Molecular biology and pharmacology of the endothelins:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York u.a.
Springer
1995
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 173 S. Ill., graph. Darst. |
| ISBN: | 3540594256 |
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Datensatz im Suchindex
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| adam_text | MOLECULAR BIOLOGY INTELLIGENCE UNIT MOLECULAR BIOLOGY AND PHARMACOLOGY
OF THE ENDOTHELINS GILLIAN A. GRAY, PH.D. DAVID J. WEBB, M.D. UNIVERSITY
DEPARTMENT OF MEDICINE WESTERN GENERAL HOSPITAL EDINBURGH, SCOTLAND,
U.K. M V I D I U ML I A V * R-G. UNDES COMPANY NEW YORK BERLIN
HEIDELBERG LONDON PANS U TOKYO HONG KONG BARCELONA BUDAPEST AUST1N
CONTENTS SECTION I: MOLECULAR BIOLOGY 1. DISCOVERY OF THE ENDOTHELIN
FAMILY OF PEPTIDES 3 DAVIDJ. WEBB HISTORICAL BACKGROUND 3 THE DISCOVERY
OF THE ENDOTHELINS 5 THE ENDOTHELIN FAMILY OF PEPTIDES 9 RELEVANCE AND
ACTIONS 9 FURTHER DEVELOPMENTS 11 2. GENERATION OF ENDOTHELIN 13 GILLIAN
A. GRAY STRUCTURAL ORGANIZATION AND TRANSCRIPTIONAL REGULATION OF THE ET
GENES 13 POST-TRANSLATIONAL PROCESSING OF PREPRO-ET 20 CLEARANCE AND
DEGRADATION OF THE ETS 28 FUTURE DIRECTIONS 28 3. MOLECULAR
CHARACTERIZATION OF ENDOTHELIN RECEPTORS 39 GILLIAN A. GRAY THE ET
RECEPTOR GENES 39 STRUCTURAL REQUIREMENTS FOR LIGAND BINDING AND
SELECTIVITY 45 DISTRIBUTION OF THE ET RECEPTOR GENES 50 ALTERATION OF ET
RECEPTOR GENE EXPRESSION AND STABILITY 52 FUTURE DIRECTIONS 53 SECTION
II: PHARMACOLOGY 4. PHARMACOLOGICAL CHARACTERIZATION OF ENDOTHELIN
RECEPTORS 61 GILLIAN A. GRAY FORMATION AND INTERNALIZATION OF THE
ET/RECEPTOR COMPLEX 62 RECEPTOR DOWN-REGULATION 63 STRUCTURAL FEATURES
THAT DETERMINE RECEPTOR SELECTIVITY 64 ENDOTHELIN RECEPTOR ANTAGONISTS
67 EVIDENCE FOR FURTHER SUBTYPES OF ET RECEPTOR 74 FUTURE DIRECTIONS 82
5. SIGNAL TRANSDUCTION MECHANISMS OF THE ENDOTHELINS 95 GILLIAN A. GRAY
G-PROTEINS 95 CALCIUM 97 PHOSPHOLIPASE C 100 PROTEIN KINASE C 100
PHOSPHOLIPASE A 2 101 PHOSPHOLIPASE D 102 TYROSINE KINASES 102 CYCLIC
AMP 102 NITRIC OXIDE AND CYCLIC GMP 103 NUCLEAR SIGNALING MECHANISMS 104
6. CARDIOVASCULAR PHARMACOLOGY OF THE ENDOTHELINS 115 PAULA J.W. SMITH,
WILLIAM G. HAYNES AND DAVID J. WEBB BLOOD PRESSURE 116 REGIONAL
PHARMACOLOGY 120 ECE AND ET GENERATION 126 PHYSIOLOGICAL ROLE OF ET L IN
MAINTENANCE OF VASCULAR TONE 128 FUTURE DIRECTIONS 134 7. THE
ENDOTHELINS IN CARDIOVASCULAR PATHOPHYSIOLOGY 147 DAVID J. WEBB AND
WILLIAM G. HAYNES HYPERTENSION 148 VASOSPASTIC DISORDERS 154 ISCHEMIC
HEART DISEASE 156 CHRONIC HEART FAILURE 157 RENAL FAILURE 158 FUTURE
DIRECTIONS 161 INDEX
|
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| indexdate | 2024-07-09T17:52:32Z |
| institution | BVB |
| isbn | 3540594256 |
| language | English |
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| physical | 173 S. Ill., graph. Darst. |
| publishDate | 1995 |
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| spelling | Molecular biology and pharmacology of the endothelins Gillian A. Gray ... New York u.a. Springer 1995 173 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biologia molecular larpcal Endotelinas (farmacologia) larpcal Endotelinas (fisiologia) larpcal Endothelinen gtt Farmacologia molecular larpcal Farmacologie gtt Moleculaire biologie gtt Endothelins Pathophysiology Endothelins pharmacology Endothelins physiology Endothilins Physiological effect Endothelin (DE-588)4255702-1 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Pharmakologie (DE-588)4045687-0 gnd rswk-swf Kardiovaskuläre Krankheit (DE-588)4024666-8 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Kardiovaskuläre Krankheit (DE-588)4024666-8 s Endothelin (DE-588)4255702-1 s DE-604 Molekularbiologie (DE-588)4039983-7 s Pharmakologie (DE-588)4045687-0 s Gray, Gillian A. Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006955302&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Molecular biology and pharmacology of the endothelins Biologia molecular larpcal Endotelinas (farmacologia) larpcal Endotelinas (fisiologia) larpcal Endothelinen gtt Farmacologia molecular larpcal Farmacologie gtt Moleculaire biologie gtt Endothelins Pathophysiology Endothelins pharmacology Endothelins physiology Endothilins Physiological effect Endothelin (DE-588)4255702-1 gnd Molekularbiologie (DE-588)4039983-7 gnd Pharmakologie (DE-588)4045687-0 gnd Kardiovaskuläre Krankheit (DE-588)4024666-8 gnd |
| subject_GND | (DE-588)4255702-1 (DE-588)4039983-7 (DE-588)4045687-0 (DE-588)4024666-8 (DE-588)4143413-4 |
| title | Molecular biology and pharmacology of the endothelins |
| title_auth | Molecular biology and pharmacology of the endothelins |
| title_exact_search | Molecular biology and pharmacology of the endothelins |
| title_full | Molecular biology and pharmacology of the endothelins Gillian A. Gray ... |
| title_fullStr | Molecular biology and pharmacology of the endothelins Gillian A. Gray ... |
| title_full_unstemmed | Molecular biology and pharmacology of the endothelins Gillian A. Gray ... |
| title_short | Molecular biology and pharmacology of the endothelins |
| title_sort | molecular biology and pharmacology of the endothelins |
| topic | Biologia molecular larpcal Endotelinas (farmacologia) larpcal Endotelinas (fisiologia) larpcal Endothelinen gtt Farmacologia molecular larpcal Farmacologie gtt Moleculaire biologie gtt Endothelins Pathophysiology Endothelins pharmacology Endothelins physiology Endothilins Physiological effect Endothelin (DE-588)4255702-1 gnd Molekularbiologie (DE-588)4039983-7 gnd Pharmakologie (DE-588)4045687-0 gnd Kardiovaskuläre Krankheit (DE-588)4024666-8 gnd |
| topic_facet | Biologia molecular Endotelinas (farmacologia) Endotelinas (fisiologia) Endothelinen Farmacologia molecular Farmacologie Moleculaire biologie Endothelins Pathophysiology Endothelins pharmacology Endothelins physiology Endothilins Physiological effect Endothelin Molekularbiologie Pharmakologie Kardiovaskuläre Krankheit Aufsatzsammlung |
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