Polyamines: regulation and molecular interaction:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | German |
| Veröffentlicht: |
New York [u.a.]
Springer [u.a.]
1995
|
| Schriftenreihe: | Molecular biology intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 236 S. graph. Darst. |
| ISBN: | 354060037X 1570592810 |
Internformat
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| 245 | 1 | 0 | |a Polyamines: regulation and molecular interaction |c Robert A. Casero |
| 264 | 1 | |a New York [u.a.] |b Springer [u.a.] |c 1995 | |
| 300 | |a 236 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 650 | 4 | |a Polyamines |x Metabolism |x Regulation | |
| 650 | 4 | |a Polyamines |x Pathophysiology | |
| 650 | 4 | |a Polyamines |x metabolism | |
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Datensatz im Suchindex
| _version_ | 1808046600873836544 |
|---|---|
| adam_text |
CONTENTS
PREFACE
.
IX
1.
INTRODUCTION
.
1
ROBERT
A.
CASERO,JR.
2.
TRANSCRIPTIONAL
CONTROL
OF
THE
ODC
GENE
.
5
G.
LYNN
LAW,
RUN-SHENG
LI,
DAVID
R
MORRIS
I.
INTRODUCTION
.
5
II.
FACTORS
DETERMINING
BASAL
PROMOTER
ACTIVITY
.6
III.
IS
ODC
A
PRIMARY
RESPONSE
GENE?
.
10
IV.
REGULATION
BY
CAMP
.
12
V.
RESPONSE
TO
PHORBOL
ESTERS
AND
MODULATION
BY
RETINOIC
ACID
.
14
VI.
CROSSTALK
BETWEEN
PKA
AND
PKC
.
16
VII.
REGULATION
BY
ONCOGENE
PRODUCTS
.
17
3.
MAMMALIAN
S-ADENOSYLMETHIONINE
DECARBOXYLASE
REGULATION
AND
PROCESSING
.
27
BRUCE
A.
STANLEY
I.
INTRODUCTION
.
27
II.
TRANSCRIPTIONAL
CONTROL
OF
SAMDC
.
31
III.
TRANSLATIONAL
CONTROL
OF
SAMDC
EXPRESSION
.
33
IV.
REGULATION
OF
RATE
OF
PROENZYME
PROCESSING
.
50
V.
ACTIVATION
OF
MATURE
ENZYME
.
57
VI.
POST-TRANSLATIONAL
MODIFICATIONS
AND
INACTIVATION
OF
ENZYME
.
59
VII.
REGULATION
THROUGH
CHANGES
IN
DEGRADATION
RATE
.
61
VIII.
SUMMARY
.
65
4.
REGULATION
OF
SPERMIDINE/SPERMINE
N'-ACETYLTRANSFERASE
.
77
LEI
XIAO,
ROBERT
A.
CASERO,
JR.
I.
INTRODUCTION
.
77
II.
THE
POLYAMINE
METABOLIC
PATHWAY:
A
VERY
BRIEF
OVERVIEW
.78
III.
THE
SPERMIDINE/SPERMINE
N'-ACETYLTRANSFERASE
PROTEIN
.
79
IV.
CLONING
AND
CHARACTERIZATION
OF
THE
SPERMIDINE/SPERMINE
N'-ACETYLTRANSFERASE
GENE
.80
V.
REGULATION/DEREGULATION
OF
SSAT
EXPRESSION
AND
PHYSIOLOGIC
CONSEQUENCES
.
85
VI.
SUMMARY
.
92
5.
BIOLOGICAL
AND
THERAPEUTIC
IMPLICATIONS
OF
THE
EFFECTS
OF
POLYAMINES
ON
CHROMATIN
CONDENSATION
.
101
HIRAK
S.
BASU,
LAURENCE
J.
MARTON
I.
SUMMARY
.
101
II.
INTRODUCTION
.
102
III.
POLYAMINE-DNA
INTERACTIONS
.
102
IV.
POLYAMINE-DNA INTERACTIONS
AND
CELL
DIVISION
.
103
V.
POSSIBLE
THERAPEUTIC
SIGNIFICANCE
OF
POLYAMINE
ANALOG
INDUCED
CHANGES
IN
CHROMATIN
STRUCTURE
.
109
VI.
UNANSWERED
QUESTIONS
AND
UNSOLVED
MYSTERIES
.
114
6.
MODULATION
OF
NMDA
RECEPTORS
BY
POLYAMINES
.
129
KEITH
WILLIAMS
I.
OVERVIEW
.
129
II.
INTRODUCTION
.
129
III.
EFFECTS
OF
POLYAMINES
ON
NATIVE
NMDA
RECEPTORS
.
136
IV.
MOLECULAR
BIOLOGY
OF
NMDA
RECEPTORS
.
140
V.
EFFECTS
OF
POLYAMINES
ON
RECOMBINANT
NMDA
RECEPTORS
.
145
VI.
IMPLICATIONS
FOR
THE
IN
VIVO
BIOLOGY
OF
POLYAMINES
.
155
VII.
CONCLUSIONS
.
158
7.
S-ADENOSYLMETHIONINE
DECARBOXYLASE
AND
SPERMIDINE/SPERMINE-N'-ACETYLTRANSFERASE
-
EMERGING
TARGETS
FOR
RATIONAL
INHIBITOR
DESIGN
.
171
PATRICK
M.
WOSTER
I.
INTRODUCTION
.
171
II.
S-ADENOSYLMETHIONINE
DECARBOXYLASE
.
173
III.
SPERMIDINE/SPERMINE-N
1
-ACETYLTRANSFERASE
.
186
8.
THE
POLYAMINE
METABOLIC
PATHWAY
AS
A
TARGET
FOR
CHEMOPREVENTION
.
205
CRAIG
M.
BERCHTOLD,
THOMAS
W.
KENSLER,
ROBERT
A.
CASERO,
JR.
I.
INTRODUCTION
.
205
II.
POLYAMINE
METABOLIC
PATHWAY
.
208
III.
POLYAMINES
IN
CHEMICAL
CARCINOGENESIS
.
211
IV.
POLYAMINE
PATHWAY
IN
CLINICAL
CHEMOPREVENTION
.
217
V.
TOXICITY
AND
PHARMACOKINETIC
STUDIES
OF
DFMO
.
220
VI.
POLYAMINE
ANALOGS
IN
CHEMOPREVENTION
.
221
VII.
INFLAMMATORY
PROCESSES
AS
A
TARGET
OF
INTERVENTION
.
223
VIII.
CONCLUSION
.
224
INDEX
.
233 |
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| language | German |
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| spelling | Polyamines: regulation and molecular interaction Robert A. Casero New York [u.a.] Springer [u.a.] 1995 236 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit Bioquimica larpcal Polyamines Metabolism Regulation Polyamines Pathophysiology Polyamines metabolism Polyamine (DE-588)4175101-2 gnd rswk-swf Pathophysiologie (DE-588)4044898-8 gnd rswk-swf Stoffwechsel (DE-588)4057699-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Polyamine (DE-588)4175101-2 s Stoffwechsel (DE-588)4057699-1 s DE-604 Pathophysiologie (DE-588)4044898-8 s Casero, Robert A. Sonstige oth DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006993199&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Polyamines: regulation and molecular interaction Bioquimica larpcal Polyamines Metabolism Regulation Polyamines Pathophysiology Polyamines metabolism Polyamine (DE-588)4175101-2 gnd Pathophysiologie (DE-588)4044898-8 gnd Stoffwechsel (DE-588)4057699-1 gnd |
| subject_GND | (DE-588)4175101-2 (DE-588)4044898-8 (DE-588)4057699-1 (DE-588)4143413-4 |
| title | Polyamines: regulation and molecular interaction |
| title_auth | Polyamines: regulation and molecular interaction |
| title_exact_search | Polyamines: regulation and molecular interaction |
| title_full | Polyamines: regulation and molecular interaction Robert A. Casero |
| title_fullStr | Polyamines: regulation and molecular interaction Robert A. Casero |
| title_full_unstemmed | Polyamines: regulation and molecular interaction Robert A. Casero |
| title_short | Polyamines: regulation and molecular interaction |
| title_sort | polyamines regulation and molecular interaction |
| topic | Bioquimica larpcal Polyamines Metabolism Regulation Polyamines Pathophysiology Polyamines metabolism Polyamine (DE-588)4175101-2 gnd Pathophysiologie (DE-588)4044898-8 gnd Stoffwechsel (DE-588)4057699-1 gnd |
| topic_facet | Bioquimica Polyamines Metabolism Regulation Polyamines Pathophysiology Polyamines metabolism Polyamine Pathophysiologie Stoffwechsel Aufsatzsammlung |
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