Cyclodextrins in pharmacy:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Dordrecht u.a.
Kluwer
1994
|
| Schriftenreihe: | Topics in inclusion science
5 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VIII, 224 S. graph. Darst. |
| ISBN: | 0792321391 |
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Datensatz im Suchindex
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| adam_text | CYCLODEXTRINS IN PHARMACY KARL-HEINZ FROMMING FREE UNIVERSITY, BERLIN,
GERMANY AND J6ZSEF SZEJTLI CYCLOLAB, BUDAPEST, HUNGARY KLUWER ACADEMIC
PUBLISHERS DORDRECHT / BOSTON / LONDON TABLE OF CONTENTS PREFACE IX
CHAPTER 1. CYCLODEXTRINS 1 1.1. CHEMICAL STRUCTURES 1 1.2. PROPERTIES OF
THE CRYSTALLINE CDS 4 1.3. PROPERTIES IN SOLUTION 9 1.4. PRODUCTION OF
CDS 13 1.5. ANALYTICAL CHEMISTRY OF CDS 15 REFERENCES 17 CHAPTER 2.
CYCLODEXTRIN DERIVATIVES 19 2.1. GENERAL ASPECTS OF CD DERIVATIZATION 19
2.2. EFFECTS OF CHEMICAL MODIFICATION ON THE PROPERTIES OF CDS 20 2.3.
METHYLATED CDS 25 2.4. HYDROXYPROPYL CDS 27 2.5. SOLUBLE POLYMERS 29
2.6. INSOLUBLE POLYMERS 31 REFERENCES 32 CHAPTER 3. PHARMACOKINETICS AND
TOXICOLOGY OF CYCLODEXTRINS 33 3.1. ENZYMIC DEGRADATION OF CDS 33 3.2.
ABSORPTION AND METABOLISM OF CDS IN MAMMALS 33 3.3. METABOLISM IN HUMANS
36 3.4. TOXICOLOGY OF CDS 37 3.4.1. ORALTOXICITY 38 3.4.2. PARENTERAL
TOXICITY 38 VI TABLE OF CONTENTS 3.4.3. MUTAGENICITY AND TERATOLOGY 40
3.4.4. DERMAL EFFECTS 40 3.4.5. PULMONARY EFFECTS 40 3.4.6. HAEMOLYTIC
EFFECTS 41 3.4.7. EYE IRRITATION 42 3.5. TOXICOLOGY OF CD DERIVATIVES 42
REFERENCES 44 CHAPTER 4. CYCLODEXTRIN INCLUSION COMPLEXES 45 4.1.
FUNDAMENTALS 45 4.2. STRUCTURE OF THE INCLUSION COMPLEXES 46 4.3. CD
COMPLEXES IN SOLUTION 50 4.3.1. THE ENERGETICS AND MECHANISM OF
HOST-GUEST INTERACTION 50 4.3.2. THE ASSOCIATION-DISSOCIATION
EQUILIBRIUM 52 4.3.3. THE SOLUBILITY ISOTHERMS 54 4.3.4. MODIFICATION OF
VARIOUS PROPERTIES OF THE INCLUDED GUEST 57 4.3.4.1. MODIFICATION OF
ABSORPTION SPECTRA BY CDS 57 4.3.4.2. INDUCED CIRCULAR DICHROISM 58
4.3.4.3. ENHANCEMENT OF FLUORESCENCE, PHOSPHORES- CENCE, LUMINESCENCE 58
4.3.4.4. NMR SPECTRA 59 4.3.4.5. PROTON DISSOCIATION OF THE HOST 60
4.3.4.6. SURFACE ACTIVITY 60 4.3.4.7. DIFFUSION 61 4.3.4.8. INCLUSION
CATALYSIS 61 4.3.4.9. MODIFICATION OF THE PARTITION COEFFICIENT 63
4.3.5. STABILIZING AND CATALYTIC EFFECTS IN SOLUTION 63 4.3.6.
PHOTOSTABILITY 68 4.4. CD COMPLEXES IN THE SOLID PHASE 71 4.4.1.
STOICHIOMETRY OF CD COMPLEXES 71 4.4.2. TERNARY COMPLEXES 73 4.4.3.
CRYSTAL STRUCTURES 74 4.4.4. STABILIZING EFFECTS IN THE SOLID STATE 76
4.5. PRIMARY CONSEQUENCES OF THE INCLUSION OF A GUEST INTO THE CD CAVITY
79 REFERENCES 81 CHAPTER 5. PREPARATION AND CHARACTERIZATION OF
CYCLODEXTRIN COMPLEXES 8 3 5.1. PREPARATION OF CD COMPLEXES 83 5.1.1. IN
SOLUTION 84 TABLE OF CONTENTS VII 5.1.2. UNDER HETEROGENEOUS CONDITIONS
85 5.1.3. IN THE SOLID PHASE 86 5.1.4. WITH HIGHLY SOLUBLE CD
DERIVATIVES 87 5.2. ANALYSIS OF CD COMPLEXES 87 5.2.1. DETERMINATION OF
THE GUEST CONTENT 87 5.2.2. DETERMINATION OF THE WATER CONTENT 88 5.3.
THERMOANALYTICAL METHODS 88 5.4. SOLID-STATE SPECTROSCOPIC METHODS 94
5.4.1. IR SPECTROSCOPY 94 5.4.2. SOLID-STATE NMR SPECTROSCOPY 95 5.4.3.
X-RAY POWDER DIFFRACTION 95 5.4.4. REFLECTANCE 97 5.5. MORPHOLOGICAL AND
MECHANICAL PROPERTIES 97 5.5.1. PARTICLE SIZE DISTRIBUTION 97 5.5.2.
CHARACTERIZATION OF FLOWING PROPERTIES AND HYGROSCOPICITY OF CD
COMPLEXES 97 5.6. WETTABILITY AND DISSOLUTION PROPERTIES 98 5.6.1.
WETTABILITY OF CD COMPLEXES 98 5.6.2. DETERMINATION OF RATE OF
DISSOLUTION OF COMPLEXED GUESTS 99 5.6.2.1. DISPERSED AMOUNT TECHNIQUE
100 5.6.2.2. ROTATING DISC METHOD 101 5.7. OTHER METHODS 103 5.7.1.
WARBURG OXIDATION 103 5.7.2. THIN-LAYER CHROMATOGRAPHY 103 REFERENCES
104 CHAPTER 6. PHARMACOKINETICS AND BIOPHARMACEUTICS 105 6.1.
PHARMACOKINETICS AND BIOPHARMACEUTICAL CONSEQUENCES OF COMPLEXATION OF
DRUGS WITH CDS 105 6.2. ENHANCEMENT OF THE PHARMACOLOGICAL EFFECTS 115
6.3. REDUCTION OF SIDE EFFECTS 120 REFERENCES 125 CHAPTER 7.
PHARMACEUTICAL-TECHNOLOGICAL ASPECTS OF CYCLODEXTRINS IN DRUG
FORMULATION 127 7.1. MODIFICATION OF UNPLEASANT TASTE AND SMELL 127 7.2.
FIXATION OF AROMA-CONTAINING SUBSTANCES AND VOLATILE DRUGS 129 7.3.
CONVERSION OF LIQUID SUBSTANCES INTO SOLID FORMULATIONS 133 7.4.
AVOIDANCE OF DRUG-DRUG AND/OR DRUG-ADDITIVE INTERACTIONS 134 7.5.
GRANULATION AND TABLETTING OF CD-CONTAINING PREPARATIONS 134 VIII TABLE
OF CONTENTS ~ 7.6. NONCOMPLEXING APPLICATIONS OF CDS 143 7.7. LIMITING
FACTORS IN CD APPLICATIONS 146 REFERENCES 148 CHAPTER 8. CYCLODEXTRINS
IN VARIOUS DRUG FORMULATIONS 151 8.0. FORMULATIONS, APPLICATIONS, FORMS
AND ADMINISTRATION ROUTES 151 8.1. PERORAL AND ORAL SOLID PREPARATIONS
(DOSAGE FORMS): POWDERS, GRANULES, CAPSULES, TABLETS 8.2. LIQUID PERORAL
PREPARATIONS 8.3. PARENTERAL PREPARATIONS: INJECTIONS, INFUSIONS,
IMPLANTS 8.4. DERMAL PREPARATIONS 8.5. RECTAL AND VAGINAL PREPARATIONS:
SUPPOSITORIES, GLOBULI 8.6. LIQUID OPHTHALMIC AND NASAL PREPARATIONS
8.7. OTHER FORMULATIONS 8.8. SUSTAINED RELEASE FORMULATIONS REFERENCES
CHAPTER 9. APPENDIX: RECIPES 9.1. HARD GELATIN CAPSULES 9.2. GRANULES
9.3. TABLETS 9.4. LIQUID PERORAL PREPARATIONS 9.5. PARENTERAL
PREPARATIONS 9.6. DERMAL PREPARATIONS 9.7. RECTAL AND VAGINAL
PREPARATIONS 9.8. LIQUID NASAL PREPARATIONS 9.9. LIQUID OPHTHALMIC
PREPARATIONS 9.10. VARIOUS FORMULATIONS 9.11. SUSTAINED RELEASE
FORMULATIONS REFERENCES CHAPTER 10. LEGAL STATUS OF CYCLODEXTRINS
SUBJECT INDEX
|
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| dewey-full | 615/.19 |
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| discipline | Chemie / Pharmazie Medizin |
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| spelling | Frömming, Karl-Heinz Verfasser aut Cyclodextrins in pharmacy Karl-Heinz Frömming and József Szejtli Dordrecht u.a. Kluwer 1994 VIII, 224 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Topics in inclusion science 5 Cyclodextrines - Emploi en thérapeutique - Essais ram Cyclodextrines - Emploi en thérapeutique ram Cyclodextrines - Pharmacocinétique ram Cyclodextrines - Toxicologie ram Cyclodextrines Cyclodextrines ram Pharmacie galénique ram Cyclodextrins Cyclodextrins in pharmaceutical technology Technology, Pharmaceutical Cyclodextrine (DE-588)4148527-0 gnd rswk-swf Pharmazeutische Technologie (DE-588)4045699-7 gnd rswk-swf Cyclodextrine (DE-588)4148527-0 s Pharmazeutische Technologie (DE-588)4045699-7 s DE-604 Szejtli, József Verfasser aut Topics in inclusion science 5 (DE-604)BV002309008 5 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007000447&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Frömming, Karl-Heinz Szejtli, József Cyclodextrins in pharmacy Topics in inclusion science Cyclodextrines - Emploi en thérapeutique - Essais ram Cyclodextrines - Emploi en thérapeutique ram Cyclodextrines - Pharmacocinétique ram Cyclodextrines - Toxicologie ram Cyclodextrines Cyclodextrines ram Pharmacie galénique ram Cyclodextrins Cyclodextrins in pharmaceutical technology Technology, Pharmaceutical Cyclodextrine (DE-588)4148527-0 gnd Pharmazeutische Technologie (DE-588)4045699-7 gnd |
| subject_GND | (DE-588)4148527-0 (DE-588)4045699-7 |
| title | Cyclodextrins in pharmacy |
| title_auth | Cyclodextrins in pharmacy |
| title_exact_search | Cyclodextrins in pharmacy |
| title_full | Cyclodextrins in pharmacy Karl-Heinz Frömming and József Szejtli |
| title_fullStr | Cyclodextrins in pharmacy Karl-Heinz Frömming and József Szejtli |
| title_full_unstemmed | Cyclodextrins in pharmacy Karl-Heinz Frömming and József Szejtli |
| title_short | Cyclodextrins in pharmacy |
| title_sort | cyclodextrins in pharmacy |
| topic | Cyclodextrines - Emploi en thérapeutique - Essais ram Cyclodextrines - Emploi en thérapeutique ram Cyclodextrines - Pharmacocinétique ram Cyclodextrines - Toxicologie ram Cyclodextrines Cyclodextrines ram Pharmacie galénique ram Cyclodextrins Cyclodextrins in pharmaceutical technology Technology, Pharmaceutical Cyclodextrine (DE-588)4148527-0 gnd Pharmazeutische Technologie (DE-588)4045699-7 gnd |
| topic_facet | Cyclodextrines - Emploi en thérapeutique - Essais Cyclodextrines - Emploi en thérapeutique Cyclodextrines - Pharmacocinétique Cyclodextrines - Toxicologie Cyclodextrines Pharmacie galénique Cyclodextrins Cyclodextrins in pharmaceutical technology Technology, Pharmaceutical Cyclodextrine Pharmazeutische Technologie |
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