Molecular biology of nucleases:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Boca Raton [u.a.]
CRC Press
1995
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 282 S. graph. Darst. |
| ISBN: | 0849376580 |
Internformat
MARC
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| 245 | 1 | 0 | |a Molecular biology of nucleases |c Nawin C. Mishra |
| 264 | 1 | |a Boca Raton [u.a.] |b CRC Press |c 1995 | |
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Datensatz im Suchindex
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|---|---|
| adam_text | MOLECULAR
BIOLOGY
of
NUCLEASES
Nawin C Mishra
Department of Biological Sciences
University of South Carolina
Columbia, South Carolina
CRC Press
Boca Raton London Tokyo
TABLE OF CONTENTS
Preface
About the Author
Chapter 1 Introduction 1
I Historical Perspectives 3
II Protein, RNA and Other Molecules as Enzymes and as
Nucleases 4
Dl Nature of Enzymatic Reactions Catalyzed by Nucleases 5
IV Classification 14
A Nature of Substrate IS
B Mode of Attack 15
C Site Specificity 19
V Assay 20
VI Genetics of Nucleases and Biological Roles 21
Chapter 2 Ribonudease 27
I General Ribonucleases 27
A Microbial Ribonucleases 27
1 RNaseT-1 29
B Mammalian Ribonucleases 29
1 Bovine Pancreatic RNase 30
2 RNase A 30
3 Human Pancreatic Ribonuclease (HPR) 31
4 Human Non-secretory Ribonuclease (HNSR) 31
5 Human Major Basic Protein (MBP),
Eosinophil Cationic Protein (ECP) and
Eosinophil Derived Neurotoxin (EDN) 32
a MBP 32
b ECP 32
c EDN 33
6 Angiogenin 33
7 Interferon Induced Mammalian Ribonuclease 33
C Plant Ribonucleases 34
D Evolution of Ribonucleases 34
II Ribonuclease Involved in RNA-Processing 34
A RNasem - 35
B RNaseP 35
C RNaseE 38
D RNaseM5 38
E RNaseD 38
F Eukaryotic RNA Splicing Enzymes 39
1 Yeast tRNA Splicing Endonuclease 39
m Ribonuclease H 40
A E coli RNaseH 40
B Retroviral Reverse Transcriptase RNase H 40
C Yeast RNaseH 41
D Other Eukaryotic RNaseH 41
E Biological Function of RNaseH 41
IV Proofreading Activity of RNA Poiymerase 42
Chapter 3 Deoxyribomiclease 43
I Classification of Enzymes 43
A Deoxyribonucleases 45
B Endonucleases 45
C Exonuclease 46
II Properties of Enzymes from Different Organisms 46
A Bacterial Enzymes 46
1 Exonuclease I 46
2 Exonuclease II 47
3 Exonuclease III 47
4 Application of the Enzyme Exonuclease III 49
5 Exomicleases IVA and IVB 49
6 Exonuclease V (RecBCD Enzyme) 49
7 RecBCD (Exo V) from Other Organisms 50
8 Exonuclease VI 50
9 Exonuclease VII 50
10 Exonucleases Associated with DNA Polymerases 51
11 Exonuclease VEtt 52
B Endonucleases 52
1 Bacterial Enzymes 52
a Endonuclease I 52
b Endonuclease II 52
c Endonuclease m 53
d Endonuclease IV 53
e Endonuclease V 53
f Endonuclease VI 53
g Endonuclease VII 53
h Other Microbial Deoxyribonucleases 53
2 Mammalian Deoxyribonuclease 54
a Deoxyribonuclease I 54
b Human DNasel 54
c RNase-DNase-crosslinked Bifunctional Enzyme 55
d Deoxyribonuclease II 55
e Other Mammalian Deoxyribonucleases 56
f Other Deoxyribonucleases 56
Chapter 4 Restriction Endonucleases 59
I Occurrence, Classification and Their General Properties 60
A Different Restriction Endonucleases and Their
Properties 60
II Type I Restriction Endonucleases 63
A Purification and General Properties 63
B Recognition Sequences and Nature of Substrate 63
C Genetics 66
D Cleavage Mechanism 67
m Type II Restriction Endonucleases 67
A Enzyme Purification and Assay 67
B General Properties of the Enzymes 68
C Reaction Conditions and the Enzyme Specificity 69
D Nature of Substrate 69
1 Synthetic Oligonucleotides 70
2 DNA with Base Analogs 70
3 MethylatedDNA 70
4 Single Stranded DNA 70
5 DNA-RNA Hybrids as Substrate 71
E Inhibition of Restriction Endonucleases 71
F Restriction Endonuclease Genes 71
IV Type DI Restriction Endonucleases 73
V Evolutionary Significance and Biological Role 73
Chapter 5 Damage Specific Nucleases 75
I Classification and Assay 75
A AP Endonucleases 75
B Enzymes that Directly Attack Phosphodiester
Linkages in the Damaged DNA Region 75
C Assay 76
II Properties of the Two Groups of Enzymes from
Different Organisms 76
A AP Endonucleases 76
1 AP Endonucleases Associated with
DNA Glycosylase Activity 76
a T4UV Endonuclease V 76
2 U luteus Enzyme 77
3 E coli Endonuclease IE 77
B AP Endonuclease Associated with Other
Enzyme Activities 79
1 E coli Exonuclease DI AP Endonuclease Activity 79
C AP Endonucleases 79
1 E coli AP Endonucleases 79
2 Fungal Apurinic Endonuclease 79
3 Drosophila AP Endonucleases 80
4 Human AP Endonucleases 80
5 Plant AP Endonuclease 80
D Direct Acting Enzymes 81
1 E coli UV Endonuclease 81
a UVR ABC Excision Nuclease 81
b E coli Endonuclease V 81
2 Human Excision Nuclease 81
Chapter 6 Topoisomerases 83
I Choreography and Topology of DNA 83
II Enzyme Assay 84
A Electron Microscopy 85
B Sedimentation Methods 85
C Agarose Gel Electrophoresis 85
DI Properties of Enzymes from Different Groups of Organisms 85
A Prokaryotic Topoisomerases 85
1 Prokaryotic Topoisomerase I 85
2 Prokaryotic Topoisomerase II 86
3 Properties of Gyrase 86
4 Other Activities of Gyrase 87
5 Prokaryotic Topoisomerase DI 87
B Eukaryotic Topoisomerases 88
1 Eukaryotic Topoisomerase I 88
2 Eukaryotic Topoisomerase II 88
C Mitochondrial Topoisomerase 89
D Viral Topoisomerases 89
IV Genetics and Biological Role 90
A Prokaryotic Topoisomerase Mutants 90
1 Topoisomerase I 90
2 Topoisomerase II 91
B Eukaryotic Topoisomerase Mutants 91
1 Topoisomerase I Mutants of Yeast 91
2 Topoisomerase II Mutants of Yeast 92
3 Topoisomerase Mutants of Higher Eukaryotes 9 2
Chapter 7 Recombinases 95
L General Description and Classification 95
A General Recombinase 95
B Site Specific Recombinase 96
1 Prokaryotic 96
2 Eukaryotic 96
C Transpositional Recombinase 96
D RNA Recombinase 96
n Properties of Different Recombinases 96
A General Recombinase 96
1 Initiase 97
2 X-solvase 97
a Bacteriophage 97
b Escharichia coli 101
c Yeast 101
d Mammalian Cells 102
3 Correctase 102
a Prokaryotic Correctase 102
E coli Mismatch Repair Enzyme 102
b Eukaryotic Correctase 103
B Site Specific Recombinase 105
C Prokaryotic Site Specific Recombinase 106
1 Integrase 106
a PI Recombinase 106
2 Invertase 107
a -Cih Invertase 108
- b Gin Invertase 108
c Hin Invertase 108
d Pin Invertase 108
e Min Invertase and Shufflon-recombinase 109
3 Resolvase 109
D Eukaryotic Site Specific Recombinase 110
1 Eukaryotic Site Specific Recombinase 110
a Yeast FLP Protein 110
b Yeast Endonuclease Seel 110
c Yeast HO Gene Product or Y-
Z Endonuclease or EndoSceD I l l
d Mammalian V(D)J-endonuclease I l l
2 Homing* Nuclease (Intron Coded Nuclease) 112
a Bacteriophage (TJ Intron
Encoded Homing Enzymes Td
and SunY 112
* b Yeast Homing Endonuclease 113
« 3 Viral Integrase 113
E Transpositional Recombinase 114
1 Prokaryotic Transposases 114
a Class I Transposases 115
b Class II Transposases 116
c Class DI Transposases 116
2 Eukaryotic Transposase 117
a Ac Transposases 117
b Spm Transposase 117
c Drosophila Transposase 117
3 Retrotransposable Elements and Retrotransposases 118
a Human Retrotransposases 118
F Control of Recombinases 119
G RNA Recombinase 119
Chapter 8 Sugar Non-Spedfic Nucleases 121
I General Description, Classification and Methods of Assay 121
II Properties of Enzymes from Different Groups of
Organisms 122
A Microbial Nucleases 122
1 Neurospora crassa Endonuclease 122
2 S, Nuclease 124
3 Yeast Nucleases 124
4 Micrococcal Nuclease 125
5 Bal 31 Nucleases 125
B Animal Nucleases 126
1 Spleen Exonucleases 126
2 Snake Venom Exonuclease 126
C Plant Nucleases 126
1 Mung Bean Endonucleases 126
Chapter 9 Non-Protein Nucleases 129
I Ribozymes 129
A RNaseP 129
1 Protein Component of RNaseP 131
B Introns as Ribozymes 132
1 Group I Intron Ribozymes 133
2 Mechanism of Catalysis by Group I
Intron Ribozyme 134
3 Assay of Ribozyme Activity of Intron
RNA or Other RNA 134
C Group D Intron Ribozymes 134
D Splicosomal SnRNA Ribozyme 136
1 Proteins which Facilitate the Ribozyme
Activity of RNA Nuclease 136
E Maturase 136
F Hammerhead RNA as Ribozyme 137
G Cis- and Trans-acting Ribozyme Endonuclease 137
II Chemzymes 138
A Chemicals and Metal Ligand Complexes as Nucleases 138
1 Piperidine 138
2 Hydrogen Peroxide 139
3 DNA Intercalating Agents 139
4 Phenanthroline 139
5 Factors Controlling the DNA Cleavage
by Chemzymes 140
B Peptides 140
DI Designer Nuclease 141
Chapter 10 Molecules that Interact with Nucleases 143
I Inhibitors 143
A Proteins as Nuclease Inhibitors 143
B RNA as Nuclease Inhibitors 144
C Other Molecules that Act as Nuclease Inhibitors 144
II Proteins that Interact with the Activity of Nuclease by
Interacting with the Substrate (Nucleic Acids) 144
DI DNA Sequences that Interact with Nucleases 145
A Chi Like Elements in Eukaryotes 147
IV Other Inhibitor Molecules 147
V Proteins that Interact with DNA or Nuclease to
Orchestrate the Activity of Nucleases 147
Chapter 11 Biological Function of Nucleases 149
I Replication 149
A Three Steps in DNA Replication 149
1 Initiation 149
2 Elongation 150
3 Termination 150
B Role of Viral Nuclease in the Degradation of
Host DNA 152
C Involvement of Nuclease During the Separation
of Daughter Helices at the End of Replication 153
D Involvement of Nucleases in the Rolling Circle
Mechanism of DNA Replication 154
E Involvement of Nuclease in the Replication of
Linear DNA 154
F Involvement of Nuclease in the Replication of
Chromosome in Eukaryotes 154
D DNA Repair 155
A Baseless Sites 155
B Sites with Altered Base or Incorrect Base 156
C Crosslinking and Other Damages 156
D DNA Repair Mechanisms 156
E Excision Repair 156
F Bypass Repair Pathways 161
G Recombinational Repair Pathway 161
H Inducible and Error Prone Repair Pathway 161
I Mismatch Repair 162
J Mismatch Repair in Mammalian Cells 162
K Incision of Damaged DNA Is a Complex
Process Involving Several Proteins 163
„ L Excision Repair Mutants of Neurospom 163
} M Excision Repair Mutants of Yeast 164
N Excision Repair Mutants of Drosophila 164
0 Excision Repair Mutants of Mammalian Cells 165
inRecombination • • • • • • • • • • • • • • • • • • • • • • 1 6 5
A Different Kinds of Genetic Recombination 166
B Recombination Mechanisms and Nucleases 167
C Gene Conversion and Postmeiotic Segregation 169
D In Vuro Recombination System 170
E Fungal Recombination Nucleases 173
F Mismatch Repairs During Recombination 173
G Recombination Pathways 174
1 RecBCD Pathway 174
2 RecFJ Pathway 174
3 RecE Pathway 174
4 Red Pathway 175
H Recombinational Control of Gene Expression 175
1 Role of Recombinase in Mammalian Antibody
Diversity, AUelic Exclusion and Class Switch 176
J T Cell Surface Receptor 178
K Engineered Expression of Genes by Recombinase 178
IV DNA Transfection or Transformation 179
V Mutation 181
VI DNA Supercoiling and Maintenance of Chromosome
Structure 183
VII Transcription 185
VDI RNA Processing 186
A RNA Trimming 186
B RNA Splicing 189
C RNA Editing 191
DC Control of Translation 191
X Viral Maturation and Encapsidation 191
XI Nuclease in Defense Mechanism 192
Xn Nucleic Acid Salvage 192
Chapter 12 Nucleases and Human Diseases 193
I Involvement of Nucleases in Human Disease 194
A Xeroderma Pigmentosum 194
B Axatia Telangiectasia 196
C Cockayne Syndrome 198
D Cancer 198
E Aging 200
F Immunological Diseases 200
G Other Human Diseases 200
H Nucleases and Neurological Disorders 201
D Reverse Genetics, Human Diseases, and Nucleases 201
DI Use of Nucleases in the Control of Human Diseases 201
Chapter 13 Nucleases as Took 203
I Nature of Transforming Principle as DNA 203
H Isolation of DNA and RNA 204
DI Nearest Neighborhood Analysis 204
IV Isolation of a Gene 204
- V Uniparental Transmission During Cytoplasmic Inheritance 205
VI Physical Map of DNA 206
Vn Use of Nuclease in the Development of Recombinant
DNA Technology and the Molecular Cloning of a Gene 207
VDL Construction of an Artificial Chromosome 207
DC New Method for Mapping Eukaryotic Chromosomes 208
A Chromosome Walking (Overlap Hybridization) 208
B Role of Nucleases in Transposon Mobility 209
X Use of Nuclease in the Physical Mapping of a
Mutational site 209
XI Biological Activity of a DNA Segment 210
A Use of Nucleases in the Identification of the
Function of a DNA Segment via
Transformation Experiments 210
B Use of Nucleases in the Deletion Mapping of
Biological Activity 210
C Use of Nuclease in Identification of the
Function of DNA Segment via Marker Rescue
Method 2 1 1
XD Organization of Eukaryotic Chromosomes 211
Xm Distinction Between Active and Inactive Genes: The
Relation Between Activity of a Gene and Nuclease
Sensitive Site 212
XIV DNA Footprinting 214
XV Construction of Mutants: Site Specific Mutation and
Protein Engineering 215
XVI Nucleases in Directed Mutagenesis 215
XVII Nick Translation and Labelling of DNA with High
Specificity Radioactivity 215
XVm Role of Nucleases in PCR 216
XDC Gene Knockout 216
XX RNase Protection Assay 216
XXI Use of Nucleases in Forensic Science 216
XXII Human Genome Project 217
Chapter 14 Nucleases and Evolution 219
I Ribozyme as Evidence for the Early World of RNA 219
n Chemzyme, Ribozyme, and Proteinzyme 220
TIT The Role of TRf*rfnVinnc* in Evolution ffl
TV Nucleases and Control of DNA Transactions and Their
Roles in Evolution 224
V Role of Nucleases in Directed Mutagenesis: Adaptive
Mutation an SOS Response 224
VI Nucleases as Multifunctional Molecules 226
VD Possible Horizontal Transmission of Nuclease Gene and
Intron 226
VDI Conclusions 227
References 229
Index 277
|
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| id | DE-604.BV010500769 |
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| indexdate | 2024-07-09T17:53:33Z |
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| language | English |
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| spelling | Mishra, Nawin C. Verfasser aut Molecular biology of nucleases Nawin C. Mishra Boca Raton [u.a.] CRC Press 1995 282 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Nucleases Nucleasen (DE-588)4172116-0 gnd rswk-swf Nucleasen (DE-588)4172116-0 s DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006997631&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Mishra, Nawin C. Molecular biology of nucleases Nucleases Nucleasen (DE-588)4172116-0 gnd |
| subject_GND | (DE-588)4172116-0 |
| title | Molecular biology of nucleases |
| title_auth | Molecular biology of nucleases |
| title_exact_search | Molecular biology of nucleases |
| title_full | Molecular biology of nucleases Nawin C. Mishra |
| title_fullStr | Molecular biology of nucleases Nawin C. Mishra |
| title_full_unstemmed | Molecular biology of nucleases Nawin C. Mishra |
| title_short | Molecular biology of nucleases |
| title_sort | molecular biology of nucleases |
| topic | Nucleases Nucleasen (DE-588)4172116-0 gnd |
| topic_facet | Nucleases Nucleasen |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006997631&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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