Bone metastasis - mechanisms and pathophysiology:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Springer [u.a.]
1996
|
| Schriftenreihe: | Medical intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 249 S. Ill., graph. Darst. |
| ISBN: | 3540607323 0412103419 |
Internformat
MARC
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| 245 | 1 | 0 | |a Bone metastasis - mechanisms and pathophysiology |c [ed.:] F. William Orr ... |
| 264 | 1 | |a New York [u.a.] |b Springer [u.a.] |c 1996 | |
| 300 | |a 249 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
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Datensatz im Suchindex
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| adam_text |
CONTENTS
1.
MECHANISMS
OF
BONE
METASTASIS
.
1
GREGORY
R.
MUNDY
AND
TOSHIYUKI
YONEDA
TYPES
OF
TUMOR
BONE
LESIONS
.
1
MECHANISMS
BY
WHICH
TUMOR
CELLS
SPREAD
TO
BONE
.
3
SUMMARY
.
12
2.
THE
ROLE
OF
MARROW
ENDOTHELIUM
IN
THE
LOCALIZATION
OF
METASTATIC
CANCER
CELLS
TO
BONE
.17
PNINA
BRODT,
MAHMUDUL
HAQ
AND
JOHN
NIP
INTRODUCTION
.
17
ADHESION
RECEPTORS
OF
THE
VASCULAR
ENDOTHELIUM
AND
THEIR
ROLE
IN
LEUKOCYTE
TRAFFICKING
AND
METASTASIS
.
18
PREFERENTIAL
ADHESION
OF
RAT
PROSTATE
ADENOCARCINOMA
CELLS
TO
BONE
MARROW-DERIVED
ENDOTHELIAL
CELLS
.
20
ADHESION
RECEPTORS
OF
BONE
MARROW
ENDOTHELIAL
CELLS
.
22
SUMMARY
AND
CONCLUSIONS
.
23
3.
STRUCTURAL
AND
MICROENVIRONMENTAL
BONE
MARROW
FACTORS
INVOLVED
IN
THE
PATHOGENESIS
OF
BONE
METASTASIS
.
31
FRANCISCO
ARGUELLO
AND
HARVEY
J.
COHEN
INTRODUCTION
.
31
THE
BONE
AND
ITS
MARROW
.
32
THE
ANATOMY
AND
HEMODYNAMICS
OF
BONE
MARROW
.33
THE
HEMATOPOIETIC
BONE
MARROW
MICROENVIRONMENT
.
34
FUTURE
PERSPECTIVE
.39
4.
BONE
MARROW-DERIVED
GROWTH
FACTORS
FOR
METASTATIC
CANCER
CELLS
.
47
GREGORY
L.
BLATCH
AND
BRUCE
R.
ZETTER
INTRODUCTION
.
47
TRANSFERRIN
.
49
FIBROBLAST-DERIVED
GROWTH
FACTORS
.
50
HEMATOPOIETIC
GROWTH
FACTORS
.52
RESORBING
BONE-DERIVED
GROWTH
FACTORS
.
53
CONCLUSIONS
.
54
5.
POTENTIAL
ROLES
FOR
ADHESION
IN
THE
PATHOGENESIS
OF
BONE
METASTASIS
.
59
PAUL
J.
KOSTENUIK,
GURMIT
SINGH
AND
F.
WILLIAM
ORR
INTRODUCTION
.59
ADHESION
OF
CANCER
CELLS
WITHIN
THE
PRIMARY
TUMOR
.
60
ADHESION
OF
CANCER
CELLS
TO
VASCULAR
LIGANDS
.
61
ADHESION
OF
CANCER
CELLS
TO
EXTRAVASCULAR
LIGANDS
.
62
POTENTIAL
ADHESIVE
LIGANDS
IN
BONE
MARROW
.
62
POTENTIAL
ADHESIVE
LIGANDS
IN
BONE
MATRIX
.
62
REGULATION
OF
COLLAGEN
RECEPTORS
BY
BONE-DERIVED
GROWTH
FACTORS
.
66
CONCLUSIONS
.
68
6.
PARATHYROID
HORMONE-RELATED
PEPTIDE
AS
A
MEDIATOR
OF
OSTEOLYSIS
AND
HYPERCALCEMIA
IN
BONE
METASTASIS
.
77
JANET
E.
HENDERSON
AND
DAVID
GOLTZMAN
HISTORICAL
PERSPECTIVE
.
77
PUTATIVE
MEDIATORS
OF
HYPERCALCEMIA
IN
MALIGNANCY
.
78
CLONING
AND
CHARACTERIZATION
OF
THE
PTHRP
GENE
.
80
REGULATION
OF
PTHRP
GENE
TRANSCRIPTION
IN
TUMORS
.
81
EVIDENCE
THAT
PTHRP
MEDIATES
HYPERCALCEMIA
IN
MALIGNANCY
.
83
THE
ROLE
OF
PTHRP
IN
OSTEOLYSIS
.
88
CONSIDERATIONS
FOR
THE
FUTURE
.
91
SUMMARY
.
94
7.
TUMOR-ASSOCIATED
MACROPHAGES
AS
MEDIATORS
OF
OSTEOLYSIS
IN
BONE
METASTASIS
.
105
N.A.
ATHANASOU
INTRODUCTION
.
105
HISTOPATHOLOGY
OF
OSTEOLYTIC
METASTASES
.
106
OSTEOCLASTS
AND
OSTEOCLASTIC
BONE
RESORPTION
.
107
BONE
RESORPTION
BY
TUMORS
AND
TUMOR-LIKE
LESIONS
CONTAINING
MACROPHAGE
POLYKARYONS
.
109
MONONUCLEAR
PHAGOCYTE
DIFFERENTIATION
TO
OSTEOCLASTIC
BONE-RESORBING
CELLS
.
112
BONE
RESORPTION
BY
TAMS
.
113
LOW
GRADE
BONE
RESORPTION
ASSOCIATED
WITH
TAMS
AND
TUMOR
CELLS
.
116
8.
MECHANISMS
OF
CANCER
CELL-MEDIATED
OSTEOLYSIS
.
123
OTTO
H.
SANCHEZ-SWEATMAN,
RAMA
KHOKHA,
GURRNIT
SINGH
AND
F.
WILLIAM
ORR
INTRODUCTION
.
123
MECHANISMS
OF
OSTEOLYSIS
IN
BONE
METASTASIS
.
124
CANCER
CELLS
AS
DIRECT
MEDIATORS
OF
LOCAL
OSTEOLYSIS
.
124
ROLE
OF
MATRIX
METALLOPROTEINASES
IN
MATRIX
DEGRADATION
BY
BONE-METASTASIZING
CANCER
CELLS
.
127
FUTURE
DIRECTIONS
.
132
9.
UROKINASE
(UPA)
AS
A
MEDIATOR
OF
OSTEOBLASTIC
SKELETAL
METASTASIS
.
137
SHAFAAT
AHMED
RABBANI
PLASMINOGEN
ACTIVATORS
AND
CANCER
.
139
PROSTATE
CANCER
AND
SKELETAL
METASTASIS
.
141
ISOLATION
OF
PROSTATIC
OSTEOBLAST
MITOGEN
.
142
EFFECT
OF
UPA
OVERPRODUCTION
BY
PROSTATE
CANCER
IN
VIVO
.
145
REVERSAL
OF
UPA
MEDIATED
EFFECTS
ON
TUMOR
GROWTH
AND
METASTASIS
.
146
ROLE
OF
UPAR
IN
TUMOR
PROGRESSION
.
149
UPAR
AND
BREAST
CANCER
.
152
EXPERIMENTAL
ANALYSIS
OF
UPAR
IN
BREAST
CANCER
.
152
THERAPEUTIC
STRATEGIES
.
153
10.
AN
ANIMAL
MODEL
FOR
THE
INVESTIGATION
OF
PROSTATE
CANCER
WITH
SPECIAL
EMPHASIS
ON
SKELETAL
METASTASIS
.
163
B.
RAMANATH
RAO,
A.A
GELDOF
AND
D.W.W.
NEWLING
INTRODUCTION
.
163
EXPERIMENTAL
DESIGN
AND
RESULTS
.
165
DISCUSSION
.
176
11.
PATHOPHYSIOLOGY
OF
HUMAN
PROSTATE
CANCER
METASTASIS
TO
BONE,
STUDIED
IN
VITRO
AND
IN
ANIMAL
MODELS
.
181
DANIEL
H.
SHEVRIN
AND
SUBHASH
C.
KUKREJA
BONE
METASTASIS
IN
PROSTATE
CANCER:
CLINICAL
OBSERVATIONS
.
181
BATSON'S
PLEXUS
AND
ANIMAL
MODELS
OF
BONE
METASTASIS
.
182
OTHER
ANIMAL
MODELS
OF
BONE
METASTASIS
.
188
MOLECULAR
MECHANISMS
RESPONSIBLE
FOR
DEVELOPMENT
OF
BONE
SELECTED
TUMOR
CELLS
.
189
C-MYC
GENE
AMPLIFICATION
AND
THE
DEVELOPMENT
OF
BONE
METASTASIS
.
189
ROLE
OF
INCREASED
BONE
RESORPTION
AND
PARATHYROID
HORMONE-RELATED
PROTEIN
IN
THE
PATHOGENESIS
OF
BONE
METASTASIS
.
190
CONCLUSION
.
192
12.
BONE
METASTASES
AND
PROSTATE
CANCER
.
195
MARKE.
STEARNS
AND
MIN
WANG
INTRODUCTION
.
195
METALLOPROTEINASES
AS
DIAGNOSTIC
AND
PROGNOSTIC
MARKERS
OF
(BONE)
METASTASES
.
196
ANIMAL
MODELS
OF
PROSTATE
BONE
METASTASES
.
198
DEVELOPMENT
OF
ANTI-METASTASES
DRUGS
.
201
LIAROZOLE:
TREATMENT
OF
PROSTATE
CANCER
BONE
METASTASES
.
202
LIAROZOLE
AND
RETINOIC
ACID
STUDIES
ON
BONE
METASTASES
IN
THE
SCID
MOUSE
MODEL
.
202
TAXOL
AND
ESTRAMUSTINE:
TREATMENT
OF
PROSTATE
(BONE)
METASTASES
.
204
INHIBITORS
OF
METALLOPROTEINASES
AS
THERAPEUTIC
AGENTS
FOR
TREATMENT
OF
BONE
METASTASES
.
209
FUTURE
DEVELOPMENTS
.
211
13.
EXPERIMENTAL
FINDINGS
ON
THE
OSTEOPROTECTIVE
POTENTIAL
OF
BISPHOSPHONATES
AGAINST
BONE
METASTASES
AND
TUMOR-INDUCED
OSTEOPATHY:
A
PLEADING
FOR
AN
EARLY
AND
PREVENTIVE
ADMINISTRATION
.
221
B.
KREMPIEN
INTRODUCTION
.
221
BISPHOSPHONATES
.
224
PATHOGENESIS
OF
BONE
METASTASES
.
227
OSTEOPROTECTIVE
POTENTIAL
OF
BISPHOSPHONATES:
EXPERIMENTAL
FINDINGS
.
228
OSTEOPROTECTIVE
POTENTIAL
OF
BISPHOSPHONATES:
THEORETICAL
AND
CLINICAL
CONSIDERATION
.
238
CONCLUSIONS
.
240
INDEX
.
245 |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV010849968 |
| illustrated | Illustrated |
| indexdate | 2024-08-22T00:42:54Z |
| institution | BVB |
| isbn | 3540607323 0412103419 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007252274 |
| oclc_num | 260209564 |
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| owner_facet | DE-355 DE-BY-UBR DE-12 DE-20 |
| physical | 249 S. Ill., graph. Darst. |
| publishDate | 1996 |
| publishDateSearch | 1996 |
| publishDateSort | 1996 |
| publisher | Springer [u.a.] |
| record_format | marc |
| series2 | Medical intelligence unit |
| spelling | Bone metastasis - mechanisms and pathophysiology [ed.:] F. William Orr ... New York [u.a.] Springer [u.a.] 1996 249 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Medical intelligence unit Knochenmetastase (DE-588)4164290-9 gnd rswk-swf Pathophysiologie (DE-588)4044898-8 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Knochenmetastase (DE-588)4164290-9 s DE-604 Pathophysiologie (DE-588)4044898-8 s Orr, Frederick William 1942- Sonstige (DE-588)115444106 oth DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007252274&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bone metastasis - mechanisms and pathophysiology Knochenmetastase (DE-588)4164290-9 gnd Pathophysiologie (DE-588)4044898-8 gnd |
| subject_GND | (DE-588)4164290-9 (DE-588)4044898-8 (DE-588)4143413-4 |
| title | Bone metastasis - mechanisms and pathophysiology |
| title_auth | Bone metastasis - mechanisms and pathophysiology |
| title_exact_search | Bone metastasis - mechanisms and pathophysiology |
| title_full | Bone metastasis - mechanisms and pathophysiology [ed.:] F. William Orr ... |
| title_fullStr | Bone metastasis - mechanisms and pathophysiology [ed.:] F. William Orr ... |
| title_full_unstemmed | Bone metastasis - mechanisms and pathophysiology [ed.:] F. William Orr ... |
| title_short | Bone metastasis - mechanisms and pathophysiology |
| title_sort | bone metastasis mechanisms and pathophysiology |
| topic | Knochenmetastase (DE-588)4164290-9 gnd Pathophysiologie (DE-588)4044898-8 gnd |
| topic_facet | Knochenmetastase Pathophysiologie Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007252274&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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