The estrogen receptor as a target for rational drug design:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Springer [u.a.]
1995
|
| Schriftenreihe: | Molecular biology intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 237 S. graph. Darst. |
| ISBN: | 1570592888 3540601481 |
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Datensatz im Suchindex
| _version_ | 1804124915602817024 |
|---|---|
| adam_text | MOLECULAR BIOLOGY INTELLIGENCE UNIT THE ESTROGEN RECEPTOR AS A TARGET
FOR RATIONAL DRUG DESIGN ERWIN VON ANGERER, PH.D. UNIVERSITAT REGENSBURG
INSTITUT FIXR PHARMAZIE REGENSBURG, GERMANY SPRINGER NEW YORK BERLIN
HEIDELBERG LONDON PARIS R.G. LANDES COMPANY TOKYO HONG KONG BARCELONA
BUDAPEST AUSTIN . CONTENTS = 1. INTRODUCTION 1 2. THE ESTROGEN RECEPTOR
5 OCCURRENCE AND FUNCTIONS 5 DETECTION AND STRUCTURAL ANALYSIS 7
ESTROGEN RECEPTOR MEDIATED CELLULAR EVENTS 11 3 . SCREENING OF DRUGS
ACTING VIA THE ESTROGEN RECEPTOR 19 4. SYNTHETIC ESTROGENS 31
THERAPEUTIC APPLICATIONS OF ESTROGENS 31 STEROIDAL STRUCTURES 32
NONSTEROIDAL STRUCTURES 34 NEW DEVELOPMENTS IN THE DESIGN OF STEROIDAL
ESTROGENS 36 NEW NONSTEROIDAL ESTROGENS 41 5. COMPOUNDS ACTING AS MIXED
AGONISTS/ANTAGONISTS 49 NONSTEROIDAL AGENTS 49 TRIPHENYLETHYLENE
DERIVATIVES RELATED TO TAMOXIFEN 50 FIXED-RING ANALOGUES OF TAMOXIFEN 59
1,1-DIPHENYLETHYLENE DERIVATIVES 71 1,2-DIPHENYLETHYLENE DERIVATIVES 73
2-PHENYLINDOLES AND RELATED HETEROCYCLES 76 CONCLUSIONS 83 STEROIDAL
COMPOUNDS 85 6. DEVELOPMENT OF PURE ANTIESTROGENS 97 PURE ANTIESTROGENS
BASED ON ESTRADIOL 97 HP-SUBSTITUTED STEROIDS 105 PURE ANTIESTROGENS
WITH NONSTEROIDAL STRUCTURES 113 OTHER NONSTEROIDAL STRUCTURES 119 7.
STRUCTURAL REQUIREMENTS FOR BINDING TO THE ESTROGEN RECEPTOR 127 8. THE
ESTROGEN RECEPTOR AS A TARGET FOR CYTOTOXIC AGENTS 137 ALKYLATING AGENTS
138 PLATINUM COMPLEXES 143 POTENTIAL DNA-INTERCALATING AGENTS 148 9.
RADIOISOTOPE-LABELED LIGANDS FOR THE ESTROGEN RECEPTOR 159
IODINE-125-LABELED LIGANDS OF THE ESTROGEN RECEPTOR ** 161 ESTROGENS
LABELED WITH OTHER RADIOISOTOPES 164 10. RADIOISOTOPE-LABELED ESTROGENS
FOR SYSTEMIC RADIOTHERAPY... 179 11. DESIGN OF DRUGS BINDING COVALENTLY
TO THE ESTROGEN RECEPTOR (RECEPTOR LABELING) 189 RADIOISOTOPE-LABELED
AGENTS 189 FLUORESCENT LABELS FOR THE ESTROGEN RECEPTOR 198
ANTIBODY-BASED LABELS 203 12. NONHORMONAL ACTIVATION OF THE ESTROGEN
RECEPTOR 211 MODULATION OF INTRACELLULAR CAMP LEVELS 211 INSULIN-LIKE
GROWTH FACTOR 1 214 OTHER GROWTH FACTORS 217 13. CONCLUSION AND FUTURE
DIRECTIONS 225 INDEX
|
| any_adam_object | 1 |
| author | Angerer, Erwin von |
| author_facet | Angerer, Erwin von |
| author_role | aut |
| author_sort | Angerer, Erwin von |
| author_variant | e v a ev eva |
| building | Verbundindex |
| bvnumber | BV010482056 |
| callnumber-first | R - Medicine |
| callnumber-label | RM295 |
| callnumber-raw | RM295 |
| callnumber-search | RM295 |
| callnumber-sort | RM 3295 |
| callnumber-subject | RM - Therapeutics and Pharmacology |
| classification_rvk | VS 5350 YM 3100 |
| ctrlnum | (OCoLC)32778816 (DE-599)BVBBV010482056 |
| dewey-full | 615/.366 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615/.366 |
| dewey-search | 615/.366 |
| dewey-sort | 3615 3366 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| format | Book |
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| indexdate | 2024-07-09T17:53:15Z |
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| spelling | Angerer, Erwin von Verfasser aut The estrogen receptor as a target for rational drug design Erwin von Angerer New York [u.a.] Springer [u.a.] 1995 237 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit Antiestrogènes - Emploi en thérapeutique ram Antiestrogènes ram Estrogènes - Récepteurs ram Drug Design Estradiol Congeners therapeutic use Estrogen Antagonists Estrogen Agonists Therapeutic use Testing Estrogen Antagonists Therapeutic use Testing Estrogen Receptors Receptors, Estrogen metabolism Antiöstrogene (DE-588)4142728-2 gnd rswk-swf Östrogene (DE-588)4075616-6 gnd rswk-swf Arzneimittel (DE-588)4003115-9 gnd rswk-swf Pharmakotherapie (DE-588)4076066-2 gnd rswk-swf Arzneimittelentwicklung (DE-588)4143176-5 gnd rswk-swf Östrogenrezeptor (DE-588)4172467-7 gnd rswk-swf Chemische Synthese (DE-588)4133806-6 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Östrogenrezeptor (DE-588)4172467-7 s Pharmakotherapie (DE-588)4076066-2 s DE-604 Arzneimittelentwicklung (DE-588)4143176-5 s Östrogene (DE-588)4075616-6 s Chemische Synthese (DE-588)4133806-6 s Arzneimittel (DE-588)4003115-9 s Antiöstrogene (DE-588)4142728-2 s GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006985162&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Angerer, Erwin von The estrogen receptor as a target for rational drug design Antiestrogènes - Emploi en thérapeutique ram Antiestrogènes ram Estrogènes - Récepteurs ram Drug Design Estradiol Congeners therapeutic use Estrogen Antagonists Estrogen Agonists Therapeutic use Testing Estrogen Antagonists Therapeutic use Testing Estrogen Receptors Receptors, Estrogen metabolism Antiöstrogene (DE-588)4142728-2 gnd Östrogene (DE-588)4075616-6 gnd Arzneimittel (DE-588)4003115-9 gnd Pharmakotherapie (DE-588)4076066-2 gnd Arzneimittelentwicklung (DE-588)4143176-5 gnd Östrogenrezeptor (DE-588)4172467-7 gnd Chemische Synthese (DE-588)4133806-6 gnd |
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| title | The estrogen receptor as a target for rational drug design |
| title_auth | The estrogen receptor as a target for rational drug design |
| title_exact_search | The estrogen receptor as a target for rational drug design |
| title_full | The estrogen receptor as a target for rational drug design Erwin von Angerer |
| title_fullStr | The estrogen receptor as a target for rational drug design Erwin von Angerer |
| title_full_unstemmed | The estrogen receptor as a target for rational drug design Erwin von Angerer |
| title_short | The estrogen receptor as a target for rational drug design |
| title_sort | the estrogen receptor as a target for rational drug design |
| topic | Antiestrogènes - Emploi en thérapeutique ram Antiestrogènes ram Estrogènes - Récepteurs ram Drug Design Estradiol Congeners therapeutic use Estrogen Antagonists Estrogen Agonists Therapeutic use Testing Estrogen Antagonists Therapeutic use Testing Estrogen Receptors Receptors, Estrogen metabolism Antiöstrogene (DE-588)4142728-2 gnd Östrogene (DE-588)4075616-6 gnd Arzneimittel (DE-588)4003115-9 gnd Pharmakotherapie (DE-588)4076066-2 gnd Arzneimittelentwicklung (DE-588)4143176-5 gnd Östrogenrezeptor (DE-588)4172467-7 gnd Chemische Synthese (DE-588)4133806-6 gnd |
| topic_facet | Antiestrogènes - Emploi en thérapeutique Antiestrogènes Estrogènes - Récepteurs Drug Design Estradiol Congeners therapeutic use Estrogen Antagonists Estrogen Agonists Therapeutic use Testing Estrogen Antagonists Therapeutic use Testing Estrogen Receptors Receptors, Estrogen metabolism Antiöstrogene Östrogene Arzneimittel Pharmakotherapie Arzneimittelentwicklung Östrogenrezeptor Chemische Synthese Aufsatzsammlung |
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