Steroid receptors and antihormones: [this volume contains the papers from a conference ... in Dallas, Texas on September 20 - 23, 1994]
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
New York Acad. of Sciences
1995
|
| Schriftenreihe: | Annals of the New York Academy of Sciences
761 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XI, 416 S. Ill., zahlr. graph. Darst. |
| ISBN: | 0897669371 089766938X |
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| adam_text | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 761
June 12, 1995
STEROID RECEPTORS AND ANTIHORMONES a
Editors and Conference Chairs
David Henderson, Daniel Philibert, Arun K. Roy, and Georges Teutsch
CONTENTS
Preface. By the Editors xi
Part I. General Overview
Steroid Hormone Antagonists: Summary and Future Challenges. By
Elwood V. Jensen 1
General Structure Activity Correlations of Antihormones. By G.
Teutsch, F. Nique, G. Lemoine, F. Bouchoux, E. Cerede,
D. Gofflo, and D. Philibert 5
Part II. Steroid Receptor Structure and Function
Nuclear Hormone Receptors Activate Direct, Inverted, and Everted
Repeats. By Barry Marc Forman and Ronald M. Evans ... 29
Ubiquitous Receptor: Structures, Immunocytochemical Localization,
and Modulation of Gene Activation by Receptors for Retinoic
Acids and Thyroid Hormones. By Ching Song, Richard A.
Hiipakka, John M. Kokontis, and Shutsung Liao 38
Connection between Immunosuppressants and Steroids via HSP90.
By Etienne Emile Baulieu 50
Part III. Receptor Mediated Antihonnone Action
Section 1. Antagonism of Androgen Action
Local Inhibition of Sebaceous Gland Growth by Topically Applied
RU 58841. By Jonathan R. Matias and Martine Gaillard 56
Sex Steroids and Epidermal Growth Factor in Benign Prostatic
Hyperplasia (BPH). By F. Sciarra 66
This volume contains the papers from a conference entitled Steroid Receptors and Antihormones,
which was held by the New York Academy of Sciences in Dallas, Texas on September 20 23, 1994.
Casodex: Preclinical Studies and Controversies. By Barry J. A.
Furr 79
Regulation of Androgen Action by Receptor Gene Inhibition. By C.
S. Song, M. H. Jung, P. C. Supakar, S. Chen, R. L.
Vellanoweth, B. Chatterjee, and A. K. Roy 97
Section 2. Estrogen Antagonists
A New Interpretation of Antiestrogen Action. By Annemarie
Hedden, Volkmar Muller, and Elwood V. Jensen 109
Cellular Mechanisms Which Distinguish between Hormone and
Antihormone Activated Estrogen Receptor. By Donald P.
McDonnell, Sharon L. Dana, Patricia A. Hoener,
Benjamin A. Lieberman, Markus O. Imhof, and Robert B.
Stein 121
A Mutant Receptor as a Mechanism of Drug Resistance to
Tamoxifen Treatment. By V. Craig Jordan, William H.
Catherino, and Douglas M. Wolf 138
Responses to Pure Antiestrogens (ICI 164384, ICI 182780) in
Estrogen Sensitive and Resistant Experimental and Clinical
Breast Cancer. By R. I. Nicholson, J. M. W. Gee, D. L.
Manning, A. E. Wakeling, M. M. Montano, and B. S.
Katzenellenbogen 148
Exploration of the Therapeutic Potential of the Antiestrogen RU
58668 in Breast Cancer Treatment. By P. Van de Velde, F.
Nique, J. Bremaud, M C. Hameau, D. Philibert, and G.
Teutsch 164
Studies on Heterocycle Based Pure Estrogen Antagonists. By E.
Von Angerer, C. Biberger, and S. Leichtl 176
Section 3. Antiprogestins
Pharmacological Properties of a New Selective Antiprogestagen:
Org 33628. By H. J. Kloosterboer, G. H. Deckers, M. E.
de Gooyer, R. Dijkema, E. O. M. Orlemans, and W. G. E.
J. SCHOONEN 192
Mechanism of Action of Antiprogestins in the Pregnant Uterus. By
K. Chwalisz, K. Stockemann, U. Fuhrmann, K. H.
Fritzemeier, A. Einspanier, and R. E. Garfield 202
Differentiation Therapy with Progesterone Antagonists. By Horst
Michna, Karsten Parczyk, Martin R. Schneider, and
Yukishige Nishino 224
Clinical Uses of Mifepristone (MFP). By Andre Ulmann, Remi
Peyron, and Louise Silvestre 248
Section 4. Adrenocorticoid Antagonists
Glucocorticoid Antagonist RU 486 Reverses Agonist Induced
Apoptosis and C Myc Repression in Human Leukemic CEM
C7 Cells. By E. B. Thompson, R. Thulasi, M. F. Saeed, and
B. H. Johnson 261
The Influence of Antiglucocorticoids on Stress and Shock. By
George Lazar, George Lazar, Jr., Elizabeth Husztik,
Erno Duda, and Manjul K. Agarwal 276
The Glucocorticoid Receptor and RU 486 in Man. By Christoph
M. Bamberger and George P. Chrousos 296
Drospirenone: a Novel Progestogen with Antimineralocorticoid and
Antiandrogenic Activity. By Peter Muhn, Ulrike
FUHRMANN, KARL HEINRICH FRITZEMEIER, ROLF
Krattenmacher, and Ekkehard Schillinger 311
Poster Papers
Effects of Forskolin on Steroid Receptors. By N. Ribarac Stepic,
Z. Zakula, E. Isenovic, and D. T. Kanazir 336
Molecular Mechanism of Inhibition of Steroid Dehydrogenases by
Licorice Derived Steroid Analogs in Modulation of Steroid
Receptor Function. By D. Ghosh, Z. Wawrzak, V. Pletnev,
M. Erman, W. L. Duax, W. Pangborn, D W. Zhu, F.
Labrie, and S X. Lin 341
Biochemical Significance of the 6 s cis Conformation of the Steroid
Hormone la,25 Dihydroxyvitamin D3 Based on the
Provitamin D Skeleton. By William H. Okamura, M. Mark
Midland, Anthony W. Norman, Marion W. Hammond,
Murray C. Dormanen, and Ilka Nemere 344
Effects of a New Vitamin D Analog, EB 1089, on Osteoblastic
Cells. By Pekka H. Maenpaa, Tuna Jaaskelainen, and
Anitta Mahonen 349
Effects of Androgens and Antiandrogens on the Conformation of
the Androgen Receptor. By C. W. Kuil and E. Mulder 351
Raloxifene is a Tissue Selective Agonist/Antagonist That Functions
through the Estrogen Receptor. By R. Fuchs Young, A. L.
Glasebrook, L. L. Short, M. W. Draper, M. K. Rippy, H.
W. Cole, D. E. Magee, J. D. Termine, and H. U. Bryant ... 355
Inhibition of Nuclear Transport Is Not Essential for Inhibition of
Receptor Function by the Type II Estrogen Antagonist ICI
164,384. By Richard J. Miksicek, Connie Lee, Karen
Topp Rapiejko, and Sherry Neff 361
Mood Disorder in Women with Early Breast Cancer Taking
Tamoxifen, an Estradiol Receptor Antagonist: an Expected or
Unexpected Effect? By S. Shariff, C. E. Cumming, A. Lees,
M. Handman, and D. C. Cumming 365
Diethylstilbestrol (DES) Related Endocrine Disturbances in
Women: a Story with No End, Yet. By Johanna Assies, Jan
Vonk, Otto Bleker, and Lambertus Lumey 369
Estrogen/Antiestrogen Responsiveness in an In Vivo/In Vitro Model
for Myometrial Tumorigenesis. By S. R. Howe, J. I. Everitt,
M. M. Gottardis, and C. Walker 373
Vascular Endothelial Growth Factor (VEGF) in Primate
Endometrium: Immunohistochemical Patterns during the Cycle
and after Chronic RU 486 Treatment in Cynomolgus
Monkeys. By R. R. Greb, R. Bukowski, J. G. Hsiu, R. F.
Williams, G. D. Hodgen, and A. L. Goodman 376
Synthesis and Biological Activity of Novel Nonsteroidal
Progesterone Receptor Antagonists. By Lawrence G.
Hamann, Luc J. Farmer, Michael G. Johnson, Mark E.
Goldman, Dale E. Mais, Alenush Davtian, Steven L.
Bender, and Todd K. Jones 383
Glucocorticoid Receptors in Mouse Melanoma Cells. By A.
Ristic Fira, R. Djordjevic Markovic, M. Radojcic, N.
Ribarac Stepic, and D. T. Kanazir 388
The Effects of Glucocorticoid Receptor (GR) Blockade by RU
38486 and GR Protection by GTT on Hemorrhagic Shock in
Rats. By Xu Ren Bao, Wu Jan, Lu Jun Hua, Shi Han Pin,
Lin Chang Quan, and Gong Xiao Qi 391
Anabolic Steroids Induce Skeletal Muscle Injury and Immediate
Early Gene Expression through a Receptor Independent
Mechanism. By Sawsan R. Abu Shakra and Frank C.
Nachtman 395
Commonly Used Therapeutic Doses of Glucocorticoids Impair
Explicit Memory. By P. A. Keenan, M. W. Jacobson, R. M.
Soleymani, and J. W. Newcomer 400
Point Mutations in the 90 kDa Heat Shock Protein Binding Region
of the Glucocorticoid Receptor Affect the Functional
Characteristics of the Receptor. By Claudio A. Caamano, M.
Ines Morano, Friedrich C. Dalman, Mary T. Hoversten,
Stanley J. Watson, William B. Pratt, and Huda Akil 403
Dexamethasone Downregulates Mineralocorticoid Receptors in A6
Amphibian Kidney Cells in Tissue Culture. By Rodney D.
Hagley and Charles O. Watlington 405
Subject Index 409
Index of Contributors 415
Financial assistance was received from:
Supporters
• INSTTTUT SCIENTIFIQUE ROUSSEL
• SCHERING AG PHARMACEUTICAL RESEARCH
Contributors
• BERLEX BIOSCIENCES
• IMMUNEX RESEARCH AND DEVELOPMENT CORPORATION
• THE R. W. JOHNSON PHARMACEUTICAL RESEARCH INSTITUTE
• MERCK RESEARCH LABORATORIES
• ORGANON INTERNATIONAL B.V.
• PFIZER CENTRAL RESEARCH
The New York Academy of Sciences believes it has a responsibility to provide an open forum for
discussion of scientific questions. The positions taken by the participants in the reported conferences
are their own and not necessarily those of the Academy. The Academy has no intent to influence
legislation by providing such forums.
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| series2 | Annals of the New York Academy of Sciences |
| spelling | Steroid receptors and antihormones [this volume contains the papers from a conference ... in Dallas, Texas on September 20 - 23, 1994] ed. by David Henderson ... New York, NY New York Acad. of Sciences 1995 XI, 416 S. Ill., zahlr. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Annals of the New York Academy of Sciences 761 Pharmakologischer Antagonist (DE-588)4198682-9 gnd rswk-swf Struktur-Aktivitäts-Beziehung (DE-588)4183784-8 gnd rswk-swf Antagonist (DE-588)4198647-7 gnd rswk-swf Steroidhormonrezeptor (DE-588)4057381-3 gnd rswk-swf Antihormon (DE-588)4002285-7 gnd rswk-swf Steroidhormon (DE-588)4057380-1 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1994 Dallas Tex. gnd-content (DE-588)1071861417 Konferenzschrift 1994 Dallas, Tex. gnd-content Steroidhormonrezeptor (DE-588)4057381-3 s Pharmakologischer Antagonist (DE-588)4198682-9 s DE-604 Steroidhormon (DE-588)4057380-1 s Antihormon (DE-588)4002285-7 s Struktur-Aktivitäts-Beziehung (DE-588)4183784-8 s DE-188 Antagonist (DE-588)4198647-7 s Henderson, David 1948- Sonstige (DE-588)1068676167 oth Annals of the New York Academy of Sciences 761 (DE-604)BV002532608 761 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006899989&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Steroid receptors and antihormones [this volume contains the papers from a conference ... in Dallas, Texas on September 20 - 23, 1994] Annals of the New York Academy of Sciences Pharmakologischer Antagonist (DE-588)4198682-9 gnd Struktur-Aktivitäts-Beziehung (DE-588)4183784-8 gnd Antagonist (DE-588)4198647-7 gnd Steroidhormonrezeptor (DE-588)4057381-3 gnd Antihormon (DE-588)4002285-7 gnd Steroidhormon (DE-588)4057380-1 gnd |
| subject_GND | (DE-588)4198682-9 (DE-588)4183784-8 (DE-588)4198647-7 (DE-588)4057381-3 (DE-588)4002285-7 (DE-588)4057380-1 (DE-588)1071861417 |
| title | Steroid receptors and antihormones [this volume contains the papers from a conference ... in Dallas, Texas on September 20 - 23, 1994] |
| title_auth | Steroid receptors and antihormones [this volume contains the papers from a conference ... in Dallas, Texas on September 20 - 23, 1994] |
| title_exact_search | Steroid receptors and antihormones [this volume contains the papers from a conference ... in Dallas, Texas on September 20 - 23, 1994] |
| title_full | Steroid receptors and antihormones [this volume contains the papers from a conference ... in Dallas, Texas on September 20 - 23, 1994] ed. by David Henderson ... |
| title_fullStr | Steroid receptors and antihormones [this volume contains the papers from a conference ... in Dallas, Texas on September 20 - 23, 1994] ed. by David Henderson ... |
| title_full_unstemmed | Steroid receptors and antihormones [this volume contains the papers from a conference ... in Dallas, Texas on September 20 - 23, 1994] ed. by David Henderson ... |
| title_short | Steroid receptors and antihormones |
| title_sort | steroid receptors and antihormones this volume contains the papers from a conference in dallas texas on september 20 23 1994 |
| title_sub | [this volume contains the papers from a conference ... in Dallas, Texas on September 20 - 23, 1994] |
| topic | Pharmakologischer Antagonist (DE-588)4198682-9 gnd Struktur-Aktivitäts-Beziehung (DE-588)4183784-8 gnd Antagonist (DE-588)4198647-7 gnd Steroidhormonrezeptor (DE-588)4057381-3 gnd Antihormon (DE-588)4002285-7 gnd Steroidhormon (DE-588)4057380-1 gnd |
| topic_facet | Pharmakologischer Antagonist Struktur-Aktivitäts-Beziehung Antagonist Steroidhormonrezeptor Antihormon Steroidhormon Konferenzschrift 1994 Dallas Tex. Konferenzschrift 1994 Dallas, Tex. |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006899989&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002532608 |
| work_keys_str_mv | AT hendersondavid steroidreceptorsandantihormonesthisvolumecontainsthepapersfromaconferenceindallastexasonseptember20231994 |