Brain tumors in adults:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia [u.a.]
Saunders
1995
|
| Schriftenreihe: | Neurologic clinics
13,4 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV S., S. 701 - 990 Ill. |
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| 245 | 1 | 0 | |a Brain tumors in adults |c Patrick Y. Wen ..., guest ed. |
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Datensatz im Suchindex
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| adam_text | BRAIN TUMORS IN ADULTS
CONTENTS
Preface xiii
Patrick Y. Wen and Peter McL. Black
The Molecular Biology of Brain Tumors 701
Fred G. Barker II and Mark A. Israel
Cancer currently is thought to arise in association with the accu¬
mulation of specific structural genetic alterations within somatic
cells. This article reviews the molecular genetic alterations associ¬
ated with human brain tumors, including mutation or deletion of
tumor suppressor genes (P53, NF1, NF2, RBI, CDKN2, APC, and
the Gorlin and MEN1 loci) and activation of proto oncogenes
(EFGR, other growth factors and receptors, ras and myc families,
ros, gli, gsp). Molecular genetic changes associated with astrocytic
tumors, oligodendrogliomas, ependymomas, medulloblastomas,
meningiomas, schwannomas, and pituitary adenomas are dis¬
cussed.
Neuroradiology of Brain Tumors 723
Richard B. Schwartz
Neuroradiology plays a vital role in the evaluation of intracranial
neoplasms. The radiologist can offer a differential diagnosis of tu¬
mor type based on imaging characteristics, enhancement patterns,
and the amount of surrounding edema. Associated complications
are usually evident on standard radiologic examinations. This ar¬
ticle discusses such standard imaging techniques and some of the
new techniques, which are proving to be very useful in providing
prognostic information.
NEUROLOGIC CLINICS
VOLUME 13 • NUMBER 4 • NOVEMBER 1995 vii
Advances in Surgery for Brain Tumors 757
Raymond Sawaya, William M. Rambo, Jr,
Maarouf A. Hammoud, and B. Lee Ligon
Significant advances in the management of neurosurgical disor¬
ders during the past decade have enhanced the safety of intracra
nial surgery, resulting in the ability of most patients with brain tu¬
mors to undergo successful resection now. Among these advances
are stereotactic surgical procedures and intraoperative monitoring
devices; future directions in neurosurgery include the application
of advances in robotics and virtual reality. The surgical considera¬
tions and complications that accompany these advances are fac¬
tors that the neurosurgeon must evaluate along with the choice of
management.
Advances in Radiation Therapy for Brain Tumors 773
Dennis C. Shrieve and Jay S. Loeffler
Despite important advances in surgery and chemotherapy much
of the recent progress that has been achieved in the treatment of
brain tumors has resulted from developments in radiation ther¬
apy. This article reviews some of the recent advances in radiother
apeutic strategies being used in the treatment of brain tumors in
adults. The overall management of each specific tumor type is dis¬
cussed.
Advances in Chemotherapy for Brain Tumors 795
Charles A. Conrad, Vladan P. Milosavljevic, and
W.K. Alfred Yung
Malignant brain tumors, particularly those of glial origin, carry a
dismal prognosis despite decades of therapeutic maneuvers.
Surgery and radiotherapy have not been curative, and adjunctive
chemotherapy has resulted only in modest increases in survival.
This article discusses the current status of chemotherapy, the
problems encountered with the interpretation of chemotherapeu
tic trials, and some of the new approaches currently being evalu¬
ated.
New Delivery Systems for Brain Tumor Therapy 813
Eric P. Sipos and Henry Brem
Therapy of brain tumors has been limited by lack of effective
methods of drug delivery. Systemic administration often fails to
achieve therapeutic concentrations of drugs within intracranial tu¬
mors despite toxic systemic levels. This article discusses new
methods for delivering therapeutic agents to brain tumors, includ¬
ing intra arterial, intrathecal, intraventricular, and interstitial ad¬
ministration techniques.
viii CONTENTS
Novel Biologic Therapies for Malignant Gliomas:
Antiangiogenesis, Immunotherapy, and Gene Therapy 827
Howard A. Fine
Despite recent advances in neurosurgical techniques and radio¬
therapy, prognosis remains poor for most patients. It is becoming
increasingly clear that novel treatment strategies are needed. This
article explores some of the promising new therapies for malig¬
nant gliomas in terms of their biologic principles and preclinical
data. Antiangiogenesis, immunotherapy, and gene therapy are
discussed.
Low Grade Gliomas 847
Lawrence D. Recht and Mark Bernstein
Supratentorial low grade gliomas comprise a group of primary
central nervous system neoplasms with characteristics of neu
roglial cells (i.e., astrocytes and oligodendrocytes) and relatively
low anaplastic potential, although through time they tend to be¬
have more aggressively. Immediate surgical intervention and sub¬
sequent radiation therapy are advocated by some workers; at pre¬
sent, however, it remains unclear whether early intervention
prolongs survival or changes the natural history of the disease, es¬
pecially in those patients who present with a seizure and a normal
interictal examination.
Oligodendrogliomas 861
Kendra Peterson and J. Gregory Cairncross
Although oligodendrogliomas cannot be considered benign tu¬
mors, many are slow growing indolent tumors for which pro¬
longed life expectancy is the rule. Others behave in a more aggres¬
sive, malignant fashion, as their histologic characteristics would
predict. The treatment for oligodendrogliomas is evolving, with
conservative management still reserved for nonanaplastic tumors,
and increasingly aggressive systemic therapies are being devel¬
oped for more aggressive or recurrent tumors.
High Grade Astrocytomas 875
Patrick Y. Wen, Howard A. Fine, Peter McL. Black,
Dennis C. Shrieve, Eben Alexander III, and Jay S. Loeffler
High grade astrocytomas are the most common primary brain tu¬
mors in adults. Until recently, there has been little progress in the
treatment of these tumors. Promising new therapies, however, are
emerging based on technologic advances in surgery and radio¬
therapy; improved understanding of the molecular, cellular, and
immunobiologic aspects of these tumors; and advances in gene
therapy. This article reviews some of the advances that have been
made in the diagnosis and treatment of high grade astrocytomas.
contents ix
Primary Central Nervous System Lymphoma 901
Ronnie J. Freilich and Lisa M. DeAngelis
The incidence of primary central nervous system lymphoma
(PCNSL) has risen significantly in both the irnmunocompetent and
immunosuppressed populations in the past two decades. PCNSL
usually is restricted to (but disseminated within) the central ner¬
vous system, including the leptomeninges and eyes. The addition
of chemotherapy to radiation therapy has improved patient sur¬
vival significantly over radiation therapy alone, but the prognosis
of PCNSL is not as good as that for comparable systemic non
Hodgkin s lymphomas. The behavior of PCNSL in the immuno¬
suppressed population differs from that in irnmunocompetent pa¬
tients, creating specific diagnostic and therapeutic challenges.
Metastatic Brain Tumors 915
Roy A. Patchell
Significant advances have been made in the diagnosis and treat¬
ment of brain metastases, and the therapeutic nihilism of the past
is not warranted for most patients with brain metastases. With
currently available treatments, most patients do not die of their
brain metastases and usually experience effective palliation of
neurologic symptoms and meaningful extension of life.
Benign Brain Tumors: Meningiomas, Pituitary Tumors,
and Acoustic Neuromas 927
Peter McL. Black
Meningiomas, pituitary adenomas, and vestibular schwannomas
are the most common benign brain tumors in adults. Together
they account for 30% to 40% of primary brain tumors. Surgery
remains the treatment of choice for most of these tumors. Recent
advances in surgical techniques and intraoperative monitoring
have decreased significantly the morbidity associated with
surgery. For patients with inoperable or recurrent tumors, there
is increasing evidence that standard external beam radiotherapy,
stereotactic radiosurgery, and stereotactic radiotherapy all have
a therapeutic role. These advances have been complemented by
progress in medical therapies for pituitary adenomas and
meningiomas.
Uncommon Brain Tumors 953
David Schiff and Patrick Y. Wen
The widespread availability of neuroimaging tests and the in¬
creasing use of stereotactic biopsy or surgical resection to obtain a
histologic diagnosis have resulted in more patients with uncom¬
mon brain tumors coming to the attention of doctors. This article
reviews the presentation and management of some of the less
common brain tumors in adults. These include pineal tumors,
X CONTENTS
medulloblastomas, ependymomas, choroid plexus tumors, gan¬
glion cell tumors, neurocytomas, dysembryoplastic neuroepithe
lial tumors, esthesioneuroblastomas, Lhermitte Duclos disease,
hemangioblastomas, chordomas, and cystic lesions.
Cumulative Index 1995 975
Subscription Information Inside back cover
CONTENTS Xi
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| spelling | Brain tumors in adults Patrick Y. Wen ..., guest ed. Philadelphia [u.a.] Saunders 1995 XIV S., S. 701 - 990 Ill. txt rdacontent n rdamedia nc rdacarrier Neurologic clinics 13,4 Hersentumoren gtt Tumeurs du cerveau - Adulte Volwassenen gtt Adult Brain Neoplasms Hirntumor (DE-588)4072521-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Hirntumor (DE-588)4072521-2 s DE-604 Wen, Patrick Y. Sonstige oth Neurologic clinics 13,4 (DE-604)BV000003008 13,4 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007035340&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| subject_GND | (DE-588)4072521-2 (DE-588)4143413-4 |
| title | Brain tumors in adults |
| title_auth | Brain tumors in adults |
| title_exact_search | Brain tumors in adults |
| title_full | Brain tumors in adults Patrick Y. Wen ..., guest ed. |
| title_fullStr | Brain tumors in adults Patrick Y. Wen ..., guest ed. |
| title_full_unstemmed | Brain tumors in adults Patrick Y. Wen ..., guest ed. |
| title_short | Brain tumors in adults |
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| topic_facet | Hersentumoren Tumeurs du cerveau - Adulte Volwassenen Adult Brain Neoplasms Hirntumor Aufsatzsammlung |
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