Melatonin and the mammalian pineal gland:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London [u.a.]
Chapman & Hall
1995
|
| Ausgabe: | 1. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVI, 331 S. Ill., graph. Darst. |
| ISBN: | 0412536005 |
Internformat
MARC
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| adam_text | Melatonin and the
Mammalian
Pineal Gland
Josephine[Arendt
Professor of Endocrinology
School of Biological Sciences
University of Surrey
Guildford, UK
CHAPMAN amp; HALL
London • Glasgow • Weinheim • New York • Tokyo • Melbourne • Madras
Contents
Foreword
Preface
Acknowledgements
1 Melatonin and the mammalian pineal gland
1 1 Introduction
Acknowledgements
References
2 Structure of the pineal gland
2 1 Anatomy
2 2 Innervation
2 3 Vascular supply of the pineal
2 4 Histology
2 5 Calcification
References
Further reading
3 Biochemistry of the pineal
3 1 Early work
3 2 Discovery of melatonin
3 3 Synthesis of melatonin
3 4 Other pineal methoxyindoles
3 5 Metabolism and pharmacokinetics of melatonin
3 6 Pineal peptides
3 7 Control of melatonin synthesis: sympathetic noradrenergic
mechanisms
XI
xiii
XV
VI CONTENTS
3 8 Other neural control mechanisms
References
Further reading
4 Light-dark control of melatonin synthesis
4 1 Introduction to biological rhythms
4 2 The melatonin rhythm: a darkness hormone
4 3 Rhythm generation in the pineal
4 4 Rhythm generation in the suprachiasmatic nucleus (SCN)
4 5 Entrainment (synchronization) by light
4 6 Melatonin secretion in relation to daylength
4 7 Light suppression of melatonin secretion
4 8 Entrainment of the melatonin rhythm with light
4 9 Phase response curves
4 10 Species variation in mechanisms of light control of the
melatonin rhythm
4 11 Light pulse phase shift in humans
4 12 Skeleton photoperiods
4 13 Blindness
4 14 Social zeitgebers in dim ligh
4 15 Non-24-hour light-dark cycles
4 16 Relative nature of the light-dark cycle
4 17 Light control of the production of other pineal indoles
References
Further reading
5 Physiology of the pineal: role in photoperiodic seasonal functions
5 1 Seasonality and daylength
5 2 Photoperiodic time measurement
5 3 Theories of photoperiodic time measurement
5 4 Pineal-dependence of photoperiod perception
5 5 Hamsters and ferrets
5 6 Sheep and goats
5 7 Temperature as a zeitgeber
5 8 Role of melatonin
5 9 Artificial creation of physiological melatonin profiles
5 10 Critical role of short duration melatonin in ungulates
5 11 Puberty
5 12 Puberty in rats
5 13 Prolactin
CONTENTS vu
5 14 Lactation
5 15 Coat growth
5 16 Other photoperiod dependent functions
5 17 Other orders
5 18 Characteristics of the melatonin signal
5 19 Melatonin implants: applications to agriculture
5 20 Mechanism of action of melatonin
References
Further reading
6 Role of the pineal gland and melatonin in circadian rhythms 161
6 1 The pineal and circadian rhythms in non-mammalian
vertebrates 163
6 2 Role of the pineal in mammalian circadian rhythms 165
6 3 Timed administration of melatonin 170
6 4 Effects of melatonin on rodent activity rhythms 170
6 5 Effects of melatonin on other circadian rhythms:
temperature 178
6 6 Effects of melatonin on the endogenous melatonin rhythm 180
6 7 Melatonin, the pineal and aging 182
6 8 Gestation and parturition 185
6 9 Estrous cycle 185
6 10 Metabolic relationships of melatonin 186
6 11 In vitro phase shifts 188
6 12 Retinal rhythms 190
6 13 Interactions of the retina, the SCN and the pineal 192
6 16 Summary 194
References 194
Further reading 197
7 The pineal in human physiology and pathology 201
7 1 Introduction 202
7 2 Pinealectomy 203
7 3 Functions of the human pineal 206
7 4 Human melatonin production - basic rhythm
characteristics 207
7 5 Association with temperature 211
7 6 Association with sleep 212
7 7 Other associations 214
7 8 Control of human melatonin secretion 214
vm CONTENTS
7 9 Post-mortem pineal studies
7 10 Evolution of melatonin secretion in normal humans
7 11 Sex, weight and height
7 12 Puberty
7 13 Development of the melatonin rhythm
7 14 Aging
7 15 Menstrual cycle
7 16 Human seasonal reproductive physiology
7 17 Possible relationships of the pineal and melatonin to the
immune system
7 18 Pathology
7 19 Melatonin in psychiatric disorder
7 20 Blindness
References
Further reading
8 Effects of melatonin: therapeutic potential and significance to
human health
8 1 Circadian rhythm disorders
8 2 Early work
8 3 Timed administration
84A PRC for melatonin
8 5 Jet lag and shift work
8 6 Blindness
8 7 Delayed sleep phase insomnia
8 8 Light and melatonin
8 9 Significance of rhythm optimization to industry
8 10 Relation between circadian and photoperiodic effects of
melatonin
8 11 Effects of melatonin on human reproductive function
8 12 Cancer
8 13 Effects on the immune system
8 14 Miscellaneous effects of melatonin
8 15 Commercial preparations of melatonin, its agonists and
antagonists
References
Further reading
9 Target sites and mechanism of action of melatonin
9 1 Introduction
•
CONTENTS ix
9 2 Target sites 292
9 3 Uptake studies 294
9 4 Binding studies 295
952- (125I)iodomelatonin 295
9 6 High- and low-affinity binding sites 302
9 7 Melatonin receptors 304
9 8 Melatonin antagonists and agonists 310
9 9 Structure of the melatonin receptor 312
References 312
Further reading 314
Appendix: Glossary 318
Further reading 320
Index 321
|
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| illustrated | Illustrated |
| indexdate | 2024-07-09T17:59:47Z |
| institution | BVB |
| isbn | 0412536005 |
| language | English |
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| spelling | Arendt, Josephine Verfasser aut Melatonin and the mammalian pineal gland Josephine Arendt 1. ed. London [u.a.] Chapman & Hall 1995 XVI, 331 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Corpus pineale gtt Melanine gtt Biological Clocks Melatonin Melatonin physiology Pineal Gland physiology Pineal gland Zirbeldrüse (DE-588)4067869-6 gnd rswk-swf Melatonin (DE-588)4038525-5 gnd rswk-swf Zirbeldrüse (DE-588)4067869-6 s Melatonin (DE-588)4038525-5 s DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007245107&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| title | Melatonin and the mammalian pineal gland |
| title_auth | Melatonin and the mammalian pineal gland |
| title_exact_search | Melatonin and the mammalian pineal gland |
| title_full | Melatonin and the mammalian pineal gland Josephine Arendt |
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| title_full_unstemmed | Melatonin and the mammalian pineal gland Josephine Arendt |
| title_short | Melatonin and the mammalian pineal gland |
| title_sort | melatonin and the mammalian pineal gland |
| topic | Corpus pineale gtt Melanine gtt Biological Clocks Melatonin Melatonin physiology Pineal Gland physiology Pineal gland Zirbeldrüse (DE-588)4067869-6 gnd Melatonin (DE-588)4038525-5 gnd |
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