Quantification and the quest for medical certainty:
Since its inception in World War II, the clinical trial has evolved into a standard procedure in determining therapeutic efficacy in many Western industrial democracies. Its features include a "control" group of patients that do not receive the experimental treatment, the random allocation...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Princeton, NJ
Princeton Univ. Press
1995
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Zusammenfassung: | Since its inception in World War II, the clinical trial has evolved into a standard procedure in determining therapeutic efficacy in many Western industrial democracies. Its features include a "control" group of patients that do not receive the experimental treatment, the random allocation of patients to either the experimental or control group, and the use of blind assessment so that the researchers do not know which patients are in either group. Even though it has been only within the past generation that the clinical trial has moved to the forefront of medical research, comparative statistics in a therapeutic context has a much longer history. From that history J Rosser Matthews chooses to discuss three crucial debates: that among clinicians before the Parisian Academy of Medicine in 1837, the debate in the German physiological literature during the 1850s, and, in the early twentieth century, the debate over the bacteriologist's diagnostic technique involving the "opsonic index." Matthews demonstrates that despite the very real differences separating clinician, physiologist, and bacteriologist, they all shared an antipathy toward the methods of the statistician. Since they viewed medical judgment as a form of "tacit knowledge," they downplayed the concerns of the medical statistician who was attempting to make medical inference into something explicit and quantitative. Only when "medical decision-making" moved from the cloistered confines of professional medical expertise into the arena of open political debate could the medical statistician (and the clinical trial) gain the upper hand |
| Beschreibung: | 195 S. |
| ISBN: | 0691037949 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV010559971 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | t | ||
| 008 | 960112s1995 |||| 00||| eng d | ||
| 020 | |a 0691037949 |9 0-691-03794-9 | ||
| 035 | |a (OCoLC)231654725 | ||
| 035 | |a (DE-599)BVBBV010559971 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-12 | ||
| 050 | 0 | |a R853.C55 | |
| 082 | 0 | |a 619/.09 |2 20 | |
| 100 | 1 | |a Matthews, J. R. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Quantification and the quest for medical certainty |c J. Rosser Matthews |
| 264 | 1 | |a Princeton, NJ |b Princeton Univ. Press |c 1995 | |
| 300 | |a 195 S. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 520 | 3 | |a Since its inception in World War II, the clinical trial has evolved into a standard procedure in determining therapeutic efficacy in many Western industrial democracies. Its features include a "control" group of patients that do not receive the experimental treatment, the random allocation of patients to either the experimental or control group, and the use of blind assessment so that the researchers do not know which patients are in either group. Even though it has been only within the past generation that the clinical trial has moved to the forefront of medical research, comparative statistics in a therapeutic context has a much longer history. From that history J | |
| 520 | |a Rosser Matthews chooses to discuss three crucial debates: that among clinicians before the Parisian Academy of Medicine in 1837, the debate in the German physiological literature during the 1850s, and, in the early twentieth century, the debate over the bacteriologist's diagnostic technique involving the "opsonic index." Matthews demonstrates that despite the very real differences separating clinician, physiologist, and bacteriologist, they all shared an antipathy toward the methods of the statistician. Since they viewed medical judgment as a form of "tacit knowledge," they downplayed the concerns of the medical statistician who was attempting to make medical inference into something explicit and quantitative. Only when "medical decision-making" moved from the cloistered confines of professional medical expertise into the arena of open political debate could the medical statistician (and the clinical trial) gain the upper hand | ||
| 648 | 7 | |a Geschichte 1750-1995 |2 gnd |9 rswk-swf | |
| 650 | 7 | |a Experimentele geneeskunde |2 gtt | |
| 650 | 7 | |a Statistische methoden |2 gtt | |
| 650 | 4 | |a Geschichte | |
| 650 | 4 | |a Medizin | |
| 650 | 4 | |a Clinical Trials as Topic |x history | |
| 650 | 4 | |a Clinical trials |x History | |
| 650 | 4 | |a History, Modern 1601- | |
| 650 | 4 | |a Medicine |x Research |x Statistical methods |x History | |
| 650 | 4 | |a Probability | |
| 650 | 0 | 7 | |a Klinische Prüfung |0 (DE-588)4031192-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Medizinische Statistik |0 (DE-588)4127563-9 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Klinische Prüfung |0 (DE-588)4031192-2 |D s |
| 689 | 0 | 1 | |a Geschichte 1750-1995 |A z |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Medizinische Statistik |0 (DE-588)4127563-9 |D s |
| 689 | 1 | 1 | |a Geschichte 1750-1995 |A z |
| 689 | 1 | |5 DE-604 | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007040240&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-007040240 | ||
Datensatz im Suchindex
| _version_ | 1804125029887115264 |
|---|---|
| adam_text | Titel: Quantification and the quest for medical certainty
Autor: Matthews, J. Rosser
Jahr: 1995
CONTENTS
Acknowledgments ix
Introduction 3
Chapter One
Probable Knowledge in the Parisian Scientific and Medical
Communities during the French Revolution 8
Chapter Two
Louis s Numerical Method in Early-Nineteenth-Century
Parisian Medicine: The Rhetoric of Quantification 14
Chapter Three
Nineteenth-Century Critics of Gavarret s Probabilistic
Approach 39
Chapter Four
The Legacy of Louis and the Rise of Physiology: Contrasting
Visions of Medical Objectivity 62
Chapter Five
The British Biometrical School and Bacteriology: The
Creation of Major Greenwood as a Medical Statistician 86
Chapter Six
The Birth of the Modern Clinical Trial: The Central Role of
the Medical Research Council 115
Chapter Seven
A. Bradford Hill and the Rise of the Clinical Trial 131
CONCLUSION 141
Notes 151
Bibliograph)/ 177
Index 191
|
| any_adam_object | 1 |
| author | Matthews, J. R. |
| author_facet | Matthews, J. R. |
| author_role | aut |
| author_sort | Matthews, J. R. |
| author_variant | j r m jr jrm |
| building | Verbundindex |
| bvnumber | BV010559971 |
| callnumber-first | R - Medicine |
| callnumber-label | R853 |
| callnumber-raw | R853.C55 |
| callnumber-search | R853.C55 |
| callnumber-sort | R 3853 C55 |
| callnumber-subject | R - General Medicine |
| ctrlnum | (OCoLC)231654725 (DE-599)BVBBV010559971 |
| dewey-full | 619/.09 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 619 - [Unassigned] |
| dewey-raw | 619/.09 |
| dewey-search | 619/.09 |
| dewey-sort | 3619 19 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| era | Geschichte 1750-1995 gnd |
| era_facet | Geschichte 1750-1995 |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03465nam a2200529 c 4500</leader><controlfield tag="001">BV010559971</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">960112s1995 |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0691037949</subfield><subfield code="9">0-691-03794-9</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)231654725</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV010559971</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-12</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">R853.C55</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">619/.09</subfield><subfield code="2">20</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Matthews, J. R.</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Quantification and the quest for medical certainty</subfield><subfield code="c">J. Rosser Matthews</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Princeton, NJ</subfield><subfield code="b">Princeton Univ. Press</subfield><subfield code="c">1995</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">195 S.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1="3" ind2=" "><subfield code="a">Since its inception in World War II, the clinical trial has evolved into a standard procedure in determining therapeutic efficacy in many Western industrial democracies. Its features include a "control" group of patients that do not receive the experimental treatment, the random allocation of patients to either the experimental or control group, and the use of blind assessment so that the researchers do not know which patients are in either group. Even though it has been only within the past generation that the clinical trial has moved to the forefront of medical research, comparative statistics in a therapeutic context has a much longer history. From that history J</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Rosser Matthews chooses to discuss three crucial debates: that among clinicians before the Parisian Academy of Medicine in 1837, the debate in the German physiological literature during the 1850s, and, in the early twentieth century, the debate over the bacteriologist's diagnostic technique involving the "opsonic index." Matthews demonstrates that despite the very real differences separating clinician, physiologist, and bacteriologist, they all shared an antipathy toward the methods of the statistician. Since they viewed medical judgment as a form of "tacit knowledge," they downplayed the concerns of the medical statistician who was attempting to make medical inference into something explicit and quantitative. Only when "medical decision-making" moved from the cloistered confines of professional medical expertise into the arena of open political debate could the medical statistician (and the clinical trial) gain the upper hand</subfield></datafield><datafield tag="648" ind1=" " ind2="7"><subfield code="a">Geschichte 1750-1995</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Experimentele geneeskunde</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Statistische methoden</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Geschichte</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Medizin</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Clinical Trials as Topic</subfield><subfield code="x">history</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Clinical trials</subfield><subfield code="x">History</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">History, Modern 1601-</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Medicine</subfield><subfield code="x">Research</subfield><subfield code="x">Statistical methods</subfield><subfield code="x">History</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Probability</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Klinische Prüfung</subfield><subfield code="0">(DE-588)4031192-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Medizinische Statistik</subfield><subfield code="0">(DE-588)4127563-9</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Klinische Prüfung</subfield><subfield code="0">(DE-588)4031192-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Geschichte 1750-1995</subfield><subfield code="A">z</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Medizinische Statistik</subfield><subfield code="0">(DE-588)4127563-9</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="1"><subfield code="a">Geschichte 1750-1995</subfield><subfield code="A">z</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007040240&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-007040240</subfield></datafield></record></collection> |
| id | DE-604.BV010559971 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-09T17:55:04Z |
| institution | BVB |
| isbn | 0691037949 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007040240 |
| oclc_num | 231654725 |
| open_access_boolean | |
| owner | DE-12 |
| owner_facet | DE-12 |
| physical | 195 S. |
| publishDate | 1995 |
| publishDateSearch | 1995 |
| publishDateSort | 1995 |
| publisher | Princeton Univ. Press |
| record_format | marc |
| spelling | Matthews, J. R. Verfasser aut Quantification and the quest for medical certainty J. Rosser Matthews Princeton, NJ Princeton Univ. Press 1995 195 S. txt rdacontent n rdamedia nc rdacarrier Since its inception in World War II, the clinical trial has evolved into a standard procedure in determining therapeutic efficacy in many Western industrial democracies. Its features include a "control" group of patients that do not receive the experimental treatment, the random allocation of patients to either the experimental or control group, and the use of blind assessment so that the researchers do not know which patients are in either group. Even though it has been only within the past generation that the clinical trial has moved to the forefront of medical research, comparative statistics in a therapeutic context has a much longer history. From that history J Rosser Matthews chooses to discuss three crucial debates: that among clinicians before the Parisian Academy of Medicine in 1837, the debate in the German physiological literature during the 1850s, and, in the early twentieth century, the debate over the bacteriologist's diagnostic technique involving the "opsonic index." Matthews demonstrates that despite the very real differences separating clinician, physiologist, and bacteriologist, they all shared an antipathy toward the methods of the statistician. Since they viewed medical judgment as a form of "tacit knowledge," they downplayed the concerns of the medical statistician who was attempting to make medical inference into something explicit and quantitative. Only when "medical decision-making" moved from the cloistered confines of professional medical expertise into the arena of open political debate could the medical statistician (and the clinical trial) gain the upper hand Geschichte 1750-1995 gnd rswk-swf Experimentele geneeskunde gtt Statistische methoden gtt Geschichte Medizin Clinical Trials as Topic history Clinical trials History History, Modern 1601- Medicine Research Statistical methods History Probability Klinische Prüfung (DE-588)4031192-2 gnd rswk-swf Medizinische Statistik (DE-588)4127563-9 gnd rswk-swf Klinische Prüfung (DE-588)4031192-2 s Geschichte 1750-1995 z DE-604 Medizinische Statistik (DE-588)4127563-9 s HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007040240&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Matthews, J. R. Quantification and the quest for medical certainty Experimentele geneeskunde gtt Statistische methoden gtt Geschichte Medizin Clinical Trials as Topic history Clinical trials History History, Modern 1601- Medicine Research Statistical methods History Probability Klinische Prüfung (DE-588)4031192-2 gnd Medizinische Statistik (DE-588)4127563-9 gnd |
| subject_GND | (DE-588)4031192-2 (DE-588)4127563-9 |
| title | Quantification and the quest for medical certainty |
| title_auth | Quantification and the quest for medical certainty |
| title_exact_search | Quantification and the quest for medical certainty |
| title_full | Quantification and the quest for medical certainty J. Rosser Matthews |
| title_fullStr | Quantification and the quest for medical certainty J. Rosser Matthews |
| title_full_unstemmed | Quantification and the quest for medical certainty J. Rosser Matthews |
| title_short | Quantification and the quest for medical certainty |
| title_sort | quantification and the quest for medical certainty |
| topic | Experimentele geneeskunde gtt Statistische methoden gtt Geschichte Medizin Clinical Trials as Topic history Clinical trials History History, Modern 1601- Medicine Research Statistical methods History Probability Klinische Prüfung (DE-588)4031192-2 gnd Medizinische Statistik (DE-588)4127563-9 gnd |
| topic_facet | Experimentele geneeskunde Statistische methoden Geschichte Medizin Clinical Trials as Topic history Clinical trials History History, Modern 1601- Medicine Research Statistical methods History Probability Klinische Prüfung Medizinische Statistik |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007040240&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT matthewsjr quantificationandthequestformedicalcertainty |