Phosphatases in cell metabolism and signal transduction: structure, function and mechanism of action
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | German |
| Published: |
New York [u.a.]
Springer [u.a.]
1995
|
| Series: | Molecular biology intelligence unit
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturangaben |
| Physical Description: | 203 S. graph. Darst. |
| ISBN: | 3540601473 1570592969 |
Staff View
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV010555203 | ||
| 003 | DE-604 | ||
| 005 | 19960617 | ||
| 007 | t | ||
| 008 | 960102s1995 gw d||| |||| 00||| ger d | ||
| 016 | 7 | |a 94618271X |2 DE-101 | |
| 020 | |a 3540601473 |c (Springer) Pp. : DM 154.00 |9 3-540-60147-3 | ||
| 020 | |a 1570592969 |c (Landes) Pp. |9 1-57059-296-9 | ||
| 035 | |a (OCoLC)32778876 | ||
| 035 | |a (DE-599)BVBBV010555203 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a ger | |
| 044 | |a gw |c DE | ||
| 049 | |a DE-355 |a DE-11 |a DE-188 | ||
| 050 | 0 | |a QP609.P5 | |
| 082 | 0 | |a 574.19/253 |2 20 | |
| 084 | |a WD 5065 |0 (DE-625)148188: |2 rvk | ||
| 084 | |a WE 5320 |0 (DE-625)148305: |2 rvk | ||
| 100 | 1 | |a Vincent, John B. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Phosphatases in cell metabolism and signal transduction |b structure, function and mechanism of action |c John B. Vincent ; Michael W. Crowder |
| 264 | 1 | |a New York [u.a.] |b Springer [u.a.] |c 1995 | |
| 300 | |a 203 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Molecular biology intelligence unit | |
| 500 | |a Literaturangaben | ||
| 650 | 7 | |a Fosfatasen |2 gtt | |
| 650 | 4 | |a Cell metabolism | |
| 650 | 4 | |a Cellular signal transduction | |
| 650 | 4 | |a Phosphatases | |
| 650 | 4 | |a Phosphoric Monoester Hydrolases |x chemistry | |
| 650 | 4 | |a Phosphoric Monoester Hydrolases |x metabolism | |
| 650 | 4 | |a Signal Transduction |x physiology | |
| 650 | 0 | 7 | |a Primärstoffwechsel |0 (DE-588)4175700-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Signaltransduktion |0 (DE-588)4318717-1 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Phosphatasen |0 (DE-588)4140462-2 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Primärstoffwechsel |0 (DE-588)4175700-2 |D s |
| 689 | 0 | 1 | |a Phosphatasen |0 (DE-588)4140462-2 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Signaltransduktion |0 (DE-588)4318717-1 |D s |
| 689 | 1 | 1 | |a Phosphatasen |0 (DE-588)4140462-2 |D s |
| 689 | 1 | |5 DE-604 | |
| 700 | 1 | |a Crowder, Michael W. |e Verfasser |4 aut | |
| 856 | 4 | 2 | |m HEBIS Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007036573&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-007036573 | ||
Record in the Search Index
| _version_ | 1804125024519454720 |
|---|---|
| adam_text | MOLECULAR
BIOLOGY
INTELLIGENCE
UNIT
PHOSPHATASES IN
CELL METABOLISM AND
SIGNAL TRANSDUCTION:
STRUCTURE, FUNCTION AND
MECHANISM OF ACTION
John B yincent, Ph D
University of Alabama
^Department of Chemistry
Tuscaloosa, Alabama, USA
Michael W Crowder, Ph D
Miami University
Department of Chemistry
Oxford, Ohio, USA
Springer
New York Berlin Heidelberg London Paris R G lANDES COMPANY
Tokyo Hong Kong Barcelona Budapest AUSTIN
CONTENTS
Preface vii
1 Introduction 1
2 Mechanisms and Models 3
Chemical Background 3
3 Protein Phosphatases Part A: Phosphoprotein
Serine/Threonine Phosphatases 7
Introduction 7
Classification 8
Inhibitors 8
Sequence Comparisons of the P-S/T-Ps 11
Sources and Structures of Protein Phosphoserine/Threonine
Phosphatases 13
Regulation of PP1 18
4 Protein Phosphatases Part B: Phosphotyrosine Phosphatases 61
Introduction 61
Classification of the PTPs 61
Structural and Mechanistic Studies on PTPs 67
Crystal Structure 73
Substrate Specificity and Inhibition 73
Regulation of the PTPs 76
Functions of PTPs 77
5 Metal-Containing Phosphatases Part A:
Alkaline Phosphatases 99
Introduction 99
Function 7r 100
Active Site Structure 100
Mechanism 102
6 Metal-Containing Phosphatases Part B:
Purple Acid Phosphatases Ill
History Ill
Structure 114
Dinuclear Iron Center 117
Tetrahedral Oxyanion Inhibitors 124
Mechanism 131
Function 141
Plant Purple Acid Phosphatases 143
Other Purple Phosphatases 145
Last Minute Addition 145
7 Low Molecular Weight Acid Phosphatases 159
Introduction 159
Substrate Specificity 159
pH Dependence 160
Structure 160
Enzyme-Substrate Complex 160
Involvement of other Amino Acids in Catalysis 171
8 High Molecular Weight Acid Phosphatases 175
Introduction 175*
Classification and Properties 175
Mechanistic Studies 176
Crystal Structure 182
Mechanism-Based Inhibition 184
Physiological Role(s) of HMWAPs 186
Conclusions 188
9 Other Phosphatases 193
Inorganic Pyrophosphatases 193
Inositol Phosphatases 194
Mn(II)-Stimulated Alkaline Phosphatases 195
ATPases 195
Bacterial Phosphodiesterases 195
10 Conclusion 199
Index 201
|
| any_adam_object | 1 |
| author | Vincent, John B. Crowder, Michael W. |
| author_facet | Vincent, John B. Crowder, Michael W. |
| author_role | aut aut |
| author_sort | Vincent, John B. |
| author_variant | j b v jb jbv m w c mw mwc |
| building | Verbundindex |
| bvnumber | BV010555203 |
| callnumber-first | Q - Science |
| callnumber-label | QP609 |
| callnumber-raw | QP609.P5 |
| callnumber-search | QP609.P5 |
| callnumber-sort | QP 3609 P5 |
| callnumber-subject | QP - Physiology |
| classification_rvk | WD 5065 WE 5320 |
| ctrlnum | (OCoLC)32778876 (DE-599)BVBBV010555203 |
| dewey-full | 574.19/253 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 574 - [Unassigned] |
| dewey-raw | 574.19/253 |
| dewey-search | 574.19/253 |
| dewey-sort | 3574.19 3253 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02256nam a2200577 c 4500</leader><controlfield tag="001">BV010555203</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">19960617 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">960102s1995 gw d||| |||| 00||| ger d</controlfield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">94618271X</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3540601473</subfield><subfield code="c">(Springer) Pp. : DM 154.00</subfield><subfield code="9">3-540-60147-3</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">1570592969</subfield><subfield code="c">(Landes) Pp.</subfield><subfield code="9">1-57059-296-9</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)32778876</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV010555203</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">ger</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">DE</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield><subfield code="a">DE-11</subfield><subfield code="a">DE-188</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QP609.P5</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">574.19/253</subfield><subfield code="2">20</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WD 5065</subfield><subfield code="0">(DE-625)148188:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WE 5320</subfield><subfield code="0">(DE-625)148305:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Vincent, John B.</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Phosphatases in cell metabolism and signal transduction</subfield><subfield code="b">structure, function and mechanism of action</subfield><subfield code="c">John B. Vincent ; Michael W. Crowder</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">New York [u.a.]</subfield><subfield code="b">Springer [u.a.]</subfield><subfield code="c">1995</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">203 S.</subfield><subfield code="b">graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Molecular biology intelligence unit</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Literaturangaben</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Fosfatasen</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cell metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cellular signal transduction</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Phosphatases</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Phosphoric Monoester Hydrolases</subfield><subfield code="x">chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Phosphoric Monoester Hydrolases</subfield><subfield code="x">metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Signal Transduction</subfield><subfield code="x">physiology</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Primärstoffwechsel</subfield><subfield code="0">(DE-588)4175700-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Signaltransduktion</subfield><subfield code="0">(DE-588)4318717-1</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Phosphatasen</subfield><subfield code="0">(DE-588)4140462-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Primärstoffwechsel</subfield><subfield code="0">(DE-588)4175700-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Phosphatasen</subfield><subfield code="0">(DE-588)4140462-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Signaltransduktion</subfield><subfield code="0">(DE-588)4318717-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="1"><subfield code="a">Phosphatasen</subfield><subfield code="0">(DE-588)4140462-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Crowder, Michael W.</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HEBIS Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007036573&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-007036573</subfield></datafield></record></collection> |
| id | DE-604.BV010555203 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:54:59Z |
| institution | BVB |
| isbn | 3540601473 1570592969 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007036573 |
| oclc_num | 32778876 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-11 DE-188 |
| owner_facet | DE-355 DE-BY-UBR DE-11 DE-188 |
| physical | 203 S. graph. Darst. |
| publishDate | 1995 |
| publishDateSearch | 1995 |
| publishDateSort | 1995 |
| publisher | Springer [u.a.] |
| record_format | marc |
| series2 | Molecular biology intelligence unit |
| spelling | Vincent, John B. Verfasser aut Phosphatases in cell metabolism and signal transduction structure, function and mechanism of action John B. Vincent ; Michael W. Crowder New York [u.a.] Springer [u.a.] 1995 203 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit Literaturangaben Fosfatasen gtt Cell metabolism Cellular signal transduction Phosphatases Phosphoric Monoester Hydrolases chemistry Phosphoric Monoester Hydrolases metabolism Signal Transduction physiology Primärstoffwechsel (DE-588)4175700-2 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf Phosphatasen (DE-588)4140462-2 gnd rswk-swf Primärstoffwechsel (DE-588)4175700-2 s Phosphatasen (DE-588)4140462-2 s DE-604 Signaltransduktion (DE-588)4318717-1 s Crowder, Michael W. Verfasser aut HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007036573&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Vincent, John B. Crowder, Michael W. Phosphatases in cell metabolism and signal transduction structure, function and mechanism of action Fosfatasen gtt Cell metabolism Cellular signal transduction Phosphatases Phosphoric Monoester Hydrolases chemistry Phosphoric Monoester Hydrolases metabolism Signal Transduction physiology Primärstoffwechsel (DE-588)4175700-2 gnd Signaltransduktion (DE-588)4318717-1 gnd Phosphatasen (DE-588)4140462-2 gnd |
| subject_GND | (DE-588)4175700-2 (DE-588)4318717-1 (DE-588)4140462-2 |
| title | Phosphatases in cell metabolism and signal transduction structure, function and mechanism of action |
| title_auth | Phosphatases in cell metabolism and signal transduction structure, function and mechanism of action |
| title_exact_search | Phosphatases in cell metabolism and signal transduction structure, function and mechanism of action |
| title_full | Phosphatases in cell metabolism and signal transduction structure, function and mechanism of action John B. Vincent ; Michael W. Crowder |
| title_fullStr | Phosphatases in cell metabolism and signal transduction structure, function and mechanism of action John B. Vincent ; Michael W. Crowder |
| title_full_unstemmed | Phosphatases in cell metabolism and signal transduction structure, function and mechanism of action John B. Vincent ; Michael W. Crowder |
| title_short | Phosphatases in cell metabolism and signal transduction |
| title_sort | phosphatases in cell metabolism and signal transduction structure function and mechanism of action |
| title_sub | structure, function and mechanism of action |
| topic | Fosfatasen gtt Cell metabolism Cellular signal transduction Phosphatases Phosphoric Monoester Hydrolases chemistry Phosphoric Monoester Hydrolases metabolism Signal Transduction physiology Primärstoffwechsel (DE-588)4175700-2 gnd Signaltransduktion (DE-588)4318717-1 gnd Phosphatasen (DE-588)4140462-2 gnd |
| topic_facet | Fosfatasen Cell metabolism Cellular signal transduction Phosphatases Phosphoric Monoester Hydrolases chemistry Phosphoric Monoester Hydrolases metabolism Signal Transduction physiology Primärstoffwechsel Signaltransduktion Phosphatasen |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007036573&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT vincentjohnb phosphatasesincellmetabolismandsignaltransductionstructurefunctionandmechanismofaction AT crowdermichaelw phosphatasesincellmetabolismandsignaltransductionstructurefunctionandmechanismofaction |