? 53
Kathleen Shaver Madden, Warren T. Kim, and Ann Cornell Bell
5. Excitotoxic Damage in Global Ischemia 61
William Pulsinelli
6. Excitotoxic Mechanisms and Focal Ischemia 69
Konstantin Alexander Hossman
7. Spreading Depression as a Contributor to Ischemic Brain Damage 75
Maiken Nedergaard
II. Calcium and Cell Death
8. Cytosolic Calcium Concentrations and Cell Death In Vitro 85
Michael Tymianski
9. Calcium Induced Neuronal Cell Death In Vivo and In Vitro: Are the
Pathophysiological Mechanisms Different? 107
Tibor Kristidn, Yibing Ouyang, and Bo K. Siesjo
10. Calcium Handling by Hippocampal Neurons Under Physiological and
Pathological Conditions 119
Maria Erecinska and Ian A. Silver
11. Mechanisms of Calcium Related Cell Death 137
Sten Orrenius, Maria Ankarcrona, and Pierluigi Nicotera
vii
viii CONTENTS
12. Ions, Channels, and Transporters Involved in Anoxic Injury of Central
Nervous System White Matter 153
Peter K. Stys
13. The Calcium Activated Protease Calpain I and Ischemia Induced
Neurodegeneration 167
Robert Siman, Donna Bozyczko Coyne, Mary J. Savage, and
Jill M. Roberts Lewis
HI. Temperature, pH, and Free Radicals
14. Brain Damage and Temperature: Cellular and Molecular Mechanisms 177
W. Dalton Dietrich, Raul Busto, Mordecai Y. T. Globus, and
Myron D. Ginsberg
15. The Effect of Hypothermia on the Expression of the Immediate Early Genes
After Ischemia 199
Fredrik Kamme and Tadeusz Wieloch
16. Acidosis Related Damage 209
Bo K. Siesjo, Ken ichiro Katsura, and Tibor Kristidn
17. Excitotoxic Neuron Death, Acidotic Endangerment, and the Paradox of
Acidotic Protection 237
Robert M. Sapolsky, Jodie Trafton, and Geoffrey C. Tombaugh
18. Lipid Peroxidation 247
Edward D. Hall
19. Protein and Lipid Oxidation Following Ischemia/Reperfusion Injury, the
Role of Polyamines: An Electron Paramagnetic Resonance Analysis 259
John M. Carney, Nathan C. Hall, Mingshan Cheng, Jungfang Wu, and
D. Allan Butterfield
20. Neuroprotective Role of CuZn Superoxide Dismutase in Ischemic Brain
Damage 271
Pak H. Chan, Charles J. Epstein, H. Kinouchi, H. Kamii, S. F. Chen,
E. Carlson, Juliette Gafni, Guoyuan Yang, and Liza Reola
IV. Inflammatory Reactions Involving Free Radicals, Cytokines, Nitric Oxide
21. Inflammatory Reactions at the Blood Endothelial Interface in Acute
Stroke 281
John M. Hallenbeck
22. Alterations in Cerebral Endothelial Cell Function in Ischemia 301
A. Lorris Betz
23. The Role of Adhesion Molecules in Reducing Cerebral Ischemic Cell
Damage 315
Michael Chopp, Rui Lan Zhang, and Nin Jiang
CONTENTS ix
24. Early Glial Reactions in Ischemic Lesions 329
Richard B. Banati, Jochen Gehrmann, andGeorg W. Kreutzberg
25. The Interactions of Nitric Oxide with Oxygen Radicals and Scavengers in
Cerebral Ischemic Injury 339
Joseph S. Beckman, Yao Zu Ye, Jun Chen, and Karl A. Conger
26. The Role of Nitric Oxide in Ischemic Damage 355
Brian S. Meldrum
27. Nitric Oxide and Cerebral Ischemia 365
Michael A. Moskowitz and Turgay Dalkara
V. Trophic Mechanisms and Protein Synthesis
28. Intracellular Signal Transduction in the Postischemic Brain: Implications for
Neurotransmission and Neuronal Survival 371
Tadeusz Wieloch, Bing Ren Hu, A. Boris Moller, Monika Cardell,
Fredrik Kamme, Junichi Kurihara, and Kazuhiko Sakata
29. Trophic Factors and Their Role in the Postischemic Brain 389
Kardy Nikolics, Franz Hefti, G. Roger Thomas, and Peter D. Gluckman
30. Expression of Neurotrophin mRNAs in the Postischemic Phase 405
Olle Lindvall, Zaal Kokaia, Johan Bengzon, Eskil Elmer, and
Merab Kokaia
31. The Potential Use of Neurotrophic Growth Factors in the Treatment of
Cerebral Ischemia 413
Seth P. Finklestein
32. Mechanisms of Neuronal Cell Death 419
Remy Sadoul, Michael Dubois Dauphin, Pierre Alain Fernandez,
Harald Frankowski, Anne Lise Quiquerez, Isabelle Martinou,
Marc Missotten, Claudio Pietra, and Jean Claude Martinou
33. Is Ischemic Cell Death of Apoptotic Type? 425
Christiane Charriaut Marlangue, Helene Pollard, and Yezekiel Ben Ari
VI. Changes in Gene Expression
34. Novel Molecular Correlates of Neuronal Death and Regeneration 433
Shu Cheng Chen, Holly D. Soares, and James I. Morgan
35. The Stress Response and Its Role in Cellular Defense Mechanisms After
Ischemia 451
Hiroshi Abe and Thaddeus S. Nowak, Jr.
36. Caffeine and Ischemia—Effects on Immediate Early Genes and Adenosine
Receptors 469
Bertil B. Fredholm, Ulrika Aden, Karin Lindstrom, Elsa Bona, and
Henrik Hagberg
x CONTENTS
37. Platelet Activating Factor is Both a Modulator of Synaptic Function and a
Mediator of Cerebral Injury and Inflammation 475
Nicolas G. Bazan and Geoffrey Allan
38. Isolation of an Ischemia Induced Gene and Early Disturbance of
Mitochondrial DNA Expression after Transient Forebrain Ischemia 485
Koji Abe, Jun ichi Kawagoe, Y. Itoyama, and Kyuya Kogure
39. Ischemic Tolerance 505
Takaaki Kirino, Tadayoshi Nakagomi, Hideaki Kanemitsu, and
Akira Tamura
Index 513
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| title | Cellular and molecular mechanisms of ischemic brain damage |
| title_auth | Cellular and molecular mechanisms of ischemic brain damage |
| title_exact_search | Cellular and molecular mechanisms of ischemic brain damage |
| title_full | Cellular and molecular mechanisms of ischemic brain damage ed. Bo K. Siesjö ... |
| title_fullStr | Cellular and molecular mechanisms of ischemic brain damage ed. Bo K. Siesjö ... |
| title_full_unstemmed | Cellular and molecular mechanisms of ischemic brain damage ed. Bo K. Siesjö ... |
| title_short | Cellular and molecular mechanisms of ischemic brain damage |
| title_sort | cellular and molecular mechanisms of ischemic brain damage |
| topic | Celbiologie gtt Hersenbeschadiging gtt Hersenischemie gtt Moleculaire biologie gtt Brain Damage, Chronic physiopathology Congresses Brain Ischemia Congresses Cerebral ischemia Etiology Congresses Cerebral ischemia Pathophysiology Atlases Hirnkrankheit (DE-588)4025013-1 gnd Neurologie (DE-588)4041888-1 gnd Ischämie (DE-588)4162456-7 gnd Molekularpathologie (DE-588)4170396-0 gnd |
| topic_facet | Celbiologie Hersenbeschadiging Hersenischemie Moleculaire biologie Brain Damage, Chronic physiopathology Congresses Brain Ischemia Congresses Cerebral ischemia Etiology Congresses Cerebral ischemia Pathophysiology Atlases Hirnkrankheit Neurologie Ischämie Molekularpathologie Aufsatzsammlung Konferenzschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007306428&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000000622 |
| work_keys_str_mv | AT siesjobok cellularandmolecularmechanismsofischemicbraindamage |