c-MYC function in neoplasia:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Springer [u.a.]
1995
|
| Schriftenreihe: | Medical intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 196 S. graph. Darst. |
| ISBN: | 3540606327 1570593124 |
Internformat
MARC
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| 041 | 0 | |a eng | |
| 049 | |a DE-355 |a DE-12 | ||
| 100 | 1 | |a Dang, Chi V. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a c-MYC function in neoplasia |c Chi V. Dang ; Linda A. Lee |
| 264 | 1 | |a New York [u.a.] |b Springer [u.a.] |c 1995 | |
| 300 | |a 196 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Medical intelligence unit | |
| 650 | 7 | |a Cancer - Aspect génétique |2 ram | |
| 650 | 7 | |a Cancérogenèse |2 ram | |
| 650 | 2 | |a Gènes myc | |
| 650 | 2 | |a Oncogènes | |
| 650 | 7 | |a Oncogènes |2 ram | |
| 650 | 2 | |a Tumeurs - Génétique | |
| 650 | 0 | 7 | |a Myc |0 (DE-588)4267356-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Krebs |g Medizin |0 (DE-588)4073781-0 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Onkogen |0 (DE-588)4131118-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Protoonkogen |0 (DE-588)4256457-8 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Onkogen |0 (DE-588)4131118-8 |D s |
| 689 | 0 | 1 | |a Myc |0 (DE-588)4267356-2 |D s |
| 689 | 0 | 2 | |a Krebs |g Medizin |0 (DE-588)4073781-0 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Krebs |g Medizin |0 (DE-588)4073781-0 |D s |
| 689 | 1 | 1 | |a Protoonkogen |0 (DE-588)4256457-8 |D s |
| 689 | 1 | 2 | |a Myc |0 (DE-588)4267356-2 |D s |
| 689 | 1 | |5 DE-604 | |
| 700 | 1 | |a Lee, Linda A. |e Verfasser |4 aut | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007113453&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-007113453 | |
Datensatz im Suchindex
| _version_ | 1808137441894203392 |
|---|---|
| adam_text |
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-
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-
-
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-
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-
-
-
-
-
-
CONTENTS
-
-
1.
INTRODUCTION
.
1
1.1
SCOPE
OF
BOOK
.
1
1.2
REGULATION
OF
CELL
PROLIFERATION
.
2
1.3
CONTROL
OF
CELL
DIFFERENTIATION
.
13
1.4
CONTROL
OF
CELL
DEATH
.
18
1.5
THE
TRANSFORMED
PHENOTYPE
.
23
1.6
CONCLUDING
REMARKS
.
27
2.
RETROVIRUSES,
CANCER
GENES,
AND
TUMOR
SUPPRESSOR
GENES
.
37
2.1
ORIGINS
OF
ONCOGENES
.
37
2.2
ONCOGENES:
ABERRATIONS
OF
SIGNAL
TRANSDUCTION
.
41
2.3
TUMOR
SUPPRESSOR
GENES:
LOSS
OF
THE
GOOD
AND
GAIN
OF
THE
BAD
AND
UGLY
.
47
2.4
MISMATCH
REPAIR
GENES
.
48
2.5
SUFFICIENCY
AND
NECESSITY
OF
GENES
FOR
ONCOGENESIS
.
50
3.
HISTORICAL
PERSPECTIVES
OF
MYC
GENE
STUDIES
.
65
3.1
RETROVIRUSES
BEARING
MYC
ONCOGENE
.
65
3.2
MOLECULAR
CLONING
OF
V-MYC
ONCOGENES
AND
IDENTIFICATION
OF
CELLULAR
HOMOLOG
.
65
3.3
INSERTIONAL
ACTIVATION
OF
C-MYC
BY
AVIAN
LEUKOSIS
VIRUS
.
68
4.
STRUCTURE
OF
THE
C-MYC
GENE
AND
ITS
TRANSCRIPTION
.
73
4.1
C-MYC
GENE
AND
MRNA
STRUCTURES
.
73
4.2
REGULATION
OF
C-MYC
TRANSCRIPTION
INITIATION
.
75
4.3
REGULATION
OF
C-MYC
TRANSCRIPTIONAL
ELONGATION
.
78
4.4
REGULATION
OF
C-MYC
MRNA
STABILITY
.
80
5.
INVOLVEMENT
OF
C-MYC
IN
HUMAN
CANCERS
.
85
5.1
INTRODUCTION
.
85
5.2
GENETIC
ALTERATIONS
OF
MYC
.
86
5.3
ALTERATIONS
OF
C-MYC
AND
ITS
PRODUCT
IN
HUMAN
CANCERS
.;
.
91
5.4
DEREGULATED
EXPRESSION
OF
MYC
CAUSES
NEOPLASTIC
TRANSFORMATION
AND
ABERRANT
DEVELOPMENT
IN
TRANSGENIC
ANIMALS
.
97
6.
PROPERTIES
OF
THE
C-MYC
PROTEIN
.109
6.1
REGULATION
OF
C-MYC
TRANSLATION
.
109
6.2
C-MYC
PROTEIN
LEVELS
.
ILL
6.3
POSTTRANSLATIONAL
MODIFICATION:
PHOSPHORYLATION
AND
GLYCOSYLATION
.
112
6.4
NUCLEAR
LOCALIZATION
AND
ASSOCIATION
WITH
THE
NUCLEAR
MATRIX
.
113
7.
FUNCTIONAL
DOMAINS
OF
C-MYC
PROTEIN
.
119
7.1
NEOPLASTIC
TRANSFORMATION
.
119
7.2
CELLULAR
DIFFERENTIATION
.
121
7.3
DNA
REPLICATION
.
122
7.4
AUTOSUPPRESSION
.
124
7.5
NUCLEAR
LOCALIZATION
.
125
7.6
NONSPECIFIC
DNA
BINDING
.
127
7.7
HELIX-LOOP-HELIX-LEUCINE
ZIPPER
OLIGOMERIZATION
DOMAIN
.
128
7.8
SPECIFIC
DNA-BINDING
DOMAIN
.
131
7.9
TRANSCRIPTIONAL
ACTIVATION
DOMAIN
.
135
7.10
MYC,
TBP
AND
YY1
.
137
7.11
INTERACTION
OF
PL
07
AND
MYC
.
138
8.
MAX
ASSOCIATION
WITH
MYC
.
151
8.1
STRUCTURE
AND
FUNCTION
.
151
8.2
MAX
PARTNER
PROTEINS
.
155
9.
DNA-BINDING
PROPERTIES
OF
MYC
.
165
10.
MYC
TARGET
GENES
IN
CELL
PROLIFERAION
AND
PROGRAMMED
CELL
DEATH
.
171
10.1
PUTATIVE
MYC
TARGET
GENES
.
171
10.2
CANDIDATE
MYC
TARGET
GENES
AND
CELL
PROLIFERATION
.
177
10.3
TRANSCRIPTIONAL
SUPPRESSION
BY
C-MYC
.
182
10.4
C-MYC
AND
APOPTOSIS
.
183
10.5
FUTURE
DIRECTIONS
AND
THERAPEUTIC
IMPLICATIONS
.
185
INDEX
.
193 |
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| author | Dang, Chi V. Lee, Linda A. |
| author_facet | Dang, Chi V. Lee, Linda A. |
| author_role | aut aut |
| author_sort | Dang, Chi V. |
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| building | Verbundindex |
| bvnumber | BV010656999 |
| ctrlnum | (OCoLC)489705601 (DE-599)BVBBV010656999 |
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| id | DE-604.BV010656999 |
| illustrated | Illustrated |
| indexdate | 2024-08-23T00:50:38Z |
| institution | BVB |
| isbn | 3540606327 1570593124 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007113453 |
| oclc_num | 489705601 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-12 |
| owner_facet | DE-355 DE-BY-UBR DE-12 |
| physical | 196 S. graph. Darst. |
| publishDate | 1995 |
| publishDateSearch | 1995 |
| publishDateSort | 1995 |
| publisher | Springer [u.a.] |
| record_format | marc |
| series2 | Medical intelligence unit |
| spelling | Dang, Chi V. Verfasser aut c-MYC function in neoplasia Chi V. Dang ; Linda A. Lee New York [u.a.] Springer [u.a.] 1995 196 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Medical intelligence unit Cancer - Aspect génétique ram Cancérogenèse ram Gènes myc Oncogènes Oncogènes ram Tumeurs - Génétique Myc (DE-588)4267356-2 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Onkogen (DE-588)4131118-8 gnd rswk-swf Protoonkogen (DE-588)4256457-8 gnd rswk-swf Onkogen (DE-588)4131118-8 s Myc (DE-588)4267356-2 s Krebs Medizin (DE-588)4073781-0 s DE-604 Protoonkogen (DE-588)4256457-8 s Lee, Linda A. Verfasser aut DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007113453&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Dang, Chi V. Lee, Linda A. c-MYC function in neoplasia Cancer - Aspect génétique ram Cancérogenèse ram Gènes myc Oncogènes Oncogènes ram Tumeurs - Génétique Myc (DE-588)4267356-2 gnd Krebs Medizin (DE-588)4073781-0 gnd Onkogen (DE-588)4131118-8 gnd Protoonkogen (DE-588)4256457-8 gnd |
| subject_GND | (DE-588)4267356-2 (DE-588)4073781-0 (DE-588)4131118-8 (DE-588)4256457-8 |
| title | c-MYC function in neoplasia |
| title_auth | c-MYC function in neoplasia |
| title_exact_search | c-MYC function in neoplasia |
| title_full | c-MYC function in neoplasia Chi V. Dang ; Linda A. Lee |
| title_fullStr | c-MYC function in neoplasia Chi V. Dang ; Linda A. Lee |
| title_full_unstemmed | c-MYC function in neoplasia Chi V. Dang ; Linda A. Lee |
| title_short | c-MYC function in neoplasia |
| title_sort | c myc function in neoplasia |
| topic | Cancer - Aspect génétique ram Cancérogenèse ram Gènes myc Oncogènes Oncogènes ram Tumeurs - Génétique Myc (DE-588)4267356-2 gnd Krebs Medizin (DE-588)4073781-0 gnd Onkogen (DE-588)4131118-8 gnd Protoonkogen (DE-588)4256457-8 gnd |
| topic_facet | Cancer - Aspect génétique Cancérogenèse Gènes myc Oncogènes Tumeurs - Génétique Myc Krebs Medizin Onkogen Protoonkogen |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007113453&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT dangchiv cmycfunctioninneoplasia AT leelindaa cmycfunctioninneoplasia |