Holdings: Ocular therapeutics and drug delivery

Ocular therapeutics and drug delivery: a multi-disciplinary approach

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Bibliographic Details
Other Authors:	Reddy, Indra K. (Editor)
Format:	Book
Language:	English
Published:	Lancaster [u.a.] Technomic 1996
Subjects:	Drug Delivery Systems Drug delivery systems Eye Diseases > drug therapy Ocular pharmacology Ophthalmic drugs Therapeutics, Ophthalmological Augenarzneimittel Wirkstofffreisetzung
Online Access:	Inhaltsverzeichnis
Physical Description:	XXV, 587 S. graph. Darst.
ISBN:	1566762138

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MARC


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adam_text	?_ OCULAR THERAPEUTICS AND DRUG DELIVERY A MULTI-DISCIPLINARY APPROACH EDITED BY INDRA K. REDDY, PH.D. ASSOCIATE PROFESSOR OF PHARMACEUTICS COLLEGE OF PHARMACY AND HEALTH SCIENCES NORTHEAST LOUISIANA UNIVERSITY TECHNOMIC VPUBLISHJNGCOJNC , LANCASTER * BASKI, TABLE OF CONTENTS FOREWORD XV PREFACE XVII ACKNOWLEDGEMENTS XXI CONTRIBUTING AUTHORS XXIII PART I: OVERVIEW, BASIC PRINCIPLES AND METHODOLOGY 1. OCULAR THERAPEUTICS AND DRUG DELIVERY: AN OVERVIEW 3 INDRA K. REDDY AND MADURAI G. GANESAN INTRODUCTION 3 STRUCTURES OF THE EYE 4 COMMON DISEASES OF THE EYE 5 ROUTES OF ADMINISTRATION FOR OCULAR THERAPEUTICS 6 OCULAR DRUG DISPOSITION 9 OCULAR BIOAVAILABILITY 12 PHARMACOKINETICS IN OCULAR DRUG DELIVERY 13 DRUG METABOLISM IN OCULAR TISSUES 14 CONVENTIONAL OPHTHALMIC DOSAGE FORMS 15 OPHTHALMIC DRUG DELIVERY SYSTEMS 15 CHEMICAL/BIOCHEMICAL APPROACHES TO DRUG DELIVERY 16 OCULAR DELIVERY OF PROTEINS AND PEPTIDES 19 ANIMAL MODELS 19 OCULAR TOXICITY 21 VII VIII TABLE OF CONTENTS CONCLUSION 22 REFERENCES 23 2. SURFACE CHEMICAL ASPECTS OF OCULAR DRUG DELIVERY SYSTEMS 31 C. P. SINGH AND DINESH O. SHAH INTRODUCTION 31 WETTING 33 HYDROGEN ION CONCENTRATION (PH) 34 VISCOSITY 36 OIL-WATER PARTITIONING 39 MICELLAR SOLUBILIZATION 42 OSMOLALITY 43 CONCLUSION 43 REFERENCES 44 3. BIOLOGICAL BARRIERS TO OCULAR DELIVERY 51 JOHN C. LANG AND MONICA M. STIEMKE INTRODUCTION 51 PROCESSES AND PHENOMENOLOGICAL BARRIERS 52 STRUCTURE AND FUNCTION 75 EXPERIMENTAL MODELS: UTILITY AND LIMITATIONS 88 CONCLUSIONS 94 APPENDIX A 95 APPENDIX B 107 APPENDIX C 109 APPENDIX D 111 APPENDIX E 112 APPENDIX F 115 APPENDIX G 120 APPENDIX H 122 REFERENCES 126 4. PHARMACOKINETIC AND PHARMACODYNAMIC CORRELATIONS OF OPHTHALMIC DRUGS 133 DIANE D.-S. TANG-LIU, ANDREW ACHEAMPONG, DU-SHIENG CHIEN AND JOEL. I. USANSKY INTRODUCTION 133 BRIMONIDINE 135 PROSTAGLANDIN F 2A PRODRUGS 137 OFLOXACIN 142 CONCLUSION 144 TABLE OF CONTENTS IX ACKNOWLEDGEMENTS 144 REFERENCES 144 5. DRUG METABOLIZING ENZYME SYSTEMS IN THE EYE 149 GONDI N. KUMAR INTRODUCTION 149 PHASE I ENZYMES 150 PHASE II ENZYMES 157 SIGNIFICANCE OF OCULAR METABOLISM 161 REFERENCES 162 PART II: PA THOPHARMACOLOGY AND CLINICAL APPLICA TIONS 6. ARTIFICIAL TEAR FORMULATIONS, IRRIGATING SOLUTIONS AND CONTACT LENS PRODUCTS 171 INDRA K. REDDY, WAHEED AZIZ AND ROBERT B. SAUSE INTRODUCTION 171 ARTIFICIAL TEAR FORMULATIONS 171 IRRIGATING SOLUTIONS 185 CONTACT LENS PRODUCTS 193 CONCLUSION 204 REFERENCES 205 7. CLINICAL PHARMACOLOGY OF THE ANTERIOR SEGMENT OF THE EYE 213 MICHAEL A. BARTLETTA AND INDRA K. REDDY INTRODUCTION 213 CLINICAL OPHTHALMIC EXAMINATION FOR THE ETIOLOGY OF DISEASE 213 COMMON OCULAR DISORDERS 214 LOCAL ANESTHETICS 218 ANTI-INFLAMMATORY AGENTS 222 ANTI-INFECTIVE AGENTS 228 CONCLUSION 239 REFERENCES 240 8. RECENT DEVELOPMENTS IN ANTI-GLAUCOMA DRUG RESEARCH 245 MARKKU LEINO AND ARTO URTTI INTRODUCTION 245 K TABLE OF CONTENTS CHOLINERGIC DRUGS 246 TOPICAL CARBONIC ANHYDRASE INHIBITORS 247 ADRENERGIC DRUGS 249 CANNABINOIDS 252 PROSTAGLANDINS 253 ETHACHRYNIC ACID 254 DELIVERY SYSTEMS AND SYSTEMIC ABSORPTION OF TOPICAL GLAUCOMA DRUGS 255 REFERENCES 257 9. VITREORETINAL DISEASES: PATHOLOGICAL ASPECTS AND THERAPEUTIC STRATEGIES 265 GHOLAM A. PEYMAN INTRODUCTION 265 ENDOPHTHALMITIS 266 PROLIFERATIVE VITREORETINOPATHY 269 VIRAL RETINITIS 272 REFERENCES 273 PART III: CHEMICAL/BIOCHEMICAL APPROACHES TO OCULAR DRUG DELIVERY 10. PRODRUGS: A CHEMICAL APPROACH TO OCULAR DRUG DELIVERY 2U VIJAY K. TAMMARA AND MICHAEL A. CRIDER INTRODUCTION 285 PRODRUG FORMS OF VARIOUS FUNCTIONAL GROUPS 287 ENZYMES RESPONSIBLE FOR BIOCONVERSION 289 KINETIC PROFILES OF PRODRUGS 294 SELECTED CASE STUDIES OF PRODRUGS 296 FUTURE PERSPECTIVES/CONCLUSIONS 323 REFERENCES 324 11. THE USE OF RETROMETABOLIC DRUG DESIGN CONCEPTS IN OPHTHALMIC DRUG DISCOVERY 335 NICHOLAS BODOR INTRODUCTION 335 RETROMETABOLIC DESIGN OF NOVEL ANTI-GLAUCOMA DRUGS 339 THE INACTIVE METABOLITE APPROACH IN THE DESIGN OF SOFT CORTICOSTEROIDS 351 SOFT ANTICHOLINERGIC AGENTS AS SHORT-ACTING MYDRIATICS 356 CONCLUSION 358 ACKNOWLEDGEMENTS 359 REFERENCES 359 TABLE OF CONTENTS XI 12. DEVELOPMENT OF SOFT DRUGS FOR OPHTHALMIC USE 363 JOHN F. HOWES INTRODUCTION 363 LOTEPREDNOL ETABONATE 363 ADAPROLOL MALEATE 372 REFERENCES 373 PART IV: FORMULA TION AND DRUG DELIVERY CONSIDERA TIONS 13. TOPICAL OPHTHALMIC FORMULATIONS: BASIC CONSIDERATIONS 377 NUTAN K. GANGRADE, NEHRU B. GADDIPATI, MADURAI G. GANESAN AND INDRA K. REDDY INTRODUCTION 377 ADJUVANTS 379 STERILITY 391 SUSPENSIONS AND PARTICULATES 395 SEMISOLID OPHTHALMIC FORMULATIONS 396 CONCLUSION 398 REFERENCES 399 14. POLYMERS IN OPHTHALMIC DRUG DELIVERY SYSTEMS 405 MANSOOR A. KHAN AND MANZER J. DURRANI INTRODUCTION 405 CLASSIFICATION 405 PHYSICOCHEMICAL PROPERTIES OF THE POLYMERS 408 APPLICATIONS OF POLYMERS IN THE EYE 417 CONCLUSIONS 430 ACKNOWLEDGEMENTS 431 REFERENCES 431 15. MICROPARTICULATES AS AN OCULAR DELIVERY SYSTEM 441 ABHAYJOSHI INTRODUCTION 441 LIMITATIONS ON OCULAR DRUG DELIVERY 442 MICROPARTICULATES AS AN INJECTABLE DRUG DELIVERY SYSTEM 445 MICROPARTICULATES AS A TOPICAL OCULAR DELIVERY SYSTEM 448 MULTIPARTICULATE MANUFACTURE AND FORMULATION CHALLENGES 455 X II TABLE OF CONTENTS CONCLUSION 456 REFERENCES 457 16. PROTEIN AND PEPTIDE DRUG DELIVERY TO THE EYE 461 AJAY K. BANGA INTRODUCTION 461 OVERVIEW OF RELEVANT STRUCTURAL DETAILS FOR PEPTIDE/PROTEIN DRUGS 463 FORMULATION CONSIDERATIONS FOR PEPTIDE/PROTEIN SOLUTIONS 463 OCULAR ADMINISTRATION OF PEPTIDES/PROTEINS FOR TOPICAL EFFECTS 468 SYSTEMIC DELIVERY OF PEPTIDES/PROTEINS THROUGH THE EYE 472 SPECIALIZED DELIVERY SYSTEMS 477 CONCLUSIONS 480 REFERENCES 480 17. EVALUATION OF PRIMARY OCULAR IRRITATION: ALTERNATIVES TO THE DRAIZE TEST 489 CHRISTINE M. HUTAK AND RICHARD B. JACARUSO INTRODUCTION 489 DRAIZE TEST 489 OBJECTIONS TO THE DRAIZE TEST 490 ALTERNATIVE IN VIVO ASSAYS 493 ALTERNATIVE IN VITRO ASSAYS 493 ANATOMY OF THE CORNEA AND ITS RELATION TO OCULAR IRRITATION AND CORNEAL OPACIFICATION 499 THE INFLAMMATORY RESPONSE 500 PERMEATOXICITY 502 EFFICACY OF IN VITRO METHODS 503 VALIDATION OF IN VITRO TESTS 505 VALIDATION OF A PROPOSED BATTERY OF IN VITRO TESTS 509 CONCLUSION 512 REFERENCES 513 PART V: INDUSTRIAL AND REGULATORY CONSIDERATIONS 18. PACKAGING ASPECTS OF OPHTHALMIC PRODUCTS 529 NEHRU B. GADOIPATI, NUTAN K. GANGRADE, MADURAI G. GANESAN AND INDRA K. REDDY INTRODUCTION 529 TABLE OF CONTENTS XIII OPHTHALMIC DROPS (SOLUTIONS/SUSPENSIONS) 530 OPHTHALMIC OINTMENTS 536 NOVEL OPHTHALMIC PACKAGES 536 OPHTHALMIC PACKAGING STANDARDS 540 CONCLUSION 540 REFERENCES 540 19. A BRIEF HISTORY OF DRUG REGULATION AND REGULATORY ISSUES GOVERNING OPHTHALMIC PRODUCTS: A BIOPHARMACEUTIC PERSPECTIVE 543 VIJAY K. TAMMARA, RAMAN K. BAWEJA, ANGELICA DORANTES AND JOHN P. HUNT INTRODUCTION 543 HISTORY OF DRUG REGULATIONS IN THE UNITED STATES 544 REGULATORY ISSUES/REQUIREMENTS 549 BIOREGULATIONS 557 LABELING REQUIREMENTS 564 SUMMARY 568 GLOSSARY 568 ACKNOWLEDGEMENTS 573 REFERENCES 573 INDEX 575 ABOUT THE EDITOR 587
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spelling	Ocular therapeutics and drug delivery a multi-disciplinary approach ed. by Indra K. Reddy Lancaster [u.a.] Technomic 1996 XXV, 587 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Drug Delivery Systems Drug delivery systems Eye Diseases drug therapy Ocular pharmacology Ophthalmic drugs Therapeutics, Ophthalmological Augenarzneimittel (DE-588)4143444-4 gnd rswk-swf Wirkstofffreisetzung (DE-588)4190018-2 gnd rswk-swf Augenarzneimittel (DE-588)4143444-4 s Wirkstofffreisetzung (DE-588)4190018-2 s DE-604 Reddy, Indra K. edt GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007060569&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Ocular therapeutics and drug delivery a multi-disciplinary approach Drug Delivery Systems Drug delivery systems Eye Diseases drug therapy Ocular pharmacology Ophthalmic drugs Therapeutics, Ophthalmological Augenarzneimittel (DE-588)4143444-4 gnd Wirkstofffreisetzung (DE-588)4190018-2 gnd
subject_GND	(DE-588)4143444-4 (DE-588)4190018-2
title	Ocular therapeutics and drug delivery a multi-disciplinary approach
title_auth	Ocular therapeutics and drug delivery a multi-disciplinary approach
title_exact_search	Ocular therapeutics and drug delivery a multi-disciplinary approach
title_full	Ocular therapeutics and drug delivery a multi-disciplinary approach ed. by Indra K. Reddy
title_fullStr	Ocular therapeutics and drug delivery a multi-disciplinary approach ed. by Indra K. Reddy
title_full_unstemmed	Ocular therapeutics and drug delivery a multi-disciplinary approach ed. by Indra K. Reddy
title_short	Ocular therapeutics and drug delivery
title_sort	ocular therapeutics and drug delivery a multi disciplinary approach
title_sub	a multi-disciplinary approach
topic	Drug Delivery Systems Drug delivery systems Eye Diseases drug therapy Ocular pharmacology Ophthalmic drugs Therapeutics, Ophthalmological Augenarzneimittel (DE-588)4143444-4 gnd Wirkstofffreisetzung (DE-588)4190018-2 gnd
topic_facet	Drug Delivery Systems Drug delivery systems Eye Diseases drug therapy Ocular pharmacology Ophthalmic drugs Therapeutics, Ophthalmological Augenarzneimittel Wirkstofffreisetzung
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007060569&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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