Ocular therapeutics and drug delivery: a multi-disciplinary approach
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Lancaster [u.a.]
Technomic
1996
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXV, 587 S. graph. Darst. |
| ISBN: | 1566762138 |
Internformat
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| 650 | 4 | |a Drug Delivery Systems | |
| 650 | 4 | |a Drug delivery systems | |
| 650 | 4 | |a Eye Diseases |x drug therapy | |
| 650 | 4 | |a Ocular pharmacology | |
| 650 | 4 | |a Ophthalmic drugs | |
| 650 | 4 | |a Therapeutics, Ophthalmological | |
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Datensatz im Suchindex
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| adam_text | ?_ OCULAR THERAPEUTICS AND DRUG DELIVERY A MULTI-DISCIPLINARY APPROACH
EDITED BY INDRA K. REDDY, PH.D. ASSOCIATE PROFESSOR OF PHARMACEUTICS
COLLEGE OF PHARMACY AND HEALTH SCIENCES NORTHEAST LOUISIANA UNIVERSITY
TECHNOMIC VPUBLISHJNGCOJNC , LANCASTER * BASKI, TABLE OF CONTENTS
FOREWORD XV PREFACE XVII ACKNOWLEDGEMENTS XXI CONTRIBUTING AUTHORS XXIII
PART I: OVERVIEW, BASIC PRINCIPLES AND METHODOLOGY 1. OCULAR
THERAPEUTICS AND DRUG DELIVERY: AN OVERVIEW 3 INDRA K. REDDY AND MADURAI
G. GANESAN INTRODUCTION 3 STRUCTURES OF THE EYE 4 COMMON DISEASES OF THE
EYE 5 ROUTES OF ADMINISTRATION FOR OCULAR THERAPEUTICS 6 OCULAR DRUG
DISPOSITION 9 OCULAR BIOAVAILABILITY 12 PHARMACOKINETICS IN OCULAR DRUG
DELIVERY 13 DRUG METABOLISM IN OCULAR TISSUES 14 CONVENTIONAL OPHTHALMIC
DOSAGE FORMS 15 OPHTHALMIC DRUG DELIVERY SYSTEMS 15 CHEMICAL/BIOCHEMICAL
APPROACHES TO DRUG DELIVERY 16 OCULAR DELIVERY OF PROTEINS AND PEPTIDES
19 ANIMAL MODELS 19 OCULAR TOXICITY 21 VII VIII TABLE OF CONTENTS
CONCLUSION 22 REFERENCES 23 2. SURFACE CHEMICAL ASPECTS OF OCULAR DRUG
DELIVERY SYSTEMS 31 C. P. SINGH AND DINESH O. SHAH INTRODUCTION 31
WETTING 33 HYDROGEN ION CONCENTRATION (PH) 34 VISCOSITY 36 OIL-WATER
PARTITIONING 39 MICELLAR SOLUBILIZATION 42 OSMOLALITY 43 CONCLUSION 43
REFERENCES 44 3. BIOLOGICAL BARRIERS TO OCULAR DELIVERY 51 JOHN C. LANG
AND MONICA M. STIEMKE INTRODUCTION 51 PROCESSES AND PHENOMENOLOGICAL
BARRIERS 52 STRUCTURE AND FUNCTION 75 EXPERIMENTAL MODELS: UTILITY AND
LIMITATIONS 88 CONCLUSIONS 94 APPENDIX A 95 APPENDIX B 107 APPENDIX C
109 APPENDIX D 111 APPENDIX E 112 APPENDIX F 115 APPENDIX G 120 APPENDIX
H 122 REFERENCES 126 4. PHARMACOKINETIC AND PHARMACODYNAMIC CORRELATIONS
OF OPHTHALMIC DRUGS 133 DIANE D.-S. TANG-LIU, ANDREW ACHEAMPONG,
DU-SHIENG CHIEN AND JOEL. I. USANSKY INTRODUCTION 133 BRIMONIDINE 135
PROSTAGLANDIN F 2A PRODRUGS 137 OFLOXACIN 142 CONCLUSION 144 TABLE OF
CONTENTS IX ACKNOWLEDGEMENTS 144 REFERENCES 144 5. DRUG METABOLIZING
ENZYME SYSTEMS IN THE EYE 149 GONDI N. KUMAR INTRODUCTION 149 PHASE I
ENZYMES 150 PHASE II ENZYMES 157 SIGNIFICANCE OF OCULAR METABOLISM 161
REFERENCES 162 PART II: PA THOPHARMACOLOGY AND CLINICAL APPLICA TIONS 6.
ARTIFICIAL TEAR FORMULATIONS, IRRIGATING SOLUTIONS AND CONTACT LENS
PRODUCTS 171 INDRA K. REDDY, WAHEED AZIZ AND ROBERT B. SAUSE
INTRODUCTION 171 ARTIFICIAL TEAR FORMULATIONS 171 IRRIGATING SOLUTIONS
185 CONTACT LENS PRODUCTS 193 CONCLUSION 204 REFERENCES 205 7. CLINICAL
PHARMACOLOGY OF THE ANTERIOR SEGMENT OF THE EYE 213 MICHAEL A. BARTLETTA
AND INDRA K. REDDY INTRODUCTION 213 CLINICAL OPHTHALMIC EXAMINATION FOR
THE ETIOLOGY OF DISEASE 213 COMMON OCULAR DISORDERS 214 LOCAL
ANESTHETICS 218 ANTI-INFLAMMATORY AGENTS 222 ANTI-INFECTIVE AGENTS 228
CONCLUSION 239 REFERENCES 240 8. RECENT DEVELOPMENTS IN ANTI-GLAUCOMA
DRUG RESEARCH 245 MARKKU LEINO AND ARTO URTTI INTRODUCTION 245 K TABLE
OF CONTENTS CHOLINERGIC DRUGS 246 TOPICAL CARBONIC ANHYDRASE INHIBITORS
247 ADRENERGIC DRUGS 249 CANNABINOIDS 252 PROSTAGLANDINS 253 ETHACHRYNIC
ACID 254 DELIVERY SYSTEMS AND SYSTEMIC ABSORPTION OF TOPICAL GLAUCOMA
DRUGS 255 REFERENCES 257 9. VITREORETINAL DISEASES: PATHOLOGICAL ASPECTS
AND THERAPEUTIC STRATEGIES 265 GHOLAM A. PEYMAN INTRODUCTION 265
ENDOPHTHALMITIS 266 PROLIFERATIVE VITREORETINOPATHY 269 VIRAL RETINITIS
272 REFERENCES 273 PART III: CHEMICAL/BIOCHEMICAL APPROACHES TO OCULAR
DRUG DELIVERY 10. PRODRUGS: A CHEMICAL APPROACH TO OCULAR DRUG DELIVERY
2U VIJAY K. TAMMARA AND MICHAEL A. CRIDER INTRODUCTION 285 PRODRUG FORMS
OF VARIOUS FUNCTIONAL GROUPS 287 ENZYMES RESPONSIBLE FOR BIOCONVERSION
289 KINETIC PROFILES OF PRODRUGS 294 SELECTED CASE STUDIES OF PRODRUGS
296 FUTURE PERSPECTIVES/CONCLUSIONS 323 REFERENCES 324 11. THE USE OF
RETROMETABOLIC DRUG DESIGN CONCEPTS IN OPHTHALMIC DRUG DISCOVERY 335
NICHOLAS BODOR INTRODUCTION 335 RETROMETABOLIC DESIGN OF NOVEL
ANTI-GLAUCOMA DRUGS 339 THE INACTIVE METABOLITE APPROACH IN THE DESIGN
OF SOFT CORTICOSTEROIDS 351 SOFT ANTICHOLINERGIC AGENTS AS SHORT-ACTING
MYDRIATICS 356 CONCLUSION 358 ACKNOWLEDGEMENTS 359 REFERENCES 359 TABLE
OF CONTENTS XI 12. DEVELOPMENT OF SOFT DRUGS FOR OPHTHALMIC USE 363 JOHN
F. HOWES INTRODUCTION 363 LOTEPREDNOL ETABONATE 363 ADAPROLOL MALEATE
372 REFERENCES 373 PART IV: FORMULA TION AND DRUG DELIVERY CONSIDERA
TIONS 13. TOPICAL OPHTHALMIC FORMULATIONS: BASIC CONSIDERATIONS 377
NUTAN K. GANGRADE, NEHRU B. GADDIPATI, MADURAI G. GANESAN AND INDRA K.
REDDY INTRODUCTION 377 ADJUVANTS 379 STERILITY 391 SUSPENSIONS AND
PARTICULATES 395 SEMISOLID OPHTHALMIC FORMULATIONS 396 CONCLUSION 398
REFERENCES 399 14. POLYMERS IN OPHTHALMIC DRUG DELIVERY SYSTEMS 405
MANSOOR A. KHAN AND MANZER J. DURRANI INTRODUCTION 405 CLASSIFICATION
405 PHYSICOCHEMICAL PROPERTIES OF THE POLYMERS 408 APPLICATIONS OF
POLYMERS IN THE EYE 417 CONCLUSIONS 430 ACKNOWLEDGEMENTS 431 REFERENCES
431 15. MICROPARTICULATES AS AN OCULAR DELIVERY SYSTEM 441 ABHAYJOSHI
INTRODUCTION 441 LIMITATIONS ON OCULAR DRUG DELIVERY 442
MICROPARTICULATES AS AN INJECTABLE DRUG DELIVERY SYSTEM 445
MICROPARTICULATES AS A TOPICAL OCULAR DELIVERY SYSTEM 448
MULTIPARTICULATE MANUFACTURE AND FORMULATION CHALLENGES 455 X II TABLE
OF CONTENTS CONCLUSION 456 REFERENCES 457 16. PROTEIN AND PEPTIDE DRUG
DELIVERY TO THE EYE 461 AJAY K. BANGA INTRODUCTION 461 OVERVIEW OF
RELEVANT STRUCTURAL DETAILS FOR PEPTIDE/PROTEIN DRUGS 463 FORMULATION
CONSIDERATIONS FOR PEPTIDE/PROTEIN SOLUTIONS 463 OCULAR ADMINISTRATION
OF PEPTIDES/PROTEINS FOR TOPICAL EFFECTS 468 SYSTEMIC DELIVERY OF
PEPTIDES/PROTEINS THROUGH THE EYE 472 SPECIALIZED DELIVERY SYSTEMS 477
CONCLUSIONS 480 REFERENCES 480 17. EVALUATION OF PRIMARY OCULAR
IRRITATION: ALTERNATIVES TO THE DRAIZE TEST 489 CHRISTINE M. HUTAK AND
RICHARD B. JACARUSO INTRODUCTION 489 DRAIZE TEST 489 OBJECTIONS TO THE
DRAIZE TEST 490 ALTERNATIVE IN VIVO ASSAYS 493 ALTERNATIVE IN VITRO
ASSAYS 493 ANATOMY OF THE CORNEA AND ITS RELATION TO OCULAR IRRITATION
AND CORNEAL OPACIFICATION 499 THE INFLAMMATORY RESPONSE 500
PERMEATOXICITY 502 EFFICACY OF IN VITRO METHODS 503 VALIDATION OF IN
VITRO TESTS 505 VALIDATION OF A PROPOSED BATTERY OF IN VITRO TESTS 509
CONCLUSION 512 REFERENCES 513 PART V: INDUSTRIAL AND REGULATORY
CONSIDERATIONS 18. PACKAGING ASPECTS OF OPHTHALMIC PRODUCTS 529 NEHRU B.
GADOIPATI, NUTAN K. GANGRADE, MADURAI G. GANESAN AND INDRA K. REDDY
INTRODUCTION 529 TABLE OF CONTENTS XIII OPHTHALMIC DROPS
(SOLUTIONS/SUSPENSIONS) 530 OPHTHALMIC OINTMENTS 536 NOVEL OPHTHALMIC
PACKAGES 536 OPHTHALMIC PACKAGING STANDARDS 540 CONCLUSION 540
REFERENCES 540 19. A BRIEF HISTORY OF DRUG REGULATION AND REGULATORY
ISSUES GOVERNING OPHTHALMIC PRODUCTS: A BIOPHARMACEUTIC PERSPECTIVE 543
VIJAY K. TAMMARA, RAMAN K. BAWEJA, ANGELICA DORANTES AND JOHN P. HUNT
INTRODUCTION 543 HISTORY OF DRUG REGULATIONS IN THE UNITED STATES 544
REGULATORY ISSUES/REQUIREMENTS 549 BIOREGULATIONS 557 LABELING
REQUIREMENTS 564 SUMMARY 568 GLOSSARY 568 ACKNOWLEDGEMENTS 573
REFERENCES 573 INDEX 575 ABOUT THE EDITOR 587
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| spelling | Ocular therapeutics and drug delivery a multi-disciplinary approach ed. by Indra K. Reddy Lancaster [u.a.] Technomic 1996 XXV, 587 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Drug Delivery Systems Drug delivery systems Eye Diseases drug therapy Ocular pharmacology Ophthalmic drugs Therapeutics, Ophthalmological Augenarzneimittel (DE-588)4143444-4 gnd rswk-swf Wirkstofffreisetzung (DE-588)4190018-2 gnd rswk-swf Augenarzneimittel (DE-588)4143444-4 s Wirkstofffreisetzung (DE-588)4190018-2 s DE-604 Reddy, Indra K. edt GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007060569&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ocular therapeutics and drug delivery a multi-disciplinary approach Drug Delivery Systems Drug delivery systems Eye Diseases drug therapy Ocular pharmacology Ophthalmic drugs Therapeutics, Ophthalmological Augenarzneimittel (DE-588)4143444-4 gnd Wirkstofffreisetzung (DE-588)4190018-2 gnd |
| subject_GND | (DE-588)4143444-4 (DE-588)4190018-2 |
| title | Ocular therapeutics and drug delivery a multi-disciplinary approach |
| title_auth | Ocular therapeutics and drug delivery a multi-disciplinary approach |
| title_exact_search | Ocular therapeutics and drug delivery a multi-disciplinary approach |
| title_full | Ocular therapeutics and drug delivery a multi-disciplinary approach ed. by Indra K. Reddy |
| title_fullStr | Ocular therapeutics and drug delivery a multi-disciplinary approach ed. by Indra K. Reddy |
| title_full_unstemmed | Ocular therapeutics and drug delivery a multi-disciplinary approach ed. by Indra K. Reddy |
| title_short | Ocular therapeutics and drug delivery |
| title_sort | ocular therapeutics and drug delivery a multi disciplinary approach |
| title_sub | a multi-disciplinary approach |
| topic | Drug Delivery Systems Drug delivery systems Eye Diseases drug therapy Ocular pharmacology Ophthalmic drugs Therapeutics, Ophthalmological Augenarzneimittel (DE-588)4143444-4 gnd Wirkstofffreisetzung (DE-588)4190018-2 gnd |
| topic_facet | Drug Delivery Systems Drug delivery systems Eye Diseases drug therapy Ocular pharmacology Ophthalmic drugs Therapeutics, Ophthalmological Augenarzneimittel Wirkstofffreisetzung |
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