Mechanisms of metallocenter assembly:
Mechanisms of Metallocenter Assembly summarizes the general principles and mechanisms involved in protein metallocenter assembly and illustrates these themes with specific examples. It provides a mechanistic framework for understanding how metals are incorporated into proteins, as well as a systemat...
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | German |
| Veröffentlicht: |
New York [u.a.]
VCH
1996
|
| Schriftenreihe: | Advances in inorganic biochemistry
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Zusammenfassung: | Mechanisms of Metallocenter Assembly summarizes the general principles and mechanisms involved in protein metallocenter assembly and illustrates these themes with specific examples. It provides a mechanistic framework for understanding how metals are incorporated into proteins, as well as a systematic analysis of the various options available to the cell for controlling metal incorporation. The authors discuss the importance of metallocenter assembly in the activation of several enzymes and selected structural proteins. The possible reasons why expression of the structural gene is not enough to obtain a functional metalloprotein also are well covered. Mechanisms of Metallocenter Assembly currently is the only book that brings together experimental findings previously scattered in the literature on the mechanisms of metal incorporation into proteins. This book is intended for biochemists, microbiologists, inorganic chemists, and other scientists who are interested in proteins that possess metal ions or metal cofactors. |
| Beschreibung: | XIV, 267 S. graph. Darst. |
| ISBN: | 1560819200 |
Internformat
MARC
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| 300 | |a XIV, 267 S. |b graph. Darst. | ||
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| 490 | 0 | |a Advances in inorganic biochemistry | |
| 520 | 3 | |a Mechanisms of Metallocenter Assembly summarizes the general principles and mechanisms involved in protein metallocenter assembly and illustrates these themes with specific examples. It provides a mechanistic framework for understanding how metals are incorporated into proteins, as well as a systematic analysis of the various options available to the cell for controlling metal incorporation. The authors discuss the importance of metallocenter assembly in the activation of several enzymes and selected structural proteins. The possible reasons why expression of the structural gene is not enough to obtain a functional metalloprotein also are well covered. Mechanisms of Metallocenter Assembly currently is the only book that brings together experimental findings previously scattered in the literature on the mechanisms of metal incorporation into proteins. This book is intended for biochemists, microbiologists, inorganic chemists, and other scientists who are interested in proteins that possess metal ions or metal cofactors. | |
| 650 | 7 | |a Chimie bioinorganique |2 ram | |
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Datensatz im Suchindex
| _version_ | 1807683895383031808 |
|---|---|
| adam_text |
CONTENTS
CONTRIBUTORS
XV
1.
GENERAL
PRINCIPLES
AND
MECHANISMS
OF
METALLOCENTER
ASSEMBLY
1
ROBERT
P.
HAUSINGER
1.1.
INTRODUCTION
1
1.2.
METALLOCENTER
ASSEMBLY
REQUIRING
NO
ACCESSORY
PROTEINS
2
1.3.
CREATION
OF
METAL
ION
BINDING
SITES
BY
POSTTRANSLATIONAL
MODIFICATION
5
1.4.
SYNTHESIS
OF
METAL
COFACTORS
6
1.5.
ELECTRON
TRANSFER-DEPENDENT
ASSEMBLY
OF
METALLOCENTERS
8
1.6.
METALLOCENTER
ASSEMBLY-SPECIFIC
CHAPERONE
PROTEINS
9
1.7.
METAL-DONOR
AUXILIARY
PROTEINS
11
1.8.
COVALENT
ATTACHMENT
OF
METALLOCENTERS
12
1.9.
SUMMARY
AND
PERSPECTIVE
14
REFERENCES
15
2.
IN
VITRO
METAL
ION
INCORPORATION
INTO
NONHEME
DIIRON
PROTEINS:
HEMERYTHRIN,
MYOHEMERYTHRIN,
AND
RUBRERYTHRIN
19
DONALD
M.
KURTZ,
JR.
2.1.
INTRODUCTION
19
2.2.
HEMERYTHRIN
AND
MYOHEMERYTHRIN
20
VIII
MECHANISMS
OF
METALLOCENTER
ASSEMBLY
2.3.
RUBRERYTHRIN
31
2.4.
PERSPECTIVE
AND
FUTURE
DIRECTIONS
35
REFERENCES
38
3.
GENERATION
OF
CALCIUM-BINDING
SITES
IN
PROTEINS
BY
FORMATION
OF
Y-CARBOXYGLUTAMIC
ACID
AND
P-HYDROXYASPARTIC
ACID/P-HYDROXYASPARAGINE
41
TORBJOM
DRAKENBERG,
MARIA
SUNNERHAGEN,
AND
JOHAN
STENFLO
3.1.
INTRODUCTION
41
3.2.
BLOOD
COAGULATION
43
3.3.
MODULAR
STRUCTURE
OF
Y-CARBOXYGLUTAMIC
ACID
(GIA)
AND
P-HYDROXYASPARTIC
ACID/FT-HYDROXYASPARAGINE
(HYA/HYN)-CONTAINING
COAGULATION
FACTORS
45
3.4.
GLA-CONTAINING
MODULES
46
3.5.
EGF-LIKE
MODULES
CONTAINING
HYA/HYN
57
3.6.
OTHER
CALCIUM-BINDING
SITES
IN
VITAMIN
K-DEPENDENT
COAGULATION
FACTORS
68
3.7.
CALCIUM-BINDING
TO
GIA
AND
HYA/HYN-CONTAINING
MODULES
IN
PROTEINS
NOT
INVOLVED
IN
BLOOD
COAGULATION
68
3.8.
SUMMARY
69
REFERENCES
70
4.
FERROCHELATASE
77
HARRY
A.
DAILEY
4.1.
INTRODUCTION
77
4.2.
CLONING
AND
EXPRESSION
OF
FERROCHELATASE
80
4.3.
CHARACTERIZED
MUTATIONS
OF
FERROCHELATASE
83
4.4.
KINETIC
PROPERTIES
84
4.5.
IRON-SULFUR
CLUSTER
OF
MAMMALIAN
FERROCHELATASE
92
4.6.
ACTIVE
SITE
MODEL
FOR
FERROCHELATASE
93
4.7.
POTENTIAL
PROTEIN-PROTEIN
INTERACTIONS
94
REFERENCES
95
5.
COBALT
INSERTION
DURING
COENZYME
B
12
BIOSYNTHESIS
99
FRANCIS
BLANCHE,
BEATRICE
CAMERON,
MICHEL
COUDER,
JOEL
CROUZET,
LAURENT
DEBUSSCHE,
AND
DENIS
THIBAUT
5.1.
INTRODUCTION
99
5.2.
TIMING
OF
COBALT
INSERTION
-
HISTORICAL
PERSPECTIVE
99
CONTENTS
LX
5.3.
COBALT
INSERTION
IN
PSEUDOMONAS
DENITRIFICANS
102
5.4.
COENZYME
FORMATION
106
5.5.
GENETICS
OF
THE
INSERTION
OF
COBALT
107
5.6.
COBALT
INSERTION
IN
OTHER
MICROORGANISMS
108
REFERENCES
109
6.
DEVELOPMENTS
IN
THE
ANALYSIS
OF
NITROGENASE
FEMO-COFACTOR
BIOSYNTHESIS
STEVEN
W.
MUCHMORE,
RICHARD
F.
JACK,
AND
DENNIS
R.
DEAN
6.1.
INTRODUCTION
111
6.2.
BIOCHEMICAL-GENETIC
ANALYSIS
OF
NITROGENASE
METALLOCLUSTER
ASSEMBLY:
A
BRIEF
HISTORICAL
PERSPECTIVE
113
6.3.
BIOSYNTHESIS
OF
FEMO-COFACTOR:
A
GENERAL
OVERVIEW
115
6.4.
THE
NIFEN
COMPLEX:
A
MOLECULAR
SCAFFOLD
FOR
METALLOCLUSTER
ASSEMBLY?
116
6.5.
HOMOCITRATE
AND
THE
INVOLVEMENT
OF
NIFV
AND
NIFQ,
AND
THE
POSSIBLE
INVOLVEMENT
OF
NIFW
AND
NIFZ,
IN
FEMO-COFACTOR
ASSEMBLY
122
6.6.
FE
PROTEIN
AND
MGATP
ARE
REQUIRED
FOR
THE
SYNTHESIS
OF
FEMO-COFACTOR
AND
ITS
INSERTION
INTO
THE
APO-MOFE
PROTEIN
123
6.7.
THE
INVOLVEMENT
OF
A
MOLECULAR
PROP
IN
FEMO-COFACTOR
INSERTION
125
6.8.
NIFB:
A
MOLECULAR
SCAFFOLD
FOR
FORMATION
OF
AN
FEMO-COFACTOR
PRECURSOR-NIFB-COFACTOR?
126
6.9.
MOBILIZATION
OF
THE
S
AND
FE
REQUIRED
FOR
FEMO-COFACTOR
FORMATION
127
6.10.
SUMMARY
AND
COMMENTS
129
REFERENCES
130
7.
FES
CLUSTER
ASSEMBLY
BY
RHODANESE:
A
REGULATED
PROCESS?
135
MARGUERITE
VOLINI
7.1.
INTRODUCTION
135
7.2.
THE
SULFURTRANSFERASES
136
7.3.
ENZYME-CATALYZED
INCORPORATION
OF
SULFUR
INTO
IRON-SULFUR
PROTEINS
137
7.4.
RHODANESE
FUNCTIONS
139
7.5.
THE
RHODANESE
OF
BOVINE
LIVER
MITOCHONDRIA
140
7.6.
THE
ACCESSIBLE
RHODANESE
OF
E.
COLI
145
7.7.
SUMMARY
AND
CONCLUSIONS
147
REFERENCES
148
X
MECHANISMS
OF
MET
ALLOCENTER
ASSEMBLY
8.
NICKEL
INCORPORATION
INTO
UREASE
151
MARY
BETH
C.
MONCRIEF
AND
ROBERT
P.
HAUSINGER
8.1.
INTRODUCTION
151
8.2.
UREASE
METALLOCENTER
ASSEMBLY
155
8.3.
SUMMARY
167
REFERENCES
168
9.
NICKEL
INCORPORATION
INTO
HYDROGENASES
173
THOMAS
MAIER
AND
AUGUST
BOCK
9.1.
INTRODUCTION
173
9.2.
BIOCHEMISTRY
OF
HYDROGENASES
174
9.3.
GENETICS
OF
NICKEL-CONTAINING
HYDROGENASES
177
9.4.
NICKEL
INCORPORATION
AND
MATURATION
OF
HYDROGENASES
181
9.5.
CONCLUSIONS
187
REFERENCES
188
10.
METAL-CENTER
ASSEMBLY
OF
THE
BACTERIAL
MULTICOPPER
ENZYME,
NITROUS
OXIDE
REDUCTASE
193
WALTER
G.
ZUMFT
AND
PETER
M.
H.
KRONECK
10.1.
INTRODUCTION
193
10.2.
GENETICS
OF
N
2
O
REDUCTASE
195
10.3.
PROPERTIES
OF
N
2
O
REDUCTASE
198
10.4.
THE
ASSEMBLY
PROCESS
208
10.5.
CONCLUSIONS
215
REFERENCES
216
11.
ROLE
OF
MELCL
AS
A
CHAPERONE
FOR
STREPTOMYCES
TYROSINASE
COPPER
ASSEMBLY
223
YAN-HWA
WU
LEE
11.1.
INTRODUCTION
223
11.2.
STREPTOMYCES
TYROSINASE
224
11.3.
IN
VITRO
RECONSTITUTION
OF
APOTYROSINASE
BY
COPPER
ION
227
11.4.
IN
VIVO
REQUIREMENT
OF
ACCESSORY
PROTEIN
MELCL
FOR
METALLOCENTER
ASSEMBLY
IN
TYROSINASE
OF
STREPTOMYCES
228
11.5.
SUMMARY
AND
PERSPECTIVE
231
REFERENCES
232
CONTENTS
XI
12.
ROLE
OF
METALLOTHIONEIN
IN
INTRACELLULAR
METAL
METABOLISM
AND
IN
ACTIVATION
OF
COPPER
AND
ZINC-DEPENDENT
PROTEINS
235
MARIUS
BROUWER
12.1.
INTRODUCTION
235
12.2.
METALLOTHIONEIN
STRUCTURE
238
12.3.
METAL-BINDING
PROPERTIES
239
12.4.
METAL
TRANSFER
FROM
METALLOTHIONEIN
TO
APOMETALLOPROTEINS
IN
VITRO
251
12.5.
ROLE
OF
METALLOTHIONEIN
IN
INTRACELLULAR
TRAFFICKING
OF
COPPER
AND
ZINC
IN
VIVO
254
12.6.
CONCLUDING
REMARKS
255
REFERENCES
256
INDEX
261 |
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| id | DE-604.BV010780438 |
| illustrated | Illustrated |
| indexdate | 2024-08-18T00:41:41Z |
| institution | BVB |
| isbn | 1560819200 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007200426 |
| oclc_num | 32468712 |
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| owner_facet | DE-355 DE-BY-UBR DE-703 DE-91G DE-BY-TUM |
| physical | XIV, 267 S. graph. Darst. |
| publishDate | 1996 |
| publishDateSearch | 1996 |
| publishDateSort | 1996 |
| publisher | VCH |
| record_format | marc |
| series2 | Advances in inorganic biochemistry |
| spelling | Mechanisms of metallocenter assembly ed. by Robert P. Hausinger ... New York [u.a.] VCH 1996 XIV, 267 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in inorganic biochemistry Mechanisms of Metallocenter Assembly summarizes the general principles and mechanisms involved in protein metallocenter assembly and illustrates these themes with specific examples. It provides a mechanistic framework for understanding how metals are incorporated into proteins, as well as a systematic analysis of the various options available to the cell for controlling metal incorporation. The authors discuss the importance of metallocenter assembly in the activation of several enzymes and selected structural proteins. The possible reasons why expression of the structural gene is not enough to obtain a functional metalloprotein also are well covered. Mechanisms of Metallocenter Assembly currently is the only book that brings together experimental findings previously scattered in the literature on the mechanisms of metal incorporation into proteins. This book is intended for biochemists, microbiologists, inorganic chemists, and other scientists who are interested in proteins that possess metal ions or metal cofactors. Chimie bioinorganique ram Metais e seus compostos (quimica) larpcal Métalloenzymes ram Métalloprotéines ram Proteinas larpcal Metalloproteins Synthesis Apoproteine (DE-588)4343737-0 gnd rswk-swf Assembly (DE-588)4378786-1 gnd rswk-swf Metallproteide (DE-588)4169623-2 gnd rswk-swf Metallion (DE-588)4169597-5 gnd rswk-swf Metallproteide (DE-588)4169623-2 s Apoproteine (DE-588)4343737-0 s Metallion (DE-588)4169597-5 s Assembly (DE-588)4378786-1 s DE-604 Hausinger, Robert P. Sonstige oth DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007200426&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Mechanisms of metallocenter assembly Chimie bioinorganique ram Metais e seus compostos (quimica) larpcal Métalloenzymes ram Métalloprotéines ram Proteinas larpcal Metalloproteins Synthesis Apoproteine (DE-588)4343737-0 gnd Assembly (DE-588)4378786-1 gnd Metallproteide (DE-588)4169623-2 gnd Metallion (DE-588)4169597-5 gnd |
| subject_GND | (DE-588)4343737-0 (DE-588)4378786-1 (DE-588)4169623-2 (DE-588)4169597-5 |
| title | Mechanisms of metallocenter assembly |
| title_auth | Mechanisms of metallocenter assembly |
| title_exact_search | Mechanisms of metallocenter assembly |
| title_full | Mechanisms of metallocenter assembly ed. by Robert P. Hausinger ... |
| title_fullStr | Mechanisms of metallocenter assembly ed. by Robert P. Hausinger ... |
| title_full_unstemmed | Mechanisms of metallocenter assembly ed. by Robert P. Hausinger ... |
| title_short | Mechanisms of metallocenter assembly |
| title_sort | mechanisms of metallocenter assembly |
| topic | Chimie bioinorganique ram Metais e seus compostos (quimica) larpcal Métalloenzymes ram Métalloprotéines ram Proteinas larpcal Metalloproteins Synthesis Apoproteine (DE-588)4343737-0 gnd Assembly (DE-588)4378786-1 gnd Metallproteide (DE-588)4169623-2 gnd Metallion (DE-588)4169597-5 gnd |
| topic_facet | Chimie bioinorganique Metais e seus compostos (quimica) Métalloenzymes Métalloprotéines Proteinas Metalloproteins Synthesis Apoproteine Assembly Metallproteide Metallion |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007200426&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT hausingerrobertp mechanismsofmetallocenterassembly |