Cytokines and the heart: molecular mechanisms of septic cardiomyopathy
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | German |
| Veröffentlicht: |
New York [u.a.]
Springer [u.a.]
1996
|
| Schriftenreihe: | Medical intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | 260 S. Ill., graph. Darst. |
| ISBN: | 3540601759 0412101114 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV010746799 | ||
| 003 | DE-604 | ||
| 005 | 19960624 | ||
| 007 | t | ||
| 008 | 960429s1996 gw ad|| |||| 00||| ger d | ||
| 016 | 7 | |a 947172955 |2 DE-101 | |
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| 082 | 0 | |a 616.1/2407 |2 20 | |
| 084 | |a YB 9317 |0 (DE-625)153176:12923 |2 rvk | ||
| 100 | 1 | |a Müller-Werdan, Ursula |d 1961- |e Verfasser |0 (DE-588)121503542 |4 aut | |
| 245 | 1 | 0 | |a Cytokines and the heart |b molecular mechanisms of septic cardiomyopathy |c Ursula Müller-Werdan ; Christopher Reithmann ; Karl Werdan |
| 264 | 1 | |a New York [u.a.] |b Springer [u.a.] |c 1996 | |
| 300 | |a 260 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Medical intelligence unit | |
| 500 | |a Literaturangaben | ||
| 650 | 4 | |a Cardiomyopathies |x physiopathology | |
| 650 | 4 | |a Cytokines |x Pathophysiology | |
| 650 | 4 | |a Cytokines |x physiology | |
| 650 | 4 | |a Heart |x Infections |x Molecular aspects | |
| 650 | 4 | |a Myocardium |x Diseases |x Molecular aspects | |
| 650 | 4 | |a Sepsis |x physiopathology | |
| 650 | 4 | |a Septic shock |x Molecular aspects | |
| 650 | 4 | |a Shock, Septic |x physiopathology | |
| 650 | 0 | 7 | |a Sepsis |0 (DE-588)4181014-4 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Herzmuskelkrankheit |0 (DE-588)4072466-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Cytokine |0 (DE-588)4205701-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Molekularbiologie |0 (DE-588)4039983-7 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Herzmuskelkrankheit |0 (DE-588)4072466-9 |D s |
| 689 | 0 | 1 | |a Sepsis |0 (DE-588)4181014-4 |D s |
| 689 | 0 | 2 | |a Cytokine |0 (DE-588)4205701-2 |D s |
| 689 | 0 | 3 | |a Molekularbiologie |0 (DE-588)4039983-7 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Reithmann, Christopher |e Verfasser |4 aut | |
| 700 | 1 | |a Werdan, Karl |e Verfasser |4 aut | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007176852&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-007176852 | |
Datensatz im Suchindex
| _version_ | 1808137385466134528 |
|---|---|
| adam_text |
CONTENTS
1.
INTRODUCTION
.
1
2.
SEPTIC
CARDIOMYOPATHY
.
5
A
SECONDARY
FORM
OF
CARDIOMYOPATHY
.
5
THE
CHARACTERISTIC
PATTERN
.
5
OCCURRENCE
IN
GRAM-NEGATIVE
AND
GRAM-POSITIVE
SEPSIS
.
8
3.
RESEARCHING
MECHANISMS
OF
SEPTIC
CARDIOMYOPATHY:
EXPERIMENTAL
MODELS
WITH
SPECIAL
EMPHASIS
ON
CARDIOMYOCYTES
.
11
THE
PROBLEM
.
11
ADULT
AND
NEONATAL
CARDIOMYOCYTES
.
11
THE
PLACE
OF
ISOLATED
CARDIOMYOCYTES
IN
RESEARCHING
MECHANISMS
OF
MYOCARDIAL
DEPRESSION
IN
SEPSIS
.
17
4.
RELEVANT
SUBSTANCES
AND
CONDITIONS
TRIGGERING
"
NEGATIVE
INOTROPIC
CASCADES
"
IN
CARDIOMYOCYTES
.
21
CATECHOLAMINES
.
21
BACTERIAL
AND
FUNGAL
TOXINS
.
38
CYTOKINES
.
53
NITRIC
OXIDE
.
72
COMPLEMENT
FACTORS
.
74
PLATELET
ACTIVATING
FACTOR
.
75
EICOSANOIDS:
THROMBOXANES,
PROSTAGLANDINS,
LEUKOTRIENES
.
76
CARDIODEPRESSANT
FACTORS
.
78
REACTIVE
OXYGEN
SPECIES
.
81
ENDORPHINS
.
90
ADDITIONAL
ALTERATIONS
OF
NEUROHUMORAL,
AUTOCRINE
AND
PARACRINE
SYSTEMS
.
91
ACTIVATED
BLOOD
CELIS
.
94
ENERGY
DEPLETION
.
98
HYPOXIA,
REOXYGENATION
AND
"
ISCHEMIA
"
.
100
5.
DERANGEMENT
OF
CARDIAC
STRUCTURE
.125
FINDINGS
IN
THE
PREANTIBIOTIC
ERA
.
125
PATHOMORPHOLOGICAL
CORRELATES
OF
SEPTIC
CARDIOMYOPATHY
IN
PATIENTS
.
125
PATHOMORPHOLOGICAL
CORRELATES
IN
ANIMAL
SEPSIS
MODELS
.
127
WHAT
REMAINS
TO
BE
DONE
?
-
A
NONPATHOLOGIST
'
S
VIEW
.
128
6.
DERANGEMENT
OF
CORONARY
CIRCULATION
AND
MYOCARDIAL
OXYGEN
SUPPLY
.
131
CORONARY
CIRCULATION
.
131
CORONARY
RESERVE
.
132
CONCLUSIONS
.
136
7.
DERANGEMENT
OF
MYOCARDIAL
METABOLISM
.
139
OVERVIEW
ON
MYOCARDIAL
METABOLISM
.
139
IMPAIRMENT
OF
MYOCARDIAL
ENERGY
METABOLISM
IN
PATIENTS
WITH
NON-SEPTIC
HEART
DISEASE
.
161
METABOLICALLY
DERANGED
CARDIOMYOPATHY
OF
SEPSIS
AND
SIRS
-
A PRELIMINARY
DRAFT
.
162
8.
DERANGEMENT
OF
INOTROPIC
AXES
OF
THE
CARDIOMYOCYTE
.
189
IS
THE
"
ENDOTOXIN-TNF-A-NITRIC
OXIDE-CARDIODEPRESSION
CASCADE
"
THE
WHOLE
STORY?
.
189
IS
ALL
ENDOTOXIN
CARDIODEPRESSION
MEDIATED
BY
TNF-A
AND
IL-1?
.
196
IS
ALL
TNF-A
CARDIODEPRESSION
MEDIATED
BY
NITRIC
OXIDE?
.
197
PSEUDOMONAS
EXOTOXIN
A:
CARDIODEPRESSION
BY
INHIBITION
OF
PROTEIN
SYNTHESIS
.
202
CDF:
BLOCKAGE
OF
CA
2+
CURRENT
AS
A
MECHANISM
OF
ACTION
.
203
DISTURBANCE
OF
MITOCHONDRIAL
FUNCTION,
ENERGY
METABOLISM
AND
CELLULAR
GLUTATHIONE
POOL
.
203
CELL
MEMBRANE
DAMAGE
AND
ITS
FUNCTIONAL
CONSEQUENCES
.
204
PARACRINE
EFFECTS
OF
ENDOTHELIAL
CELIS
AND
OF
LEUKOCYTES
ON
CARDIOMYOCYTE
FUNCTION
.
205
CARDIODEPRESSION
IN
SEPSIS:
"
THE
MOST
PROVEN
CONCEPTS
"
IN
PERSPECTIVE
.
207
9.
CYTOKINES
IN
NONSEPTIC
HEART
DISEASES
.
215
INCREASED
CIRCULATING
CYTOKINES
IN
PATIENTS
WITH
NONSEPTIC
HEART
DISEASES
.
215
CYTOKINE
EFFECTS
IN
NON-SEPTIC
HEART
DISEASES
.
215
MYOCARDIAL
ISCHEMIA
AND
ISCHEMIA-REPERFUSION
INJURY
.
223
MYOCARDIAL
DEPRESSION
IN
STATES
OF
SIRS
.
1T1
CARDIOVASCULAR
IMPAIRMENT
DUERING
CYTOKINE
TREATMENT
OF
CANCER
PATIENTS
228
THE
EVOLVING
KNOWLEDGE
ABOUT
THE
ROLE
OF
CYTOKINES
IN
HEART
DISEASES
.
230
10.
TOWARDS
A
MORE
CAUSAL
TREATMENT
OF
SEPTIC
CARDIOMYOPATHY
.
235
CATECHOLAMINE
TREATMENT
OF
SEPTIC
VERSUS
NONSEPTIC
HEART
FAILURE:
IS
DESENSITIZATION
DIFFERENT?
.
235
CAN
WE
IMPROVE
SEPTIC
CARDIOMYOPATHY
BY
EXTRACORPOREAL
MEASURES?
.
238
ANTIBODIES
AGAINST
TOXINS
AND
MEDIATORS:
FIRST
ATTEMPTS
OF
A
CAUSAL
TREATMENT
OF
SEPTIC
CARDIOMYOPATHY
.
238
TREATMENT
OF
VASCULAR
AND
CARDIAC
DYSFUNCTION
IN
SEPSIS
MAY
REQUIRE
DIFFERENTIAL
CAUSAL
APPROACHES
.
241
PERSPECTIVES
.
242
11.
SYNOPSIS:
HYPOTHETICAL
VERSUS
PROVEN
MOLECULAR
MECHANISMS
OF
SEPTIC
CARDIOMYOPATHY
IN
HUMANS
.
247
INDEX
.
253 |
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| dewey-search | 616.1/2407 |
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| id | DE-604.BV010746799 |
| illustrated | Illustrated |
| indexdate | 2024-08-23T00:49:44Z |
| institution | BVB |
| isbn | 3540601759 0412101114 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007176852 |
| oclc_num | 32820272 |
| open_access_boolean | |
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| owner_facet | DE-355 DE-BY-UBR |
| physical | 260 S. Ill., graph. Darst. |
| publishDate | 1996 |
| publishDateSearch | 1996 |
| publishDateSort | 1996 |
| publisher | Springer [u.a.] |
| record_format | marc |
| series2 | Medical intelligence unit |
| spelling | Müller-Werdan, Ursula 1961- Verfasser (DE-588)121503542 aut Cytokines and the heart molecular mechanisms of septic cardiomyopathy Ursula Müller-Werdan ; Christopher Reithmann ; Karl Werdan New York [u.a.] Springer [u.a.] 1996 260 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Medical intelligence unit Literaturangaben Cardiomyopathies physiopathology Cytokines Pathophysiology Cytokines physiology Heart Infections Molecular aspects Myocardium Diseases Molecular aspects Sepsis physiopathology Septic shock Molecular aspects Shock, Septic physiopathology Sepsis (DE-588)4181014-4 gnd rswk-swf Herzmuskelkrankheit (DE-588)4072466-9 gnd rswk-swf Cytokine (DE-588)4205701-2 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Herzmuskelkrankheit (DE-588)4072466-9 s Sepsis (DE-588)4181014-4 s Cytokine (DE-588)4205701-2 s Molekularbiologie (DE-588)4039983-7 s DE-604 Reithmann, Christopher Verfasser aut Werdan, Karl Verfasser aut DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007176852&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Müller-Werdan, Ursula 1961- Reithmann, Christopher Werdan, Karl Cytokines and the heart molecular mechanisms of septic cardiomyopathy Cardiomyopathies physiopathology Cytokines Pathophysiology Cytokines physiology Heart Infections Molecular aspects Myocardium Diseases Molecular aspects Sepsis physiopathology Septic shock Molecular aspects Shock, Septic physiopathology Sepsis (DE-588)4181014-4 gnd Herzmuskelkrankheit (DE-588)4072466-9 gnd Cytokine (DE-588)4205701-2 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| subject_GND | (DE-588)4181014-4 (DE-588)4072466-9 (DE-588)4205701-2 (DE-588)4039983-7 |
| title | Cytokines and the heart molecular mechanisms of septic cardiomyopathy |
| title_auth | Cytokines and the heart molecular mechanisms of septic cardiomyopathy |
| title_exact_search | Cytokines and the heart molecular mechanisms of septic cardiomyopathy |
| title_full | Cytokines and the heart molecular mechanisms of septic cardiomyopathy Ursula Müller-Werdan ; Christopher Reithmann ; Karl Werdan |
| title_fullStr | Cytokines and the heart molecular mechanisms of septic cardiomyopathy Ursula Müller-Werdan ; Christopher Reithmann ; Karl Werdan |
| title_full_unstemmed | Cytokines and the heart molecular mechanisms of septic cardiomyopathy Ursula Müller-Werdan ; Christopher Reithmann ; Karl Werdan |
| title_short | Cytokines and the heart |
| title_sort | cytokines and the heart molecular mechanisms of septic cardiomyopathy |
| title_sub | molecular mechanisms of septic cardiomyopathy |
| topic | Cardiomyopathies physiopathology Cytokines Pathophysiology Cytokines physiology Heart Infections Molecular aspects Myocardium Diseases Molecular aspects Sepsis physiopathology Septic shock Molecular aspects Shock, Septic physiopathology Sepsis (DE-588)4181014-4 gnd Herzmuskelkrankheit (DE-588)4072466-9 gnd Cytokine (DE-588)4205701-2 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Cardiomyopathies physiopathology Cytokines Pathophysiology Cytokines physiology Heart Infections Molecular aspects Myocardium Diseases Molecular aspects Sepsis physiopathology Septic shock Molecular aspects Shock, Septic physiopathology Sepsis Herzmuskelkrankheit Cytokine Molekularbiologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007176852&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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