The Na+/H+ exchanger:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | German |
| Veröffentlicht: |
New York [u.a.]
Springer [u.a.]
1996
|
| Schriftenreihe: | Molecular biology intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 317 S. Ill., graph. Darst. |
| ISBN: | 3540608923 0412104717 |
Internformat
MARC
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| 245 | 1 | 0 | |a The Na+/H+ exchanger |c Larry Fliegel |
| 264 | 1 | |a New York [u.a.] |b Springer [u.a.] |c 1996 | |
| 300 | |a 317 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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Datensatz im Suchindex
| _version_ | 1808137307321008128 |
|---|---|
| adam_text |
CONTENTS
P
ART
I
1.
BIOCHEMISTRY
AND
MOLECULAR
BIOLOGY
OF
THE
NA7H
+
EXCHANGER:
AN
OVERVIEW
.
1
LARRY
FLIEGEL
AND
PAVEL
DIBROV
A.
INTRODUCTION
.
1
B.
PHARMACOLOGY
AND
MOLECULAR
BIOLOGY
OF
THE
MAMMALIAN
NA7H
+
EXCHANGER
.
4
C.
STRUCTURE
OF
THE
TRANSMEMBRANE
REGION
OF
THE
NHE1
ISOFORM
OF
THE
NA7H
+
EXCHANGER
.
4
D.
THE
ROLE
OF
THE
CYTOPLASMIC
REGION
OF
THE
NA7H
+
EXCHANGER
.
8
E.
REGULATION
OF
EXPRESSION
OF
THE
NA7H
+
EXCHANGER
(NHE1)
.
10
F.
THE
IMPORTANCE
OF
THE
NA7H
+
EXCHANGER
IN
MUSCLE
(IN
HEALTH
AND
DISEASE)
.
10
G.
IMPORTANCE
OF
NA7H*
EXCHANGE
AND
INTRACELLULAR
PH
IN
TUMOR
CELLS
.
11
H.
FUTURE
PROSPECTS
.
12
2.
NA7H
+
EXCHANGE
IN
MAMMALIAN
KIDNEY
.21
ORSON
W.
MOE
AND
ROBERT
J.
ALPEM
A.
INTRODUCTION
.
21
B.
NA7H
+
EXCHANGE
IN
THE
MAMMALIAN
NEPHRON
AND
DISTRIBUTION
OF
MOLECULAR
ISOFORMS
.
22
C.
ACUTE
REGULATION
OF
RENAL
NA7H
+
EXCHANGER
.
28
D.
CHRONIC
REGULATION
OF
RENAL
NA
+
/H
+
EXCHANGER
.
34
3.
REGULATION
OF
THE
NA7H
+
EXCHANGER
IN
VASCULAR
SMOOTH
MUSCLE
.
47
BRADFORD
C.
BERK
A.
INTRODUCTION
.
47
B.
THE
VSMC
IN
THE
BLOOD
VESSEL
WALL
.
48
C.
NA7H
+
EXCHANGE
AND
VSMC
FUNCTION
IN
VIVO:
TONE
AND
GROWTH
.
49
D.
REGULATION
OF
THE
NA7H
+
EXCHANGER
IN
VSMC
.
51
E.
REGULATION
OF
NA7H
+
EXCHANGER
FUNCTION
IN
VSMC
.
55
F.
ROLE
OF
VSMC
NA7H
+
EXCHANGER
IN
HYPERTENSION
.59
4.
MOLECULAR
STUDIES
OF
INTESTINAL
EPITHELIAL
NA7H
+
EXCHANGERS
.
69
C.
H.
CHRIS
YUN,
CHUNG-MING
TSE
AND
MARK
DONOWITZ
A.
INTRODUCTION
.
69
B.
MEMBERS
OF
THE
NA
+
/H
+
EXCHANGER
GENE
FAMILY
.
69
C.
CELLULAR
DISTRIBUTION
OF
NA
+
/H
+
EXCHANGERS
.
72
D.
REGULATION
OF
NA7H
+
EXCHANGERS
.
73
5.
REGULATION
OF
EXPRESSION
OF
THE
NA
+
/H
+
EXCHANGER
(NHE1)
PROMOTER
.
91
LARRY
FLIEGEL
AND
JASON
R.B.
DYCK
A.
INTRODUCTION
.
91
B.
CLONING
AND
ANALYSIS
OF
THE
NHE1
PROMOTER
.
92
C.
COMPARISON
OF
THE
MOUSE,
HUMAN
AND
RABBIT
NHE1
PROMOTERS
.
95
D.
SUMMARY
AND
FUTURE
DIRECTIONS
.
96
6.
ROLE
OF
THE
NA
+
/H
+
ANTIPORTER
ISOFORMS
IN
CELL
VOLUME
REGULATION
.
101
LAMARA
SHRODE,
ANA
CABADO,
GREG
GOSS
AND
SERGIO
GRINSTEIN
A.
INTRODUCTION
.
101
B.
CLINICAL
SIGNIFICANCE
AND
PATHOPHYSIOLOGY
OF
VOLUME
REGULATION
.
102
C.
ROLE
OF
NA
+
/H
+
EXCHANGER
IN
RVI
.
102
D.
MECHANISMS
OF
ACTIVATION
OF
THE
NHE
.
104
E.
ISOFORMS
OF
THE
NA
+
/H
+
EXCHANGER
.
ILL
F.
RESPONSIVENESS
OF
THE
INDIVIDUAL
ISOFORMS
TO
OSMOLARITY
.
114
G.
CONCLUDING
REMARKS
.
116
7.
CHARACTERISTICS
OF
THE
PLASMA
MEMBRANE
NA
+
/H
+
EXCHANGER
GENE
FAMILY
.
123
JOHN
ORLOWSKI
AND
GARY
SHULL
A.
MOLECULAR
HETEROGENEITY
.
124
B.
GENOMIC
ORGANIZATION
.
128
C.
TISSUE
EXPRESSION
.
128
D.
MEMBRANE
TOPOLOGY
.
130
E.
FUNCTIONAL
CHARACTERISTICS
.
132
F.
REGULATION
OFNA7H
+
EXCHANGER
ACTIVITY
.
133
G.
STRUCTURAL
COMPONENTS
OF
THE
NA
+
/H
+
EXCHANGER
.
137
H.
CONCLUDING
REMARKS
.
139
8.
THE
REGULATORY
CYTOPLASMIC
DOMAIN
OF
THE
NA
+
/H*
EXCHANGER
.
149
BERNHARD
M.
SCHMITT,
TOSHITARO
IKEDA,
MUNEKAZU
SHIGEKAWA
AND
SHIGEO
WAKABAYASHI
A.
INTRODUCTION
.
149
B.
GROSS
FUNCTIONAL
ANATOMY
OF
THE
CYTOPLASMIC
DOMAIN
.
150
C.
PHOSPHORYLATION
.
152
D.
CALCIUM/CALMODULIN
.
153
E.
REGULATORY
COFACTORS
AND
"
PH
MAINTENANCE
DOMAIN
"
.
160
F.
G-PROTEINS
AND
OTHERS
.
161
G.
OUTLOOK
.
164
P
ART
II
9.
ROLE
OF
THE
SARCOLEMMAL
NA
+
/H
+
EXCHANGER
IN
ARRHYTHMOGENESIS
DURING
REPERFUSION
OF
ISCHEMIC
MYOCARDIUM
.
173
METIN
AVKIRAN
AND
MASAHIRO
YASUTAKE
A.
INTRODUCTION
.
173
B.
AN
INVOLVEMENT
OF
FREE
OXYGEN
RADICALS?
.
174
C.
EVIDENCE
FOR
A
KEY
ROLE
FOR
THE
NA7H
+
EXCHANGER
.
175
D.
CALCIUM-THE
COMMON
ARRHYTHMOGENIC
MEDIATOR
.
180
E.
CONCLUDING
COMMENTS
.
181
10.
ROLE
OF
SODIUM-HYDROGEN
EXCHANGE
IN
MEDIATING
MYOCARDIAL
ISCHEMIC
AND
REPERFUSION
INJURY.
MECHANISM
AND
THERAPEUTIC
IMPLICATIONS
.
189
MORRIS
KARMAZYN
A.
INTRODUCTION
.
189
B.
IMPORTANCE
OF
INTRACELLULAR
PH
REGULATORY
MECHANISMS
FOR
MAINTENANCE
OF
CARDIAC
FUNCTION
.
193
C.
EVIDENCE
THAT
NA7H
+
EXCHANGE
REGULATES
INTRACELLULAR
NA
+
AND
CA
2+
CONCENTRATIONS
IN
THE
HEART
.
193
D.
NA
+
/H*
EXCHANGE
AND
MYCARDIAL
ISCHEMIC
AND
REPERFUSION
INJURY
.
195
E.
SUMMARY,
CONCLUSIONS
AND
FUTURE
DIRECTIONS
.
209
11.
EXPRESSION
AND
ACTIVITY
OF
THE
SODIUM-HYDROGEN
EXCHANGER
IN
CARDIAC
SARCOLEMMA
IN
HEALTH
AND
DISEASE
.
217
GRANT
N.
PIERCE,
TRACY
SLOTIN,
LARRY
FLIEGEL,
JAMES
S.
C.
GILCHRIST
AND
THANE
G.
MADDAFORD
A.
INTRACELLULAR
HYDROGEN
AND
CELL
FUNCTION
.
217
B.
KINETICS
OFNA
+
/H
+
EXCHANGE
IN
CARDIAC
SARCOLEMMA
.
218
C.
RESPONSE
OF
THE
NA7H
+
EXCHANGER
TO
DISEASE
.
220
P
ART
III
12.
MOLECULAR
DISSECTION
OF
BACTERIAL
NA
+
/H
+
ANTIPORTERS
.
231
SHIMON
SCHULDINER
AND
ETANA
PADAN
A.
INTRODUCTION
.
231
B.
MOLECULAR
NATURE
AND
PROPERTIES
OF
THE
NA
+
/H
+
ANTIPORTERS
.
233
C.
NA
+
EXCRETION
MACHINERY
OTHER
THAN
THE
NA
+
/H
+
ANTIPORTERS
IN
E.
COLI
.
247
13.
SODIUM
TOLERANCE
AND
EXPORT
FROM
YEAST
CELLS
.
255
KAREN
M.
HAHNENBERGER,
ZHENGPINGJIA,
LARRY
FLIEGEL,
SEAN
HEMMINGSEN
AND
PAUL
G.
YOUNG
A.
INTRODUCTION
.
255
B.
THE
FUNGAL
SODIUM/PROTON
ANTIPORTER
.
256
C.
THE
ZS0D2
SODIUM/PROTON
ANTIPORTER
FROM
ZYGOSACCHAROMYCES
ROUXII
.
260
D.
USE
OF
THE
CYTOSENSOR
MICROPHYSIOMETER
TO
DEMONSTRATE
BIDIRECTIONAL
EXCHANGE
ON
SOD2
.
260
E.
PMR2/ENA1
P-TYPE
SODIUM
EXPORT
PUMPS
.
261
F.
HETEROLOGOUS
EXPRESSION
OF
THE
SOD2
SODIUM/PROTON
ANTIPORTER.
264
G.
CONCLUDING
REMARKS
.
264
P
ART
IV
14.
THERAPEUTIC
POTENTIAL
OF
INHIBITORS
OF
NA
+
/H
+
EXCHANGE
ACTIVITY
IN
TUMOR
SELECTIVE
THERAPY
.
269
MOTOYUKI
YAMAGATA
AND
IAN
F.
TANNOCK
A.
INTRODUCTION
.
269
B.
THE
ACIDIC
MICROENVIRONMENT
OF
TUMORS
.
269
C.
REGULATION
OF
INTRACELLULAR
PH
(PH.)
.
270
D.
ROLE
OF
THE
NA
+
/H
+
EXCHANGER
IN
PROLIFERATION
AND
SURVIVAL
OF
TUMORS
CELLS
.
274
E.
POTENTIAL
THERAPEUTIC
APPLICATION
OF
INHIBITORS
OF
THE
NA
+
/H
+
EXCHANGER
.
275
F.
REGULATION
OF
PH.
AND
HYPERTHERMIA
.
284
G.
REGULATION
OF
PH;
AND
RADIATION
.
285
H.
REGULATION
OF
PH;
AND
CHEMOTHERAPY
.
286
I.
SUMMARY
.
286
P
ART
V
15.
THE
NHE
FAMILY
OF
NA
+
/H
+
EXCHANGERS;
ITS
KNOWN
AND
PUTATIVE
MEMBERS,
AND
WHAT
CAN
BE
LEARNED
BY
COMPARING
THEM
WITH
EACH
OTHER
.
295
OTTO
FROHLICH
A.
INTRODUCTION
.
295
B.
THE
MEMBERS
OF
THE
NHE
FAMILY
OF
NA
+
/H
+
EXCHANGERS
.
296
C.
A
COMPARISON
OF
THE
MEMBERS
OF
THE
NHE
FAMILY
.
298
D.
ARE
ALL
MEMBERS
OF
THE
LIST
TRUE
NA
+
/H
+
EXCHANGERS?
.
301
E.
ESTABLISHING
A
CONSENSUS
HYDROPATHY
PROFILE
OF
NHE
PROTEINS.
303
F.
SUMMARY
.
305
INDEX
.
309 |
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV010822401 |
| classification_rvk | WE 5420 |
| ctrlnum | (OCoLC)845186431 (DE-599)BVBBV010822401 |
| dewey-full | 612/.01575 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology |
| dewey-raw | 612/.01575 |
| dewey-search | 612/.01575 |
| dewey-sort | 3612 41575 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV010822401 |
| illustrated | Illustrated |
| indexdate | 2024-08-23T00:48:30Z |
| institution | BVB |
| isbn | 3540608923 0412104717 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007232595 |
| oclc_num | 845186431 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 317 S. Ill., graph. Darst. |
| publishDate | 1996 |
| publishDateSearch | 1996 |
| publishDateSort | 1996 |
| publisher | Springer [u.a.] |
| record_format | marc |
| series2 | Molecular biology intelligence unit |
| spelling | The Na+/H+ exchanger Larry Fliegel New York [u.a.] Springer [u.a.] 1996 317 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit Carrier-Proteine (DE-588)4213127-3 gnd rswk-swf Natriumion (DE-588)4171261-4 gnd rswk-swf Cotransport (DE-588)4246072-4 gnd rswk-swf Wasserstoffion (DE-588)4189272-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Natriumion (DE-588)4171261-4 s Wasserstoffion (DE-588)4189272-0 s Cotransport (DE-588)4246072-4 s Carrier-Proteine (DE-588)4213127-3 s DE-604 Fliegel, Larry Sonstige oth DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007232595&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The Na+/H+ exchanger Carrier-Proteine (DE-588)4213127-3 gnd Natriumion (DE-588)4171261-4 gnd Cotransport (DE-588)4246072-4 gnd Wasserstoffion (DE-588)4189272-0 gnd |
| subject_GND | (DE-588)4213127-3 (DE-588)4171261-4 (DE-588)4246072-4 (DE-588)4189272-0 (DE-588)4143413-4 |
| title | The Na+/H+ exchanger |
| title_auth | The Na+/H+ exchanger |
| title_exact_search | The Na+/H+ exchanger |
| title_full | The Na+/H+ exchanger Larry Fliegel |
| title_fullStr | The Na+/H+ exchanger Larry Fliegel |
| title_full_unstemmed | The Na+/H+ exchanger Larry Fliegel |
| title_short | The Na+/H+ exchanger |
| title_sort | the na h exchanger |
| topic | Carrier-Proteine (DE-588)4213127-3 gnd Natriumion (DE-588)4171261-4 gnd Cotransport (DE-588)4246072-4 gnd Wasserstoffion (DE-588)4189272-0 gnd |
| topic_facet | Carrier-Proteine Natriumion Cotransport Wasserstoffion Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007232595&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT fliegellarry thenahexchanger |