Interleukin 6 type cytokines: [this volume is the result of a conference ... held in Poznań, Poland, June 19 - 22, 1994]
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| Format: | Buch |
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| Sprache: | English |
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New York, NY
New York Acad. of Sciences
1995
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| Schriftenreihe: | Annals of the New York Academy of Sciences
762 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XV, 522 S. Ill., zahlr. graph. Darst. |
| ISBN: | 0897669312 0897669320 |
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Datensatz im Suchindex
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| adam_text | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 762
July 21, 1995
INTERLEUKIN 6 TYPE CYTOKINES
Editors and Conference Organizers
Andrzej Mackiewicz, Aleksander Koj, and Pravin B. Sehgal
CONTENTS
Preface. By Andrzej Mackiewicz, Aleksander Koj, and Pravin B.
Sehgal xiii
Welcoming Remarks. By J. Gadzinowski xv
Part I. The Cytokines
Interleukin 6 Type Cytokines. By Pravin B. Sehgal, Ling Wang, Ravi
Rayanade, Heng Pan, and Lola Margulies 1
Transcription Factors NF IL6 and APRF Involved in gpl30 mediated
Signaling Pathway. By S. Akira, Y. Nishio, T. Tanaka, M. Inoue,
T. Matsusaka, X. J. Wang, S. Wei, N. Yoshida, and
T. Kishimoto 15
LIF and Related Cytokines in the Regulation of Mammalian Development.
By Colin L. Stewart and Emily Cullinan 29
Interleukin (IL) ll mediated Signal Transduction. By Yu Chung Yang and
Tinggui Yin 31
In Vivo Properties of Oncostatin M. By Philip M. Wallace, John F.
MacMaster, Jill R. Rillema, Katherine A. Rouleau, Marcia B.
Hanson, Samuel A. Burstein, and Mohammed Shoyab 42
Signal Transduction through IL 6 Receptor: Involvement of Multiple
Protein Kinsases, Stat Factors, and a Novel H7 sensitive Pathway. By
Koichi Nakajima, Tadashi Matsuda, Yoshio Fujitani, Hirotada
Kojima, Yojiro Yamanaka, Kazuto Nakae, Takashi Takeda, and
Toshio Hirano 55
Part II. Expression and Cytokine Networks
Cytokine Networks and Corticosteroid Receptors. By A. Falus, J. Biro,
and E. RakAsz 71
Regulation of Interleukin 6 Gene Expression by Steroids. By Anuradha
Ray, Dong Hong Zhang, Mark D. Siegel, and Prabir Ray .... 79
Interleukin 11 in Respiratory Inflammation. By O. Einarsson, G. P. Geba,
Z. Zhou, M. L. Landry, R. A. Panetteeri, Jr., D. Tristram,
R. Welliver, A. Metinko, and J. A. Elias 89
* This volume is the result of a conference entitled Interleukin 6 Type Cytokines sponsored
by the New York Academy of Sciences and the State Committee for Scientific Research, Warsaw,
Poland and held in Poznari, Poland June 19 22, 1994.
Do Post transcriptional Mechanisms Participate in Induction of C reactive
Protein and Serum Amyloid A by IL 6 and IL 1 ? By Irving Kushner,
Shun lin Jiang, Dongxiao Zhang, Gerard Lozanski, and David
Samols 102
Modified Proteins as Possible Signals in the Acute Phase Response. By
Aleksander Koj and Amalia Guzdek 108
Part III. Structure Function Relationships
Interleukin 6 Chaperones in Blood. By Lester T. May, Mackevin I.
Ndubuisi, Kirit Patel, and Dorys Garcia 120
Development of Human IL 6 Receptor Antagonists. By P. J. Brakenhoff,
Floris D. De Hon, and Lucien A. Aarden 129
The Molecular Design of Human IL 6 Receptor Antagonists. By A. Lahm,
R. Savino, A. L. Salvati, A. Cabibbo, L. Ciapponi, A. Demartis,
C. Toniatti, G. Paonessa, S. Altamura, and G. Ciliberto 136
Alanine scanning Mutagenesis of Human Interleukin 11: Identification of
Regions Important for Biological Activity. By Marta Czupryn,
Frann Bennett, Jennifer Dube, Kathy Grant, Hubert Scoble,
Hemchand Sookdeo, and John M. McCoy 152
Inter Species Chimeras of Leukemia Inhibitory Factor Define a Human
Receptor Binding Site. By Catherine M. Owczarek, Meredith J.
Layton, Donald Metcalf, Roslyn Clark, Nicholas M. Gough,
and Nicos A. Nicola 165
The Crystal Structure of Murine Leukemia Inhibitory Factor. By R. C.
Robinson, L. M. Grey, D. Staunton, D. I. Stuart, J. K. Heath,
and E. Y. Jones 179
Part IV. Receptors and Signal Transducers
Function of Hematopoietin Receptor Subunits in Hepatic Cells and
Fibroblasts. By Chun Fai Lai, Karen K. Morella, Yanping Wang,
Satoru Kumaki, David Gearing, Steven F. Ziegler, David J.
TWEARDY, SUSANA P. CAMPOS, AND HEINZ BAUMANN 189
The Soluble Interleukin 6 Receptor. By Stefan Rose John, Marc Ehlers,
Joachim Grotzinger, and Jurgen Mullberg 207
Membrane bound and Soluble Interleukin 6 Receptor: Studies on Structure,
Regulation of Expression, and Signal Transduction. By Peter C.
Heinrich, Lutz Graeve, Stefan Rose John, Jens Schneider
Mergener, Elke DrrTRicH, Andrea Erren, Claudia Gerhartz,
Ulrike Hemmann, Claudia Lutticken, Ursula Wegenka,
Oliver Weiergraber, and Friedemann Horn 222
Transcription Factors as Targets of Cytokine Signals. By Warren S. L.
Liao, Szu Yao Lu, Jianyi Huang, Li Li, and Zhanyong Bing . . . 238
Isolation of Two Interleukin 6 Response Element Binding Proteins from
Acute Phase Rat Livers. By Jurgen Ripperger, Stefan Fritz, Karin
rlchter, blrgit dreier, kurt schneider, k.laus l6chner, rolf
Marschalek, Gertrud Hocke, Friedrich Lottspeich, and
Georg H. Fey 252
Functional Analysis ofIL 6 and IL 6DBP/C/EBPP by Gene Targeting. By
Elena Fattori, Carolina Sellltto, Manuela Cappelletti,
Domenico Lazzaro, Diana Bella via, Isabella Screpanti,
Alberto Gulino, Frank Costantini, and Valeria Poli 262
Part V. In Vivo Physiology and Pathology
In Lethally Irradiated Mice Interleukin 12 Protects Bone Marrow but
Sensitizes Intestinal Tract to Damage from Ionizing Radiation. By
R. Neta, S. M. Stiefel, and N. Ali 274
Adenovirus Vectors for Cytokine Gene Expression. By Carl D. Richards,
Todd Braciak, Zhou Xing, Frank Graham, and Jack Gauldie . . 282
Interleukin 6 Type Cytokines in Myeloproliferative Disease. By Robert G.
Hawley 294
Pleiotropic Defects of IL 6 deficient Mice Including Early Hematopoiesis, T
and B Cell Function, and Acute Phase Responses. By Manfred Kopf,
Alistair Ramsay, Frank Brombacher, Heinz Baumann, Giulia
Freer, Chris Galanos, Jose Carlos Gutierrez Ramos, and
Georges Kohler 308
Interleukin 6 Type Cytokine induced Changes in Acute Phase Protein
Glycosylation. By Willem Van Dijk and Andrzej Mackiewicz .... 319
Co ordinate Inhibition of the Production of TNF, IL 1, and IL 6 by Small
Molecules. By Anthony C. Allison and Elsie M. Eugui 331
Part VI. Preclinical and Clinical Therapeutics
Interleukin 6: Effects on Tumor Models in Mice and on the Cellular
Regulation of Transcription Factor IRF 1. By Michel Revel, Anne
Katz, Lea Eisenbach, Michael Feldman, Nechama Haran
Ghera, Sheila Harroch, and Judith Chebath 342
Clinical Trials with IL 6. By Jeffrey S. Weber 357
Phase IA/IB Evaluation of Mammalian Cell derived Glycosylated
Recombinant Human Interleukin (SIGOSIX) before and after Cytotoxic
Chemotherapy. By P. S. Rttch, C. Keever, J. Schiller, S. Rivkin,
P. L. Witt, S. E. Grossberg, R. L. Truitt, H. Burris, D. D. Von
Hoff, L. Vaickus, D. Drechsler, E. C. Borden, A. Galazka, J. B.
Breitmeyer, and A. Abdul Ahad 359
Interleukin 6 Type Cytokines and Their Receptors for Gene Therapy of
Melanoma. By Andrzej Mackiewicz, Maciej Wiznerowicz, Elke
ROEB, JERZY NOWAK, TOMASZ PAWLOWSKI, HEINZ BAUMANN, PETER
C. Heinrich, and Stefan Rose John 361
Interleukin 6 Type Cytokines in Diagnostics and Therapeutics: Roundtable
Discussion. Participants: Ayad Abdul Ahad, Heinz Baumann, Jack
A. Elias, Georg Fey, Michael S. Gordon, Peter C. Heinrich,
Friedemann Horn, Aleksander Koj, Manfred Kopf, Valeria
Poli, Michel Revel, Pravin B. Sehgal, Philip M. Wallace, and
Jeffrey S. Weber 375
Poster Papers
Increase of High Molecular Weight Fibrinogen after Surgery for Renal
Cancer. By G. Adler, W. Eichman, I. Targonska, and M.
Szczepanski 388
Interleukin 6 Production in Children with Acute Lymphoblastic Leukemia.
By A. Chybicka, J. Boguslawska Jaworska, and W. Jaworski . . . 391
Selectin P (PADGEM, GMP 140) mediated Adhesion of Human Platelets
to Neutrophils in Vitro and Immune Complex induced Peritonitis in
Rats is Influenced by Interleukin 8. By A. Dembinska Kiec, M.
BURCHERT, J. DULAK, M. POLUS, M. PAWELEC, A. SlEDLECKI, AND
B. A. Peskar 395
Blood Serum Concentration of C Reactive Protein and Interleukin 6 in
Diagnosis of Neonatal Infection. By K. Drews, J. Szczapa, J. Zak,
R. Andrzejewska, L. Zak, and A. Mackiewicz 398
Residues 77 95 of the Human Interleukin 6 Protein Are Responsible for
Receptor Binding and Residues 41 56 for Signal Transduction. By
Marc Ehlers, Joachim Grotzinger, Floris D. De Hon, Jurgen
Mullberg, Just P. J. Brakenhoff, Axel Wollmer, and Stefan
Rose John 400
Interleukin 6 and Interleukin 6 Receptor mRNA Expression in Rat Central
Nervous System. By R. A. Gadient and U. Otten 403
ELISA Detection of Circulating Levels of LIF, OSM, and CNTF in Septic
Shock. By Catherine Guillet, Maryvonne Fourcin, Sylvie
Chevalier, Annick Pouplard, and Hugues Gascan 407
A Region within the Cytoplasmic Domain of the Interleukin 6 Signal
Transducer gpl30 Important for Ligand induced Endocytosis of the IL
6 Receptor. By Elke Dittrich, Claudia Gerhartz, Stefan Rose
John, Jurgen Mullberg, Tanja Stoyan, Peter C. Heinrich, and
Lutz Graeve 410
Interleukin 6 Type Cytokines Affect Glycosylation of Acute Phase Proteins
in Vitro. By Katarzyna Gryska, Artur Slupianek, Maria Laciak,
Heinz Baumann, and Andrzej Mackiewicz 413
Cytokines and the Activity of Tyrosine Aminotransferase and Superoxide
Dismutase in Rat Hepatoma Cells in Culture. By Amalia Guzdek,
Krystyna Stalinska, and Joanna Bereta 416
Effects of HGF and RA on the Class 1 and Class 2 Rat Acute Phase
Proteins. By Amalia Guzdek and Aleksander Koj 419
Structural and Biological Chracterization of Murine Human Interleukin 6
Chimeras. By A. Hammacher, L. D. Ward, J. Weinstock, and R. J.
Simpson 422
Renal Mesangial Cells Have the Capacity to Synthesize and React to
Leukemia Inhibitory Factor. By A. Hartner, M. Goppelt Strube,
G. M. Hocke, G. H. Fey, and R. B. Sterzel 424
The LIF Response Element Confers LIF induced Transcriptional Control in
P19 Embryonal Carcinoma Cells. By Gertrud M. Hocke 426
Pituitary Glycoprotein Hormones and Interleukins Secretion: In Vitro and
in Vivo Human Study. By J. Komorowski, M. Pawlikowski, and H.
Stepien 429
Serum Levels of IL 6 in Mycosis Fungoides, Psoriasis, and Lichen Planus.
By B. Toruniowa, D. Krasowska, M. Koziot, A. Ksiazek, and
A. PlETRZAK 432
Interleukin 6 and Interleukin 4 related Proteins (C reactive Protein and
IgE) Are Prognostic Factors of Asbestos related Cancer. By A. Lange,
L. Karabon, and J. Tomeczko 435
IL 6 Is Present in Sera of Bone Marrow transplanted Patients in Aplastic
Period, and High Levels of IL 6 During Acute Graft versus Host
Disease Are Associated with Severe Gut Symptoms. By L. Karabon,
A. Moniewska, A. Laba, C. Swider, and A. Lange 439
Plasma Acute Phase Proteins and Metalloproteins in Children with
Neuroblastoma at Diagnosis. By L. Lipinska, T. Izbicki, T.
Laskowska Klita, and D. Perek 443
The Value of Determining the Interleukin 6 Levels in Epithelial Ovarian
Cancer. By J. Markowska, K. Wiktorowicz, Z. Szewierski, and
R. Madry 446
Immunohistochemical Localization of Interleukin 6 like Immunoreactivity to
Peripheral Nerve like Structures in Normal and Inflamed Human Skin.
By K. Nordlind, C. Libing, A. A. Ahmed, A. Ljungberg, and S.
Liden 450
Kinetics of the Activation of the LIF Response Factor in Ml Myeloid
Leukemic Cells. By R. P. Piekorz, R. BlAsius, G. H. Fey,
and G. M. Hocke 452
Interleukin 6 Levels in Sera and Bronchoalveolar Lavages of Patients with
Selected Disorders. By Z. Pojda, J. Struzyna, M. Maruszynski, T.
Plusa, and A. Jung 455
IL 6 Receptor mediated Growth Inhibition by All trans Retinoic Acid but
not by Interferon a in Human Myeloma Cells. By Kari Pulkki,
Marko Neva, Kari Koskela, Hanna Ollikainen, Kari Remes,
and Tarja Terttu Pelliniemi 457
Purification of the Interleukin 6 inducible Complex II Reveals Two Proteins
Capable of Binding to the IL 6 Response Element. By J. A. Ripperger,
S. Fritz, G. M. Hocke, and G. H. Fey 459
TIMP 1 Protein Expression Is Stimulated by IL ip and IL 2 in Primary Rat
Hepatocytes. By Elke Roeb, Lutz Graeve, Jurgen Mullberg,
Siegfried Matern, and Stefan Rose John 462
Changes in IL 6 Receptor Subunit mRNA Expression in Primary Mouse
Hepatocyte Cultures and Murine and Rat Hepatoma Cell Lines. By
Hanna Roktta, Piotr Pierzchalski, and Krystyna Stalinska . . 465
Diurnal Variations of Plasma Interleukin 6 in Man: Methodological
Implications of Continuous Use of Indwelling Cannulae. By Walther
Seiler, Hildegard Muller, and Cristoph Hiemke 468
Stoichiometry of the Interleukin 6 High Affinity Receptor Complex. By
L. D. Ward, G. J. Howlett, A. Hammacher, R. L. Moritz, and
R. J. Simpson 471
Interleukin 6 Serum Levels in Depressed Patients before and after Treatment
with Fluoxetine. By A. Sluzewska, J. K. Rybakowski, M. Laciak, A.
Macktewicz, M. Sobieska, and K. Wiktorowicz 474
Possible Relationship between Interleukin 6 and Response of
Immunoglobulin E to Surgical Trauma. By Andrew Szczeklik, Jacek
Jawien, Beda M. Stadler, Jadwiga Radwan, Wieslawa
PlWOWARSKA, AND AnTONI DziATKOWTAK 477
Molecular Cloning and Functional Expression of Mouse cDNAs Encoding
the Membrane Receptor and the Soluble Receptor for D Factor/LIF. By
Mikio Tomida 480
Monoclonal Antibodies Define Different Functional Epitopes on gpl30
Signal Transducer. By Sylvie Chevalier, Claude Clement, Olivier
Robledo, Bernard Klein, Hugues Gascan, and John Wijdenes . 482
Functional Reconstitution of IL 6 Signaling in a Myeloid Leukemic Cell
Line. By P. Wulf, R. P. Piekorz, and G. M. Hocke 485
Lesion induced Interleukin 6 mRNA Expression in Rat Sciatic Nerve. By
Jian Zhong and Rolf Heumann 488
Effect of Interferon a on Mitotic Index and Corticosterone Secretion in
Early Stage of Adrenal Cortex Regeneration. By Wojciech
ZlELENIEWSKI . 491
Acute Phase Proteins and Interleukin 6 Serum Levels in Patients with
Chronic Arterial Occlusion. By Waclaw Majewski, Ryszard
Staniszewski, Artur Slupianek, Aleksander Gorny, and
Andrzej Mackiewicz 493
Inflammatory Cytokines in Peritoneal Fluid of Women with Endometriosis.
By J. Skrzypczak, P. Jedrzejczak, M. Kasprzak, E. Puk, and
M. Kurpisz 496
Increased Resistance of CSF 1 deficient, Macrophage deficient, TNFa
deficient, and IL la deficient op/op Mice to Endotoxin. By
Malgorzata Szperl, Aftab A. Ansari, Elzbieta Urbanowska,
Przemyslaw Szwech, Pawel Kalinski, and Wieslaw Wiktor
Jedrzejczak 499
Characterization of the IL 6/LIF Response Factor by Proteolytic Analysis.
By K. Schneider, J. Ripperger, G. H. Fey, and G. M. Hocke .... 502
Acute Phase Response and Interleukin 6 after Operative Laparoscopy and
Microsurgery in Gynecology. By Krzysztof Drews, Krzysztof
Szymanowski, Jana Skrzpczak, Piotr Jedrzejczak, and
TomaszZak 505
Acute Phase Proteins in Endometriosis. By Krzysztof Drews, Jana
Skrzypczak, Tomasz Zak, Krzysztof Szymanowski, and Andrzej
Mackiewicz 508
Subject Index 511
Index of Contributors 519
Financial assistance was received from:
Supporters
• Academy of Medicine, Poznan
• Ares Serono, Switzerland
|
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| dewey-hundreds | 600 - Technology (Applied sciences) 500 - Natural sciences and mathematics |
| dewey-ones | 616 - Diseases 500 - Natural sciences and mathematics |
| dewey-raw | 616.079 500 |
| dewey-search | 616.079 500 |
| dewey-sort | 3616.079 |
| dewey-tens | 610 - Medicine and health 500 - Natural sciences and mathematics |
| discipline | Allgemeine Naturwissenschaft Medizin |
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| genre | (DE-588)1071861417 Konferenzschrift 1994 Posen gnd-content |
| genre_facet | Konferenzschrift 1994 Posen |
| id | DE-604.BV010437235 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:52:32Z |
| institution | BVB |
| isbn | 0897669312 0897669320 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006955567 |
| oclc_num | 246514732 |
| open_access_boolean | |
| owner | DE-12 DE-355 DE-BY-UBR DE-20 DE-188 |
| owner_facet | DE-12 DE-355 DE-BY-UBR DE-20 DE-188 |
| physical | XV, 522 S. Ill., zahlr. graph. Darst. |
| publishDate | 1995 |
| publishDateSearch | 1995 |
| publishDateSort | 1995 |
| publisher | New York Acad. of Sciences |
| record_format | marc |
| series | Annals of the New York Academy of Sciences |
| series2 | Annals of the New York Academy of Sciences |
| spelling | Interleukin 6 type cytokines [this volume is the result of a conference ... held in Poznań, Poland, June 19 - 22, 1994] ed. by Andrzej Mackiewicz ... Interleukin-6-type cytokines New York, NY New York Acad. of Sciences 1995 XV, 522 S. Ill., zahlr. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Annals of the New York Academy of Sciences 762 Cytokine (DE-588)4205701-2 gnd rswk-swf Interleukin 6 (DE-588)4246734-2 gnd rswk-swf Interleukine (DE-588)4162019-7 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1994 Posen gnd-content Interleukine (DE-588)4162019-7 s DE-604 Interleukin 6 (DE-588)4246734-2 s Cytokine (DE-588)4205701-2 s Mackiewicz, Andrzej Sonstige oth Annals of the New York Academy of Sciences 762 (DE-604)BV002532608 762 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006955567&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Interleukin 6 type cytokines [this volume is the result of a conference ... held in Poznań, Poland, June 19 - 22, 1994] Annals of the New York Academy of Sciences Cytokine (DE-588)4205701-2 gnd Interleukin 6 (DE-588)4246734-2 gnd Interleukine (DE-588)4162019-7 gnd |
| subject_GND | (DE-588)4205701-2 (DE-588)4246734-2 (DE-588)4162019-7 (DE-588)1071861417 |
| title | Interleukin 6 type cytokines [this volume is the result of a conference ... held in Poznań, Poland, June 19 - 22, 1994] |
| title_alt | Interleukin-6-type cytokines |
| title_auth | Interleukin 6 type cytokines [this volume is the result of a conference ... held in Poznań, Poland, June 19 - 22, 1994] |
| title_exact_search | Interleukin 6 type cytokines [this volume is the result of a conference ... held in Poznań, Poland, June 19 - 22, 1994] |
| title_full | Interleukin 6 type cytokines [this volume is the result of a conference ... held in Poznań, Poland, June 19 - 22, 1994] ed. by Andrzej Mackiewicz ... |
| title_fullStr | Interleukin 6 type cytokines [this volume is the result of a conference ... held in Poznań, Poland, June 19 - 22, 1994] ed. by Andrzej Mackiewicz ... |
| title_full_unstemmed | Interleukin 6 type cytokines [this volume is the result of a conference ... held in Poznań, Poland, June 19 - 22, 1994] ed. by Andrzej Mackiewicz ... |
| title_short | Interleukin 6 type cytokines |
| title_sort | interleukin 6 type cytokines this volume is the result of a conference held in poznan poland june 19 22 1994 |
| title_sub | [this volume is the result of a conference ... held in Poznań, Poland, June 19 - 22, 1994] |
| topic | Cytokine (DE-588)4205701-2 gnd Interleukin 6 (DE-588)4246734-2 gnd Interleukine (DE-588)4162019-7 gnd |
| topic_facet | Cytokine Interleukin 6 Interleukine Konferenzschrift 1994 Posen |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006955567&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002532608 |
| work_keys_str_mv | AT mackiewiczandrzej interleukin6typecytokinesthisvolumeistheresultofaconferenceheldinpoznanpolandjune19221994 AT mackiewiczandrzej interleukin6typecytokines |