Organ and bone marrow transplantation:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia [u.a.]
Saunders
1996
|
| Schriftenreihe: | Immunology and allergy clinics of North America
16,2 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII S., S. 221 - 484 |
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Datensatz im Suchindex
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| adam_text | ORGAN AND BONE MARROW TRANSPLANTATION
CONTENTS
Preface xi
William T. Shearer and Thomas A. Fleisher
Solid Organ Transplantation: Immunologic Theory and
Immunosuppressive Strategy 221
Barry D. Kahan
Current therapeutic approaches to solid organ transplantation are
based upon Medawar s hypothesis that graft rejection is trans¬
ferred in specific fashion systemically by lymphocytes and abro¬
gated by neonatal exposure. Our failure to ensure graft success
relates not only to the gaps in our knowledge of immunologic
events, but also to a lack of understanding of the pathophysiology
of transplanted organs. Allograft rejection and immunosuppres
sion are among the topics discussed in detail in this article.
Renal Transplantation 243
Mohamed H. Sayegh and Charles B. Carpenter
Renal transplantation is the treatment of choice for end stage
renal disease. Recipients of kidney transplants need to be main¬
tained on chronic maintenance immunosuppression with poten¬
tially toxic medications to prevent rejection, including steroids,
azathioprine, and cyclosporine. Rejection, however, continues to
be the most common cause of graft dysfunction, although
cyclosporine toxicity may be difficult to differentiate unless a
transplant biopsy is performed. Infections, especially with immu
nomodulating viruses, and posttransplant malignancies are
among the most serious posttransplant complications that appear
to be related to the level of overall immunosuppression. Several
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
VOLUME 16 • NUMBER 2 • MAY 1996 V
new immunosuppressive drugs are currently being tested in clini¬
cal trials with the goal of achieving optimal immunosuppression
to prevent graft rejection and improve graft survival, while min¬
imizing serious toxicity.
A Clinical Perspective of Heart and Lung Transplantation 265
James B. Young, Adaani Frost, and H. David Short III
Heart, heart lung, and lung transplantation play important roles
in the therapy of certain patients with end stage heart or lung
disease. Complications are similar to other allografts, in many
respects, but unique in terms of the degree of arteriopathy devel¬
oping in heart transplant patients and bronchiolitis obliterans
complicating transplanted lungs. Despite these difficulties and
some limitations in organ function, recipients of these grafts gen¬
erally enjoy remarkable rehabilitation.
Liver and Intestine Transplantation 293
Jorge Reyes, Satoru Todo, and Thomas E. Starzl
We have recently achieved several major advances in clinical
transplantation, which are addressed separately and include the
introduction and development of the new immunosuppressive
drug FK506 (Tacrolimus); the feasibility of intestinal transplanta¬
tion with or without other abdominal organs; and the discovery
of the phenomenon of bidirectional cell migration and consequent
systemic as well as graft chimerism, which we believe is the
essential component for the long term acceptance of any kind of
whole organ graft.
Pancreas Transplantation 313
Scott A. Gruber and David E. R. Sutherland
Currently, the major role of pancreas transplantation is as an
adjunct to kidney transplantation in preuremic, uremic, or post
uremic diabetic patients. Nonuremic patients with hyperlabile
diabetes or emerging complications must be carefully selected for
the procedure. At least some immunosuppression is required
even for recipients of a segmental graft from a nondiabetic identi¬
cal twin donor, because in its absence the original autoimmune
process will recur in the graft. Immunosuppression sufficient to
prevent rejection is usually sufficient to prevent recurrence of
disease. The recipient s problems with diabetes must be such that
the potential side effects of immunosuppressive therapy are an
acceptable trade off.
Transplantation of Fetal Tissues 333
Aftab A. Ansari and J. Bruce Sundstrom
Fetal tissue transplants and cell replacement therapy are being
actively pursued for the treatment of a number of clinical disor
vi CONTENTS
ders, including Parkinson s, Huntington s, and Alzheimer s dis¬
eases. While clinical studies continue, the basic scientific issues
concerning the physiologic and immunologic aspects of such
therapeutic measures remain to be elucidated. This article de¬
scribes these physiologic and immunologic issues related to fetal
tissue transplantation and provides a summary of the prospects
and limitations of the clinical application of fetal tissue trans¬
plantation and the transplantation of fetal liver, thymus, and
immortalized genetically altered fetal stem cells.
HLA Identical Sibling and Haploidentical, T Cell Depleted
Bone Marrow Transplantation for Immunodeficiency 361
A. Fischer
Most primary immunodeficiencies consist of intrinsic defects of
lymphocytic or phagocytic cell lineages. Therefore, replacement
of genetically impaired hematopoietic stem cells by normal hema
topoietic stem cells is a logical therapeutic approach. In this
article, results of haploidentical, T cell depleted bone marrow
transplantation are compared with results of HLA identical bone
marrow transplanation.
Stem Cell Transplantation from Unrelated Donors for
Correction of Primary Immunodeficiencies 377
Alexandra H. Filipovich
The use of unrelated donor stem cell transplantation has in¬
creased exponentially over the past 5 years. The greatest benefits
of URD BMT have accrued to younger patients, those with favor¬
able pretransplant disease characteristics, and patients treated at
transplant centers that have considerable experience with URD
BMT specifically. Children with nonmalignant congenital disor¬
ders and immunodeficiencies in particular enjoy the highest long
term survival rates among recipients of unrelated donor BMT.
Success rates range between 40% and 90% for the majority of
immunodeficiency diagnoses curable by allogeneic transplanta¬
tion. Early results of quality of life assessments support the notion
that the functional status of long term survivors of URD BMT is
comparable to that of patients treated with matched sibling BMT.
In the current era, children with a variety of lethal congenital
immunodeficiencies lacking sibling donors deserve consideration
for unrelated grafting at institutions with specific expertise in
this therapy.
Bone Marrow Transplantation for Hematologic
Malignancies and Cancer 393
Peter A. McSweeney and Rainer Storb
Over 20 years marrow transplantation has evolved from an exper¬
imental treatment for patients with advanced acute leukemia to
CONTENTS Vii
the treatment of choice for any acute leukemia that has recurred
at least once, for relapsed aggressive non Hodgkin s lymphoma
(NHL) or Hodgkin s disease, for acute myeloid leukemia in first
remission, and for chronic myelocytic leukemia. It is the only
curative treatment for chronic lymphocytic leukemia, myelodys
plasia, multiple myeloma, and low grade NHL. Increasingly it is
used as treatment for some solid tumors where best results have
been seen when bone marrow transplantation is used as an
adjuvant therapy for patients with low tumor burden. Critical to
further progress is the development of more effective, yet safer
conditioning programs to eradicate host tumor and immune cells.
Continued research with recombinant molecules and the expected
proliferation of recombinant and pharmaceutical products should
facilitate continued improvements in results of clinical marrow
transplantation.
Bone Marrow Transplantation for Metabolic Diseases 429
Robertson Parkman and Gay Crooks
Controversy still exists as to the role of allogeneic bone marrow
transplantations for the treatment of metabolic diseases. In this
article, the present status of bone marrow transplantation for
metabolic diseases is reviewed in terms of the pathophysiology
of individual diseases.
Cord Blood Stem and Progenitor Cell Therapy for
Immunodeficiency and Other Disorders 439
Hal E. Broxmeyer
Cord blood, a rich source of hematopoietic stem and progenitor
cells, has been used for transplantation in both a sibling and an
unrelated setting. More than 100 transplants have been done for
a variety of nonmalignant diseases, including genetic immunode¬
ficiencies and malignant disorders. The clinical results are encour¬
aging and have demonstrated engraftment and low levels of
graft versus host disease. Cord blood transplantation has been
helped by the establishment of cord blood banks. Although there
is much still to be learned regarding the biology, immunology,
and transplantation of cord blood, the future of this form of
transplantation is extremely promising.
Gene Therapy for Congenital Immunodeficiency Diseases 453
Kenneth I. Weinberg and Donald B. Kohn
Significant progress has been made in understanding the patho
genesis and molecular basis of the primary immunodeficiency
diseases. Because genetically corrected cells of patients with these
disorders may have a selective survival advantage, the primary
immunodeficiency diseases have been a principal focus of initial
clinical efforts at gene therapy. The technical challenges that must
Viii CONTENTS
be surmounted for successful gene therapy and the approaches
currently under investigation are described. The status of initial
clinical trials of gene therapy for the primary immunodeficiency
disorders is summarized.
Index 477
Subscription Information Inside back cover
CONTENTS X
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| spelling | Organ and bone marrow transplantation William T. Shearer, ... guest ed. Philadelphia [u.a.] Saunders 1996 XII S., S. 221 - 484 txt rdacontent n rdamedia nc rdacarrier Immunology and allergy clinics of North America 16,2 Beenmergtransplantatie gtt Transplantatie gtt Bone Marrow Transplantation Bone marrow Transplantation Organ Transplantation Transplantation of organs, tissues, etc Transplantationsimmunologie (DE-588)4275245-0 gnd rswk-swf Transplantation (DE-588)4060675-2 gnd rswk-swf Knochenmarktransplantation (DE-588)4164288-0 gnd rswk-swf Transplantatabstoßung (DE-588)4137807-6 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Knochenmarktransplantation (DE-588)4164288-0 s DE-604 Transplantation (DE-588)4060675-2 s Transplantatabstoßung (DE-588)4137807-6 s Transplantationsimmunologie (DE-588)4275245-0 s Shearer, William T. Sonstige oth Immunology and allergy clinics of North America 16,2 (DE-604)BV000645505 16,2 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007221501&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Organ and bone marrow transplantation Immunology and allergy clinics of North America Beenmergtransplantatie gtt Transplantatie gtt Bone Marrow Transplantation Bone marrow Transplantation Organ Transplantation Transplantation of organs, tissues, etc Transplantationsimmunologie (DE-588)4275245-0 gnd Transplantation (DE-588)4060675-2 gnd Knochenmarktransplantation (DE-588)4164288-0 gnd Transplantatabstoßung (DE-588)4137807-6 gnd |
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| title | Organ and bone marrow transplantation |
| title_auth | Organ and bone marrow transplantation |
| title_exact_search | Organ and bone marrow transplantation |
| title_full | Organ and bone marrow transplantation William T. Shearer, ... guest ed. |
| title_fullStr | Organ and bone marrow transplantation William T. Shearer, ... guest ed. |
| title_full_unstemmed | Organ and bone marrow transplantation William T. Shearer, ... guest ed. |
| title_short | Organ and bone marrow transplantation |
| title_sort | organ and bone marrow transplantation |
| topic | Beenmergtransplantatie gtt Transplantatie gtt Bone Marrow Transplantation Bone marrow Transplantation Organ Transplantation Transplantation of organs, tissues, etc Transplantationsimmunologie (DE-588)4275245-0 gnd Transplantation (DE-588)4060675-2 gnd Knochenmarktransplantation (DE-588)4164288-0 gnd Transplantatabstoßung (DE-588)4137807-6 gnd |
| topic_facet | Beenmergtransplantatie Transplantatie Bone Marrow Transplantation Bone marrow Transplantation Organ Transplantation Transplantation of organs, tissues, etc Transplantationsimmunologie Transplantation Knochenmarktransplantation Transplantatabstoßung Aufsatzsammlung |
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