Retroviral reverse transcriptases:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Springer [u.a.]
1996
|
| Schriftenreihe: | Molecular biology intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 206 S. Ill., graph. Darst. |
| ISBN: | 3540608907 0412103818 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804125305378439168 |
|---|---|
| adam_text | MOLECULAR
BIOLOGY
INTELLIGENCE
UNIT
RETROVIRAL REVERSE
T RANSCRIPTASES
Simon Litvak
Institut de Biochimie et Genetique Cellulaires du CNRS
Bordeaux, France
Springer
New York Berlin Heidelberg London Paris
Tokyo Hong Kong Barcelona Budapest
R G LANDES COMPANY
AUSTIN
CONTENTS
1 The Emergence of Reverse Transcriptase 1
Discovery of Retroviral Reverse Transcriptase 1
Reverse Transcriptase from Nonretroviral Sources 7
A Role in the Intracellular Transfer of Genetic Material
via a Reverse Transcription Step? 23
2 The Biosynthesis of Reverse Transcriptase 33
The Retroviral Proteases 35
Read-Through Suppression 37
Ribosomal Frameshifting 40
Maturation of the Retroviral pol Gene — Emphasis on HIV-1 46
3 Structure of Retroviral Reverse Transcriptase 57
The Structure of the DNA Polymerase Domain
of HIV-1 Reverse Transcriptase 59
Structural Similarities Among Different Polymerases Crystal
Structures of the Klenow Fragment of E coli DNA Polymerase,
HIV-1 Reverse Transcriptase and T7 RNA Polymerase 65
The Structure of the RNase H Domain
of HIV-1 Reverse Transcriptase 68
Structural and Possible Functional Similarities Between HIV-1
Integrase, E coli RuvC and HIV-1 and E coli RNase H 71
4 The Initiation Complex of Reverse Transcription 83
Selection of Primer tRNA and Binding to the Retroviral Genome 83
The Role of Nucleic Acid/Nucleic Acid Interactions
in tRNA Selection 85
A Role for Gag-Pol Pr^O6*8130 Precursor
in Primer tRNA Selection? 91
Reverse Transcriptase and tRNA Selection 92
Modulation of Reverse Transcriptase Activity by Primer tRNA 99
The Annealing of Primer tRNA to the Primer Binding Site
of the Retroviral RNA Genome 100
Does the Gag-Derived Nucleocapsid Protein Play a Role
in Primer tRNA Selection and Further Annealing
to the Retroviral PBS Sequence? 104
5 Elongation and Recombination Events
in Reverse Transcription and Fidelity
of Retroviral Reverse Transcriptases 115
Retroviral Reverse Transcription 115
Recombination and Reverse Transcription 121
Fidelity of Retroviral Reverse Transcriptases 124
6 Retroviral Ribonuclease H 141
The RNase H Domain of Retroviral Reverse Transcriptase 144
Catalytic Properties 148
Role of RNase H in Primer tRNA Release
During Reverse Transcription 153
Inhibitors of Retroviral RNase H 156
7 Reverse Transcriptase Inhibitors 161
Small Ligands as Inhibitors of Reverse Transcriptase 163
Inhibition by Oligonucleotides 174
HIV-1 Reverse Transcriptase Dimerization as a Target 187
Inhibitors of Retroviral RNase H 187
Index 199
|
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| id | DE-604.BV010819851 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:59:27Z |
| institution | BVB |
| isbn | 3540608907 0412103818 |
| language | English |
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| physical | 206 S. Ill., graph. Darst. |
| publishDate | 1996 |
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| publisher | Springer [u.a.] |
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| series2 | Molecular biology intelligence unit |
| spelling | Litvak, Simon Verfasser aut Retroviral reverse transcriptases Simon Litvak New York [u.a.] Springer [u.a.] 1996 206 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit RNA-directed DNA polymérase Rétroviridae Nucleotidyltransferases Retroviridae Reverse Transcriptase Inhibitors Reverse transcriptase Transcription Factors Reverse Transkriptase (DE-588)4221839-1 gnd rswk-swf Retroviren (DE-588)4121587-4 gnd rswk-swf Reverse Transkriptase (DE-588)4221839-1 s Retroviren (DE-588)4121587-4 s DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007230593&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Litvak, Simon Retroviral reverse transcriptases RNA-directed DNA polymérase Rétroviridae Nucleotidyltransferases Retroviridae Reverse Transcriptase Inhibitors Reverse transcriptase Transcription Factors Reverse Transkriptase (DE-588)4221839-1 gnd Retroviren (DE-588)4121587-4 gnd |
| subject_GND | (DE-588)4221839-1 (DE-588)4121587-4 |
| title | Retroviral reverse transcriptases |
| title_auth | Retroviral reverse transcriptases |
| title_exact_search | Retroviral reverse transcriptases |
| title_full | Retroviral reverse transcriptases Simon Litvak |
| title_fullStr | Retroviral reverse transcriptases Simon Litvak |
| title_full_unstemmed | Retroviral reverse transcriptases Simon Litvak |
| title_short | Retroviral reverse transcriptases |
| title_sort | retroviral reverse transcriptases |
| topic | RNA-directed DNA polymérase Rétroviridae Nucleotidyltransferases Retroviridae Reverse Transcriptase Inhibitors Reverse transcriptase Transcription Factors Reverse Transkriptase (DE-588)4221839-1 gnd Retroviren (DE-588)4121587-4 gnd |
| topic_facet | RNA-directed DNA polymérase Rétroviridae Nucleotidyltransferases Retroviridae Reverse Transcriptase Inhibitors Reverse transcriptase Transcription Factors Reverse Transkriptase Retroviren |
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