Molecular immunology:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Oxford [u.a.]
IRL Press at Oxford Univ. Press
1996
|
| Ausgabe: | 2. ed. |
| Schriftenreihe: | Frontiers in molecular biology
11 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVIII, 386 S. Ill., graph. Darst. |
| ISBN: | 0199633797 0199633789 |
Internformat
MARC
| LEADER | 00000nam a2200000 cb4500 | ||
|---|---|---|---|
| 001 | BV010628422 | ||
| 003 | DE-604 | ||
| 005 | 20161109 | ||
| 007 | t | ||
| 008 | 960222s1996 ad|| |||| 00||| eng d | ||
| 020 | |a 0199633797 |9 0-19-963379-7 | ||
| 020 | |a 0199633789 |9 0-19-963378-9 | ||
| 035 | |a (OCoLC)246934609 | ||
| 035 | |a (DE-599)BVBBV010628422 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 |a DE-703 |a DE-91G |a DE-11 |a DE-19 | ||
| 082 | 0 | |a 574.29 | |
| 084 | |a WF 9910 |0 (DE-625)148480: |2 rvk | ||
| 084 | |a XD 3100 |0 (DE-625)152552:12905 |2 rvk | ||
| 084 | |a BIO 220f |2 stub | ||
| 084 | |a MED 450f |2 stub | ||
| 084 | |a CHE 880f |2 stub | ||
| 245 | 1 | 0 | |a Molecular immunology |c ed. by B. David Hames ... |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a Oxford [u.a.] |b IRL Press at Oxford Univ. Press |c 1996 | |
| 300 | |a XVIII, 386 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Frontiers in molecular biology |v 11 | |
| 650 | 0 | 7 | |a Immunchemie |0 (DE-588)4161366-1 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Immunchemie |0 (DE-588)4161366-1 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Hames, B. D. |e Sonstige |4 oth | |
| 830 | 0 | |a Frontiers in molecular biology |v 11 |w (DE-604)BV010329078 |9 11 | |
| 856 | 4 | 2 | |m HEBIS Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007089848&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-007089848 | ||
Datensatz im Suchindex
| _version_ | 1804125102126661632 |
|---|---|
| adam_text | Molecular
Immunology
SECOND EDITION
EDITED BY
B David Hames
Department of Biochemistry
and Molecular Biology
University of Leeds
and
David M Glover
Cancer Research Laboratories
Department of Anatomy and Physiology
University of Dundee
OIRL PRESS at
OXFORD UNIVERSITY PRESS
Oxford New York Tokyo
Contents
List of contributors xiv
Abbreviations xvi
1 Mechanism and control of immunoglobulin gene
rearrangement 1
RUSTY LANSFORD,AMIOKADA,JIANZHUCHEN,EUGENEMOLTZ,
TKEITH BLACKWELL, FREDERICK WALT, and GARYRATHBUN
1 Introduction 1
2 Overview of B cell differentiation 1
3 The antibody molecule 3
3 1 Structure of the Ig molecule 3
3 2 Structure of Ig genes and proteins 4
4 Mechanism of Ig gene assembly 7
4 1 Overview of the V(D)J recombination mechanism 8
4 2 Recombination recognition sequences 10
4 3 Deletion versus inversion 12
4 4 Unusual aspects of the V(D)J recombination mechanism 15
4 5 Lymphoid-specific activities involved in V(D)J recombination 17
4 6 Generally expressed components of recombinase 19
5 Organization of H chain variable region gene segments 21
5 1 The-murine IgH locus 21
5 2 The human IgH locus 24
5 3 The murine K LC locus 26
5 4 The human K LC locus 26
5 5 The murine X LC locus 27
5 6 The human X LC locus 27
5 7 Surrogate LC genes 28
6 H chain gene expression 30
6 1 Ig gene transcription and translation 30
7 Generation of the antibody repertoire 31
7 1 Primary diversification mechanisms 31
viii | CONTENTS
7 2 Other diversification mechanisms 32
8 Regulation of Ig gene expression 32
8 1 HC gene expression 32
8 2 LC gene expression 33
8 3 Expression of incompletely assembled H chain genes 33
9 Regulation of Ig gene assembly 35
9 1 Ordered assembly and expression of Ig genes 35
92H chain gene assembly 37
93L chain gene assembly 37
94K versus LC gene assembly (LC isotype exclusion) 38
9 5 Molecular characterization of early B cell stages based on
surface marker expression 39
9 6 Potential role of SLC receptors in regulating precursor B cell
development 40
9 7 Allelic exclusion 40
9 8 Ig receptor editing 43
9 9 Potential restrictions in the primary murine VH repertoire
associated with the V(D)J rearrangement process 43
10 Molecular mechanisms that regulate antigen receptor gene
assembly 45
10 1 Accessibility 45
10 2 Model systems to study control of V(D)J recombination 46
10 3 Molecular mechanisms of accessibility 47
10 4 Abnormalities in recombinational accessibility 52
11 IgH class switching 52
11 1 Overview 52
11 2 Organization~of Ig Ch genes 53
11 3 Mechanism of S region mediated CSR 55
11 4 Non-deletional CSR 58
11 5 Control of CSR 59
Acknowledgements 64
References 64
2 T cell antigen receptor genes 101
MARKMDAVISandYUEH-HSIUCHIEN
1 Introduction 101
2 TCR polypeptides 102
CONTENTS | ix
3 TCR genes 103
4 Rearrangement and expression of T cell receptor genes in the
thymus 106
4 1 Programmed 78 TCR rearrangements 108
4 2 Allelic exclusion 108
4 3 Choice of 78 versus a(3 lineage 109
5 TCR repertoire selection in the thymus 109
5 1 Failure to rearrange an expressible TCR heterodimer 110
5 2 Negative selection 110
5 3 Positive selection 111
6 a(3 TCR recognition of peptide/MHC complexes 113
7 Affinity of a|3 TCRs for peptide/MHC ligands 116
8 Superantigens 118
9 78 T cell recognition 119
9 1 Specificity of diverse 78 T cells 119
9 2 Function of diverse 78 T cells 122
9 3 Monomorphic 78 T cells 122
References 123
3 T lymphocyte signal transduction 132
COXTERHORST,HERGENSPITS,FRANKSTAAL,andMARK EXLEY
1 Introduction 132
2 Antigen recognition by T cell receptors 132
3 Structure of the T cell receptor for antigen 137
3 1 The components of the TCR/CD3 complex 138
3 2 Assembly in the endoplasmic reticulum 139
4 Signal transduction through the TCR/CD3 complex 145
4 1 Signal transduction molecules associated with CD3-£ and CD3-e 147
4 2 On the role of CD3-£ and -e in transgenic and mutant mice 154
5 The primary co-stimulatory events 160
5 1 The role of CD4 and CD8 161
5 2 Signal transduction events induced by triggering of CD28 and
CTLA-4 166
5 3 Alternative T cell co-stimulatory structures 170
5 4 The phosphotyrosine phosphatase CD45 172
x I CONTENTS
6 Conclusions 174
Acknowledgements 175
References 175
4 Structure and function of MHC class I and class II
antigens 189
DAVIDA JEWELL and IANAWILSON
1 Introduction 189
2 Gene arrangement of MHC 191
3 Antigen presentation 191
4 Structure of MHC class I antigens 194
5 Peptide-MHC class I interactions 198
6 Class I vs class II structures 204
Acknowledgements 208
References 208
5 Molecular mechanisms of antigen processing 212
JOHNJMONACO
1 Introduction 212
2 The class I (endogenous) antigen processing pathway 214
2 1 MHC-linked transport protein (Tap) genes 214
2 2 MHC=linked proteasome subunit genes 221
2 3 Molecular chaperones in the class I pathway 223
2 4 Specificity and polymorphism in the endogenous antigen
processing pathway 224
3 The class II (exogenous) pathway 226
3 1 Proteases involved in the class II pathway 226
3 2 The role of invariant chain (Ij) 227
3 3 Class II antigen processing mutants 232
3 4 Presentation of endogenous antigen by MHC class II molecules 233
4 Conclusions 234
Acknowledgements 235
References 235
CONTENTS | xi
6 B cell activation 248
GERRY GBKLAUS
1 Introduction 248
11B cell response to specific antigens 248
1 2 Responses to polyclonal activators 248
1 3 Cell surface glycoproteins on B cells 249
2 Surface immunoglobulin (slg) receptors 250
2 1 The effects of anti-Ig on mature B cells 250
2 2 Signal transduction via slg receptors 251
3 The CD19/CD21 complex 256
4 FcyRII (CD32) 257
5 CD23 259
6 Class II MHC 260
7 CD45 (leucocyte common antigen, murine Ly5) 261
8 CD40 262
8 1 Functional role of CD40 262
8 2 The CD40 ligand 263
9 Other signalling molecules on B cells 263
9 1 CD72 (murine Lyb2) 263
9 2 CD20 263
9 3 CD22 (formerly Lyb8 in the mouse) 264
9 4 CD38 264
10 T cell-dependent B cell activation 265
10 1 MHC-restricted and unrestricted B cell activation 265
10 2 Events occurring during T cell-B cell interaction 266
10 3 Cylokine-driven B cell proliferation and differentiation 269
11 Conclusions 271
References 272
7 Advances in antibody engineering 283
MARTINEEVERHOEYEN and JOHNHCWINDUST
1 Introduction 283
2 Antibody structure 283
3 Antibody gene cloning 285
xii | CONTENTS
4 Recombinant antibody gene expression 285
4 1 Expression in animal cells 285
4 2 Expression in Escherichia coli 287
4 3 Expression in other microorganisms 291
4 4 Expression in plants 293
5 Combinatorial libraries and phage display 294
5 1 Combinatorial libraries 294
5 2 Phage display of antibody fragments 296
6 Applications of engineered antibodies 301
6 1 Structure-function studies 301
6 2 Antibodies for in vivo use 302
6 3 Bispecific and bivalent antibodies 306
6 4 Bifunctional antibodies 307
6 5 Antibody domains as scaffolds for insertion of functional sites 308
6 6 Molecular recognition units (MRUs) 309
6 7 Catalytic antibodies 309
7 Conclusions 310
References 311
8 The complement system 326
KENNETHBMREID
1 Introduction 326
2 Activation of the classical pathway 330
2 1 Structure, activation, and control of CI 330
2 2 Activation of the classical pathway via mannan binding protein (MBP) 333
2 3 Molecular cloning of Clq 334
2 4 Molecular cloning of Clr and Cls 335
2 5 Molecular cloning of mannan binding protein (MBP) 336
2 6 Molecular cloning of mannan binding protein-associated serine
protease (MASP) 336
2 7 Molecular cloning of CI inhibitor (Cl-Inh) 337
3 Activation of the alternative pathway 338
3 1 Factor D 338
3 2 Properdin—a positive regulator of the alternative pathway 339
4 Complement class III products of the MHC 339
4 1 Component C4: structure and activation 340
CONTENTS | xiii
4 2 Component C2 and factor B: activation and role in formation of
the C3 convertases 340
4 3 Molecular genetics of C4 343
4 4 Molecular genetics of component C2 and factor B 346
4 5 Molecular map of the MHC class III region 349
5 Components C3 and C5 349
5 1 Component C3 349
5 2 Component C5 354
6 Regulation of complement activation by control of the C3 and
C5 convertases Factor 1 and the members of the RCA
(regulator of complement activation) cluster 354
6 1 Factor 1 356
6 2 Plasma control proteins: C4b-binding protein and factor H 358
6 3 Membrane-associated regulatory proteins 360
7 The C3a, C4a, and C5a anaphylatoxins 364
/
8 Complement receptor type 3 and pl50,95: members of the
LFA-1 family of cell adhesion molecules designated the
leucocyte-specific p2 integrins 364
9 The terminal attack complex C5b-9 and the relationship of C8
and C9 to perforin from killer lymphocytes 366
References 370
Index 383
|
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV010628422 |
| classification_rvk | WF 9910 XD 3100 |
| classification_tum | BIO 220f MED 450f CHE 880f |
| ctrlnum | (OCoLC)246934609 (DE-599)BVBBV010628422 |
| dewey-full | 574.29 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 574 - [Unassigned] |
| dewey-raw | 574.29 |
| dewey-search | 574.29 |
| dewey-sort | 3574.29 |
| dewey-tens | 570 - Biology |
| discipline | Biologie Chemie Medizin |
| edition | 2. ed. |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01547nam a2200421 cb4500</leader><controlfield tag="001">BV010628422</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20161109 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">960222s1996 ad|| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0199633797</subfield><subfield code="9">0-19-963379-7</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0199633789</subfield><subfield code="9">0-19-963378-9</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)246934609</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV010628422</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield><subfield code="a">DE-703</subfield><subfield code="a">DE-91G</subfield><subfield code="a">DE-11</subfield><subfield code="a">DE-19</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">574.29</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WF 9910</subfield><subfield code="0">(DE-625)148480:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">XD 3100</subfield><subfield code="0">(DE-625)152552:12905</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">BIO 220f</subfield><subfield code="2">stub</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">MED 450f</subfield><subfield code="2">stub</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">CHE 880f</subfield><subfield code="2">stub</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Molecular immunology</subfield><subfield code="c">ed. by B. David Hames ...</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">2. ed.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford [u.a.]</subfield><subfield code="b">IRL Press at Oxford Univ. Press</subfield><subfield code="c">1996</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XVIII, 386 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Frontiers in molecular biology</subfield><subfield code="v">11</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Immunchemie</subfield><subfield code="0">(DE-588)4161366-1</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Immunchemie</subfield><subfield code="0">(DE-588)4161366-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hames, B. D.</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="830" ind1=" " ind2="0"><subfield code="a">Frontiers in molecular biology</subfield><subfield code="v">11</subfield><subfield code="w">(DE-604)BV010329078</subfield><subfield code="9">11</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HEBIS Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007089848&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-007089848</subfield></datafield></record></collection> |
| id | DE-604.BV010628422 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:56:13Z |
| institution | BVB |
| isbn | 0199633797 0199633789 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007089848 |
| oclc_num | 246934609 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-703 DE-91G DE-BY-TUM DE-11 DE-19 DE-BY-UBM |
| owner_facet | DE-355 DE-BY-UBR DE-703 DE-91G DE-BY-TUM DE-11 DE-19 DE-BY-UBM |
| physical | XVIII, 386 S. Ill., graph. Darst. |
| publishDate | 1996 |
| publishDateSearch | 1996 |
| publishDateSort | 1996 |
| publisher | IRL Press at Oxford Univ. Press |
| record_format | marc |
| series | Frontiers in molecular biology |
| series2 | Frontiers in molecular biology |
| spelling | Molecular immunology ed. by B. David Hames ... 2. ed. Oxford [u.a.] IRL Press at Oxford Univ. Press 1996 XVIII, 386 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Frontiers in molecular biology 11 Immunchemie (DE-588)4161366-1 gnd rswk-swf Immunchemie (DE-588)4161366-1 s DE-604 Hames, B. D. Sonstige oth Frontiers in molecular biology 11 (DE-604)BV010329078 11 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007089848&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Molecular immunology Frontiers in molecular biology Immunchemie (DE-588)4161366-1 gnd |
| subject_GND | (DE-588)4161366-1 |
| title | Molecular immunology |
| title_auth | Molecular immunology |
| title_exact_search | Molecular immunology |
| title_full | Molecular immunology ed. by B. David Hames ... |
| title_fullStr | Molecular immunology ed. by B. David Hames ... |
| title_full_unstemmed | Molecular immunology ed. by B. David Hames ... |
| title_short | Molecular immunology |
| title_sort | molecular immunology |
| topic | Immunchemie (DE-588)4161366-1 gnd |
| topic_facet | Immunchemie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007089848&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV010329078 |
| work_keys_str_mv | AT hamesbd molecularimmunology |