Local immunosuppression of organ transplants:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Springer [u.a.]
1996
|
| Schriftenreihe: | Medical intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 217 S. Ill., graph. Darst. |
| ISBN: | 3540611975 0412110911 |
Internformat
MARC
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| 245 | 1 | 0 | |a Local immunosuppression of organ transplants |c Scott A. Gruber |
| 264 | 1 | |a New York [u.a.] |b Springer [u.a.] |c 1996 | |
| 300 | |a 217 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Medical intelligence unit | |
| 650 | 0 | 7 | |a Tiermodell |0 (DE-588)4140660-6 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Transplantation |0 (DE-588)4060675-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Targeted drug delivery |0 (DE-588)4302415-4 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Immunsuppression |0 (DE-588)4026641-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Immunsuppressivum |0 (DE-588)4161389-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Lokaltherapie |0 (DE-588)4206752-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Transplantat |0 (DE-588)4185918-2 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Transplantat |0 (DE-588)4185918-2 |D s |
| 689 | 0 | 1 | |a Immunsuppression |0 (DE-588)4026641-2 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Transplantat |0 (DE-588)4185918-2 |D s |
| 689 | 1 | 1 | |a Immunsuppression |0 (DE-588)4026641-2 |D s |
| 689 | 1 | 2 | |a Lokaltherapie |0 (DE-588)4206752-2 |D s |
| 689 | 1 | 3 | |a Tiermodell |0 (DE-588)4140660-6 |D s |
| 689 | 1 | |5 DE-604 | |
| 689 | 2 | 0 | |a Transplantation |0 (DE-588)4060675-2 |D s |
| 689 | 2 | 1 | |a Immunsuppressivum |0 (DE-588)4161389-2 |D s |
| 689 | 2 | 2 | |a Targeted drug delivery |0 (DE-588)4302415-4 |D s |
| 689 | 2 | |5 DE-604 | |
| 700 | 1 | |a Gruber, Scott A. |e Sonstige |4 oth | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007256507&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-007256507 | |
Datensatz im Suchindex
| _version_ | 1808227830061858816 |
|---|---|
| adam_text |
CONTENTS
SECTION
A:
BACKGROUND
1.
LOCAL
REGULATION
OF
ALLOGRAFT
REJECTION
.
3
SCOTT
A.
GRUBER,
SHENGGUANG
XIAO
AND
STEPHEN
E.
HUGHES
SENSITIZATION/IMMUNOSTIMULATION
.
4
GRAFT
ANTIGEN
PRESENTATION/RECOGNITION
.
4
ATTACHMENT
OF
LEUKOCYTES
TO
GRAFT
VASCULAR
ENDOTHELIUM
AND
TRANSMIGRATION
THROUGH
THE
VESSEL
WALL
.
5
MIGRATION
AND
SELECTIVE
RETENTION
OF
CELLS
WITHIN
THE
GRAFT
.6
IN
SITU
MATURATION/PROLIFERATION
.
6
EFFECTOR/INFLAMMATORY
AND
REGULATORY
MECHANISMS
.7
SUMMARY
.
8
2.
PHARMACOKINETIC
ADVANTAGE
OF
REGIONAL
DRUG
DELIVERY
.
13
STEPHEN
E.
HUGHES,
SARDHA
PERERA
AND
SCOTT
A.
GRUBER
CALCULATION
OF
THE
SYSTEMIC
ADVANTAGE
.
14
CALCULATION
OF
THE
REGIONAL
ADVANTAGE
.
14
CALCULATION
OF
SELECTIVITY
.
14
ADDITIONAL
CONSIDERATIONS
.
15
3.
EARLY
STUDIES
OF
LOCAL
IMMUNOSUPPRESSION
(1964-1984)
.
17
STEPHEN
E.
HUGHES,
SARDHA
PERERA
AND
SCOTT
A.
GRUBER
REGIONAL
DRUG
DELIVERY
.
17
LOCAL
GRAFT
IRRADIATION
.
19
CONCLUSION
.
20
SECTION
B:
PUMP-BASED
LOCAL
INFUSION
IN
RAT
ALLOGRAFT
MODELS
4.
SELECTIVE
IMMUNOSUPPRESSION
BY
LOCAL
TREATMENT
OF
THE
ALLOGRAFT:
STUDIES
ON
INTRARENAL
PREDNISOLONE
AND
INTRACARDIAC
BUDESONIDE
DELIVERY
IN
THE
RAT
.
25
T.
J.
M.
RUERS
IMMUNOLOGICAL
ASPECTS
OF
LOCAL
TREATMENT
.
25
PHARMACOLOGICAL
AND
THERAPEUTIC
ASPECTS
OF
LOCAL
TREATMENT
.
34
5.
LOCAL
IMMUNOSUPPRESSION
OF
RAT
CARDIAC,
LIVER,
AND
SMALL
BOWEL
ALLOGRAFTS
.
39
MOU-ER
WANG,
STANISLAW
M.
STEPKOWSKI
AND
BARRY
D.
KAHAN
INTRODUCTION
.39
INTRAGRAFT
IMMUNE
RESPONSE
.
39
LOCAL
IMMUNOSUPPRESSION
OF
HEART
ALLOGRAFTS
.
41
LOCAL
IMMUNOSUPPRESSION
OF
LIVER
AND
SMALL
BOWEL
ALLOGRAFTS
.
42
CONCLUSION
.
42
6.
INHIBITION
OF
CARDIAC
ALLOGRAFT
REJECTION
BY
CONTINUOUS
LOCAL
INFUSION
OF
16,16
DI-METHYL
PGE
2.
47
M.
WAYNE
FLYE
AND
SAMUEL
YU
IN
VIVO
EFFECTS
OF
PGE
2
.
48
EFFECTS
OF
PGE
2
IN
ORGAN
TRANSPLANTATION
.
48
MECHANISM
OF
PROSTAGLANDIN
INHIBITION
OF
T
HELPER
1
(THL)
AND
TH2
CELLS
.
50
DEVELOPMENT
OF
ANERGY
.
51
SYSTEMIC
VERSUS
INTRAGRAFT
TREATMENT
OF
CARDIAC
ALLOGRAFT
RECIPIENTS
WITH
16,16
DI-M
PGE
2
.
51
INDUCTION
OF
DONOR-SPECIFIC
TOLERANCE
.
52
IMMUNOGENICITY
OF
THE
LONG-TERM
ACCEPTED
CARDIAC
ALLOGRAFT
.
53
MONOCYTE
MIGRATION
.
53
PGE
2
TOXICITY
.
53
CONCLUSION
.
54
7.
INTRARENAL
ADMINISTRATION
OF
ANTI
T
CELL-MONOCLONAL
ANTIBODY
.
59
NORIO
YOSHIMURA,
CHOI
JOO
LEE
AND
TAKAHIRO
OKA
EXPERIMENTAL
MODEL
OF
LOCAL
INTRAARTERIAL
INFUSION
OF
MOAB
.59
PRODUCTION
AND
PREPARATION
OF
MOAB
(OX
19)
.
60
RENAL
TRANSPLANTATION
AND
ADMINISTRATION
OF
OX
19
.
60
EFFECT
OF
LOCAL
TREATMENT
WITH
MOAB
ON
RENAL
ALLOGRAFT
SURVIVAL
.
60
HISTOLOGICAL
EXAMINATION
OF
RENAL
ALLOGRAFTS
.
61
IMMUNOLOGICAL
EVENTS
WITHIN
THE
GRAFT
AND
SPLEEN
.
63
CYTOKINE
RELEASE
FROM
SPLENOCYTES
.
64
DISCUSSION
.
64
SUMMARY
.
66
8.
INTRAPORTAL
DELIVERY
OF
IMMUNOSUPPRESSANTS
TO
INTRAHEPATIC
ISLET
ALLOGRAFTS
.
69
DONALD
C.
DAFOE
AND
EDWARD
J.
ALFREY
INTRODUCTION
.
69
EXPERIMENTAL
MODEL
.
70
IMMUNOSUPPRESSIVE
AGENTS
.
72
DISCUSSION
.
76
SECTION
C:
PUMP-BASED
LOCAL
INFUSION
IN
CANINE
ALLOGRAFT
MODELS
9.
LOCAL
HEPARIN,
6-MERCAPTOPURINE,
PREDNISOLONE,
AND
MIZORIBINE
DELIVERY
IN
A
CANINE
RENAL
ALLOGRAFT
MODEL
.
81
SCOTT
A.
GRUBER,
SHENGGUANG
XIAO
AND
STEPHEN
E.
HUGHES
RATIONALE
FOR
AND
FEASIBILITY
OF
THE
CANINE
MODEL
.
81
PHARMACOKINETIC
ADVANTAGE
OF
LOCAL
6-MERCAPTOPURINE
(6-MP)
INFUSION
.
84
PHARMACODYNAMICS
OF
LOCAL
HEPARIN
INFUSION
.85
LOCAL
VERSUS
SYSTEMIC
6-MP
INFUSION
.
85
LOCAL
VERSUS
SYSTEMIC
PREDNISOLONE
INFUSION
.89
PHARMACOKINETICS
AND
PHARMACODYNAMICS
OF
INTRARENAL
MIZORIBINE
(MZB)
INFUSION
.
91
CONCLUSION
.
94
10.
INTRAPORTAL
CYCLOSPORINE
A
IN
CANINE
LIVER
TRANSPLANTATION
.
97
SAIHO
KO,
YOSHIYUKI
NAKAJIMA
AND
HIROSHIGE
NAKANO
INTRODUCTION
.
97
IMMUNOSUPPRESSIVE
EFFECTS
OF
INTRAPORTAL
CSA
.
97
INFLUENCE
OF
INTRAPORTAL
CSA
ON
SYSTEMIC
SIDE
EFFECTS
.
99
PHARMACOLOGICAL
PROFILE
OF
INTRAPORTAL
CSA
IN
CANINE
LIVER
TRANSPLANTATION
.
99
MECHANISM
OF
LOCAL
IMMUNOSUPPRESSION
.
101
CONSIDERATION
OF
CLINICAL
APPLICATION
OF
INTRAPORTAL
CSA
.
103
SUMMARY
.
104
SECTION
D:
OTHER
DRUG
TARGETING
SYSTEMS
FOR
ACHIEVING
LOCAL
IMMUNOSUPPRESSION
11.
LIPOSOMAL
CYCLOSPORINE
A
.
109
CHRIS
E.
FREISE,
NANCY
L.
ASCHER
AND
JOHN
P.
ROBERTS
BACKGROUND
.
109
DEVELOPMENT
AND
CHARACTERIZATION
OF
A
CSA
LIPOSOME
.
110
IN
VITRO
CHARACTERISTICS
OF
CSA
LIPOSOMES
.
112
EFFECT
OF
CSA
LIPOSOMES
ON
NEPHROTOXICITY
.
113
INCREASED
EFFICACY
OF
CSA
LIPOSOME
IN
A
RAT
LIVER
TRANSPLANT
MODEL
.
115
12.
LIPOSOMAL
FK506
IN
A
CANINE
HEPATIC
ALLOGRAFT
MODEL
.
119
SAIHO
KO,
YOSHIYUKI
NAKAJIMA
AND
HIROSHIGE
NAKANO
INTRODUCTION
.
119
GENERAL
CHARACTERISTICS
OF
THE
LIPOSOMES
.
120
LIPOSOMAL
INCORPORATION
OF
FK506
.
120
PHARMACOKINETICS
OF
LIPOSOMAL
FK506
.
121
IMMUNOSUPPRESSIVE
EFFECTS
OF
LIPOSOMAL
FK506
.
121
BENEFITS
OF
LIPOSOMAL
INCORPORATION
WITH
RESPECT
TO
THE
ADVERSE
EFFECTS
OF
FK5O6
.
127
CONCLUSION
.
128
SUMMARY
.
128
13.
CYCLOSPORINE
AEROSOL
IN
LUNG
TRANSPLANTATION
.
131
GILBERT
J.
BURCKART,
ROBERT
J.
KEENAN,
ALDO
T.
LACONO
AND
BARTLEY
P.
GRIFFITH
ANIMAL
STUDIES
.
132
HUMAN
STUDIES
.
135
PHARMACOKINETIC
STUDIES
.
137
SUMMARY
.
137
14.
SITE-SPECIFIC
IMMUNOSUPPRESSION
WITH
TOPICAL
AGENTS
.
141
KIRBY
S.
BLACK
AND
CHARLES
W.
HEWITT
SIGNIFICANCE
OF
TOPICAL
IMMUNOSUPPRESSANTS
.
141
BACKGROUND
.
142
MECHANISMS
OF
SITE
.
144
COMMERCIAL
APPLICATION
.
147
SUMMARY
.
148
15*
LOCAL
IMMUNOSUPPRESSION
IN
CORNEAL
TRANSPLANTATION
.
153
ALI
R
DJALILIAN
AND
EDWARD
J.
HOLLAND
INTRODUCTION
.
153
CORTICOSTEROIDS
.
154
CYCLOSPORINE
A
(CSA)
.
155
FK506
.
156
MONOCLONAL
ANTIBODIES
.
156
EXPERIMENTAL
AGENTS
AND
TECHNIQUES
.
157
SUMMARY
.
157
16.
CONTROLLED-RELEASE
DRUG
MATRICES
FOR
LOCAL
IMMUNOSUPPRESSION
OF
ORGAN
TRANSPLANTS
.
161
STEVEN
F.
BOLLING,
VINOD
LABHASETWAR
AND
ROBERT
J.
LEVY
INTRODUCTION
.
161
RATIONALE
.
162
REVIEW
OF
EXPERIMENTAL
RESULTS
.
162
FUTURE
PERSPECTIVES
.
167
17.
GENE
TRANSFER
TO
THE
TRANSPLANTED
ORGAN
.
169
JONATHAN
S.
BROMBERG
AND
LIHUI
QIN
RATIONALE
.
169
GENERAL
CONSIDERATIONS
IN
TRANSPLANTATION
.
170
EFFECTOR
MOLECULES
.
171
TRANSFER
VECTORS
.
172
EXPRESSION
.
174
EXPERIMENTAL
RESULTS
.
175
FUTURE
DIRECTIONS
.
175
18.
IMMUNOMODULATION
OF
ISLET
ALLOGRAFTS
WITH
GENETICALLY
MODIFIED
MUSCLE
CELLS
.
181
MING
YU,
A.
ALFRED
CHAHINE,
CHRISTIAN
STOECKERT
AND
HENRY
T
LAU
IMMUNE
RECOGNITION
.
181
APC
-
T
CELL
INTERACTIONS
.
182
LEVELS
OF
INTERVENTION
.
182
LOCAL
DELIVERY
OF
IMMUNOSUPPRESSIVE
MOLECULES
.
185
MUSCLE
CELLS
AS
PLATFORMS
FOR
DELIVERY
OF
IMMUNOSUPPRESSION
.
186
PRIMARY
MUSCLE
CELLS
AS
PLATFORMS
FOR
DELIVERY
OF
IMMUNOSUPPRESSION
.
188
CONCLUSION
.
190
19.
SERTOLI
CELLS
IN
ISLET
TRANSPLANTATION:
TESTICULAR
IMMUNE
PRIVILEGE
.
193
HELENA
P.
SELAWRY
THE
ABDOMINAL
TESTIS
AND
ISLET
ALLOGRAFT
SURVIVAL
.
194
ABDOMINAL
INTRATESTICULAR
ISLET
XENOGRAFT
SURVIVAL
.
195
MECHANISM
OF
TESTICULAR
IMMUNE
PRIVILEGE
.
197
INTRATESTICULAR
ISLET
ALLOGRAFT
SURVIVAL
IN
PRIMATES
.
202
DEVELOPMENT
OF
AN
ECTOPIC
IMMUNOLOGICALLY
PRIVILEGED
SITE
WITH
SERTOLI
CELLS
.
204
EFFECT
OF
TESTIS
ENVIRONMENT
ON
GRAFTED
ISLET
FUNCTION
.
205
CONCLUSION
.
207
SECTION
E:
CONCLUSION
.
211
SCOTT
A.
GRUBER
INDEX
.
213 |
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV010857676 |
| classification_rvk | YI 6522 |
| ctrlnum | (OCoLC)260209780 (DE-599)BVBBV010857676 |
| discipline | Medizin |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV010857676 |
| illustrated | Illustrated |
| indexdate | 2024-08-24T00:47:19Z |
| institution | BVB |
| isbn | 3540611975 0412110911 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007256507 |
| oclc_num | 260209780 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-12 |
| owner_facet | DE-355 DE-BY-UBR DE-12 |
| physical | 217 S. Ill., graph. Darst. |
| publishDate | 1996 |
| publishDateSearch | 1996 |
| publishDateSort | 1996 |
| publisher | Springer [u.a.] |
| record_format | marc |
| series2 | Medical intelligence unit |
| spelling | Local immunosuppression of organ transplants Scott A. Gruber New York [u.a.] Springer [u.a.] 1996 217 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Medical intelligence unit Tiermodell (DE-588)4140660-6 gnd rswk-swf Transplantation (DE-588)4060675-2 gnd rswk-swf Targeted drug delivery (DE-588)4302415-4 gnd rswk-swf Immunsuppression (DE-588)4026641-2 gnd rswk-swf Immunsuppressivum (DE-588)4161389-2 gnd rswk-swf Lokaltherapie (DE-588)4206752-2 gnd rswk-swf Transplantat (DE-588)4185918-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Transplantat (DE-588)4185918-2 s Immunsuppression (DE-588)4026641-2 s DE-604 Lokaltherapie (DE-588)4206752-2 s Tiermodell (DE-588)4140660-6 s Transplantation (DE-588)4060675-2 s Immunsuppressivum (DE-588)4161389-2 s Targeted drug delivery (DE-588)4302415-4 s Gruber, Scott A. Sonstige oth DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007256507&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Local immunosuppression of organ transplants Tiermodell (DE-588)4140660-6 gnd Transplantation (DE-588)4060675-2 gnd Targeted drug delivery (DE-588)4302415-4 gnd Immunsuppression (DE-588)4026641-2 gnd Immunsuppressivum (DE-588)4161389-2 gnd Lokaltherapie (DE-588)4206752-2 gnd Transplantat (DE-588)4185918-2 gnd |
| subject_GND | (DE-588)4140660-6 (DE-588)4060675-2 (DE-588)4302415-4 (DE-588)4026641-2 (DE-588)4161389-2 (DE-588)4206752-2 (DE-588)4185918-2 (DE-588)4143413-4 |
| title | Local immunosuppression of organ transplants |
| title_auth | Local immunosuppression of organ transplants |
| title_exact_search | Local immunosuppression of organ transplants |
| title_full | Local immunosuppression of organ transplants Scott A. Gruber |
| title_fullStr | Local immunosuppression of organ transplants Scott A. Gruber |
| title_full_unstemmed | Local immunosuppression of organ transplants Scott A. Gruber |
| title_short | Local immunosuppression of organ transplants |
| title_sort | local immunosuppression of organ transplants |
| topic | Tiermodell (DE-588)4140660-6 gnd Transplantation (DE-588)4060675-2 gnd Targeted drug delivery (DE-588)4302415-4 gnd Immunsuppression (DE-588)4026641-2 gnd Immunsuppressivum (DE-588)4161389-2 gnd Lokaltherapie (DE-588)4206752-2 gnd Transplantat (DE-588)4185918-2 gnd |
| topic_facet | Tiermodell Transplantation Targeted drug delivery Immunsuppression Immunsuppressivum Lokaltherapie Transplantat Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007256507&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT gruberscotta localimmunosuppressionoforgantransplants |