Genetics and biochemistry of antibiotic production:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Boston [u.a.]
Butterworth-Heinemann
1995
|
| Schriftenreihe: | Biotechnology series
28 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXII, 679 S. graph. Darst. |
| ISBN: | 075069095X |
Internformat
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Datensatz im Suchindex
| _version_ | 1804125340020244480 |
|---|---|
| adam_text | GENETICS AND BIOCHEMISTRY OF ANTIBIOTIC PRODUCTION EDITED BY LEO C.
VINING AND COLIN STUTTARD DALHOUSIE UNIVERSITY HALIFAX, NOVA SCOTIA,
CANADA BUTTERWORTH-HEINEMANN BOSTON LONDON OXFORD SINGAPORE SYDNEY
TORONTO WELLINGTON CONTENTS PREFACE XXI SECTION A. GENETIC AND
ENVIRONMENTAL CONTROL OF ANTIBIOTIC PRODUCTION 1 OVERVIEW BY LEO C
VINING 1. GLOBAL PHYSIOLOGICAL CONTROLS 9 JANICE L. DOULL AND LEO C.
VINING 1 . 1 INTRODUCTION 9 1.2 REGULATORY MECHANISMS 11 1.3 OPERATION
OF GLOBAL CONTROL SYSTEMS 30 1.4 GLOBAL CONTROL OF SECONDARY METABOLISM
40 REFERENCES 54 2. GENETICS OF ANTIBIOTIC PRODUCTION IN STREPTOMYCES
COELICOLOR A3(2), A MODEL STREPTOMYCETE 65 DAVID A. HOPWOOD, KEITH F.
CHATER AND MERVYN J. BIBB 2.1 INTRODUCTION 65 2.2 THE PATHWAY GENES 69
2.3 TRANSITION FROM PRIMARY TO SECONDARY METABOLISM 85 2.4 GENES WITH
PLEIOTROPIC EFFECTS ON THE PRODUCTION OF ANTIBIOTICS 87 2.5 CONCLUSION
96 REFERENCES 97 XM XIV CONTENTS 3. AUTOREGULATORS 103 SUEHARU
HORINOUCHI AND TERUHIKO BEPPU 3.1 INTRODUCTION 103 3.2 STREPTOMYCETE
AUTOREGULATORS 104 3.3 GENETICS OF A-FACTOR BIOSYNTHESIS 110 3.4 BINDING
PROTEINS 111 3.5 REGULATORY CASCADE FOR STREPTOMYCIN BIOSYNTHESIS 113
3.6 A MODEL FOR REGULATION OF STREPTOMYCIN BIOSYNTHESIS 115 3.7
CONCLUSIONS 117 REFERENCES 118 SECTION B. PEPTIDE AND PEPTIDE-DERIVED
ANTIBIOTICS 121 OVERVIEW BY LEO C. VINING AND HANS VON DOHREN 4.
PEPTIDES 129 HANS VON DOHREN 4.1 INTRODUCTION 129 4.2 OVERVIEW OF
PEPTIDES FROM BACILLI 130 4.3 GENETICS OF PEPTIDE BIOSYNTHESIS 133 4.4
OTHER SYSTEMS IN PERSPECTIVE 145 4.5 REGULATORY MECHANISMS IN PEPTIDE
PRODUCERS 154 4.6 ENZYMOLOGY OF PEPTIDE BIOSYNTHESIS 157 4.7 TOWARDS THE
DESIGN OF ENZYME SYSTEMS 160 4.8 SUMMARY 161 REFERENCES 161 5.
PEPTIDOLACTONES 173 ULLRICH KELLER 5.1 INTRODUCTION 173 5.2 BIOSYNTHESIS
OF ACYL PEPTIDOLACTONES 174 5.3 AROMATIC CARBOXYLIC ACID ACTIVATING
ENZYMES 177 5.4 CHROMOPEPTIDOLACTONE SYNTHETASES 183 5.5 BIOSYNTHESIS OF
NONACYL PEPTIDOLACTONES 188 5.6 CONCLUSIONS 192 REFERENCES 193 6.
BIALAPHOS 197 CHARLES J. THOMPSON AND HARUO SETO 6.1 INTRODUCTION 197
CONTENTS XV 6.2 ORIGIN OF THE BA CARBON SKELETON 200 6.3 BIOSYNTHESIS
VIA PHOSPHONOPYRUVATE 200 6.4 REGULATION 214 6.5 RESISTANCE 215 6.6
CONSERVATION OF THE BA BIOSYNTHESIS GENES 217 6.7 IMPLICATIONS FOR
METABOLIC PATHWAY EVOLUTION 218 REFERENCES 219 7. THIOPEPTIDES 223
WILLIAM R. STROHL AND HEINZ-GUNTER FLOSS 7.1 INTRODUCTION 223 7.2
BIOCHEMISTRY OF THIOPEPTIDES 225 7.3 GENETICS OF RESISTANCE AND
BIOSYNTHESIS 231 7.4 THIOPEPTIDE RESISTANCE GENES IN S. AZUREUS 234
REFERENCES 236 8. BETA-LACTAMS 239 SUSAN E. JENSEN AND ARNOLD L. DEMAIN
8.1 INTRODUCTION 239 8.2 PENICILLINS, CEPHALOSPORINS AND CEPHAMYCINS 240
8.3 CLAVULANIC ACID 250 8.4 CARBAPENEMS 252 8.5 MONOCYCLIC /3-LACTAMS
253 8.6 REGULATION OF /3-LACTAM BIOSYNTHESIS 254 REFERENCES 260 9.
GLYCOPEPTIDES 269 MILTON J. ZMIJEWSKI, JR. AND JEFFREY T. FAYERMAN 9.1
INTRODUCTION 269 9.2 GENETICS AND MOLECULAR BIOLOGY 270 9.3 RESISTANCE
272 9.4 BIOSYNTHESIS 273 9.5 CONCLUDING REMARKS 279 REFERENCES 279 10.
LANTIBIOTICS 28 3 MICHAEL J. GASSON 10.1 INTRODUCTION 283 10.2
LANTIBIOTIC STRUCTURES 285 10.3 BIOSYNTHESIS OF LANTIBIOTICS 288 10.4
LANTIBIOTIC BIOSYNTHESIS GENE ORGANIZATION 296 10.5 GENETIC ELEMENTS
ENCODING LANTIBIOTIC GENES 298 XVI CONTENTS 10.6 PROTEIN-ENGINEERED
LANTIBIOTICS 299 10.7 LANTIBIOTIC MODE OF ACTION 302 10.8 CONCLUDING
REMARKS 302 REFERENCES 303 11. MICROCINS 307 FELIPE MORENO, JOSE LUIS
SAN MILLDN, CONCEPTION HERNDNDEZ-CHICO AND ROBERTO KOLTER 11.1
INTRODUCTION 307 11.2 DISCOVERY OF MICROCINS 308 11.3 MICROCINS A, D AND
E 309 11.4 MICROCINS C AND H 310 11.5 MICROCINB 311 11.6 COLICINV 313
11.7 TRANSCRIPTIONAL REGULATION 315 11.8 CHROMOSOMAL MICROCIN GENES IN
E. COLI 315 11.9 CONCLUDING REMARKS 317 REFERENCES 319 SECTION C.
POLYKETIDE-DERIVED ANTIBIOTICS 323 OVERVIEW BY LEO C. VINING AND DAVID
A. HOPWOOD 12. ANTHRACYCLINES 331 C. RICHARD HUTCHINSON 12.1
INTRODUCTION 331 12.2 DISCOVERY 332 12.3 BIOLOGICAL ACTIVITY 332 12.4
FERMENTATION 334 12.5 BIOSYNTHESIS 334 12.6 GENETICS OF ANTHRACYCLINE
PRODUCTION 339 12.7 PRODUCTION OF NEW ANTHRACYCLINES 352 REFERENCES 353
13. TETRACYCLINES 359 VLADISLAV BEHAL AND IAIN S. HUNTER 13.1
INTRODUCTION 359 13.2 BIOGENESIS 360 13.3 ENZYMES OF SECONDARY
METABOLISM 361 13.4 ENZYMES OF PRIMARY METABOLISM 365 13.5 CELLULAR
LOCATION OF ENZYMES 366 13.6 GENETICS AND MOLECULAR GENETICS 366
CONTENTS XVII 13.7 REGULATION OF BIOSYNTHESIS 374 13.8 REGULATORY
MECHANISMS IN THE MYCELIUM 378 13.9 SUPPLY OF ANTIBIOTIC PRECURSORS 379
13.10 FERMENTATION ANALYSES AND MODELLING 379 13.11 PRODUCTION BY
IMMOBILIZED CELLS 380 REFERENCES 380 14. MACROLIDES 385 LEONARD KATZ AND
STEFANO DONADIO 14.1 INTRODUCTION 385 14.2 CLONING OF MACROLIDE
BIOSYNTHESIS GENES 387 14.3 MACROCYCLIC LACTONE POLYKETIDE SYNTHASES
392 14.4 MODIFICATION OF THE LACTONE RING 403 14.5 BIOSYNTHESIS AND
MODIFICATION OF SUGARS 406 14.6 RESISTANCE 410 14.7 REGULATION 412 14.8
FUTURE PROSPECTS 413 REFERENCES 415 15. AVERMECTINS 421 DOUGLAS J.
MACNEIL 15.1 INTRODUCTION 421 15.2 BIOSYNTHESIS 423 15.3 GENETICS OF
AVERMECTIN BIOSYNTHESIS 427 15.4 CONCLUSIONS 439 REFERENCES 440 16.
POLYETHERS 443 ASHLEY W. BIRCH AND JOHN A. ROBINSON 16.1 INTRODUCTION
443 16.2 BIOCHEMICAL ASPECTS OF POLYETHER BIOSYNTHESIS 445 16.3 GENETICS
OF POLYETHER BIOSYNTHESIS 465 REFERENCES 472 17. ANSAMYCINS 477 JUISHEN
CHIAO, TIANHUI XIA, BAIGEN MEI, ZHIKUN JIN AND WEILING GU 17.1
INTRODUCTION 477 17.2 ORGANISMS PRODUCING ANSAMYCINS 478 17.3 RIFAMYCIN
BIOSYNTHESIS 480 17.4 REGULATION OF RIFAMYCIN AND MACBECIN BIOSYNTHESIS
484 17.5 SHIKIMATE PATHWAY REGULATION 484 17.6 NITROGEN INCORPORATION
INTO RIFAMYCIN 487 CONTENTS 1.1 NITROGEN ASSIMILATION 488 17.8 NITROGEN
CONTROL OF RIFAMYCIN PRODUCTION 489 17.9 EFFECTS OF INORGANIC PHOSPHATE
492 17.10 EFFECT OF B-FACTOR ON RIFAMYCIN BIOSYNTHESIS 493 17.11
GENETICS OF RIFAMYCIN BIOSYNTHESIS 493 REFERENCES 494 SECTION D. OTHER
BIOSYNTHETIC GROUPS OF ANTIBIOTICS 4 OVERVIEW BY LEO C. VINING 18.
CHLORAMPHENICOL 505 LEO C. VINING AND COLIN STUTTARD 18.1 INTRODUCTION
505 18.2 BIOSYNTHESIS 507 18.3 GENETICS 512 18.4 PHYSIOLOGICAL
REGULATION 515 18.5 RESISTANCE 523 REFERENCES 527 19. STREPTOMYCIN AND
RELATED AMINOGLYCOSIDES 531 WOLFGANG PIEPERSBERG 19.1 INTRODUCTION 531
19.2 STREPTOMYCIN: OCCURRENCE AND BIOLOGY 532 19.3 BIOSYNTHESIS IN 5.
GRISEUS 534 19.4 CLONING AND ANALYSIS OF STR GENES 541 19.5 REGULATION
OF STREPTOMYCIN PRODUCTION GENES 553 19.6 CONCLUSIONS AND PERSPECTIVES
561 REFERENCES 562 20. AMINOGLYCOSIDES AND AMINOCYCLITOLS 571 KUNIMOTO
HOTTA, JULIAN DAVIES AND MORIMASA YAGISAWA 20.1 INTRODUCTION 571 20.2
AGACS ISOLATED SINCE 1981 573 20.3 BUTIROSIN 578 20.4 SEMISYNTHETIC
AGACS 579 20.5 BIOSYNTHESIS OF THE ASTROMICIN (FORTIMICIN) GROUP 581
20.6 AGAC RESISTANCE GENES OTHER THAN SELF-RESISTANCE GENES 586 20.7
GENE CLONING IN MICROMONOSPORA SPECIES 590 20.8 CONCLUDING REMARKS 592
CONTENTS XIX REFERENCES 592 21. POLYOXINS AND RELATED NUCLEOSIDES 597
KIYOSHI ISONO 21.1 INTRODUCTION 597 21.2 POLYOXINS 598 21.3 NIKKOMYCINS
(NEOPOLYOXINS) 607 21.4 POLYOXINN 611 21.5 BLASTICIDIN S AND MILDIOMYCIN
611 21.6 OTHER NUCLEOSIDE ANTIBIOTICS RELATED TO POLYOXINS 614 21.7
CONCLUSIONS 614 REFERENCES 615 22. AGROCINS 619 BRUCE G. CLARE 22.1
INTRODUCTION 619 22.2 AGROBACTERIUM SPECIES AND BIOVARS 620 22.3
AGROCINS: CHEMISTRY, BIOACTIVITY AND SPECIFICITY 620 22.4 AGROCINS:
GENETICS OF BIOSYNTHESIS 623 22.5 AGROCINS: BIOCHEMISTRY AND
BIOSYNTHESIS 625 22.6 AGROCINS AND AGROCINOPINES: GENETICS OF
SENSITIVITY 625 22.7 AGROCINS: BIOLOGICAL CONTROL 627 22.8 CONCLUSIONS
630 REFERENCES 630 23. ISOPRENOID ANTIBIOTICS 633 DAVID E. CANE 23.1
INTRODUCTION 633 23.2 ISOPRENOID CHAIN-ELONGATION ENZYMES 635 23.3
SESQUITERPENE SYNTHASES 642 23.4 WHAT NEXT ? 649 REFERENCES 651 INDEX
657
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| dewey-sort | 3615 3329 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| format | Book |
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| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-11 |
| owner_facet | DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-11 |
| physical | XXII, 679 S. graph. Darst. |
| publishDate | 1995 |
| publishDateSearch | 1995 |
| publishDateSort | 1995 |
| publisher | Butterworth-Heinemann |
| record_format | marc |
| series | Biotechnology series |
| series2 | Biotechnology series |
| spelling | Genetics and biochemistry of antibiotic production ed. by Leo C. Vining ... Boston [u.a.] Butterworth-Heinemann 1995 XXII, 679 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biotechnology series 28 Antibactériens Antibiotica gtt Antibiotiques ram Biochimie ram Biologie moléculaire Biosynthese gtt Biotechnologie Genetica gtt Genetische manipulatie gtt Génie génétique microbien ram Génétique microbienne ram Microorganismes - Biotechnologie ram Microorganismes - Métabolisme ram Anti-Bacterial Agents Antibiotics Biotechnology Biochemistry Microbial biotechnology Microbial genetic engineering Microbial genetics Microbial metabolism Molecular Biology Sekundärmetabolit (DE-588)4300564-0 gnd rswk-swf Antibiotikum (DE-588)4002257-2 gnd rswk-swf Biochemie (DE-588)4006777-4 gnd rswk-swf Gentechnologie (DE-588)4071722-7 gnd rswk-swf Antibiotikum (DE-588)4002257-2 s Gentechnologie (DE-588)4071722-7 s DE-604 Sekundärmetabolit (DE-588)4300564-0 s Biochemie (DE-588)4006777-4 s Vining, Leo C. Sonstige oth Biotechnology series 28 (DE-604)BV000007885 28 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007254984&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Genetics and biochemistry of antibiotic production Biotechnology series Antibactériens Antibiotica gtt Antibiotiques ram Biochimie ram Biologie moléculaire Biosynthese gtt Biotechnologie Genetica gtt Genetische manipulatie gtt Génie génétique microbien ram Génétique microbienne ram Microorganismes - Biotechnologie ram Microorganismes - Métabolisme ram Anti-Bacterial Agents Antibiotics Biotechnology Biochemistry Microbial biotechnology Microbial genetic engineering Microbial genetics Microbial metabolism Molecular Biology Sekundärmetabolit (DE-588)4300564-0 gnd Antibiotikum (DE-588)4002257-2 gnd Biochemie (DE-588)4006777-4 gnd Gentechnologie (DE-588)4071722-7 gnd |
| subject_GND | (DE-588)4300564-0 (DE-588)4002257-2 (DE-588)4006777-4 (DE-588)4071722-7 |
| title | Genetics and biochemistry of antibiotic production |
| title_auth | Genetics and biochemistry of antibiotic production |
| title_exact_search | Genetics and biochemistry of antibiotic production |
| title_full | Genetics and biochemistry of antibiotic production ed. by Leo C. Vining ... |
| title_fullStr | Genetics and biochemistry of antibiotic production ed. by Leo C. Vining ... |
| title_full_unstemmed | Genetics and biochemistry of antibiotic production ed. by Leo C. Vining ... |
| title_short | Genetics and biochemistry of antibiotic production |
| title_sort | genetics and biochemistry of antibiotic production |
| topic | Antibactériens Antibiotica gtt Antibiotiques ram Biochimie ram Biologie moléculaire Biosynthese gtt Biotechnologie Genetica gtt Genetische manipulatie gtt Génie génétique microbien ram Génétique microbienne ram Microorganismes - Biotechnologie ram Microorganismes - Métabolisme ram Anti-Bacterial Agents Antibiotics Biotechnology Biochemistry Microbial biotechnology Microbial genetic engineering Microbial genetics Microbial metabolism Molecular Biology Sekundärmetabolit (DE-588)4300564-0 gnd Antibiotikum (DE-588)4002257-2 gnd Biochemie (DE-588)4006777-4 gnd Gentechnologie (DE-588)4071722-7 gnd |
| topic_facet | Antibactériens Antibiotica Antibiotiques Biochimie Biologie moléculaire Biosynthese Biotechnologie Genetica Genetische manipulatie Génie génétique microbien Génétique microbienne Microorganismes - Biotechnologie Microorganismes - Métabolisme Anti-Bacterial Agents Antibiotics Biotechnology Biochemistry Microbial biotechnology Microbial genetic engineering Microbial genetics Microbial metabolism Molecular Biology Sekundärmetabolit Antibiotikum Biochemie Gentechnologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007254984&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000007885 |
| work_keys_str_mv | AT viningleoc geneticsandbiochemistryofantibioticproduction |