Antibody therapeutics:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York u.a.
Springer u.a.
1995
|
| Schriftenreihe: | Molecular biology intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 153 S. Ill., graph. Darst. |
| ISBN: | 1570592721 3540594914 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV010491705 | ||
| 003 | DE-604 | ||
| 005 | 19951123 | ||
| 007 | t | ||
| 008 | 951123s1995 ad|| |||| 00||| eng d | ||
| 016 | 7 | |a 945917775 |2 DE-101 | |
| 020 | |a 1570592721 |9 1-57059-272-1 | ||
| 020 | |a 3540594914 |9 3-540-59491-4 | ||
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| 035 | |a (DE-599)BVBBV010491705 | ||
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| 100 | 1 | |a Harris, William J. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Antibody therapeutics |c William J. Harris ; Charles Cunningham |
| 264 | 1 | |a New York u.a. |b Springer u.a. |c 1995 | |
| 300 | |a 153 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Molecular biology intelligence unit | |
| 650 | 0 | 7 | |a Immuntherapie |0 (DE-588)4026640-0 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Antikörper |0 (DE-588)4002290-0 |2 gnd |9 rswk-swf |
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| 689 | 0 | 1 | |a Immuntherapie |0 (DE-588)4026640-0 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Cunningham, Charles |e Verfasser |4 aut | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006990835&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-006990835 | |
Datensatz im Suchindex
| _version_ | 1808137484566003712 |
|---|---|
| adam_text |
-
-
CONTENTS
-
-
1.
THE
STRUCTURE
OF
ANTIBODIES
.
1
INTRODUCTION
.
1
FINE
STRUCTURE
OF
IMMUNOGLOBULINS
.
5
STRUCTURE
AND
ASSEMBLY
OF
FV
FRAGMENTS
.
6
CONCLUSIONS
.
14
2.
ANTIBODY
MODELING
AND
DE
NOVO
ANTIBODY
DESIGN
.
19
INTRODUCTION
.
19
MODELING
FRAMEWORK
REGIONS
.
21
MODELING
CDR
CONFORMATION
.
21
MODELING
CDR3-H
.
23
MODELING
THE
ANTIGEN
BINDING
SURFACE
.
23
MODELING
ANTIGEN-ANTIBODY
INTERACTIONS
(DOCKING)
.
24
DESIGNING
NEW
PROPERTIES
.
24
DESIGNING
ANTIBODIES
DE
NOVO
.
25
CONCLUSIONS
.
26
3.
IMMUNOTHERAPY
.
29
INTRODUCTION
.
29
IMMUNOGLOBULIN
THERAPY
.
30
HYPERIMMUNE
SERUM
THERAPY
.
33
CONCLUSIONS
.
36
4.
CLINICAL
STUDIES
WITH
MURINE
AND
CHIMERIC
MONOCLONAL
ANTIBODIES
.
39
INTRODUCTION
.
39
CHIMERIC
ANTIBODIES
.
40
PHARMACOKINETICS
OF
MURINE
AND
CHIMERIC MONOCLONAL
ANTIBODIES
.
42
CLINICAL
STUDIES
.
43
THERAPEUTIC
STUDIES
.
46
CONCLUSIONS
.
59
5.
HUMAN
MONOCLONAL
ANTIBODIES
.
69
INTRODUCTION
.
69
ISOLATION
OF
HIGH
AFFINITY
HUMAN
B
CELLS
.
71
CLINICAL
STUDIES
WITH
HUMAN
MONOCLONAL
ANTIBODIES
.
74
6.
HUMANIZED
ANTIBODIES
.
85
INTRODUCTION
.
85
STRUCTURE
OF
HUMANIZED
ANTIBODIES
.
85
CDR
GRAFTING
.
87
RESHAPING
TECHNOLOGIES
.
90
NEW
TECHNOLOGIES
IN
HUMANIZING
ANTIBODIES
.
94
PRECLINICAL
STUDIES
WITH
HUMANIZED
ANTIBODIES
.
99
CLINICAL
STUDIES
WITH
HUMANIZED
ANTIBODIES
.
100
PRIMATIZED
ANTIBODIES
.
103
FUTURE
PROSPECTS
WITH
HUMANIZED
ANTIBODIES
.
103
7.
BACTERIOPHAGE
ANTIBODY
DISPLAY
LIBRARIES
.
ILL
INTRODUCTION
.
ILL
BACKGROUND
.
ILL
CONSTRUCTION
OF
HUMAN
BACTERIOPHAGE
LIBRARIES
.
112
HUMAN
ANTIBODY
GENE
LIBRARIES
.
114
LARGE
COMBINATORIAL
LIBRARIES
OF
VH
AND
VI
DOMAIN
GENES
.
117
SEMI-SYNTHETIC
ANTIBODY
LIBRARIES
.
117
AFFINITY
IMPROVEMENT
.
119
EPITOPE
IMPRINTING
.
121
THE
FUTURE
OF
THERAPEUTICS
FROM
PHAGE
DISPLAY
LIBRARIES
.
123
8.
TRANSGENIC
MICE
WITH
HUMAN
IMMUNOGLOBULINS
.
129
INTRODUCTION
.
129
DEVELOPMENT
OF
MICE
DEFICIENT
IN
B
CELLS
.
131
MINI-LOCUS
TRANSGENE
CONSTRUCTS
AND
THEIR
DIVERSITY
.
133
TRANSGENIC
MICE
MAKING
INTACT
HUMAN
ANTIBODIES
.
136
DIVERSITY
OF
USAGE
OFV
GENES
.
137
CONCLUSIONS
.
138
9.
NEW
PERSPECTIVES
FOR
ANTIBODY
THERAPEUTICS
.
141
INTRODUCTION
.
141
ANTIBODY
AFFINITY
AND
SPECIFICITY
.
141
BIVALENT
AND
BIFUNCTIONAL
ANTIBODY
FRAGMENTS
.
143
INTRACELLULAR
ANTIBODIES
.
143
EXTENDING THE
SCOPE
AND
IMMUNOSILENCE
OF
THERAPEUTIC
ANTIBODIES
.
146
PEPTIDE
MIMETICS
OF
ANTIBODIES
.
146
SUMMARY
.
148
INDEX
.
151 |
| any_adam_object | 1 |
| author | Harris, William J. Cunningham, Charles |
| author_facet | Harris, William J. Cunningham, Charles |
| author_role | aut aut |
| author_sort | Harris, William J. |
| author_variant | w j h wj wjh c c cc |
| building | Verbundindex |
| bvnumber | BV010491705 |
| classification_rvk | VS 9200 WC 4400 XD 3115 |
| ctrlnum | (OCoLC)38958043 (DE-599)BVBBV010491705 |
| dewey-full | 615.37 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.37 |
| dewey-search | 615.37 |
| dewey-sort | 3615.37 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Biologie Medizin |
| format | Book |
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| id | DE-604.BV010491705 |
| illustrated | Illustrated |
| indexdate | 2024-08-23T00:51:19Z |
| institution | BVB |
| isbn | 1570592721 3540594914 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006990835 |
| oclc_num | 38958043 |
| open_access_boolean | |
| owner | DE-29 DE-29T DE-355 DE-BY-UBR DE-188 |
| owner_facet | DE-29 DE-29T DE-355 DE-BY-UBR DE-188 |
| physical | 153 S. Ill., graph. Darst. |
| publishDate | 1995 |
| publishDateSearch | 1995 |
| publishDateSort | 1995 |
| publisher | Springer u.a. |
| record_format | marc |
| series2 | Molecular biology intelligence unit |
| spelling | Harris, William J. Verfasser aut Antibody therapeutics William J. Harris ; Charles Cunningham New York u.a. Springer u.a. 1995 153 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit Immuntherapie (DE-588)4026640-0 gnd rswk-swf Antikörper (DE-588)4002290-0 gnd rswk-swf Antikörper (DE-588)4002290-0 s Immuntherapie (DE-588)4026640-0 s DE-604 Cunningham, Charles Verfasser aut DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006990835&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Harris, William J. Cunningham, Charles Antibody therapeutics Immuntherapie (DE-588)4026640-0 gnd Antikörper (DE-588)4002290-0 gnd |
| subject_GND | (DE-588)4026640-0 (DE-588)4002290-0 |
| title | Antibody therapeutics |
| title_auth | Antibody therapeutics |
| title_exact_search | Antibody therapeutics |
| title_full | Antibody therapeutics William J. Harris ; Charles Cunningham |
| title_fullStr | Antibody therapeutics William J. Harris ; Charles Cunningham |
| title_full_unstemmed | Antibody therapeutics William J. Harris ; Charles Cunningham |
| title_short | Antibody therapeutics |
| title_sort | antibody therapeutics |
| topic | Immuntherapie (DE-588)4026640-0 gnd Antikörper (DE-588)4002290-0 gnd |
| topic_facet | Immuntherapie Antikörper |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006990835&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT harriswilliamj antibodytherapeutics AT cunninghamcharles antibodytherapeutics |